CA2201419A1 - Human t-cell lymphotropic virus type i envelope protein and human monoclonal antibodies specific therefor - Google Patents
Human t-cell lymphotropic virus type i envelope protein and human monoclonal antibodies specific thereforInfo
- Publication number
- CA2201419A1 CA2201419A1 CA 2201419 CA2201419A CA2201419A1 CA 2201419 A1 CA2201419 A1 CA 2201419A1 CA 2201419 CA2201419 CA 2201419 CA 2201419 A CA2201419 A CA 2201419A CA 2201419 A1 CA2201419 A1 CA 2201419A1
- Authority
- CA
- Canada
- Prior art keywords
- envelope protein
- htlv
- human
- monoclonal antibodies
- antibodies specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Isolated and purified envelope protein of HTLV-I is provided devoid of non-envelope protein of HTLV-I and having substantially the same conformation as the envelope protein in native HTLV-I. The protein is produced recombinantly using a dual vaccinia/T7 polymerase system. Non-glycosylated and glycosylated forms of the protein are produced. Glycosylated forms are recognized by antibodies specific for the envelope protein of HTLV-I. Monoclonal antibodies are provided which are specific for the HTLV-I envelope protein and non-binding to HTLV-I envelope protein in denatured form.
The HTLV-I envelope protein is cross-reactive with antibodies of HTLV-II and STLV. The envelope protein is useful in diagnosis of infection by HTLV-I and HTLV-II.
The HTLV-I envelope protein is cross-reactive with antibodies of HTLV-II and STLV. The envelope protein is useful in diagnosis of infection by HTLV-I and HTLV-II.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/626,542 | 1996-04-02 | ||
US08/626,542 US5722533A (en) | 1995-11-30 | 1996-04-02 | Device exerting a protective action against fluid seepages in electrical switches and the like |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2201419A1 true CA2201419A1 (en) | 1997-10-02 |
CA2201419C CA2201419C (en) | 2005-07-12 |
Family
ID=24510834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2201419 Expired - Fee Related CA2201419C (en) | 1996-04-02 | 1997-04-01 | Human t-cell lymphotropic virus type i envelope protein and human monoclonal antibodies specific therefor |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2201419C (en) |
-
1997
- 1997-04-01 CA CA 2201419 patent/CA2201419C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2201419C (en) | 2005-07-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20150401 |