CA2246747A1 - Method of promoting bone growth with hyaluronic acid and growth factors - Google Patents
Method of promoting bone growth with hyaluronic acid and growth factorsInfo
- Publication number
- CA2246747A1 CA2246747A1 CA002246747A CA2246747A CA2246747A1 CA 2246747 A1 CA2246747 A1 CA 2246747A1 CA 002246747 A CA002246747 A CA 002246747A CA 2246747 A CA2246747 A CA 2246747A CA 2246747 A1 CA2246747 A1 CA 2246747A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- hyaluronic acid
- growth
- bone growth
- site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Abstract
A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at the site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used in a composition range of 0.1-4 % by weight and preferred growth factor is bFGF, present in a concentration range of about 10-6 to 100 mg/ml.
Claims (10)
1. A bone growth-promoting composition comprising hyaluronic acid and a growth factor, wherein said composition has a viscosity and biodegradability sufficient to persist at a site of desired bone growth for a period of time sufficient to promote bone growth.
2. A composition according to claim 1 wherein said hyaluronic acid is uncrosslinked.
3. A composition according to claim 1 wherein said composition comprises 0.1 to 4% by weight of hyaluronic acid in solution.
4. A composition according to claim 1 wherein said growth factor comprises bFGF.
5. A composition according to claim 4 wherein said bFGF is present in said composition in a range of about 10 -6 to 100 mg/ml of said composition.
6. A method of promoting bone growth at a site of desired bone growth comprising the step of applying to said site a composition comprising hyaluronic acid and a growth factor, wherein said composition has a viscosity and biodegradability sufficient to persist at said site for a period of time sufficient to promote bone growth.
7. A method according to claim 6 wherein said hyaluronic acid is uncrosslinked.
8. A method according to claim 6 wherein said hyaluronic acid in said composition comprises about 0.1-4% by weight of said composition.
9. A method according to claim 6 wherein said growth factor comprises bFGF.
10. A method according to claim 9 wherein said bFGF is present in a range of about 10 -6 to 100 mg/ml in said composition.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61169096A | 1996-03-05 | 1996-03-05 | |
US08/611,690 | 1996-03-05 | ||
US9797A | 1997-03-05 | 1997-03-05 | |
PCT/US1997/004810 WO1997032591A1 (en) | 1996-03-05 | 1997-03-05 | Method of promoting bone growth with hyaluronic acid and growth factors |
USUNKNOWN | 2006-09-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2246747A1 true CA2246747A1 (en) | 1997-09-12 |
CA2246747C CA2246747C (en) | 2011-01-04 |
Family
ID=29422949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2246747A Expired - Fee Related CA2246747C (en) | 1996-03-05 | 1997-03-05 | Method of promoting bone growth with hyaluronic acid and growth factors |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2246747C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7902172B2 (en) | 1996-03-05 | 2011-03-08 | Depuy Spine, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
-
1997
- 1997-03-05 CA CA2246747A patent/CA2246747C/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7902172B2 (en) | 1996-03-05 | 2011-03-08 | Depuy Spine, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
Also Published As
Publication number | Publication date |
---|---|
CA2246747C (en) | 2011-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20140305 |