CA2271769A1 - Use of conotoxin peptides imi and mii as cardiovascular agents - Google Patents

Use of conotoxin peptides imi and mii as cardiovascular agents Download PDF

Info

Publication number
CA2271769A1
CA2271769A1 CA002271769A CA2271769A CA2271769A1 CA 2271769 A1 CA2271769 A1 CA 2271769A1 CA 002271769 A CA002271769 A CA 002271769A CA 2271769 A CA2271769 A CA 2271769A CA 2271769 A1 CA2271769 A1 CA 2271769A1
Authority
CA
Canada
Prior art keywords
conotoxin
waves
mii
neurones
imi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002271769A
Other languages
English (en)
French (fr)
Inventor
J. Michael Mcintosh
Baldomero M. Olivera
Doju Yoshikami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2271769A1 publication Critical patent/CA2271769A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002271769A 1996-11-18 1997-11-17 Use of conotoxin peptides imi and mii as cardiovascular agents Abandoned CA2271769A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3114196P 1996-11-18 1996-11-18
US60/031,141 1996-11-18
PCT/US1997/020669 WO1998022126A1 (en) 1996-11-18 1997-11-17 USE OF CONOTOXIN PEPTIDES ImI AND MII AS CARDIOVASCULAR AGENTS

Publications (1)

Publication Number Publication Date
CA2271769A1 true CA2271769A1 (en) 1998-05-28

Family

ID=21857857

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002271769A Abandoned CA2271769A1 (en) 1996-11-18 1997-11-17 Use of conotoxin peptides imi and mii as cardiovascular agents

Country Status (5)

Country Link
EP (1) EP0948346A4 (de)
JP (1) JP2001505878A (de)
AU (1) AU735724B2 (de)
CA (1) CA2271769A1 (de)
WO (1) WO1998022126A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2308115A1 (en) * 1997-10-24 1999-05-06 University Of Utah Research Foundation Interaction of alpha-conotoxin peptides with neuronal nicotinic acetylcholine receptors
AUPP627498A0 (en) * 1998-10-02 1998-10-22 University Of Queensland, The Novel peptides - i
US6797808B1 (en) * 1999-01-29 2004-09-28 University Of Utah Research Foundation α-conotoxin peptides
CA2743116C (en) * 1999-01-29 2016-06-21 University Of Utah Research Foundation Alpha-conotoxin peptides with a 4/7 motif
US7851444B2 (en) 2002-12-02 2010-12-14 Xenome Ltd. χ-conotoxin peptides (-1)
EP2386566A3 (de) 2002-12-02 2012-02-15 Xenome Ltd Chi-Conotoxin-Peptide (II)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189020A (en) * 1989-11-22 1993-02-23 Neurex Corporation Method of reducing neuronal damage using omega conotoxin peptides
GB2262886B (en) * 1991-12-17 1995-09-06 Lilly Industries Ltd N-channel calcium antagonists useful for treating bronchial diseases
US5514774A (en) * 1993-06-29 1996-05-07 University Of Utah Research Foundation Conotoxin peptides

Also Published As

Publication number Publication date
AU735724B2 (en) 2001-07-12
EP0948346A1 (de) 1999-10-13
EP0948346A4 (de) 2004-05-12
JP2001505878A (ja) 2001-05-08
AU5255598A (en) 1998-06-10
WO1998022126A1 (en) 1998-05-28

Similar Documents

Publication Publication Date Title
Kuffler et al. Peptidergic and muscarinic excitation at amphibian sympathetic synapses.
Wang et al. Inhibition of neurons in the amygdala by dorsal raphe stimulation: mediation through a direct serotonergic pathway
Rock et al. Gabapentin actions on ligand-and voltage-gated responses in cultured rodent neurons
Ascher Inhibitory and excitatory effects of dopamine on Aplysia neurones
Trimmer et al. Effects of nicotinic and muscarinic agents on an identified motoneurone and its direct afferent inputs in larval Manduca sexta
Diochot et al. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis
Hill et al. Depression of nociceptive and other neurones in the brain by iontophoretically applied met-enkephalin
Gallagher et al. Cholinergic transmission in cat parasympathetic ganglia.
Benabid et al. Thalamic nucleus ventro-postero-lateralis inhibits nucleus parafascicularis response to noxious stimuli through a non-opioid pathway
Galligan et al. Differential localization of 5-HT1 receptors on myenteric and submucosal neurons
Waterhouse et al. Interaction of serotonin with somatosensory cortical neuronal responses to afferent synaptic inputs and putative neurotransmitters
Fujimoto et al. Calcium localization in the sympathetic ganglion of the bullfrog and effects of caffeine
Green et al. Antinociception opioids and the cholinergic system
Margineanu et al. ucb L059, a novel anticonvulsant, reduces bicuculline-induced hyperexcitability in rat hippocampal CA3 in vivo
Catacuzzeno et al. Ion channels in glioma malignancy
AU735724B2 (en) Use of conotoxin peptides ImI and MII as cardiovascular agents
Sah et al. Long-term blockade by toxin F of nicotinic synaptic potentials in cultured sympathetic neurons
Zhao et al. Idazoxan blocks the action of noradrenaline but not spinal inhibition from electrical stimulation of the locus coeruleus and nucleus Kolliker-Fuse of the cat
Sawynok et al. Role of ascending and descending noradrenergic pathways in the antinociceptive effect of baclofen and clonidine
Tebēcis Properties of cholinoceptive neurones in the medial geniculate nucleus
Suzuki et al. Hyperpolarizing potentials induced by Ca‐mediated K‐conductance increase in hamster submandibular ganglion cells
Jones et al. Spontaneous activity mediated by NMDA receptors in immature rat entorhinal cortex in vitro
Schulman Anatomical distribution and physiological effects of enkephalin in rat inferior olive
Curtis et al. Cocaine effects on brain noradrenergic neurons of anesthetized and unanesthetized rats
Randic et al. Effects of substance P analogues on spinal dorsal horn neurons

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead