CA2247151A1 - Microencapsulated fluorinated gases for use as imaging agents - Google Patents

Microencapsulated fluorinated gases for use as imaging agents

Info

Publication number
CA2247151A1
CA2247151A1 CA002247151A CA2247151A CA2247151A1 CA 2247151 A1 CA2247151 A1 CA 2247151A1 CA 002247151 A CA002247151 A CA 002247151A CA 2247151 A CA2247151 A CA 2247151A CA 2247151 A1 CA2247151 A1 CA 2247151A1
Authority
CA
Canada
Prior art keywords
fluorinated gases
imaging agents
microparticles
microencapsulated
perfluorocarbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002247151A
Other languages
French (fr)
Other versions
CA2247151C (en
Inventor
Howard Bernstein
Julie Ann Straub
Edith Mathiowitz
Henry T. Brush
Richard E. Wing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acusphere Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27086474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2247151(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/611,248 external-priority patent/US5611344A/en
Application filed by Individual filed Critical Individual
Publication of CA2247151A1 publication Critical patent/CA2247151A1/en
Application granted granted Critical
Publication of CA2247151C publication Critical patent/CA2247151C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Acoustics & Sound (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)

Abstract

It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein.
The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.
CA002247151A 1996-03-05 1997-02-27 Microencapsulated fluorinated gases for use as imaging agents Expired - Fee Related CA2247151C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US611,248 1990-11-09
US08/611,248 US5611344A (en) 1996-03-05 1996-03-05 Microencapsulated fluorinated gases for use as imaging agents
US08/745,676 US5853698A (en) 1996-03-05 1996-11-08 Method for making porous microparticles by spray drying
US745,676 1996-11-08
PCT/US1997/003117 WO1997032609A2 (en) 1996-03-05 1997-02-27 Microencapsulated fluorinated gases for use as imaging agents

Publications (2)

Publication Number Publication Date
CA2247151A1 true CA2247151A1 (en) 1997-09-12
CA2247151C CA2247151C (en) 2008-05-20

Family

ID=27086474

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002247151A Expired - Fee Related CA2247151C (en) 1996-03-05 1997-02-27 Microencapsulated fluorinated gases for use as imaging agents

Country Status (20)

Country Link
US (1) US6132699A (en)
EP (1) EP0904113B1 (en)
JP (1) JP3178724B2 (en)
AT (1) ATE266426T1 (en)
AU (1) AU721209B2 (en)
BR (1) BR9707936B1 (en)
CA (1) CA2247151C (en)
CZ (1) CZ281298A3 (en)
DE (1) DE69729088T2 (en)
DK (1) DK0904113T3 (en)
ES (1) ES2221687T3 (en)
HU (1) HU226714B1 (en)
ID (1) ID17753A (en)
IL (1) IL126073A (en)
MY (1) MY124549A (en)
NO (1) NO312940B1 (en)
NZ (1) NZ331460A (en)
PT (1) PT904113E (en)
TW (1) TWI246426B (en)
WO (1) WO1997032609A2 (en)

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US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
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CA2631492A1 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
DE102008045152A1 (en) * 2008-07-09 2010-01-14 Universität Duisburg-Essen Artificial oxygen carriers and their use
KR101061224B1 (en) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 캡슐 Capsule for measuring flow information using lines
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JP2011140527A (en) * 2011-04-20 2011-07-21 Acusphere Inc Dosage formulation of ultrasound contrast agent

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Also Published As

Publication number Publication date
WO1997032609A2 (en) 1997-09-12
NZ331460A (en) 1998-12-23
ES2221687T3 (en) 2005-01-01
PT904113E (en) 2004-09-30
JP3178724B2 (en) 2001-06-25
HUP9902897A2 (en) 2000-01-28
BR9707936A (en) 2000-01-04
MY124549A (en) 2006-06-30
NO984089L (en) 1998-09-04
DE69729088T2 (en) 2005-05-12
CZ281298A3 (en) 1999-01-13
JP2000501745A (en) 2000-02-15
IL126073A0 (en) 1999-05-09
CA2247151C (en) 2008-05-20
IL126073A (en) 2002-02-10
BR9707936B1 (en) 2010-12-14
EP0904113A2 (en) 1999-03-31
AU2139297A (en) 1997-09-22
ID17753A (en) 1998-01-22
EP0904113B1 (en) 2004-05-12
HUP9902897A3 (en) 2000-03-28
HK1020428A1 (en) 2000-04-20
NO984089D0 (en) 1998-09-04
HU226714B1 (en) 2009-07-28
WO1997032609A3 (en) 1998-01-29
DK0904113T3 (en) 2004-08-30
DE69729088D1 (en) 2004-06-17
US6132699A (en) 2000-10-17
NO312940B1 (en) 2002-07-22
ATE266426T1 (en) 2004-05-15
TWI246426B (en) 2006-01-01
AU721209B2 (en) 2000-06-29

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