CA2201419A1 - Human t-cell lymphotropic virus type i envelope protein and human monoclonal antibodies specific therefor - Google Patents

Human t-cell lymphotropic virus type i envelope protein and human monoclonal antibodies specific therefor

Info

Publication number
CA2201419A1
CA2201419A1 CA 2201419 CA2201419A CA2201419A1 CA 2201419 A1 CA2201419 A1 CA 2201419A1 CA 2201419 CA2201419 CA 2201419 CA 2201419 A CA2201419 A CA 2201419A CA 2201419 A1 CA2201419 A1 CA 2201419A1
Authority
CA
Canada
Prior art keywords
envelope protein
htlv
human
monoclonal antibodies
antibodies specific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2201419
Other languages
French (fr)
Other versions
CA2201419C (en
Inventor
Steven Kok Hing Foung
Gregory A. Dekaban
Jacqueline Arp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Western Ontario
Leland Stanford Junior University
Original Assignee
University of Western Ontario
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/626,542 external-priority patent/US5722533A/en
Application filed by University of Western Ontario, Leland Stanford Junior University filed Critical University of Western Ontario
Publication of CA2201419A1 publication Critical patent/CA2201419A1/en
Application granted granted Critical
Publication of CA2201419C publication Critical patent/CA2201419C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Isolated and purified envelope protein of HTLV-I is provided devoid of non-envelope protein of HTLV-I and having substantially the same conformation as the envelope protein in native HTLV-I. The protein is produced recombinantly using a dual vaccinia/T7 polymerase system. Non-glycosylated and glycosylated forms of the protein are produced. Glycosylated forms are recognized by antibodies specific for the envelope protein of HTLV-I. Monoclonal antibodies are provided which are specific for the HTLV-I envelope protein and non-binding to HTLV-I envelope protein in denatured form.
The HTLV-I envelope protein is cross-reactive with antibodies of HTLV-II and STLV. The envelope protein is useful in diagnosis of infection by HTLV-I and HTLV-II.
CA 2201419 1996-04-02 1997-04-01 Human t-cell lymphotropic virus type i envelope protein and human monoclonal antibodies specific therefor Expired - Fee Related CA2201419C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/626,542 1996-04-02
US08/626,542 US5722533A (en) 1995-11-30 1996-04-02 Device exerting a protective action against fluid seepages in electrical switches and the like

Publications (2)

Publication Number Publication Date
CA2201419A1 true CA2201419A1 (en) 1997-10-02
CA2201419C CA2201419C (en) 2005-07-12

Family

ID=24510834

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2201419 Expired - Fee Related CA2201419C (en) 1996-04-02 1997-04-01 Human t-cell lymphotropic virus type i envelope protein and human monoclonal antibodies specific therefor

Country Status (1)

Country Link
CA (1) CA2201419C (en)

Also Published As

Publication number Publication date
CA2201419C (en) 2005-07-12

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Legal Events

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EEER Examination request
MKLA Lapsed

Effective date: 20150401