CA2211877A1 - Inhibiteurs de la transcription du virus de l'immunodeficience humaine et procedes pour les utiliser - Google Patents
Inhibiteurs de la transcription du virus de l'immunodeficience humaine et procedes pour les utiliserInfo
- Publication number
- CA2211877A1 CA2211877A1 CA 2211877 CA2211877A CA2211877A1 CA 2211877 A1 CA2211877 A1 CA 2211877A1 CA 2211877 CA2211877 CA 2211877 CA 2211877 A CA2211877 A CA 2211877A CA 2211877 A1 CA2211877 A1 CA 2211877A1
- Authority
- CA
- Canada
- Prior art keywords
- oligonucleotide
- seq
- hiv
- nucleotide sequence
- transcription
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 230000002195 synergetic effect Effects 0.000 description 1
- 108700004027 tat Genes Proteins 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- AIDS & HIV (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
On décrit des procédés pour inhiber la transcription, en utilisant un oligonucléotide de synthèse complémentaire du brin de Watson d'un génome d'ADN à deux brins. On décrit également des oligonucléotides de synthèse qui inhibent spécifiquement la transcription du génome du VIH-1, ainsi que des compositions pharmaceutiques contenant les oligonucléotides de synthèse de l'invention et des procédés de traitement d'infections causées par le VIH, utilisant ces oligonucléotides ou des compositions pharmaceutiques les contenant.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38065095A | 1995-01-30 | 1995-01-30 | |
| US08/380,650 | 1995-01-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2211877A1 true CA2211877A1 (fr) | 1996-08-08 |
Family
ID=23501985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2211877 Abandoned CA2211877A1 (fr) | 1995-01-30 | 1996-01-24 | Inhibiteurs de la transcription du virus de l'immunodeficience humaine et procedes pour les utiliser |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0807172A1 (fr) |
| AU (1) | AU4767896A (fr) |
| CA (1) | CA2211877A1 (fr) |
| WO (1) | WO1996023878A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6776986B1 (en) | 1996-06-06 | 2004-08-17 | Novartis Ag | Inhibition of HIV-1 replication by antisense RNA expression |
| US5919677A (en) * | 1997-05-09 | 1999-07-06 | The Research Foundation Of State University Of New York | Eukaryotic and retroviral antisense initiator elements |
| US6001558A (en) * | 1997-06-25 | 1999-12-14 | Ortho Clinical Diagnostics, Inc. | Amplification and detection of HIV-1 and/or HIV 2 |
| US20130130231A1 (en) * | 2002-11-26 | 2013-05-23 | Isaac Bentwich | Bioinformatically detectable group of novel viral regulatory genes and uses thereof |
| US20150104873A1 (en) * | 2012-07-11 | 2015-04-16 | University of Nevada, Las Vegas | Genome Surgery with Paired, Permeant Endonuclease Construct |
| WO2022266414A1 (fr) | 2021-06-18 | 2022-12-22 | Ionis Pharmaceuticals, Inc. | Composés et méthodes pour réduire l'expression d'ifnar1 |
| WO2022266415A1 (fr) * | 2021-06-18 | 2022-12-22 | Ionis Pharmaceuticals, Inc. | Composés et méthodes pour réduire l'expression d'ifnar1 |
-
1996
- 1996-01-24 CA CA 2211877 patent/CA2211877A1/fr not_active Abandoned
- 1996-01-24 AU AU47678/96A patent/AU4767896A/en not_active Abandoned
- 1996-01-24 WO PCT/US1996/001008 patent/WO1996023878A1/fr not_active Application Discontinuation
- 1996-01-24 EP EP96903669A patent/EP0807172A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996023878A1 (fr) | 1996-08-08 |
| AU4767896A (en) | 1996-08-21 |
| EP0807172A1 (fr) | 1997-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |