CA2235686A1 - Indolin-2-one derivatives, process for their production and the pharmaceutical compositions containing them - Google Patents
Indolin-2-one derivatives, process for their production and the pharmaceutical compositions containing themInfo
- Publication number
- CA2235686A1 CA2235686A1 CA002235686A CA2235686A CA2235686A1 CA 2235686 A1 CA2235686 A1 CA 2235686A1 CA 002235686 A CA002235686 A CA 002235686A CA 2235686 A CA2235686 A CA 2235686A CA 2235686 A1 CA2235686 A1 CA 2235686A1
- Authority
- CA
- Canada
- Prior art keywords
- indolin
- derivatives
- alkyl
- production
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
Abstract
The subject of the invention is indolin-2-one derivatives of formula:
IMG>
in which:
- W represents a-CH2- or -SO2- group;
- Cy forms, with the carbon to which it is bonded, a non-aromatic, saturated or unsaturated C3-C12 hydrocarbon ring which is optionally condensed or substituted by one or a number of (Cl-C7)alkyl groups, it being possible for the said groups to substitute the same carbon atom one or a number of times, or by a C3-C6 spirocycloalkyl;
- T represents a(Cl-C4)alkylene which is optionally interrupted by a (C3-C6)cycloalkylene, the said alkylenes optionally being substituted one or a number of times on the same carbon atom by a(Cl-C3)alkyl; or alternatively T represents a direct bond;
- Z represents in particular an amino group;
- Rl and R2, as well as R3 and R4, are either hydrogen or substituents, such as, for example, a halogen, an alkyl, and the like.
Application: Medicines having an affinity for vasopressin and/or oxytocin receptors.
IMG>
in which:
- W represents a-CH2- or -SO2- group;
- Cy forms, with the carbon to which it is bonded, a non-aromatic, saturated or unsaturated C3-C12 hydrocarbon ring which is optionally condensed or substituted by one or a number of (Cl-C7)alkyl groups, it being possible for the said groups to substitute the same carbon atom one or a number of times, or by a C3-C6 spirocycloalkyl;
- T represents a(Cl-C4)alkylene which is optionally interrupted by a (C3-C6)cycloalkylene, the said alkylenes optionally being substituted one or a number of times on the same carbon atom by a(Cl-C3)alkyl; or alternatively T represents a direct bond;
- Z represents in particular an amino group;
- Rl and R2, as well as R3 and R4, are either hydrogen or substituents, such as, for example, a halogen, an alkyl, and the like.
Application: Medicines having an affinity for vasopressin and/or oxytocin receptors.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR95/12533 | 1995-10-24 | ||
| FR9512533A FR2740136B1 (en) | 1995-10-24 | 1995-10-24 | INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| PCT/FR1996/001666 WO1997015556A1 (en) | 1995-10-24 | 1996-10-24 | 3-spiro-indolin-2-one derivatives as vasopressin and/or oxytocin receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2235686A1 true CA2235686A1 (en) | 1997-05-01 |
| CA2235686C CA2235686C (en) | 2007-06-26 |
Family
ID=38279097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002235686A Expired - Fee Related CA2235686C (en) | 1995-10-24 | 1996-10-24 | Indolin-2-one derivatives, process for their production and the pharmaceutical compositions containing them |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2235686C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935721B2 (en) | 2005-04-11 | 2011-05-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their uses as therapeutic agents |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| WO2008060789A2 (en) | 2006-10-12 | 2008-05-22 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
| SG10201703086VA (en) | 2008-10-17 | 2017-05-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their use as therapeutic agents |
| EP2350091B1 (en) | 2008-10-17 | 2015-06-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| AR077252A1 (en) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | ESPIROOXINDOL COMPOUND ENANTIOMERS AND THEIR USES AS THERAPEUTIC AGENTS |
| RU2544852C2 (en) | 2009-10-14 | 2015-03-20 | Ксенон Фармасьютикалз Инк. | Method for synthesis of spiro-oxyindole compounds |
| US9504671B2 (en) | 2010-02-26 | 2016-11-29 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| TW201636017A (en) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
-
1996
- 1996-10-24 CA CA002235686A patent/CA2235686C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935721B2 (en) | 2005-04-11 | 2011-05-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their uses as therapeutic agents |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2235686C (en) | 2007-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20131024 |