CA2247151A1 - Microencapsulated fluorinated gases for use as imaging agents - Google Patents

Microencapsulated fluorinated gases for use as imaging agents

Info

Publication number
CA2247151A1
CA2247151A1 CA002247151A CA2247151A CA2247151A1 CA 2247151 A1 CA2247151 A1 CA 2247151A1 CA 002247151 A CA002247151 A CA 002247151A CA 2247151 A CA2247151 A CA 2247151A CA 2247151 A1 CA2247151 A1 CA 2247151A1
Authority
CA
Canada
Prior art keywords
fluorinated gases
imaging agents
microparticles
microencapsulated
perfluorocarbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002247151A
Other languages
French (fr)
Other versions
CA2247151C (en
Inventor
Howard Bernstein
Julie Ann Straub
Edith Mathiowitz
Henry T. Brush
Richard E. Wing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acusphere Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27086474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2247151(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/611,248 external-priority patent/US5611344A/en
Application filed by Individual filed Critical Individual
Publication of CA2247151A1 publication Critical patent/CA2247151A1/en
Application granted granted Critical
Publication of CA2247151C publication Critical patent/CA2247151C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Acoustics & Sound (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporated therein.
The microencapsulated perfluorocarbon is manufactured with a diameter suitable for the targeted tissue to be imaged, for example, for intravenous or oral administration. In one embodiment, bioadhesive microparticles are formed for enhanced imaging of mucosal surfaces.
CA002247151A 1996-03-05 1997-02-27 Microencapsulated fluorinated gases for use as imaging agents Expired - Fee Related CA2247151C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/611,248 US5611344A (en) 1996-03-05 1996-03-05 Microencapsulated fluorinated gases for use as imaging agents
US745,676 1996-11-08
US08/745,676 US5853698A (en) 1996-03-05 1996-11-08 Method for making porous microparticles by spray drying
US611,248 1996-11-08
PCT/US1997/003117 WO1997032609A2 (en) 1996-03-05 1997-02-27 Microencapsulated fluorinated gases for use as imaging agents

Publications (2)

Publication Number Publication Date
CA2247151A1 true CA2247151A1 (en) 1997-09-12
CA2247151C CA2247151C (en) 2008-05-20

Family

ID=27086474

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002247151A Expired - Fee Related CA2247151C (en) 1996-03-05 1997-02-27 Microencapsulated fluorinated gases for use as imaging agents

Country Status (20)

Country Link
US (1) US6132699A (en)
EP (1) EP0904113B1 (en)
JP (1) JP3178724B2 (en)
AT (1) ATE266426T1 (en)
AU (1) AU721209B2 (en)
BR (1) BR9707936B1 (en)
CA (1) CA2247151C (en)
CZ (1) CZ281298A3 (en)
DE (1) DE69729088T2 (en)
DK (1) DK0904113T3 (en)
ES (1) ES2221687T3 (en)
HU (1) HU226714B1 (en)
ID (1) ID17753A (en)
IL (1) IL126073A (en)
MY (1) MY124549A (en)
NO (1) NO312940B1 (en)
NZ (1) NZ331460A (en)
PT (1) PT904113E (en)
TW (1) TWI246426B (en)
WO (1) WO1997032609A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
ZA9811087B (en) * 1997-12-04 1999-06-03 Bracco Research Sa Automatic liquid injection system and method
US6223455B1 (en) † 1999-05-03 2001-05-01 Acusphere, Inc. Spray drying apparatus and methods of use
WO2001041685A2 (en) * 1999-12-10 2001-06-14 Iscience Corporation Treatment of ocular disease
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US6793626B2 (en) 2001-01-17 2004-09-21 Fuji Photo Film Co., Ltd. Ultrasonic scatterer, ultrasonic imaging method and ultrasonic imaging apparatus
DE10119522A1 (en) * 2001-04-20 2002-12-05 Innovacell Biotechnologie Gmbh Preparation and application of a suspension composition with an ultrasound contrast medium
DK1458360T3 (en) 2001-12-19 2011-08-29 Novartis Ag Pulmonary release of aminoglycosides
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20050171425A1 (en) * 2004-01-16 2005-08-04 Phantoms-By-Design Medical devices having MRI-enhancing encapsulated fluids
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
RU2344833C2 (en) * 2004-06-04 2009-01-27 Экьюсфиэр, Инк. Contrast medium for ultrasonic imaging
WO2007070843A2 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
EP1973523A2 (en) * 2005-12-15 2008-10-01 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
DE102008045152A1 (en) * 2008-07-09 2010-01-14 Universität Duisburg-Essen Artificial oxygen carriers and their use
KR101061224B1 (en) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 캡슐 Capsule for measuring flow information using lines
NL2003660C2 (en) * 2009-10-16 2011-04-19 Giskit B V Composition and method for medical imaging of body cavities.
JP2011140527A (en) * 2011-04-20 2011-07-21 Acusphere Inc Dosage formulation of ultrasound contrast agent

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4442843A (en) * 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
DE3141641A1 (en) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION
US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4757128A (en) * 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4888176A (en) * 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5618514A (en) * 1983-12-21 1997-04-08 Nycomed Imaging As Diagnostic and contrast agent
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
GB8504916D0 (en) * 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
JPH07110815B2 (en) * 1985-11-18 1995-11-29 ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム Polychelating agent for image and spectral enhancement (and spectral shift)
US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
US5080885A (en) * 1986-01-14 1992-01-14 Alliance Pharmaceutical Corp. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
US5077036A (en) * 1986-01-14 1991-12-31 Alliance Pharmaceutical Corp. Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume fluorocarbon combined with a phospholipid
DE3785054T2 (en) * 1986-01-24 1993-07-08 Childrens Hosp Medical Center STABLE EMULSIONS OF STRONGLY FLUORED ORGANIC COMPOUNDS.
EP0245019A3 (en) * 1986-04-30 1989-05-10 Michael A. Davis Low density contrast medium for diagnosis of pathologic conditions
FR2602774B1 (en) * 1986-07-29 1990-10-19 Atta NOVEL POLYHYDROXYLATED AND PERFLUOROALKYLATED AMPHIPHILIC MOLECULES HAVING SURFACTANT PROPERTIES
US4789724A (en) * 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US5219538A (en) * 1987-03-13 1993-06-15 Micro-Pak, Inc. Gas and oxygen carrying lipid vesicles
US4857311A (en) * 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
IE61591B1 (en) * 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
EP0586875A1 (en) * 1988-02-05 1994-03-16 Schering Aktiengesellschaft Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents
US5171755A (en) * 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US4993415A (en) * 1988-08-19 1991-02-19 Alliance Pharmaceutical Corp. Magnetic resonance imaging with perfluorocarbon hydrides
DE3828905A1 (en) * 1988-08-23 1990-03-15 Schering Ag MEDIALLY COMPOSED OF CAVITATE OR CLATHRATE MAKING HOST / GUEST COMPLEX AS A CONTRAST
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
DE3926934A1 (en) * 1989-08-16 1991-02-21 Deutsches Krebsforsch HYPERTHERMIC MICROWAVE APPLICATOR FOR WARMING A LIMITED ENVIRONMENT IN A DISSIPATIVE MEDIUM
JPH062134B2 (en) * 1989-09-08 1994-01-12 株式会社東芝 Ultrasonic diagnostic equipment
US5334381A (en) * 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5230882A (en) * 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
DE4004430A1 (en) * 1990-02-09 1991-08-14 Schering Ag CONSTRUCTED POLYALDEHYDE CONSTITUENTS
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5578292A (en) * 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5215680A (en) * 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
CA2068334C (en) * 1990-10-05 1996-09-03 Claude Giddey Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US5236693A (en) * 1990-11-14 1993-08-17 Brigham And Women's Hospital Medical ultrasound contrast agent and method of using same
DE4100470A1 (en) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echo contrast agent
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
US5107842A (en) * 1991-02-22 1992-04-28 Molecular Biosystems, Inc. Method of ultrasound imaging of the gastrointestinal tract
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5496535A (en) * 1991-04-12 1996-03-05 Alliance Pharmaceutical Corp. Fluorocarbon contrast media for use with MRI and radiographic imaging
US5147631A (en) 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
DE69219331T3 (en) * 1991-06-03 2001-06-07 Nycomed Imaging As, Oslo IMPROVEMENTS REGARDING CONTRAST AGENTS
AU667672B2 (en) * 1991-06-18 1996-04-04 Imarx Therapeutics, Inc. Novel liposomal drug delivery systems
FI940027A7 (en) * 1991-07-05 1994-01-04 Nycomed Imaging As Improvements to the contrast agents themselves or improvements related to them
FR2679150A1 (en) * 1991-07-17 1993-01-22 Atta PREPARATIONS CONSISTING OF A FLUOROCARBIDE OR HIGHLY FLUORINE COMPOUND AND A LIPOPHILIC-FLUOROPHILIC ORGANIC COMPOUND, AND THEIR USES.
NZ244147A (en) * 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
RU2114637C1 (en) * 1991-09-17 1998-07-10 Сонус Фармасьютикалз, Инк. Biologically compatible contrast medium and method for producing ultrasonic images
MX9205298A (en) * 1991-09-17 1993-05-01 Steven Carl Quay GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US5344640A (en) * 1991-10-22 1994-09-06 Mallinckrodt Medical, Inc. Preparation of apatite particles for medical diagnostic imaging
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5344393A (en) * 1992-02-28 1994-09-06 Alliance Pharmaceutical Corp. Use of synthetic oxygen carriers to facilitate oxygen delivery
DE4219723A1 (en) * 1992-06-13 1993-12-16 Schering Ag Microparticles, processes for their production and their use in diagnostics
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
JPH08151335A (en) * 1994-09-27 1996-06-11 Otsuka Pharmaceut Co Ltd Ultrasonic contrast medium and production thereof
DE19510690A1 (en) * 1995-03-14 1996-09-19 Schering Ag Polymeric nano- and / or microparticles, processes for their production, and use in medical diagnostics and therapy
WO1996040277A2 (en) * 1995-06-07 1996-12-19 Brown University Research Foundation Spray dried polymeric microparticles containing imaging agents
US5955143A (en) * 1995-12-21 1999-09-21 Drexel University Hollow polymer microcapsules and method of producing the same
DE19602930A1 (en) 1996-01-18 1997-07-24 Schering Ag Porous matrices made of low molecular weight substances for the generation of stable gas bubble suspensions, their use as ultrasound contrast agents and processes for their production

Also Published As

Publication number Publication date
CZ281298A3 (en) 1999-01-13
DK0904113T3 (en) 2004-08-30
NO984089L (en) 1998-09-04
AU2139297A (en) 1997-09-22
NO984089D0 (en) 1998-09-04
NO312940B1 (en) 2002-07-22
AU721209B2 (en) 2000-06-29
TWI246426B (en) 2006-01-01
ID17753A (en) 1998-01-22
JP2000501745A (en) 2000-02-15
BR9707936A (en) 2000-01-04
HK1020428A1 (en) 2000-04-20
IL126073A (en) 2002-02-10
HU226714B1 (en) 2009-07-28
EP0904113A2 (en) 1999-03-31
ATE266426T1 (en) 2004-05-15
DE69729088T2 (en) 2005-05-12
NZ331460A (en) 1998-12-23
EP0904113B1 (en) 2004-05-12
BR9707936B1 (en) 2010-12-14
DE69729088D1 (en) 2004-06-17
WO1997032609A2 (en) 1997-09-12
MY124549A (en) 2006-06-30
CA2247151C (en) 2008-05-20
IL126073A0 (en) 1999-05-09
HUP9902897A3 (en) 2000-03-28
ES2221687T3 (en) 2005-01-01
PT904113E (en) 2004-09-30
JP3178724B2 (en) 2001-06-25
HUP9902897A2 (en) 2000-01-28
US6132699A (en) 2000-10-17
WO1997032609A3 (en) 1998-01-29

Similar Documents

Publication Publication Date Title
CA2247151A1 (en) Microencapsulated fluorinated gases for use as imaging agents
CA2260938A1 (en) Polymer-lipid microencapsulated gases for use as imaging agents
CA2340221A1 (en) Injectable formulations of nanoparticulate naproxen
CA2107466A1 (en) Low density microspheres and their use as contrast agents for computed tomography
USD361811S (en) Tossing ball
ATE477793T1 (en) A TABLET THAT DISAPPOINTS QUICKLY IN THE MOUTH
CA2259297A1 (en) Parenteral paclitaxel in a stable non-toxic formulation
CA2206233A1 (en) Combination dosage form comprising cetirizine and pseudoephedrine
EP1273313A3 (en) Triclosan containing medical devices
CA2222676A1 (en) New pharmaceutical composition with anaesthetic effect
CA2401400A1 (en) Balloon structure with ptfe component
CA2406650A1 (en) Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
MXPA01006926A (en) Formulations for treating disease and methods of using same.
ID29578A (en) INDENO-, NAFTO- AND BENZOSICLOHEPTIHIHIDROTIAZOL DERIVES AND ITS MANUFACTURING AND USE AS ANORECTIC DRUGS
USD432225S (en) Air freshener in the shape of a baseball jersey
CA2391439A1 (en) Brittle-coating, soft core dosage form
CA2290482A1 (en) Fructan containing composition for the prevention and treatment of colon cancer
AU2001272614A1 (en) Polyamide compositions with improved antistatic and hydrophilic properties
NZ511445A (en) Substantially non-toxic biologically active mucosal adjuvants in vertebrate subjects
EP1806144A3 (en) Use of SARP-1 for the treatment and/or prevention of scleroderma
JP2001084839A5 (en)
ATE303797T1 (en) ORAL FLUDARA PURE FORMULATION WITH RAPID RELEASE OF THE ACTIVE INGREDIENTS
ID28958A (en) PROCESS OF PREPARATION 4,6-DISUBSTITUTION OF 2-ISOSIANATOP IRIMIDIN AND ITS USE AS THE MEDIUM OF ACTIVE COMPOUND SYNTHES
CA2292638A1 (en) Composition comprising ketanserin and l-carnitine or an alkanoyl l-carnitine for the treatment of crps
RU99121750A (en) Method of producing aluminum oxynitride dichloride

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150227