CA2238275A1 - Metalloproteinase inhibitors - Google Patents
Metalloproteinase inhibitorsInfo
- Publication number
- CA2238275A1 CA2238275A1 CA002238275A CA2238275A CA2238275A1 CA 2238275 A1 CA2238275 A1 CA 2238275A1 CA 002238275 A CA002238275 A CA 002238275A CA 2238275 A CA2238275 A CA 2238275A CA 2238275 A1 CA2238275 A1 CA 2238275A1
- Authority
- CA
- Canada
- Prior art keywords
- metalloproteinase inhibitors
- co2h
- alkyl
- heterocyclic ring
- nhco2r
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 abstract 1
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 abstract 1
- -1 oxo- Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of general formula (I) wherein X is a -CO2H, -NH(OH)CHO or -CONHOH group; R1 is a cylcoalkyl, cycloalkenyl or non-aromatic heterocyclic ring containing up to 3 heteroatoms, any of which may be (i) substituted by one ore more substituents selected from C1-C6 alkyl, C2-C6 alkenyl, halo, cyano (-CN), -CO2H, -CO2R, -CONH2, -CONHR, -CON(R)2, -OH, -OR, oxo-, -SH, -SR, -NHCOR, and -NHCO2R
wherein R is C1-C6 alkyl or benzyl and/or (ii) fused to a cycloalky or heterocyclic ring; and R2, R3. R4 and R5 are as defined in the specification are matrix metalloproteinase inhibitors.
wherein R is C1-C6 alkyl or benzyl and/or (ii) fused to a cycloalky or heterocyclic ring; and R2, R3. R4 and R5 are as defined in the specification are matrix metalloproteinase inhibitors.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9523937.2A GB9523937D0 (en) | 1995-11-23 | 1995-11-23 | Metalloproteinase inhibitors |
| GB9523937.2 | 1995-11-23 | ||
| GB9610985.5 | 1996-05-24 | ||
| GBGB9610985.5A GB9610985D0 (en) | 1996-05-24 | 1996-05-24 | Metalloproteinase inhibitors |
| PCT/GB1996/002877 WO1997019053A1 (en) | 1995-11-23 | 1996-11-21 | Metalloproteinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2238275A1 true CA2238275A1 (en) | 1997-05-29 |
| CA2238275C CA2238275C (en) | 2005-10-04 |
Family
ID=35395922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002238275A Expired - Fee Related CA2238275C (en) | 1995-11-23 | 1996-11-21 | Metalloproteinase inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2238275C (en) |
-
1996
- 1996-11-21 CA CA002238275A patent/CA2238275C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2238275C (en) | 2005-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |