CA2218281A1 - Method and apparatus for noninvasively determining hematocrit - Google Patents

Method and apparatus for noninvasively determining hematocrit

Info

Publication number
CA2218281A1
CA2218281A1 CA002218281A CA2218281A CA2218281A1 CA 2218281 A1 CA2218281 A1 CA 2218281A1 CA 002218281 A CA002218281 A CA 002218281A CA 2218281 A CA2218281 A CA 2218281A CA 2218281 A1 CA2218281 A1 CA 2218281A1
Authority
CA
Canada
Prior art keywords
hematocrit
blood
sgd
current
determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002218281A
Other languages
French (fr)
Other versions
CA2218281C (en
Inventor
Paul W. Ruben
Allan L. Kaminsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microcor Inc
Original Assignee
Microcor, Inc.
Paul W. Ruben
Allan L. Kaminsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/425,404 external-priority patent/US5526808A/en
Priority claimed from US08/602,700 external-priority patent/US5642734A/en
Application filed by Microcor, Inc., Paul W. Ruben, Allan L. Kaminsky filed Critical Microcor, Inc.
Publication of CA2218281A1 publication Critical patent/CA2218281A1/en
Application granted granted Critical
Publication of CA2218281C publication Critical patent/CA2218281C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4869—Determining body composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems

Abstract

This invention is a method and apparatus for non-invasiveness in determining hematocrit, utilizing the frequency dependent electrical impedance characteristics of whole blood by electrically stimulating a patient body portion containing a vascular compartment with a current source over a range of frequencies. A hematocrit measurement system includes a signal generator and demodulator [SGD] (34) that sends an applied signal to an electrode pod (36) that applies a current to a limb of a patient. The electrode pod (36) receives resulting measured voltage signals and provides them to the SGD. The SGD provides to a personal computer [PC] (42) signals indicative of the current passing through the limb of the patient and the resulting voltage. The voltage and current may be measured for various frequencies over, for example, a range from about 10 kHz to about 10 MHz. The electrical impedance from the blood alone is isolated from the total limb impedance from the blood, tissue, bone, etc. by determining the difference between measurement at different blood volumes. The hematocrit is determined by the PC based on inphase and quadrature data provided by the SGD. A neural network (52) may be useful in determining the hematocrit from the blood impedance patterns.
CA002218281A 1995-04-20 1996-04-03 Method and apparatus for noninvasively determining hematocrit Expired - Fee Related CA2218281C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/425,404 1995-04-20
US08/425,404 US5526808A (en) 1990-10-04 1995-04-20 Method and apparatus for noninvasively determining hematocrit
US48449095A 1995-06-07 1995-06-07
US08/484,490 1995-06-07
US08/602,700 US5642734A (en) 1990-10-04 1996-02-16 Method and apparatus for noninvasively determining hematocrit
US08/602,700 1996-02-16
PCT/US1996/004547 WO1996032883A1 (en) 1995-04-20 1996-04-03 Method and apparatus for noninvasively determining hematocrit

Publications (2)

Publication Number Publication Date
CA2218281A1 true CA2218281A1 (en) 1996-10-24
CA2218281C CA2218281C (en) 2004-08-17

Family

ID=27411466

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002218281A Expired - Fee Related CA2218281C (en) 1995-04-20 1996-04-03 Method and apparatus for noninvasively determining hematocrit

Country Status (6)

Country Link
EP (1) EP0955871A4 (en)
JP (1) JP3844779B2 (en)
CN (1) CN1244779A (en)
AU (1) AU5383796A (en)
CA (1) CA2218281C (en)
WO (1) WO1996032883A1 (en)

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ES2143911B1 (en) * 1997-03-06 2000-12-01 Nte Sa METHOD AND APPARATUS FOR MEASURING THE CONCENTRATION AND COMPOSITION OF BIOMASS.
JP2002501802A (en) * 1998-02-04 2002-01-22 ダーマル セラピー （バルバドス） インク． METHOD AND APPARATUS FOR NON-INVASIVE MEASUREMENT OF GLUCOSE IN BODY FLUID
AU2001261847A1 (en) * 2000-05-16 2001-11-26 Microcor, Inc. System and method for in-vivo hematocrit measurement using impedance and pressure plethysmography
US6615077B1 (en) 2000-08-14 2003-09-02 Renal Research Institute, Llc Device and method for monitoring and controlling physiologic parameters of a dialysis patient using segmental bioimpedence
US7228170B2 (en) 2000-08-14 2007-06-05 Renal Research Institute, Llc Device and method for monitoring and controlling physiologic parameters of a dialysis patient using segmental bioimpedance
US7491174B2 (en) 2003-03-25 2009-02-17 Renal Research Institute, Llc Device and method for performing electrical impedance tomography
AU2004236588B2 (en) * 2003-05-12 2009-07-09 Cheetah Medical, Inc. System, method and apparatus for measuring blood flow and blood volume
CN100457021C (en) * 2003-06-03 2009-02-04 奥森斯有限公司 Method and system for use in non-invasive optical measurements of blood parameters
US8535497B2 (en) 2003-12-04 2013-09-17 Panasonic Corporation Method of measuring blood component, sensor used in the method, and measuring device
CN100432663C (en) 2003-12-04 2008-11-12 松下电器产业株式会社 Hematocrit(hct) measuring method, sensor used for same, and measuring instrument
KR101108381B1 (en) 2004-04-19 2012-01-30 파나소닉 주식회사 Method for measuring blood components and biosensor and measuring instrument for use therein
US7356366B2 (en) 2004-08-02 2008-04-08 Cardiac Pacemakers, Inc. Device for monitoring fluid status
CA2597264C (en) 2005-02-15 2017-07-25 Cheetah Medical Ltd. System, method and apparatus for measuring blood flow and blood volume
US9713447B2 (en) 2005-11-10 2017-07-25 Biovotion Ag Device for determining the glucose level in body tissue
JP4640608B2 (en) * 2005-12-12 2011-03-02 ソニー株式会社 Detection apparatus and detection method
JP5071768B2 (en) * 2006-12-08 2012-11-14 学校法人日本大学 Blood flow velocity measuring device
JP5071767B2 (en) * 2006-12-08 2012-11-14 学校法人日本大学 Biological tissue blood flow measurement device
US8876725B2 (en) 2007-02-23 2014-11-04 Cheetah Medical, Inc. Method and system for estimating exercise capacity
US9095271B2 (en) 2007-08-13 2015-08-04 Cheetah Medical, Inc. Dynamically variable filter
EP2131737B1 (en) 2007-03-07 2015-04-29 Cheetah Medical, Inc. Method and system for monitoring sleep
WO2008129535A1 (en) 2007-04-19 2008-10-30 Cheetah Medical Ltd. Method, apparatus and system for predicting electromechanical dissociation
US7981281B2 (en) 2008-07-09 2011-07-19 Baxter International, Inc. Dialysis system having regimen generation methodology
US8062513B2 (en) 2008-07-09 2011-11-22 Baxter International Inc. Dialysis system and machine having therapy prescription recall
US8168063B2 (en) 2008-07-09 2012-05-01 Baxter International Inc. Dialysis system having filtering method for determining therapy prescriptions
US8057679B2 (en) 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
US9514283B2 (en) 2008-07-09 2016-12-06 Baxter International Inc. Dialysis system having inventory management including online dextrose mixing
US10631745B2 (en) * 2008-09-22 2020-04-28 Cheetah Medical, Inc. System and method for determining blood flow
US9247905B2 (en) 2009-04-17 2016-02-02 Biovotion Ag Wide band field response measurement for glucose determination
US8282829B2 (en) 2009-05-20 2012-10-09 Baxter International Inc. System and method for automated data collection of twenty-four hour ultrafiltration and other patient parameters using wired or wireless technology
US8926551B2 (en) 2009-07-07 2015-01-06 Baxter Healthcare Inc. Peritoneal dialysis therapy with large dialysis solution volumes
JP2011078443A (en) * 2009-10-02 2011-04-21 Tanita Corp Biometric measurement apparatus
CN103648374B (en) * 2011-02-17 2016-08-17 高通股份有限公司 For determining the method and system of mammal cardiovascular
CN102694509B (en) * 2011-03-22 2017-02-15 北京汉朔科技有限公司 An integrated electro-physiological signal amplifier with an AC excitation function
JP5726662B2 (en) * 2011-07-22 2015-06-03 学校法人上智学院 Blood impedance measuring device, artificial dialysis device, and method for operating blood impedance measuring device
KR102073221B1 (en) 2011-07-25 2020-02-04 치타 메디컬, 인코퍼레이티드 Method and system for monitoring hemodynamics
US8623660B2 (en) * 2011-09-30 2014-01-07 Lifescan Scotland Limited Hand-held test meter with phase-shift-based hematocrit measurement circuit
CN103149132B (en) * 2013-03-18 2015-02-25 深圳市理邦精密仪器股份有限公司 Detection system for improving accuracy of measuring packed cell volume accuracy and operating control method
US20150196224A1 (en) * 2014-01-16 2015-07-16 Dermal Therapy (Barbados) Inc. Implantable Sensor and Method for Such Sensor
MX2016013984A (en) 2014-05-23 2017-04-06 Nova Biomedical Corp Hemolysis detection method and system.
CN105403691B (en) * 2016-01-01 2017-08-18 赛奥生物科技（青岛）有限公司 A kind of Blood Kit analysis system
EP3542368A1 (en) * 2016-11-21 2019-09-25 Sensome Characterizing and identifying biological structure
CA3069303A1 (en) * 2017-07-11 2019-01-17 Fresenius Medical Care Holdings, Inc. Techniques for determining fluid volumes using bioimpedance information
JP6895876B2 (en) * 2017-12-13 2021-06-30 アークレイ株式会社 Measuring method and measuring device to measure hematocrit value in blood
WO2020232706A1 (en) * 2019-05-23 2020-11-26 麦层移动健康管理有限公司 Method and device for measuring body fluid and its changes and for measuring blood flow changes

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US3994284A (en) * 1975-12-31 1976-11-30 Systron Donner Corporation Flow rate computer adjunct for use with an impedance plethysmograph and method
US4425920A (en) * 1980-10-24 1984-01-17 Purdue Research Foundation Apparatus and method for measurement and control of blood pressure
DE3202067C2 (en) * 1982-01-23 1984-06-20 Holger Dr. 5100 Aachen Kiesewetter Device for determining the hematocrit value
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US5404879A (en) * 1993-01-19 1995-04-11 Hewlett-Packard Method and apparatus for automatic non-invasive monitoring of a patient's blood pressure
JP3345481B2 (en) * 1993-09-22 2002-11-18 興和株式会社 Pulse wave spectrometer

Also Published As

Publication number Publication date
CA2218281C (en) 2004-08-17
WO1996032883A1 (en) 1996-10-24
AU5383796A (en) 1996-11-07
CN1244779A (en) 2000-02-16
EP0955871A4 (en) 2000-03-22
JP3844779B2 (en) 2006-11-15
EP0955871A1 (en) 1999-11-17
JP2001500392A (en) 2001-01-16

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