CA2236001A1 - Biologically active eph family ligands - Google Patents

Biologically active eph family ligands

Info

Publication number
CA2236001A1
CA2236001A1 CA 2236001 CA2236001A CA2236001A1 CA 2236001 A1 CA2236001 A1 CA 2236001A1 CA 2236001 CA2236001 CA 2236001 CA 2236001 A CA2236001 A CA 2236001A CA 2236001 A1 CA2236001 A1 CA 2236001A1
Authority
CA
Canada
Prior art keywords
biologically active
family ligands
eph family
ligand
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2236001
Other languages
French (fr)
Other versions
CA2236001C (en
Inventor
Samuel Davis
Nicholas W. Gale
George D. Yancopoulos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1996/017201 external-priority patent/WO1997015667A1/en
Publication of CA2236001A1 publication Critical patent/CA2236001A1/en
Application granted granted Critical
Publication of CA2236001C publication Critical patent/CA2236001C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A novel ligand (Efl-6) that binds the Elk subfamily of Eph receptors is identified, and methods for making the soluble Elf-6 ligand in biologically active form is described. A cDNA clone encoding this novel protein enables production of the recombinant protein, which is useful to support neuronal and other Eph receptor-bearing cell populations.
CA002236001A 1995-10-25 1996-10-25 Biologically active eph family ligands Expired - Fee Related CA2236001C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US701595P 1995-10-25 1995-10-25
US60/007,015 1995-10-25
PCT/US1996/017201 WO1997015667A1 (en) 1995-10-25 1996-10-25 Biologically active eph family ligands

Publications (2)

Publication Number Publication Date
CA2236001A1 true CA2236001A1 (en) 1997-05-01
CA2236001C CA2236001C (en) 2007-04-10

Family

ID=29405581

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002236001A Expired - Fee Related CA2236001C (en) 1995-10-25 1996-10-25 Biologically active eph family ligands

Country Status (1)

Country Link
CA (1) CA2236001C (en)

Also Published As

Publication number Publication date
CA2236001C (en) 2007-04-10

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Effective date: 20121025