CA2214899A1 - Process for glucan preparation and therapeutic uses of glucan - Google Patents

Process for glucan preparation and therapeutic uses of glucan

Info

Publication number
CA2214899A1
CA2214899A1 CA002214899A CA2214899A CA2214899A1 CA 2214899 A1 CA2214899 A1 CA 2214899A1 CA 002214899 A CA002214899 A CA 002214899A CA 2214899 A CA2214899 A CA 2214899A CA 2214899 A1 CA2214899 A1 CA 2214899A1
Authority
CA
Canada
Prior art keywords
glucan
beta
extracting
cells
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002214899A
Other languages
French (fr)
Other versions
CA2214899C (en
Inventor
Graham Edmund Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TR THERAPEUTICS Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPN1661A external-priority patent/AUPN166195A0/en
Application filed by Individual filed Critical Individual
Priority to CA002562918A priority Critical patent/CA2562918C/en
Publication of CA2214899A1 publication Critical patent/CA2214899A1/en
Application granted granted Critical
Publication of CA2214899C publication Critical patent/CA2214899C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

A process for the production of .beta.-(1,3)(1,6) glucan from a glucan containing cellular source is described, together with compositions and uses/methods of treatment involving glucan. The process of the invention comprises the steps of: (a) extracting glucan containing cells with alkali and heat, in order to remove alkali soluble components; (b) acid extracting the cells of step (a) with an acid and heat to form a suspension; (c) extracting the suspension obtained of step (b) or recovered hydrolyzed cells with an organic solvent which is non-miscible with water and which has a density greater than that of water separating the resultant aqueous phase, solvent containing phase and interface so that substantially only the aqueous phase comprising .beta.-(1,3)(1,6) glucan particulate material remains; wherein the extraction with said organic solvent provides separation of glucan subgroups comprising branched .beta.-(1,3)(1,6)-glucan, and essentially unbranched .beta.-(1,3) glucan which is associated with residual non-glucan contaminents; and (d) drying the glucan material from step (c) to give microparticulate glucan.
CA002214899A 1995-03-13 1996-03-13 Process for glucan preparation and therapeutic uses of glucan Expired - Fee Related CA2214899C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002562918A CA2562918C (en) 1995-03-13 1996-03-13 Process for glucan preparation and therapeutic uses of glucan

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPN1661 1995-03-13
AUPN1661A AUPN166195A0 (en) 1995-03-13 1995-03-13 Process for glucan extraction
PCT/AU1996/000138 WO1996028476A1 (en) 1995-03-13 1996-03-13 Process for glucan preparation and therapeutic uses of glucan

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002562918A Division CA2562918C (en) 1995-03-13 1996-03-13 Process for glucan preparation and therapeutic uses of glucan

Publications (2)

Publication Number Publication Date
CA2214899A1 true CA2214899A1 (en) 1996-09-19
CA2214899C CA2214899C (en) 2007-01-02

Family

ID=37603360

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002214899A Expired - Fee Related CA2214899C (en) 1995-03-13 1996-03-13 Process for glucan preparation and therapeutic uses of glucan

Country Status (1)

Country Link
CA (1) CA2214899C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115397260A (en) * 2020-03-27 2022-11-25 东丽株式会社 Powdered oligosaccharide composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115397260A (en) * 2020-03-27 2022-11-25 东丽株式会社 Powdered oligosaccharide composition

Also Published As

Publication number Publication date
CA2214899C (en) 2007-01-02

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150313

MKLA Lapsed

Effective date: 20150313