CA2218370A1 - Chewable tablet with effervescent action - Google Patents

Chewable tablet with effervescent action

Info

Publication number
CA2218370A1
CA2218370A1 CA002218370A CA2218370A CA2218370A1 CA 2218370 A1 CA2218370 A1 CA 2218370A1 CA 002218370 A CA002218370 A CA 002218370A CA 2218370 A CA2218370 A CA 2218370A CA 2218370 A1 CA2218370 A1 CA 2218370A1
Authority
CA
Canada
Prior art keywords
free
active substances
effervescent agent
chewable tablet
tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002218370A
Other languages
French (fr)
Other versions
CA2218370C (en
Inventor
Gerhard Gergely
Irmgard Gergely
Thomas Gergely
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/EP1996/003165 external-priority patent/WO1997004754A1/en
Publication of CA2218370A1 publication Critical patent/CA2218370A1/en
Application granted granted Critical
Publication of CA2218370C publication Critical patent/CA2218370C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The chewing tablets proposed contain a small amount of effervescent agent (which gives a pleasant fizzy feeling in the mouth), active substances and fillers in amounts chosen so that the tablets will nevertheless dissolve, with the exception of any insoluble or poorly soluble active substances, in 100 ml of water at 15 to 20°C in less that 120, preferably 90, seconds. This is achieved by virtue of the fact that the acid and/or carbonate particles in the effervescent agent are coated with a preferably readily, i.e.
rapidly, soluble hydrocolloid and/or the active substance is free of encapsulation agents and the tablet mixture is free of lubricants. Tablet weight is 600 to 1500 mg, preferably only 700 to 1200 mg.
CA002218370A 1995-07-31 1996-07-18 Chewable tablet with effervescent action Expired - Lifetime CA2218370C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH2230/95-3 1995-07-31
CH223095 1995-07-31
PCT/EP1996/003165 WO1997004754A1 (en) 1995-07-31 1996-07-18 Chewing tablets with an effervescent action

Publications (2)

Publication Number Publication Date
CA2218370A1 true CA2218370A1 (en) 1997-02-13
CA2218370C CA2218370C (en) 2006-10-03

Family

ID=37101767

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002218370A Expired - Lifetime CA2218370C (en) 1995-07-31 1996-07-18 Chewable tablet with effervescent action

Country Status (1)

Country Link
CA (1) CA2218370C (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858121B2 (en) 2003-12-31 2010-12-28 Cima Labs, Inc. Effervescent oral fentanyl dosage form and methods of administering fentanyl
US7862832B2 (en) 2003-12-31 2011-01-04 Cima Labs, Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering
US7862833B2 (en) 2003-12-31 2011-01-04 Cima Labs, Inc. Effervescent oral opiate dosage forms and methods of administering opiates

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974590B2 (en) 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US20030091629A1 (en) 1998-03-27 2003-05-15 Cima Labs Inc. Sublingual buccal effervescent

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858121B2 (en) 2003-12-31 2010-12-28 Cima Labs, Inc. Effervescent oral fentanyl dosage form and methods of administering fentanyl
US7862832B2 (en) 2003-12-31 2011-01-04 Cima Labs, Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering
US7862833B2 (en) 2003-12-31 2011-01-04 Cima Labs, Inc. Effervescent oral opiate dosage forms and methods of administering opiates

Also Published As

Publication number Publication date
CA2218370C (en) 2006-10-03

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20160718