CA2256028A1 - Axial ejection in a multipole mass spectrometer - Google Patents

Axial ejection in a multipole mass spectrometer

Info

Publication number
CA2256028A1
CA2256028A1 CA002256028A CA2256028A CA2256028A1 CA 2256028 A1 CA2256028 A1 CA 2256028A1 CA 002256028 A CA002256028 A CA 002256028A CA 2256028 A CA2256028 A CA 2256028A CA 2256028 A1 CA2256028 A1 CA 2256028A1
Authority
CA
Canada
Prior art keywords
ions
lens
mass
voltage
field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002256028A
Other languages
French (fr)
Other versions
CA2256028C (en
Inventor
James W. Hager
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DH Technologies Development Pte Ltd
Original Assignee
Mds Inc.
James W. Hager
Applied Biosystems (Canada) Limited
Dh Technologies Development Pte. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mds Inc., James W. Hager, Applied Biosystems (Canada) Limited, Dh Technologies Development Pte. Ltd. filed Critical Mds Inc.
Publication of CA2256028A1 publication Critical patent/CA2256028A1/en
Application granted granted Critical
Publication of CA2256028C publication Critical patent/CA2256028C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H01J49/427—Ejection and selection methods
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/422—Two-dimensional RF ion traps
    • H01J49/4225—Multipole linear ion traps, e.g. quadrupoles, hexapoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

A method of operating a mass spectrometer having an elongated multipole rod set, in which a two-dimensional RF field radially contains trapped ions in a mass to charge range of interest, and in which the ions are contained axially by a barrier field on an end lens and to which a low voltage DC is applied. Trapped ions are axially mass selectively ejected by taking advantage of the mixing of the degrees of freedom induced by the fringing fields and other anti-harmonicities in the vicinity of the end lens. Thus, ions can be mass selectively ejected at the exit end at the same time as ions are being admitted into the entrance end of the rod set, thereby taking better advantage of the ion flux from a continuous ion source. The axial mass selective ejection is performed by applying an auxiliary AC voltage to the end lens, and by scanning either the auxiliary AC voltage or the RF voltage on the rod set. Trapped ions can be concentrated near the exit lens by applying an axial field in the direction of the lens, or can be depleted by applying the axial field in the opposite direction. The axial field can be oscillated to dissociate trapped ions.
CA002256028A 1996-06-06 1997-06-02 Axial ejection in a multipole mass spectrometer Expired - Lifetime CA2256028C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65695496A 1996-06-06 1996-06-06
US08/656,954 1996-06-06
PCT/CA1997/000381 WO1997047025A1 (en) 1996-06-06 1997-06-02 Axial ejection in a multipole mass spectrometer

Publications (2)

Publication Number Publication Date
CA2256028A1 true CA2256028A1 (en) 1997-12-11
CA2256028C CA2256028C (en) 2007-01-16

Family

ID=24635275

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002256028A Expired - Lifetime CA2256028C (en) 1996-06-06 1997-06-02 Axial ejection in a multipole mass spectrometer

Country Status (6)

Country Link
EP (1) EP0902963B1 (en)
JP (1) JP3818671B2 (en)
AU (1) AU718774B2 (en)
CA (1) CA2256028C (en)
DE (1) DE69715190T2 (en)
WO (1) WO1997047025A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177668B1 (en) 1996-06-06 2001-01-23 Mds Inc. Axial ejection in a multipole mass spectrometer
AU7022298A (en) * 1997-05-12 1998-12-08 Mds Inc. Rf-only mass spectrometer with auxiliary excitation
US5998787A (en) * 1997-10-31 1999-12-07 Mds Inc. Method of operating a mass spectrometer including a low level resolving DC input to improve signal to noise ratio
EP1057209B1 (en) * 1998-01-23 2011-11-23 PerkinElmer Health Sciences, Inc. Mass spectrometry with multipole ion guide
WO1999062101A1 (en) * 1998-05-29 1999-12-02 Analytica Of Branford, Inc. Mass spectrometry with multipole ion guides
GB9820210D0 (en) 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
US6504148B1 (en) 1999-05-27 2003-01-07 Mds Inc. Quadrupole mass spectrometer with ION traps to enhance sensitivity
WO2001015201A2 (en) * 1999-08-26 2001-03-01 University Of New Hampshire Multiple stage mass spectrometer
JP4578613B2 (en) * 2000-04-03 2010-11-10 キヤノンアネルバ株式会社 Q-pole mass spectrometer
US6720554B2 (en) * 2000-07-21 2004-04-13 Mds Inc. Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps
US7060972B2 (en) 2000-07-21 2006-06-13 Mds Inc. Triple quadrupole mass spectrometer with capability to perform multiple mass analysis steps
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
US6703607B2 (en) * 2002-05-30 2004-03-09 Mds Inc. Axial ejection resolution in multipole mass spectrometers
US6770871B1 (en) 2002-05-31 2004-08-03 Michrom Bioresources, Inc. Two-dimensional tandem mass spectrometry
GB2391694B (en) 2002-08-01 2006-03-01 Microsaic Systems Ltd Monolithic micro-engineered mass spectrometer
US7045797B2 (en) * 2002-08-05 2006-05-16 The University Of British Columbia Axial ejection with improved geometry for generating a two-dimensional substantially quadrupole field
JP4659395B2 (en) * 2004-06-08 2011-03-30 株式会社日立ハイテクノロジーズ Mass spectrometer and mass spectrometry method
JP5062834B2 (en) * 2005-01-17 2012-10-31 マイクロマス ユーケー リミテッド Mass spectrometer
US7312442B2 (en) * 2005-09-13 2007-12-25 Agilent Technologies, Inc Enhanced gradient multipole collision cell for higher duty cycle
CA2626089C (en) * 2005-11-30 2016-10-04 Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division Method and apparatus for mass selective axial transport using pulsed axial field
DE102006016896B4 (en) * 2006-04-11 2009-06-10 Bruker Daltonik Gmbh Orthogonal Time-of-Flight Mass Spectrometer of Low Mass Discrimination
TWI484529B (en) * 2006-11-13 2015-05-11 Mks Instr Inc Ion trap mass spectrometer, method of obtaining mass spectrum using the same, ion trap, method of and apparatus for trapping ions in ion trap
GB0717146D0 (en) 2007-09-04 2007-10-17 Micromass Ltd Mass spectrometer
EP2112683A1 (en) * 2008-04-22 2009-10-28 IEE INTERNATIONAL ELECTRONICS & ENGINEERING S.A. Differential mobility spectrometer and operating method therefor
US20110204221A1 (en) * 2008-10-14 2011-08-25 Hiroyuki Satake Mass spectrometer and method of mass spectrometry
WO2010119568A1 (en) 2009-04-17 2010-10-21 株式会社日立製作所 Ion detection device
JP5767843B2 (en) 2011-04-01 2015-08-19 株式会社日立製作所 Ion detector
WO2014197341A2 (en) * 2013-06-02 2014-12-11 Perkinelmer Health Sciences, Inc. Collision cells and methods using them
DE112016000226B4 (en) * 2015-01-15 2020-10-15 Hitachi High-Tech Corporation Mass spectrometry device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206506A (en) * 1991-02-12 1993-04-27 Kirchner Nicholas J Ion processing: control and analysis
US5179278A (en) * 1991-08-23 1993-01-12 Mds Health Group Limited Multipole inlet system for ion traps
US5420425A (en) * 1994-05-27 1995-05-30 Finnigan Corporation Ion trap mass spectrometer system and method
EP0738000B1 (en) * 1995-03-18 2000-02-16 Bruker Daltonik GmbH Intermediary storage of ions for spectrometric investigations

Also Published As

Publication number Publication date
CA2256028C (en) 2007-01-16
AU2946197A (en) 1998-01-05
AU718774B2 (en) 2000-04-20
WO1997047025A1 (en) 1997-12-11
DE69715190T2 (en) 2003-04-30
DE69715190D1 (en) 2002-10-10
JP2000510638A (en) 2000-08-15
EP0902963B1 (en) 2002-09-04
EP0902963A1 (en) 1999-03-24
JP3818671B2 (en) 2006-09-06

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Effective date: 20170602