CA2247151A1 - Microencapsulated fluorinated gases for use as imaging agents - Google Patents

Microencapsulated fluorinated gases for use as imaging agents

Info

Publication number
CA2247151A1
CA2247151A1 CA 2247151 CA2247151A CA2247151A1 CA 2247151 A1 CA2247151 A1 CA 2247151A1 CA 2247151 CA2247151 CA 2247151 CA 2247151 A CA2247151 A CA 2247151A CA 2247151 A1 CA2247151 A1 CA 2247151A1
Authority
CA
Canada
Prior art keywords
microencapsulated
use
fluorinated gases
microparticles
imaging agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2247151
Other languages
French (fr)
Other versions
CA2247151C (en
Inventor
Howard Bernstein
Julie Ann Straub
Edith Mathiowitz
Henry T. Brush
Richard E. Wing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acusphere Inc
Original Assignee
Acusphere, Inc.
Howard Bernstein
Julie Ann Straub
Edith Mathiowitz
Henry T. Brush
Richard E. Wing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US611,248 priority Critical
Priority to US08/611,248 priority patent/US5611344A/en
Priority to US745,676 priority
Priority to US08/745,676 priority patent/US5853698A/en
Application filed by Acusphere, Inc., Howard Bernstein, Julie Ann Straub, Edith Mathiowitz, Henry T. Brush, Richard E. Wing filed Critical Acusphere, Inc.
Priority to PCT/US1997/003117 priority patent/WO1997032609A2/en
Publication of CA2247151A1 publication Critical patent/CA2247151A1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27086474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2247151(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application granted granted Critical
Publication of CA2247151C publication Critical patent/CA2247151C/en
Anticipated expiration legal-status Critical
Application status is Expired - Fee Related legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48Diagnostic techniques
    • A61B8/481Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparation Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparation Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Abstract

It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein.
The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.
CA 2247151 1996-03-05 1997-02-27 Microencapsulated fluorinated gases for use as imaging agents Expired - Fee Related CA2247151C (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US611,248 1996-03-05
US08/611,248 US5611344A (en) 1996-03-05 1996-03-05 Microencapsulated fluorinated gases for use as imaging agents
US745,676 1996-11-08
US08/745,676 US5853698A (en) 1996-03-05 1996-11-08 Method for making porous microparticles by spray drying
PCT/US1997/003117 WO1997032609A2 (en) 1996-03-05 1997-02-27 Microencapsulated fluorinated gases for use as imaging agents

Publications (2)

Publication Number Publication Date
CA2247151A1 true CA2247151A1 (en) 1997-09-12
CA2247151C CA2247151C (en) 2008-05-20

Family

ID=27086474

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2247151 Expired - Fee Related CA2247151C (en) 1996-03-05 1997-02-27 Microencapsulated fluorinated gases for use as imaging agents

Country Status (20)

Country Link
US (1) US6132699A (en)
EP (1) EP0904113B1 (en)
JP (1) JP3178724B2 (en)
AT (1) AT266426T (en)
AU (1) AU721209B2 (en)
BR (1) BR9707936B1 (en)
CA (1) CA2247151C (en)
CZ (1) CZ9802812A3 (en)
DE (2) DE69729088D1 (en)
DK (1) DK0904113T3 (en)
ES (1) ES2221687T3 (en)
HK (1) HK1020428A1 (en)
HU (1) HU226714B1 (en)
ID (1) ID17753A (en)
IL (1) IL126073A (en)
NO (1) NO312940B1 (en)
NZ (1) NZ331460A (en)
PT (1) PT904113E (en)
TW (1) TWI246426B (en)
WO (1) WO1997032609A2 (en)

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US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
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US20070178166A1 (en) * 2005-12-15 2007-08-02 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
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DE102008045152A1 (en) * 2008-07-09 2010-01-14 Universität Duisburg-Essen Artificial oxygen carriers and their use
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Also Published As

Publication number Publication date
AT266426T (en) 2004-05-15
BR9707936A (en) 2000-01-04
IL126073D0 (en) 1999-05-09
DE69729088D1 (en) 2004-06-17
DE69729088T2 (en) 2005-05-12
WO1997032609A3 (en) 1998-01-29
EP0904113B1 (en) 2004-05-12
BR9707936B1 (en) 2010-12-14
JP3178724B2 (en) 2001-06-25
NZ331460A (en) 1998-12-23
PT904113E (en) 2004-09-30
JP2000501745A (en) 2000-02-15
DK0904113T3 (en) 2004-08-30
CA2247151C (en) 2008-05-20
HU9902897A2 (en) 2000-01-28
CZ9802812A3 (en) 1999-01-13
HK1020428A1 (en) 2005-02-25
ID17753A (en) 1998-01-22
NO984089A (en) 1998-09-04
EP0904113A2 (en) 1999-03-31
ES2221687T3 (en) 2005-01-01
TWI246426B (en) 2006-01-01
US6132699A (en) 2000-10-17
WO1997032609A2 (en) 1997-09-12
NO312940B1 (en) 2002-07-22
HU9902897A3 (en) 2000-03-28
AU721209B2 (en) 2000-06-29
AU2139297A (en) 1997-09-22
NO984089D0 (en) 1998-09-04
IL126073A (en) 2002-02-10
DK904113T3 (en)
HU226714B1 (en) 2009-07-28

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