CA2250736C - Derives de 3'-dimethylamine, 9-etheroxime erythromycine a, protegee en 2' - Google Patents

Derives de 3'-dimethylamine, 9-etheroxime erythromycine a, protegee en 2' Download PDF

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Publication number
CA2250736C
CA2250736C CA002250736A CA2250736A CA2250736C CA 2250736 C CA2250736 C CA 2250736C CA 002250736 A CA002250736 A CA 002250736A CA 2250736 A CA2250736 A CA 2250736A CA 2250736 C CA2250736 C CA 2250736C
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CA
Canada
Prior art keywords
group
erythromycin
lower alkyl
oxime
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002250736A
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English (en)
Other versions
CA2250736A1 (fr
Inventor
Chengxi Yang
Hemantkumar H. Patel
Yi-Yin Ku
Jih-Hua Liu
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Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36123395&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2250736(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/627,795 external-priority patent/US5719272A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CA2250736A1 publication Critical patent/CA2250736A1/fr
Application granted granted Critical
Publication of CA2250736C publication Critical patent/CA2250736C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention a pour objet un procédé pour préparer un dérivé de 6-O-méthyle érythromycine A à l'aide d'un intermédiaire qui est une 9-éthéroxime érythromycine A, protégée en 2'. Un groupe de protection préféré pour la position 2' est acétyle. L'invention concerne aussi des dérivés de 9-éthéroxime érythromycine A protégée en 2' ainsi qu'un procédé pour inhiber la formation de sels quaternaires au niveau de l'amine en position 3', sans nécessiter de groupes protecteurs 3'N.
CA002250736A 1996-04-02 1997-02-06 Derives de 3'-dimethylamine, 9-etheroxime erythromycine a, protegee en 2' Expired - Fee Related CA2250736C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/627,795 1996-04-02
US08/627,795 US5719272A (en) 1996-04-02 1996-04-02 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
PCT/US1997/001952 WO1997036912A1 (fr) 1996-04-02 1997-02-06 Derives de 3'-dimethylamine, 9-etheroxime erythromycine a, protegee en 2'

Publications (2)

Publication Number Publication Date
CA2250736A1 CA2250736A1 (fr) 1997-10-09
CA2250736C true CA2250736C (fr) 2006-03-28

Family

ID=36123395

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002250736A Expired - Fee Related CA2250736C (fr) 1996-04-02 1997-02-06 Derives de 3'-dimethylamine, 9-etheroxime erythromycine a, protegee en 2'

Country Status (1)

Country Link
CA (1) CA2250736C (fr)

Also Published As

Publication number Publication date
CA2250736A1 (fr) 1997-10-09

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