CA2214565C - Nouvelles cryptophycines obtenues par synthese - Google Patents

Nouvelles cryptophycines obtenues par synthese Download PDF

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Publication number
CA2214565C
CA2214565C CA002214565A CA2214565A CA2214565C CA 2214565 C CA2214565 C CA 2214565C CA 002214565 A CA002214565 A CA 002214565A CA 2214565 A CA2214565 A CA 2214565A CA 2214565 C CA2214565 C CA 2214565C
Authority
CA
Canada
Prior art keywords
cryptophycin
taken together
unit
compound
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002214565A
Other languages
English (en)
Other versions
CA2214565A1 (fr
Inventor
Richard E. Moore
Marcus A. Tius
Russell A. Barrow
Jian Liang
Thomas H. Corbett
Frederick A. Valeriote
Thomas K. Hemscheidt
Trimurtulu Golakoti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaii
Wayne State University
Original Assignee
University of Hawaii
Wayne State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/400,057 external-priority patent/US6013626A/en
Priority claimed from US08/482,141 external-priority patent/US5952298A/en
Application filed by University of Hawaii, Wayne State University filed Critical University of Hawaii
Priority claimed from PCT/US1996/003246 external-priority patent/WO1996040184A1/fr
Publication of CA2214565A1 publication Critical patent/CA2214565A1/fr
Application granted granted Critical
Publication of CA2214565C publication Critical patent/CA2214565C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés de cryptophycines ainsi que des procédés de production de cryptophycines obtenus par synthèse totale. L'invention traite également de procédés d'utilisation de ces cryptophycines comme produits pharmaceutiques pour inhiber la prolifération des cellules de mammifères et pour traiter les néoplasies.
CA002214565A 1995-03-07 1996-03-07 Nouvelles cryptophycines obtenues par synthese Expired - Lifetime CA2214565C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/400,057 US6013626A (en) 1993-12-21 1995-03-07 Cryptophycins from synthesis
US08/400,057 1995-03-07
US08/482,141 US5952298A (en) 1993-12-21 1995-06-07 Cryptophycins
US08/482,141 1995-06-07
PCT/US1996/003246 WO1996040184A1 (fr) 1995-03-07 1996-03-07 Nouvelles cryptophycines obtenues par synthese

Publications (2)

Publication Number Publication Date
CA2214565A1 CA2214565A1 (fr) 1996-12-19
CA2214565C true CA2214565C (fr) 2007-05-29

Family

ID=38147734

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002214565A Expired - Lifetime CA2214565C (fr) 1995-03-07 1996-03-07 Nouvelles cryptophycines obtenues par synthese

Country Status (1)

Country Link
CA (1) CA2214565C (fr)

Also Published As

Publication number Publication date
CA2214565A1 (fr) 1996-12-19

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Effective date: 20160307