CA2226121A1 - Parevines et tachytegrines - Google Patents

Parevines et tachytegrines Download PDF

Info

Publication number
CA2226121A1
CA2226121A1 CA002226121A CA2226121A CA2226121A1 CA 2226121 A1 CA2226121 A1 CA 2226121A1 CA 002226121 A CA002226121 A CA 002226121A CA 2226121 A CA2226121 A CA 2226121A CA 2226121 A1 CA2226121 A1 CA 2226121A1
Authority
CA
Canada
Prior art keywords
compound
amino acid
peptides
peptide
homocysteine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002226121A
Other languages
English (en)
Inventor
Robert I. Lehrer
Sylvia S.L. Harwig
Conway Cheng Chang
Chee Liang Gu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ardea Biociences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2226121A1 publication Critical patent/CA2226121A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Biophysics (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

On décrit des composés à base d'agents antimicrobiens, des protégrines et des tachyplésines, qui présentent une charge positive nette d'au moins +1 au pH physiologique et comprennent 15 à 50 % d'acides aminés basiques et une séquence d'acides aminés de formule A1-A2-A3-C4*-C5*-C6*-A7-C8-A9-A10-A11-A12-C13-A14-C15*-C16*-C17*-A18, dans une fourchette de taille de 11 à 24 acides aminés quand la formule ci-dessus est prolongée aux terminaisons N- ou C- par des acides aminés complémentaires non intervenants, où la terminaison N- peut être acylatée et la terminaison C- amidatée ou estérifiée, et où des ponts disulfure peuvent être présents ou absents sous une forme linéaire stabilisée -SH. Dans une variante, C8 et C13 représentent cystéine, homocystéine ou pénicillamine; C4*-C6* et C15*-C16* représentent aussi ces éléments ou tout acide aminé naturel sauf les acides glutamique et aspartique et la proline, excepté quand C4*, C17* ou les deux sont éventuellement absents, la proline étant alors seule exclue en C5* et C15*; A1-A3 et A18 peuvent être présent ou absents et représentent tout acide aminé naturel sauf les acides glutamique et aspartique, la proline et la cystéine; A7 et A14 représentent un acide aminé hydrophobe ou court; A9-A12 doivent pouvoir former une spine .beta. dans le composé, et au moins un acide aminé situé entre A9 et A12 doit être basique.
CA002226121A 1995-07-06 1996-07-03 Parevines et tachytegrines Abandoned CA2226121A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89895P 1995-07-06 1995-07-06
US60/000,898 1995-07-06

Publications (1)

Publication Number Publication Date
CA2226121A1 true CA2226121A1 (fr) 1997-01-23

Family

ID=21693490

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002226121A Abandoned CA2226121A1 (fr) 1995-07-06 1996-07-03 Parevines et tachytegrines

Country Status (4)

Country Link
EP (1) EP0836617A4 (fr)
JP (1) JPH11509842A (fr)
CA (1) CA2226121A1 (fr)
WO (1) WO1997002287A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653442B1 (en) 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
USRE38828E1 (en) * 1995-07-06 2005-10-11 Intrabiotics Pharmaceuticals, Inc. Parevins and tachytegrins
US6307016B1 (en) 1995-07-06 2001-10-23 Intrabiotics Pharmaceuticals, Inc. Parevins and tachytegrins
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins
CA2238429A1 (fr) * 1995-11-22 1997-05-29 Intrabiotics Pharmaceuticals, Inc. Compositions et procedes pour la prevention et le traitement de l'inflammation de la muqueuse buccale
AU6567098A (en) * 1997-03-20 1998-10-12 Regents Of The University Of California, The Use of protegrins for periodontal indications
US6015941A (en) * 1997-10-31 2000-01-18 Pioneer Hi-Bred International, Inc. Peptide derivatives of tachyplesin having antimicrobial activity
US6043220A (en) * 1997-12-03 2000-03-28 Intrabiotics Pharmaceuticals, Inc. Threonine-containing protegrins
KR101365712B1 (ko) * 2005-03-21 2014-02-24 시타코트 에이비 스페이서 분자를 경유하는 ｓ―ｓ 가교를 통한 결합에 의하여 기질에 공유 결합된 시스테인 성분을 포함하는 항미생물제
ITMI20122263A1 (it) * 2012-12-28 2014-06-29 Azienda Ospedaliero Universitaria Di Parma Nuovi peptidi cationici ciclici ad attività antimicrobica
CN108366560A (zh) * 2016-03-31 2018-08-03 积水化学工业株式会社 抗菌抗病毒性组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA09696A (en) * 1991-05-02 1993-08-30 Seikagaku Kogyo Co Ltd Novel polypeptides with affinity to lipopolysaccharides and their uses
US5434074A (en) * 1991-07-05 1995-07-18 Gibson; D. Wade Cytomegalovirus proteinase
US5488035A (en) * 1991-12-06 1996-01-30 Pioneer Hi-Bred International, Inc. Peptide with inhibitory activity towards plant pathogenic fungi
US5708145A (en) * 1993-07-20 1998-01-13 University Of California Immunglobulins reactive with protegrins
US5580852A (en) * 1993-12-17 1996-12-03 Pioneer Hi-Bred International, Inc. Derivatives of tachyplesin having inhibitory activity towards plant pathogenic fungi
US5589364A (en) * 1994-07-29 1996-12-31 Magainin Pharmaceuticals Inc. Recombinant production of biologically active peptides and proteins

Also Published As

Publication number Publication date
WO1997002287A1 (fr) 1997-01-23
EP0836617A1 (fr) 1998-04-22
JPH11509842A (ja) 1999-08-31
AU714294B2 (en) 1999-12-23
EP0836617A4 (fr) 2000-06-28
AU6452996A (en) 1997-02-05

Similar Documents

Publication Publication Date Title
AU689487B2 (en) Protegrins
EP0871654B1 (fr) Protegrines
US5464823A (en) Mammalian antibiotic peptides
AU720467B2 (en) Fine tuned protegrins
US8686113B2 (en) Antibiotic peptides
WO1996037508A9 (fr) Protegrines
US5693486A (en) DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
CA2226121A1 (fr) Parevines et tachytegrines
US20040152638A1 (en) Protegrins
US6307016B1 (en) Parevins and tachytegrins
US6653442B1 (en) Protegrins
CA2312191A1 (fr) Protegrines contenant de la threonine
US5998374A (en) Clavaspirins
WO1998038309A9 (fr) Clavaspirines
USRE38828E1 (en) Parevins and tachytegrins
AU714294C (en) Parevins and tachytegrins
CA2238610A1 (fr) Protegrines finement mises au point

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20080703