CA2223898C - Derives d'hexahydroxybiphenyle bromes - Google Patents

Derives d'hexahydroxybiphenyle bromes Download PDF

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Publication number
CA2223898C
CA2223898C CA002223898A CA2223898A CA2223898C CA 2223898 C CA2223898 C CA 2223898C CA 002223898 A CA002223898 A CA 002223898A CA 2223898 A CA2223898 A CA 2223898A CA 2223898 C CA2223898 C CA 2223898C
Authority
CA
Canada
Prior art keywords
compound
hiv
biphenyl
dimethoxy
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002223898A
Other languages
English (en)
Other versions
CA2223898A1 (fr
Inventor
Kuo-Hsiung Lee
Yoshiki Kashiwada
Lan Xie
Louis Mark Cosentino
Mark Manak
Jing-Xi Xie
Yung-Chi Cheng
Robert E. Kilkuskie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Panacos Pharmaceuticals Inc
Original Assignee
University of North Carolina at Chapel Hill
Panacos Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/477,939 external-priority patent/US5612341A/en
Application filed by University of North Carolina at Chapel Hill, Panacos Pharmaceuticals Inc filed Critical University of North Carolina at Chapel Hill
Publication of CA2223898A1 publication Critical patent/CA2223898A1/fr
Application granted granted Critical
Publication of CA2223898C publication Critical patent/CA2223898C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

On a synthétisé des dérivés de 4,4'-diméthoxy-5,6,5',6'-biméthylènedioxy-2,2'-diméthoxycarbonyle biphényle (DDB) et on a découvert que ces dérivés ont une activité anti-VIH. Parmi les composés étudiés, le 3,3'-dibromo DDB et le 3-bromo-DDB présentent initialement l'activité anti-VIH la plus importante.
CA002223898A 1995-06-07 1996-06-07 Derives d'hexahydroxybiphenyle bromes Expired - Fee Related CA2223898C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/477,939 1995-06-07
US08/477,939 US5612341A (en) 1995-06-07 1995-06-07 Brominated hexahydroxybiphenyl derivatives
PCT/US1996/010080 WO1996040111A1 (fr) 1995-06-07 1996-06-07 Derives d'hexahydroxybiphenyle bromes

Publications (2)

Publication Number Publication Date
CA2223898A1 CA2223898A1 (fr) 1996-12-19
CA2223898C true CA2223898C (fr) 2007-07-17

Family

ID=38288351

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002223898A Expired - Fee Related CA2223898C (fr) 1995-06-07 1996-06-07 Derives d'hexahydroxybiphenyle bromes

Country Status (1)

Country Link
CA (1) CA2223898C (fr)

Also Published As

Publication number Publication date
CA2223898A1 (fr) 1996-12-19

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