CA2237879A1 - Derives de nitrile de 19-nor-steroides a utiliser en radiotherapie et (ou) en imagerie relatives au cancer - Google Patents

Derives de nitrile de 19-nor-steroides a utiliser en radiotherapie et (ou) en imagerie relatives au cancer Download PDF

Info

Publication number
CA2237879A1
CA2237879A1 CA 2237879 CA2237879A CA2237879A1 CA 2237879 A1 CA2237879 A1 CA 2237879A1 CA 2237879 CA2237879 CA 2237879 CA 2237879 A CA2237879 A CA 2237879A CA 2237879 A1 CA2237879 A1 CA 2237879A1
Authority
CA
Canada
Prior art keywords
alpha
cyano
ligand
ligands
attached
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2237879
Other languages
English (en)
Inventor
Hasrat Ali
Johan E. Van Lier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA 2237879 priority Critical patent/CA2237879A1/fr
Publication of CA2237879A1 publication Critical patent/CA2237879A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
CA 2237879 1998-05-19 1998-05-19 Derives de nitrile de 19-nor-steroides a utiliser en radiotherapie et (ou) en imagerie relatives au cancer Abandoned CA2237879A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2237879 CA2237879A1 (fr) 1998-05-19 1998-05-19 Derives de nitrile de 19-nor-steroides a utiliser en radiotherapie et (ou) en imagerie relatives au cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2237879 CA2237879A1 (fr) 1998-05-19 1998-05-19 Derives de nitrile de 19-nor-steroides a utiliser en radiotherapie et (ou) en imagerie relatives au cancer

Publications (1)

Publication Number Publication Date
CA2237879A1 true CA2237879A1 (fr) 1999-11-19

Family

ID=29275738

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2237879 Abandoned CA2237879A1 (fr) 1998-05-19 1998-05-19 Derives de nitrile de 19-nor-steroides a utiliser en radiotherapie et (ou) en imagerie relatives au cancer

Country Status (1)

Country Link
CA (1) CA2237879A1 (fr)

Similar Documents

Publication Publication Date Title
Choe et al. Synthesis of 11. beta.-[18F] Fluoro-5. alpha.-dihydrotestosterone and 11. beta.-[18F] Fluoro-19-nor-5. alpha.-dihydrotestosterone: Preparation via halofluorination-reduction, receptor binding, and tissue distribution
ZIELINSKI et al. 16 α-[125I] Iodo-11 β Methoxy-17 β-Estradiol: A Radiochemical Probe for Estrogen-Sensitive Tissues
EP0310645B1 (fr) Composes utiles notamment pour la radiotherapie ou l'imagerie du cancer
Vanbrocklin et al. Preparation and evaluation of 17-ethynyl-substituted 16α-[18F] fluoroestradiols: selective receptor-based PET imaging agents
Ali et al. Synthesis, receptor binding, and tissue distribution of 7. alpha.-and 11. beta.-substituted (17. alpha., 20E)-and (17. alpha., 20Z)-21-[125I] iodo-19-norpregna-1, 3, 5 (10), 20-tetraene-3, 17-diols
Nakatsuka et al. Synthesis and evaluation of (17. alpha., 20E)-21-[125I] iodo-19-norpregna-1, 3, 5 (10), 20-tetraene-3, 17-diol and (17. alpha., 20E)-21-[125I] iodo-11. beta.-methoxy-19-norpregna-1, 3, 5 (10), 20-tetraene-3, 17-diol [17. alpha.-iodovinyl) estradiol derivatives] as high specific activity potential radiopharmaceuticals
Seimbille et al. Synthesis of 2, 16α-and 4, 16α-difluoroestradiols and their 11β-methoxy derivatives as potential estrogen receptor-binding radiopharmaceuticals
e Silva et al. Synthesis and biological evaluation of two new radiolabelled estrogens:[125I](E)-3-methoxy-17α-iodovinylestra-1, 3, 5 (10), 6-tetraen-17β-ol and [125I](Z)-3-methoxy-17α-iodovinylestra-1, 3, 5 (10), 6-tetraen-17β-ol
Ali et al. 2-and 4-Fluorinated 16. alpha.-[125I] iodoestradiol derivatives: synthesis and effect on estrogen receptor binding and receptor-mediated target tissue uptake
Ali et al. 7. alpha.-Methyl-and 11. beta.-ethoxy-substitution of iodine-125-labeled [125I] 16. alpha.-iodoestradiol: effect on estrogen receptor-mediated target tissue uptake
US5002753A (en) Specific ligands for estrogen and progestagen steroid hormone receptors, application and intermediate synthesis products
Silva et al. Synthesis and biological evaluation of two new radiolabelled estrogens:[125I](E)-3-methoxy-17a-iodovinylestra-1, 3, 5 (10), 6-tetraen-17b-ol and [125I](Z)-3-methoxy-17a-iodovinylestra-1, 3, 5 (10), 6-tetraen-17b-ol
IE842575L (en) Estrane and androstane derivatives
CA2237879A1 (fr) Derives de nitrile de 19-nor-steroides a utiliser en radiotherapie et (ou) en imagerie relatives au cancer
Kabalka et al. Synthesis and evaluation of a new series of 17α-[123I] iodovinyl estradiols
Hoyte et al. Synthesis and Evaluation of 7. alpha.-Iodo-5. alpha.-dihydrotestosterone as a Potential Radioligand for Androgen Receptor
Ali et al. Synthesis and biological properties of 7α-cyano derivatives of the (17α, 20E/Z)-[125I] iodovinyl-and 16α-[125I] iodo-estradiols
Ali et al. Synthesis, receptor binding and biodistribution of the gem-21-chloro-21-iodovinylestradiol derivatives
Stalford et al. The metabolism of 16-fluoroestradiols in vivo: Chemical strategies for restricting the oxidative biotransformations of an estrogen-receptor imaging agent
Marton et al. A New Precursor for the Radiosynthesis of 6-O-(2-[18F] Fluoroethyl)-6-Odesmethyl-diprenorphine ([18F] FE-DPN) by Nucleophilic Radiofluorination
Ali et al. Synthesis of the 7α-cyano-(17α, 20E/Z)-[125I] iodovinyl-19-nortestosterones: potential radioligands for androgen and progesterone receptors
Hoyte et al. The synthesis and testing of E-17α-(2-iodovinyl)-5α-dihydrotestosterone and Z-17α-(2-iodovinyl)-5α-dihydrotestosterone as γ-emitting ligands for the androgen receptor
Choe et al. 6α-[18F] Fluoroprogesterone: synthesis via halofluorination-oxidation, receptor binding and tissue distribution
de Groot et al. Synthesis of 6α-[18F] fluoroprogesterone: a first step towards a potential receptor-ligand for PET
Merrick et al. A reevaluation of an agent proposed for imaging oestrogen receptors: 17α-[125I]-iodovinyl-11β-methoxyoestradiol-3-methyl ether ([125I] VMEME)

Legal Events

Date Code Title Description
FZDE Dead