CA2225682A1 - Procede de ralentissement dynamique de la cinetique du cycle cellulaire, destine a potentialiser les lesions cellulaires - Google Patents

Procede de ralentissement dynamique de la cinetique du cycle cellulaire, destine a potentialiser les lesions cellulaires Download PDF

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Publication number
CA2225682A1
CA2225682A1 CA002225682A CA2225682A CA2225682A1 CA 2225682 A1 CA2225682 A1 CA 2225682A1 CA 002225682 A CA002225682 A CA 002225682A CA 2225682 A CA2225682 A CA 2225682A CA 2225682 A1 CA2225682 A1 CA 2225682A1
Authority
CA
Canada
Prior art keywords
cells
agent
cell
tci
dthd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002225682A
Other languages
English (en)
Inventor
Philip M. Grimley
Sunil Mehta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henry M Jackson Foundation for Advancedment of Military Medicine Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2225682A1 publication Critical patent/CA2225682A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention se rapporte à un procédé amélioré destiné à induire des lésions cellulaires, par l'administration d'un agent de ralentissement (RA) à une population cellulaire cible en une concentration suffisante et dans des conditions appropriées pour retarder, mais non interrompre la progression des cellules cibles dans le cycle cellulaire, et l'administration simultanée ou ultérieure à celle de l'agent de ralentissement, d'un agent d'agression cytotoxique ciblé (TCI). L'invention se rapporte également à un système indicateur en microculture et à des procédures d'analyse de données auxiliaires visant à identifier, concevoir et utiliser de nouveaux agents comme agents de ralentissement ou agents d'agression cytotoxiques ciblés, ainsi qu'à améliorer les associations synergiques des agents existants. Dans des modes de réalisation de l'invention, l'agent de ralentissement peut être un inhibiteur de ribonucléotide réductase, de dihydrofolate réductase, de thymidylate synthase, d'ADN polymérase, de protéine kinase ou de topoisomérase. En outre, selon des variantes de l'invention on utilise, comme agent TCI, les indole carbazoles tels que la staurosporine, K252a, KT5926, et KT5720. Dans une variante spécifique, l'agent de ralentissement est la thymidine et l'agent TCI est la staurosporine.
CA002225682A 1995-06-27 1996-06-26 Procede de ralentissement dynamique de la cinetique du cycle cellulaire, destine a potentialiser les lesions cellulaires Abandoned CA2225682A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US54695P 1995-06-27 1995-06-27
US66893296A 1996-06-24 1996-06-24
US08/668,932 1996-06-24
US60/000,546 1996-06-24
PCT/US1996/010921 WO1997001344A2 (fr) 1995-06-27 1996-06-26 Procede de ralentissement dynamique de la cinetique du cycle cellulaire, destine a potentialiser les lesions cellulaires

Publications (1)

Publication Number Publication Date
CA2225682A1 true CA2225682A1 (fr) 1997-01-16

Family

ID=26667798

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002225682A Abandoned CA2225682A1 (fr) 1995-06-27 1996-06-26 Procede de ralentissement dynamique de la cinetique du cycle cellulaire, destine a potentialiser les lesions cellulaires

Country Status (5)

Country Link
EP (1) EP0835111A2 (fr)
JP (1) JPH11509193A (fr)
AU (1) AU715527B2 (fr)
CA (1) CA2225682A1 (fr)
WO (1) WO1997001344A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009005300A (es) * 2006-11-17 2009-06-08 Schering Corp Combinacion de un inhibidor de acido desoxirribonucleico polimerasa-alfa y un inhibidor de una cinasa de punto de verificacion para trastornos proliferativos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4448534A (en) * 1978-03-30 1984-05-15 American Hospital Corporation Antibiotic susceptibility testing
US5166140A (en) * 1987-05-05 1992-11-24 City Of Hope Use of certain nucleoside analogs to attenuate cancer cell resistance to DNA damaging chemotherapy
DE3827974A1 (de) * 1988-08-18 1990-02-22 Boehringer Mannheim Gmbh Kombinationspraeparate von proteinkinase-c-inhibitoren mit lipiden, lipid-analoga, cytostatica oder inhibitoren von phospholipasen
WO1992019765A1 (fr) * 1991-05-08 1992-11-12 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Procede de conception de traitements du cancer, procedes et compositions pharmaceutiques de traitements du cancer
EP0593663A4 (en) * 1991-07-03 1996-10-30 Regeneron Pharma Method and assay system for neurotrophin activity
EP0612248B1 (fr) * 1991-11-15 2003-08-20 Smithkline Beecham Corporation composition contenant le cisplatin et le topotécane comme agent antitumoral
JPH08500112A (ja) * 1992-08-12 1996-01-09 ジ・アップジョン・カンパニー タキソールと組み合わせるプロテインキナーゼ阻害剤および関連化合物
ZA941290B (en) * 1993-02-26 1995-08-25 Res Dev Foundation Combination cisplatin/tamoxifen therapy for human cancers
EP0703917A1 (fr) * 1993-06-17 1996-04-03 Novartis AG Compose d'indolocarbazole utilise comme inhibiteur de proteine-kinase c

Also Published As

Publication number Publication date
AU715527B2 (en) 2000-02-03
WO1997001344A3 (fr) 1997-03-27
EP0835111A2 (fr) 1998-04-15
WO1997001344A2 (fr) 1997-01-16
JPH11509193A (ja) 1999-08-17
AU6396096A (en) 1997-01-30

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20040628