CA2271750A1 - Prolonged anesthesia in joints and body spaces - Google Patents
Prolonged anesthesia in joints and body spaces Download PDFInfo
- Publication number
- CA2271750A1 CA2271750A1 CA002271750A CA2271750A CA2271750A1 CA 2271750 A1 CA2271750 A1 CA 2271750A1 CA 002271750 A CA002271750 A CA 002271750A CA 2271750 A CA2271750 A CA 2271750A CA 2271750 A1 CA2271750 A1 CA 2271750A1
- Authority
- CA
- Canada
- Prior art keywords
- local anesthetic
- body spaces
- joints
- sustained release
- augmenting agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010002091 Anaesthesia Diseases 0.000 title 1
- 230000037005 anaesthesia Effects 0.000 title 1
- 230000002035 prolonged effect Effects 0.000 title 1
- 239000003589 local anesthetic agent Substances 0.000 abstract 3
- 230000003190 augmentative effect Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000013268 sustained release Methods 0.000 abstract 2
- 239000012730 sustained-release form Substances 0.000 abstract 2
- 238000002690 local anesthesia Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Sustained release local anesthetic formulations are administered intra articularly and/or into body spaces/cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release material prolonging the release of the local anesthetic and optionally a pharmaceutically acceptable, i.e., non-toxic, augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable without the augmenting agent.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5160197P | 1997-07-02 | 1997-07-02 | |
US60/051,601 | 1997-07-02 | ||
PCT/US1998/014000 WO1999001114A1 (en) | 1997-07-02 | 1998-07-02 | Prolonged anesthesia in joints and body spaces |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2271750A1 true CA2271750A1 (en) | 1999-01-14 |
CA2271750C CA2271750C (en) | 2004-04-27 |
Family
ID=21972300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002271750A Expired - Fee Related CA2271750C (en) | 1997-07-02 | 1998-07-02 | Prolonged anesthesia in joints and body spaces |
Country Status (10)
Country | Link |
---|---|
US (3) | US6248345B1 (en) |
EP (1) | EP1009390A4 (en) |
JP (1) | JP2000511941A (en) |
KR (1) | KR100367144B1 (en) |
AU (1) | AU739384B2 (en) |
BR (1) | BR9815499A (en) |
CA (1) | CA2271750C (en) |
IL (1) | IL129951A0 (en) |
NO (1) | NO992373L (en) |
WO (1) | WO1999001114A1 (en) |
Families Citing this family (197)
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AU733867B2 (en) | 1996-06-24 | 2001-05-31 | Euro-Celtique S.A. | Methods for providing safe local anesthesia |
AU739384B2 (en) | 1997-07-02 | 2001-10-11 | Euro-Celtique S.A. | Prolonged anesthesia in joints and body spaces |
EP1010435B1 (en) * | 1997-09-05 | 2010-11-03 | Maruho K.K. | Nanocapsule preparations for treating intraarticular diseases |
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US7973068B2 (en) * | 1998-10-20 | 2011-07-05 | Omeros Corporation | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation |
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WO2002032398A2 (en) * | 2000-10-16 | 2002-04-25 | Massachusetts Institute Of Technology | Lipid-protein-sugar particles for drug delivery |
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-
1998
- 1998-07-02 AU AU84765/98A patent/AU739384B2/en not_active Ceased
- 1998-07-02 BR BR9815499-0A patent/BR9815499A/en active Application Revival
- 1998-07-02 KR KR10-1999-7006120A patent/KR100367144B1/en not_active IP Right Cessation
- 1998-07-02 WO PCT/US1998/014000 patent/WO1999001114A1/en not_active Application Discontinuation
- 1998-07-02 EP EP98935543A patent/EP1009390A4/en not_active Withdrawn
- 1998-07-02 IL IL12995198A patent/IL129951A0/en not_active IP Right Cessation
- 1998-07-02 CA CA002271750A patent/CA2271750C/en not_active Expired - Fee Related
- 1998-07-02 US US09/109,324 patent/US6248345B1/en not_active Expired - Lifetime
- 1998-07-02 JP JP11507462A patent/JP2000511941A/en active Pending
-
1999
- 1999-05-18 NO NO992373A patent/NO992373L/en not_active Application Discontinuation
-
2001
- 2001-04-02 US US09/824,465 patent/US6534081B2/en not_active Expired - Fee Related
-
2003
- 2003-03-18 US US10/391,242 patent/US20030175357A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20000069908A (en) | 2000-11-25 |
US6534081B2 (en) | 2003-03-18 |
EP1009390A1 (en) | 2000-06-21 |
KR100367144B1 (en) | 2003-01-14 |
CA2271750C (en) | 2004-04-27 |
US6248345B1 (en) | 2001-06-19 |
IL129951A0 (en) | 2000-02-29 |
BR9815499A (en) | 2001-01-02 |
NO992373L (en) | 2000-02-22 |
JP2000511941A (en) | 2000-09-12 |
EP1009390A4 (en) | 2004-05-06 |
US20030175357A1 (en) | 2003-09-18 |
NO992373D0 (en) | 1999-05-18 |
US20020054915A1 (en) | 2002-05-09 |
AU8476598A (en) | 1999-01-25 |
WO1999001114A1 (en) | 1999-01-14 |
AU739384B2 (en) | 2001-10-11 |
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EEER | Examination request | ||
MKLA | Lapsed |