CA2202348A1 - Indole derivatives as 5ht1-like agonists - Google Patents

Indole derivatives as 5ht1-like agonists

Info

Publication number
CA2202348A1
CA2202348A1 CA 2202348 CA2202348A CA2202348A1 CA 2202348 A1 CA2202348 A1 CA 2202348A1 CA 2202348 CA2202348 CA 2202348 CA 2202348 A CA2202348 A CA 2202348A CA 2202348 A1 CA2202348 A1 CA 2202348A1
Authority
CA
Canada
Prior art keywords
agonists
alkyl
pharmaceutically acceptable
indole derivatives
headache
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2202348
Other languages
French (fr)
Other versions
CA2202348C (en
Inventor
Alan Daniel Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Research and Development Co NV SA
Original Assignee
Alan Daniel Brown
Pfizer Research And Development Company, N.V./S.A.
Pfizer Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9420503A external-priority patent/GB9420503D0/en
Application filed by Alan Daniel Brown, Pfizer Research And Development Company, N.V./S.A., Pfizer Limited filed Critical Alan Daniel Brown
Publication of CA2202348A1 publication Critical patent/CA2202348A1/en
Application granted granted Critical
Publication of CA2202348C publication Critical patent/CA2202348C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates (including hydrates) of either entity, wherein R1 is (a) R2 is R3R4C(OH)A; V is C=O or CH2; W is O or NR5; R3 and R4 are each independently selected from H and C1-C4 alkyl; or, together with the carbon atom to which they are attached, form a 4- or 5-membered carbocyclic ring; R5 is H, benzyl, C1-C5 alkanoyl or SO2(C1-C4)alkyl; A is C2-C3 alkylene;
m is 0 or 1; and n is 0 or 1; with the provisos that when n is 1 and V is C=O
then W is NH, and when n is 1 and V is CH2 then W is O; are selective 5-HT1-like agonists useful in the treatment of, inter alia, migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.
CA 2202348 1994-10-11 1995-09-29 Indole derivatives as 5ht1-like agonists Expired - Fee Related CA2202348C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9420503A GB9420503D0 (en) 1994-10-11 1994-10-11 Therapeutic agents
GB9420503.6 1994-10-11
PCT/EP1995/003884 WO1996011195A1 (en) 1994-10-11 1995-09-29 Indole derivatives as 5ht1-like agonists

Publications (2)

Publication Number Publication Date
CA2202348A1 true CA2202348A1 (en) 1996-04-18
CA2202348C CA2202348C (en) 2000-05-09

Family

ID=29421791

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2202348 Expired - Fee Related CA2202348C (en) 1994-10-11 1995-09-29 Indole derivatives as 5ht1-like agonists

Country Status (1)

Country Link
CA (1) CA2202348C (en)

Also Published As

Publication number Publication date
CA2202348C (en) 2000-05-09

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed