CA2242102C - Derives de la quinazoline servant d'agents antitumoraux - Google Patents
Derives de la quinazoline servant d'agents antitumoraux Download PDFInfo
- Publication number
- CA2242102C CA2242102C CA002242102A CA2242102A CA2242102C CA 2242102 C CA2242102 C CA 2242102C CA 002242102 A CA002242102 A CA 002242102A CA 2242102 A CA2242102 A CA 2242102A CA 2242102 C CA2242102 C CA 2242102C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- alkylamino
- alkoxy
- amino
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention porte sur des dérivés de la quinazoline de formule (I) ou l'un de ses sels pharmaceutiquement acceptables. Dans la formule, X<1> est une liaison directe ou un groupe tel que CO, C(R<2>)2 et CH(OR<2>); Q<1> est phényle, naphtyle ou un fragment hétéroaryle à 5 ou 6 chaînons et comporte facultativement jusqu'à trois substituants; m vaut 1 ou 2; R<1> peut être un groupe tel que H, halogéno, et trifluorométhyle; et Q<2> peut être phényle ou un fragment bicyclique, hétérocyclique à 9 ou 10 chaînons et comporte facultativement jusqu'à trois substituants. L'invention porte également sur leur procédé de préparation, sur des préparations pharmaceutiques les contenant et sur leurs propriétés inhibitrices du récepteur de la tyrosine kinase utilisées pour le traitement des maladies prolifératives telles que le cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9603095.2A GB9603095D0 (en) | 1996-02-14 | 1996-02-14 | Quinazoline derivatives |
| GB9603095.2 | 1996-02-14 | ||
| PCT/GB1997/000344 WO1997030034A1 (fr) | 1996-02-14 | 1997-02-10 | Derives de la quinazoline servant d'agents antitumoraux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2242102A1 CA2242102A1 (fr) | 1997-08-21 |
| CA2242102C true CA2242102C (fr) | 2006-08-22 |
Family
ID=36940286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002242102A Expired - Fee Related CA2242102C (fr) | 1996-02-14 | 1997-02-10 | Derives de la quinazoline servant d'agents antitumoraux |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2242102C (fr) |
-
1997
- 1997-02-10 CA CA002242102A patent/CA2242102C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2242102A1 (fr) | 1997-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140211 |
|
| MKLA | Lapsed |
Effective date: 20140211 |