CA2251060A1 - Promedicaments acyles de la n-hydroxymethylthalidomide a effet immunomodulateur - Google Patents
Promedicaments acyles de la n-hydroxymethylthalidomide a effet immunomodulateurInfo
- Publication number
- CA2251060A1 CA2251060A1 CA002251060A CA2251060A CA2251060A1 CA 2251060 A1 CA2251060 A1 CA 2251060A1 CA 002251060 A CA002251060 A CA 002251060A CA 2251060 A CA2251060 A CA 2251060A CA 2251060 A1 CA2251060 A1 CA 2251060A1
- Authority
- CA
- Canada
- Prior art keywords
- acylated
- prodrugs
- hydroxy methyl
- immunomodulator
- action
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940002612 prodrug Drugs 0.000 title abstract 3
- 239000000651 prodrug Substances 0.000 title abstract 3
- LZHQPJSJEITGHB-UHFFFAOYSA-N 2-[1-(hydroxymethyl)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione Chemical class O=C1N(CO)C(=O)CCC1N1C(=O)C2=CC=CC=C2C1=O LZHQPJSJEITGHB-UHFFFAOYSA-N 0.000 title 1
- 239000002955 immunomodulating agent Substances 0.000 title 1
- 229940121354 immunomodulator Drugs 0.000 title 1
- 230000002584 immunomodulator Effects 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 abstract 1
- -1 R2 is H Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 229940088679 drug related substance Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960003433 thalidomide Drugs 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19613976A DE19613976C1 (de) | 1996-04-09 | 1996-04-09 | Thalidomid-Prodrugs mit immunmodulatorischer Wirkung |
DE19613976.7 | 1996-04-09 | ||
PCT/EP1997/001475 WO1997037988A1 (fr) | 1996-04-09 | 1997-03-22 | Promedicaments acyles de la n-hydroxymethylthalidomide a effet immunomodulateur |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2251060A1 true CA2251060A1 (fr) | 1997-10-16 |
CA2251060C CA2251060C (fr) | 2006-09-12 |
Family
ID=36999576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002251060A Expired - Fee Related CA2251060C (fr) | 1996-04-09 | 1997-03-22 | Promedicaments acyles de la n-hydroxymethylthalidomide a effet immunomodulateur |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2251060C (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7320991B2 (en) | 2001-02-27 | 2008-01-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Analogs of thalidomide as potential angiogenesis inhibitors |
US7973057B2 (en) | 2003-09-17 | 2011-07-05 | The United States Of America As Represented By The Department Of Health And Human Services | Thalidomide analogs |
US8853253B2 (en) | 2003-09-17 | 2014-10-07 | P2D, Inc. | Thalidomide analogs |
US9084783B2 (en) | 2011-12-02 | 2015-07-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
-
1997
- 1997-03-22 CA CA002251060A patent/CA2251060C/fr not_active Expired - Fee Related
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7320991B2 (en) | 2001-02-27 | 2008-01-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Analogs of thalidomide as potential angiogenesis inhibitors |
US8716315B2 (en) | 2001-02-27 | 2014-05-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Analogs of thalidomide as potential angiogenesis inhibitors |
US7973057B2 (en) | 2003-09-17 | 2011-07-05 | The United States Of America As Represented By The Department Of Health And Human Services | Thalidomide analogs |
US8546430B2 (en) | 2003-09-17 | 2013-10-01 | P2D, Inc. | Thalidomide analogs |
US8853253B2 (en) | 2003-09-17 | 2014-10-07 | P2D, Inc. | Thalidomide analogs |
US9084783B2 (en) | 2011-12-02 | 2015-07-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
US9623020B2 (en) | 2011-12-02 | 2017-04-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
US10220028B2 (en) | 2011-12-02 | 2019-03-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
Also Published As
Publication number | Publication date |
---|---|
CA2251060C (fr) | 2006-09-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |