CA2222785A1 - Vitamin d analogues - Google Patents

Vitamin d analogues

Info

Publication number
CA2222785A1
CA2222785A1 CA002222785A CA2222785A CA2222785A1 CA 2222785 A1 CA2222785 A1 CA 2222785A1 CA 002222785 A CA002222785 A CA 002222785A CA 2222785 A CA2222785 A CA 2222785A CA 2222785 A1 CA2222785 A1 CA 2222785A1
Authority
CA
Canada
Prior art keywords
hydroxy
groups
hydrocarbylene
methyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002222785A
Other languages
French (fr)
Other versions
CA2222785C (en
Inventor
Martin John Calverley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsa Ktieselskab)
Martin John Calverley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9524812.6A external-priority patent/GB9524812D0/en
Application filed by Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsa Ktieselskab), Martin John Calverley filed Critical Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsa Ktieselskab)
Publication of CA2222785A1 publication Critical patent/CA2222785A1/en
Application granted granted Critical
Publication of CA2222785C publication Critical patent/CA2222785C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages

Abstract

The present invention relates to compounds of formula (I) in which formula X
is hydrogen or hydroxy; R1 and R2 stand for methyl or ethyl, or, when taken together with the carbon atom bearing the group X, can form a C3-C5 carbocyclic ring; Q is either a single bond or a C1-C8 hydrocarbylene in which one of any methylene groups not directly bonded to the carbonyl group may optionally be replaced by an oxygen atom (or methyl by hydroxy); Y is either a single bond or C1-C8 hydrocarbylene; and derivatives of (I) in which one or more of the hydroxy groups are masked as groups which can be reconverted to hydroxy groups in vivo. The compounds show antiinflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.
CA002222785A 1995-12-05 1996-12-02 Vitamin d analogues Expired - Fee Related CA2222785C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9524812.6 1995-12-05
GBGB9524812.6A GB9524812D0 (en) 1995-12-05 1995-12-05 Chemical compounds
PCT/DK1996/000502 WO1997020811A1 (en) 1995-12-05 1996-12-02 Vitamin d analogues

Publications (2)

Publication Number Publication Date
CA2222785A1 true CA2222785A1 (en) 1997-06-12
CA2222785C CA2222785C (en) 2006-04-04

Family

ID=4161813

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002222785A Expired - Fee Related CA2222785C (en) 1995-12-05 1996-12-02 Vitamin d analogues

Country Status (1)

Country Link
CA (1) CA2222785C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007131364A1 (en) * 2006-05-16 2007-11-22 Mcgill University Hybrid molecules having mixed vitamin d receptor agonism and histone deacetylase inhibitory properties

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007131364A1 (en) * 2006-05-16 2007-11-22 Mcgill University Hybrid molecules having mixed vitamin d receptor agonism and histone deacetylase inhibitory properties

Also Published As

Publication number Publication date
CA2222785C (en) 2006-04-04

Similar Documents

Publication Publication Date Title
CA2073983A1 (en) Novel vitamin d analogues
DE69129193D1 (en) Triterpenderivat
EP0990650B8 (en) Tricyclic pyrrole or pyrazole derivatives
DE69409811T2 (en) NEW VITAMIN D DERIVATIVES
CA2157114A1 (en) Process for the preparation of 9-desoxotaxanes
GR3022768T3 (en) Novel vitamin d analogues.
AU7691396A (en) Vitamin d analogues
ES2000368A6 (en) Substituted-di-t-butylphenols.
AU3025697A (en) Novel vitamin d analogues
CA2266479A1 (en) Vitamin d analogues
CA2140247A1 (en) Novel vitamin d analogues
ATE154596T1 (en) NEW VITAMIN D DERIVATIVES
CA2222785A1 (en) Vitamin d analogues
IL127154A0 (en) Pharmaceutical compositions containing cyclosporine and a carrier comprising at least an ester of alpha-glycerophoshoric acid
SE1214315T5 (en)
SE9503420D0 (en) Method of making metal composite powder
MX9702486A (en) The manufacture of levobupivacaine and analogues thereof from l-lysine.
MX9800217A (en) Macrolides.

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed