CA2223259A1 - Pharmaceutical formulations of highly lipophilic camptothecin derivatives - Google Patents
Pharmaceutical formulations of highly lipophilic camptothecin derivativesInfo
- Publication number
- CA2223259A1 CA2223259A1 CA002223259A CA2223259A CA2223259A1 CA 2223259 A1 CA2223259 A1 CA 2223259A1 CA 002223259 A CA002223259 A CA 002223259A CA 2223259 A CA2223259 A CA 2223259A CA 2223259 A1 CA2223259 A1 CA 2223259A1
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical formulations
- camptothecin derivatives
- highly lipophilic
- lipophilic camptothecin
- highly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A pharmaceutical formulation, as a solution or suspension of pH from 2 to 6, of camptothecin or a lipophilic camptothecin derivative, having a water solubility of less than 5 micrograms/ml, in N-methylpyrrolidin-2-one.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/461,385 US5726181A (en) | 1995-06-05 | 1995-06-05 | Formulations and compositions of poorly water soluble camptothecin derivatives |
US08/461,385 | 1995-06-05 | ||
PCT/EP1996/002438 WO1996039143A1 (en) | 1995-06-05 | 1996-06-04 | Pharmaceutical formulations of highly lipophilic camptothecin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2223259A1 true CA2223259A1 (en) | 1996-12-12 |
CA2223259C CA2223259C (en) | 2007-08-14 |
Family
ID=38434459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002223259A Expired - Lifetime CA2223259C (en) | 1995-06-05 | 1996-06-04 | Pharmaceutical formulations of highly lipophilic camptothecin derivatives |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2223259C (en) |
-
1996
- 1996-06-04 CA CA002223259A patent/CA2223259C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2223259C (en) | 2007-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX9709094A (en) | Pharmaceutical formulations of highly lipophilic camptothecin derivatives. | |
CA2342390A1 (en) | Sustained release ranolazine formulations | |
CA2189328A1 (en) | Tocopherol compositions for delivery of biologically active agents | |
IL103571A0 (en) | Water soluble camptothecin derivatives,their preparation and pharmaceutical compositions containing them | |
CA2182244A1 (en) | Camptothecin derivatives | |
AU3032195A (en) | Optically active 5H-pyrrolo(3,4-b)pyrazine derivative, its preparation and pharmaceutical compositions containing it | |
IL145789A0 (en) | Derivatives of propionic acid, their preparation and pharmaceutical compositions containing them | |
WO2003022210A3 (en) | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating diseases therewith | |
CA2258548A1 (en) | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases | |
UA40663C2 (en) | controlled release, solid pharmaceutical composition adapted for oral administration | |
IL104446A0 (en) | Acetic acid derivatives,their preparation and pharmaceutical compositions containing them | |
AU2724292A (en) | Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-d-neuraminic acid | |
IL117889A0 (en) | Pharmaceutical compositions containing lipophilic compounds | |
CA2053826A1 (en) | Pharmaceutical compositions active in the therapy of neurological affections in aids patients | |
BG103750A (en) | Salt of a derivative of naphthyridinecarbonic acid | |
WO2000045800A3 (en) | Immunosurpressive effects of pteridine derivatives | |
AU7588696A (en) | Pyrido{2, 3-D} pyrimidine derivatives and pharmaceutical compositions thereof | |
IL102814A0 (en) | Pyrazine derivatives,their preparation and pharmaceutical compositions comprising them | |
IL105375A0 (en) | Acetic acid derivatives,their preparation and pharmaceutical compositions containing them | |
CA2175971A1 (en) | Stable liquid composition containing urate oxidase and lyophilized composition for its preparation | |
IL118162A0 (en) | Nanoparticles for oral administration of pharmaceutical agents of low solubility | |
CA2356959A1 (en) | Water-insoluble drug delivery system | |
CA2127472A1 (en) | New adenosine derivatives, preparation methods and pharmaceutical compositions containing them | |
HUP0002650A3 (en) | 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b]-indole-1-acetamide derivatives, process for their preparation and pharmaceutical compositions containing them | |
HUP9900987A3 (en) | Camptothecin derivatives process for their preparation, use thereof as antitumor agents and pharmaceutical compositions containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20160606 |
|
MKEX | Expiry |
Effective date: 20160606 |