CA2246747A1 - Method of promoting bone growth with hyaluronic acid and growth factors - Google Patents

Method of promoting bone growth with hyaluronic acid and growth factors

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Publication number
CA2246747A1
CA2246747A1 CA002246747A CA2246747A CA2246747A1 CA 2246747 A1 CA2246747 A1 CA 2246747A1 CA 002246747 A CA002246747 A CA 002246747A CA 2246747 A CA2246747 A CA 2246747A CA 2246747 A1 CA2246747 A1 CA 2246747A1
Authority
CA
Canada
Prior art keywords
composition
hyaluronic acid
growth
bone growth
site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002246747A
Other languages
French (fr)
Other versions
CA2246747C (en
Inventor
Michael Radomsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DePuy Spine LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1997/004810 external-priority patent/WO1997032591A1/en
Publication of CA2246747A1 publication Critical patent/CA2246747A1/en
Application granted granted Critical
Publication of CA2246747C publication Critical patent/CA2246747C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at the site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used in a composition range of 0.1-4 % by weight and preferred growth factor is bFGF, present in a concentration range of about 10-6 to 100 mg/ml.

Claims (10)

1. A bone growth-promoting composition comprising hyaluronic acid and a growth factor, wherein said composition has a viscosity and biodegradability sufficient to persist at a site of desired bone growth for a period of time sufficient to promote bone growth.
2. A composition according to claim 1 wherein said hyaluronic acid is uncrosslinked.
3. A composition according to claim 1 wherein said composition comprises 0.1 to 4% by weight of hyaluronic acid in solution.
4. A composition according to claim 1 wherein said growth factor comprises bFGF.
5. A composition according to claim 4 wherein said bFGF is present in said composition in a range of about 10 -6 to 100 mg/ml of said composition.
6. A method of promoting bone growth at a site of desired bone growth comprising the step of applying to said site a composition comprising hyaluronic acid and a growth factor, wherein said composition has a viscosity and biodegradability sufficient to persist at said site for a period of time sufficient to promote bone growth.
7. A method according to claim 6 wherein said hyaluronic acid is uncrosslinked.
8. A method according to claim 6 wherein said hyaluronic acid in said composition comprises about 0.1-4% by weight of said composition.
9. A method according to claim 6 wherein said growth factor comprises bFGF.
10. A method according to claim 9 wherein said bFGF is present in a range of about 10 -6 to 100 mg/ml in said composition.
CA2246747A 1996-03-05 1997-03-05 Method of promoting bone growth with hyaluronic acid and growth factors Expired - Fee Related CA2246747C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US61169096A 1996-03-05 1996-03-05
US08/611,690 1996-03-05
US9797A 1997-03-05 1997-03-05
PCT/US1997/004810 WO1997032591A1 (en) 1996-03-05 1997-03-05 Method of promoting bone growth with hyaluronic acid and growth factors
USUNKNOWN 2006-09-29

Publications (2)

Publication Number Publication Date
CA2246747A1 true CA2246747A1 (en) 1997-09-12
CA2246747C CA2246747C (en) 2011-01-04

Family

ID=29422949

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2246747A Expired - Fee Related CA2246747C (en) 1996-03-05 1997-03-05 Method of promoting bone growth with hyaluronic acid and growth factors

Country Status (1)

Country Link
CA (1) CA2246747C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7902172B2 (en) 1996-03-05 2011-03-08 Depuy Spine, Inc. Method of promoting bone growth with hyaluronic acid and growth factors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7902172B2 (en) 1996-03-05 2011-03-08 Depuy Spine, Inc. Method of promoting bone growth with hyaluronic acid and growth factors

Also Published As

Publication number Publication date
CA2246747C (en) 2011-01-04

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