CA2221842A1 - Antagonistes du recepteur adrenergique alpha 1a - Google Patents

Antagonistes du recepteur adrenergique alpha 1a Download PDF

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Publication number
CA2221842A1
CA2221842A1 CA002221842A CA2221842A CA2221842A1 CA 2221842 A1 CA2221842 A1 CA 2221842A1 CA 002221842 A CA002221842 A CA 002221842A CA 2221842 A CA2221842 A CA 2221842A CA 2221842 A1 CA2221842 A1 CA 2221842A1
Authority
CA
Canada
Prior art keywords
alkyl
alkoxy
halogen
aryl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002221842A
Other languages
English (en)
Inventor
Jennie Nerenberg
Mark G. Bock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2221842A1 publication Critical patent/CA2221842A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur certains nouveaux composés, leurs dérivés, leur synthèse, et leur utilisation comme antagonistes sélectif du récepteur adrénergique alpha-Ia et dont l'une des applications est le traitement de l'hyperplasie prostatique bénigne. Ces composés ont une capacité sélective de relaxation des tissus des muscles lisses enrichis en sous-types de récepteurs alpha 1a sans production simultanée d'hypotension. Or, l'un de ces tissus entoure la muqueuse urétrale. En conséquence l'une des applications de ces composants à action instantanée est de fournir un intense soulagement aux hommes souffrant d'hyperplasie prostatique bénigne en réduisant les obstacles s'opposant au passage de l'urine. L'une des autres applications résulte de sa combinaison avec un composé inhibiteur de la 5-alpha réductase humaine, combinaison qui permet d'apporter un soulagement important et permanent des effets de l'hyperplasie prostatique bénigne.
CA002221842A 1995-06-06 1996-06-04 Antagonistes du recepteur adrenergique alpha 1a Abandoned CA2221842A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US470,164 1990-01-25
US47016495A 1995-06-06 1995-06-06

Publications (1)

Publication Number Publication Date
CA2221842A1 true CA2221842A1 (fr) 1996-12-12

Family

ID=23866530

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221842A Abandoned CA2221842A1 (fr) 1995-06-06 1996-06-04 Antagonistes du recepteur adrenergique alpha 1a

Country Status (5)

Country Link
EP (1) EP0831824A4 (fr)
JP (1) JP2001516330A (fr)
AU (1) AU705661B2 (fr)
CA (1) CA2221842A1 (fr)
WO (1) WO1996039140A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2355263A (en) 1999-09-30 2001-04-18 Merck & Co Inc Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
GB2355457A (en) 1999-09-30 2001-04-25 Merck & Co Inc Novel spirotricyclic substituted azacycloalkane derivatives useful as alpha 1a adrenoceptor antagonists
JPWO2004092179A1 (ja) * 2003-04-14 2006-07-06 日本曹達株式会社 スピロ誘導体、製造法および抗酸化薬
US7935712B2 (en) 2005-07-19 2011-05-03 Merck Sharp & Dohme Corp. Spirochromanone derivatives as acetyl coenzyme A carboxylase (ACC) inhibitors
WO2007063385A2 (fr) * 2005-12-01 2007-06-07 Pfizer Products Inc. Antagonistes des recepteurs de l'histamine 3 pour des amines spirocycliques
AU2007326950B2 (en) * 2006-11-29 2010-10-14 Pfizer Products Inc. Spiroketone acetyl-CoA carboxylase inhibitors
US8138197B2 (en) 2007-01-12 2012-03-20 Msd K.K. Spirochromanon derivatives
PE20081559A1 (es) 2007-01-12 2008-11-20 Merck & Co Inc DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
US5403847A (en) * 1992-11-13 1995-04-04 Synaptic Pharmaceutical Corporation Use of α1C specific compounds to treat benign prostatic hyperlasia
CA2155108A1 (fr) * 1993-02-12 1994-08-18 John J. Baldwin Spirocycles renfermant de l'azote

Also Published As

Publication number Publication date
WO1996039140A1 (fr) 1996-12-12
EP0831824A4 (fr) 2001-05-02
EP0831824A1 (fr) 1998-04-01
AU6149796A (en) 1996-12-24
AU705661B2 (en) 1999-05-27
JP2001516330A (ja) 2001-09-25

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Legal Events

Date Code Title Description
FZDE Dead