CA2240845A1 - New barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds - Google Patents
New barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compoundsInfo
- Publication number
- CA2240845A1 CA2240845A1 CA002240845A CA2240845A CA2240845A1 CA 2240845 A1 CA2240845 A1 CA 2240845A1 CA 002240845 A CA002240845 A CA 002240845A CA 2240845 A CA2240845 A CA 2240845A CA 2240845 A1 CA2240845 A1 CA 2240845A1
- Authority
- CA
- Canada
- Prior art keywords
- bicycle
- monocycle
- compounds
- several times
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
Abstract
Compounds of formula (I) in which X, Y and Z are independently of one another oxygen, sulphur or NH; R1 represents a group W-V: W is a valence dash or a straight-chained or branched C1-C8 alkyl or a C2-C8 alkenyl group which is optionally once or several times substituted, V is an optionally substituted monocycle or bicycle which can contain one or several heteroatoms, or W-V is a C1-C20 alkyl group which can be interrupted by heteroatoms, one or several carbon atoms are optionally substituted; R2 and R3 represent hydrogen or one of the two represents lower alkyl or lower aryl; R4 and R5 denote independently of each other for A-D, wherein A represents a dash alkyl, alkenyl, acyl, alkylsulfonyl, sulfonyl, alkylaminocarbonyl, aminocarbonyl, alkoxycarbonyl, oxy-carbonyl, alkylaminothiocarbonyl, aminothio-carbonyl which is optionally once or several times substituted; D represents a hydrogen, monocycle or bicycle, the monocycle or bicycle is optionally once or several times interrupted by heteroatoms and the monocycle or bicycle is once or several times substituted, or R4 and R5 together with the adjacent N atom form a ring; pharmacologically acceptable salts and prodrugs thereof and optically active forms, processes for their production and pharmaceutical agents which contain these compounds having a matrix metalloprotease-inhibitory action.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19548624.2 | 1995-12-23 | ||
| DE19548624A DE19548624A1 (en) | 1995-12-23 | 1995-12-23 | New barbituric acid derivatives, processes for their preparation and medicaments containing these compounds |
| PCT/EP1996/005766 WO1997023465A1 (en) | 1995-12-23 | 1996-12-20 | New barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2240845A1 true CA2240845A1 (en) | 1997-07-03 |
| CA2240845C CA2240845C (en) | 2006-09-19 |
Family
ID=37057008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002240845A Expired - Fee Related CA2240845C (en) | 1995-12-23 | 1996-12-20 | New barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2240845C (en) |
-
1996
- 1996-12-20 CA CA002240845A patent/CA2240845C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2240845C (en) | 2006-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX9805063A (en) | New barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds. | |
| CA2143636A1 (en) | Derivatives of valproic and 2-valproenoic acid amides and use as anticonvulsants | |
| EP0257102A4 (en) | Agents for treating neurophathy | |
| MA22344A1 (en) | PROCESS FOR THE PREPARATION OF NEW ERYTHROMICIN DERIVATIVES | |
| DE3167757D1 (en) | Dibenz(b,f)(1,4)oxazepine derivatives, process for preparing the same, and pharmaceutical compositions comprising the same | |
| WO1988009789A3 (en) | 3-indolepyruvic acid derivatives and pharmaceutical use thereof | |
| KR880003958A (en) | Novel cefem compound and preparation method thereof | |
| CA2280270A1 (en) | Acrylonitrile compounds, process for their production and pesticides containing them | |
| DE69022294T2 (en) | N-Heteroaryl-purin-6-amines, process for their preparation and their use as medicines. | |
| GR3019123T3 (en) | 2,4-Pyrimidinedione derivatives and medicines containing them | |
| ATE144249T1 (en) | COMPOUNDS REFERRED TO IN THE INTRACEREBRAL AREA AND THEIR APPLICATION | |
| DK0488897T3 (en) | Guanidine derivatives, processes for their preparation and pharmaceutical agents containing them | |
| ATE53032T1 (en) | 2-THIAZOLYLIMIDAZO(1,2-A)PYRIMIDINE AND THEIR SALTS, PROCESSES FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS AND PREPARATIONS CONTAINING THEM. | |
| CA2240845A1 (en) | New barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds | |
| KR930006006A (en) | Substituted pyridinylamino-1H-indole, 1H-indazole, 2H-indazole, benzo [b] thiophene and 1,2-benzisothiazole, methods for their preparation and their use as medicaments | |
| IE822917L (en) | Optically active penems | |
| ATE275403T1 (en) | CALCIUM SALTS OF 1,5-BENZODIAZEPINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICATIONS CONTAINING SAME | |
| FR2441617A1 (en) | NOVEL S-TRIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| ATE152709T1 (en) | TETRAHYDROCYCLOPENT(B>INDOLE-METHANAMINES AND RELATED COMPOUNDS, AND METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS | |
| IE873182L (en) | Triazaspirodecanylmethylindolone derivatives | |
| DE69019007T2 (en) | Cyclohexane acetamide derivatives. | |
| BE900556A (en) | NEW PROCESS FOR THE PREPARATION OF CEPHALOSPORIN TYPE ANTIBIOTICS. | |
| EP0826674A4 (en) | Novel pyrimidine derivatives efficacious as psychotropic drug and process for the production thereof | |
| NO963374L (en) | Substituted 4H-pyrans | |
| HUP0004386A2 (en) | Methylenebisphosphonic acid derivatives, process for producing them and medicaments containing the same as active agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |