CA2248598A1 - Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors - Google Patents

Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors

Info

Publication number
CA2248598A1
CA2248598A1 CA002248598A CA2248598A CA2248598A1 CA 2248598 A1 CA2248598 A1 CA 2248598A1 CA 002248598 A CA002248598 A CA 002248598A CA 2248598 A CA2248598 A CA 2248598A CA 2248598 A1 CA2248598 A1 CA 2248598A1
Authority
CA
Canada
Prior art keywords
nitric oxide
oxide synthase
synthase inhibitors
derivatives useful
hydroxyamidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002248598A
Other languages
French (fr)
Other versions
CA2248598C (en
Inventor
Rolando E. Gapud
Timothy J. Hagen
E. Ann Hallinan
Donald W. Hansen, Jr.
Robert E. Manning
Suzanne S. Metz
Barnett S. Pitzele
Foe S. Tjoeng
Mihaly V. Toth
Keith R. Webber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/689,463 external-priority patent/US5945408A/en
Application filed by Individual filed Critical Individual
Publication of CA2248598A1 publication Critical patent/CA2248598A1/en
Application granted granted Critical
Publication of CA2248598C publication Critical patent/CA2248598C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors as defined by Formula I:
(see formula I) Substituents A, X and R1 to R8 are as defined in the application.
CA002248598A 1996-03-06 1997-03-05 Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors Expired - Fee Related CA2248598C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1290496P 1996-03-06 1996-03-06
US60/012,904 1996-03-06
US08/689,463 US5945408A (en) 1996-03-06 1996-08-08 Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US08/689,463 1996-08-08
PCT/US1997/003282 WO1997032844A1 (en) 1996-03-06 1997-03-05 Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors

Publications (2)

Publication Number Publication Date
CA2248598A1 true CA2248598A1 (en) 1997-09-12
CA2248598C CA2248598C (en) 2006-02-14

Family

ID=35892345

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002248598A Expired - Fee Related CA2248598C (en) 1996-03-06 1997-03-05 Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors

Country Status (1)

Country Link
CA (1) CA2248598C (en)

Also Published As

Publication number Publication date
CA2248598C (en) 2006-02-14

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Legal Events

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Effective date: 20080305