CA2217131A1 - Cellules modifiees et procedes anti-rejet de xenogreffes - Google Patents

Cellules modifiees et procedes anti-rejet de xenogreffes Download PDF

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Publication number
CA2217131A1
CA2217131A1 CA002217131A CA2217131A CA2217131A1 CA 2217131 A1 CA2217131 A1 CA 2217131A1 CA 002217131 A CA002217131 A CA 002217131A CA 2217131 A CA2217131 A CA 2217131A CA 2217131 A1 CA2217131 A1 CA 2217131A1
Authority
CA
Canada
Prior art keywords
cell
cells
antigen
porcine
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002217131A
Other languages
English (en)
Inventor
Caroline Donnelly
Albert Edge
Christopher Yatko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diacrin Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2217131A1 publication Critical patent/CA2217131A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés pour inhiber le rejet de cellules transplantées chez un patient receveur allogène ou xénogène. Ces procédés consistent à modifier au moins un antigène à la surface d'une cellule de donneur préalablement à la transplantation de façon à réduire l'immunogénicité de la cellule chez un patient receveur. On modifie de préférence un antigène MHC de classe I situé sur la cellule donneur, en mettant la cellule en contact avec un molécule qui se lie à l'antigène, tel qu'un anticorps, l'un de ses fragments ou l'un de ses dérivés. Il est ainsi possible de transplanter la cellule modifiée dans un sujet receveur de façon à inhiber le phénomène de rejet induit par des cellules immunitaires, notamment les lymphocytes T, les cellules NK et/ou les cellules LAK.
CA002217131A 1995-04-20 1996-04-19 Cellules modifiees et procedes anti-rejet de xenogreffes Abandoned CA2217131A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42708395A 1995-04-20 1995-04-20
US08/427,083 1995-04-20

Publications (1)

Publication Number Publication Date
CA2217131A1 true CA2217131A1 (fr) 1996-12-05

Family

ID=23693422

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002217131A Abandoned CA2217131A1 (fr) 1995-04-20 1996-04-19 Cellules modifiees et procedes anti-rejet de xenogreffes

Country Status (4)

Country Link
EP (1) EP0822977A1 (fr)
AU (1) AU5713696A (fr)
CA (1) CA2217131A1 (fr)
WO (1) WO1996038543A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9619894D0 (en) * 1996-09-24 1996-11-06 Celltech Therapeutics Ltd Pharmaceutical products
AU739277B2 (en) * 1997-09-10 2001-10-11 Emory University Methods for inhibiting rejection of transplanted tissues by bone grafting
JP2003505475A (ja) * 1999-07-23 2003-02-12 ダイアクリン インク 筋細胞、及び心臓修復におけるそれらの利用
EP1294857A2 (fr) * 2000-06-09 2003-03-26 Universitätsklinikum Charite Medizinische Fakultät der Humboldt-Universität zu Berlin Lymphocytes t genetiquement modifies, leur procede de production et leur utilisation
AU2002316448A1 (en) * 2001-06-29 2003-03-03 The Government Of The United State Of America As Represent By The Secretary Of The Department Of Hea Method of promoting engraftment of a donor transplant in a recipient host
AU2006244197A1 (en) 2005-05-09 2006-11-16 Mytogen, Inc. Cellular cardiomyoplasty as supportive therapy in patients with heart disease
US7764379B1 (en) 2005-12-20 2010-07-27 Axsun Technologies, Inc. Semiconductor laser natural gas analysis system and method

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283058A (en) * 1990-08-30 1994-02-01 The General Hospital Corporation Methods for inhibiting rejection of transplanted tissue

Also Published As

Publication number Publication date
AU5713696A (en) 1996-12-18
EP0822977A1 (fr) 1998-02-11
WO1996038543A1 (fr) 1996-12-05

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Legal Events

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FZDE Dead