CA2199131A1 - Retroviral vector hybrids and the use thereof for gene transfer - Google Patents

Retroviral vector hybrids and the use thereof for gene transfer

Info

Publication number
CA2199131A1
CA2199131A1 CA002199131A CA2199131A CA2199131A1 CA 2199131 A1 CA2199131 A1 CA 2199131A1 CA 002199131 A CA002199131 A CA 002199131A CA 2199131 A CA2199131 A CA 2199131A CA 2199131 A1 CA2199131 A1 CA 2199131A1
Authority
CA
Canada
Prior art keywords
gene transfer
retroviral vector
hybrids
region
regions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002199131A
Other languages
French (fr)
Other versions
CA2199131C (en
Inventor
Christopher Baum
Carol Stocking-Harbers
Wolfram Ostertag
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vision 7 GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19503952A external-priority patent/DE19503952A1/en
Application filed by Individual filed Critical Individual
Priority claimed from PCT/EP1995/003175 external-priority patent/WO1996007747A1/en
Publication of CA2199131A1 publication Critical patent/CA2199131A1/en
Application granted granted Critical
Publication of CA2199131C publication Critical patent/CA2199131C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The disclosure relates to replication defective retroviral vector hybrids characterized by the fact that they contain: ( a) in the leader region as U5 region and/or tRNA primer binding site, the U5 region and/or tRNA
primer binding site of MESV; and (b) as U3 and R
regions in 3'-LTR, the U3 and R regions from a Friend murine leukaemia virus (F-MuLV). The proposed hybrids are particularly suitable for effective gene transfer in haematopoietic stem cells.
CA002199131A 1994-09-08 1995-08-10 Retroviral vector hybrids and the use thereof for gene transfer Expired - Fee Related CA2199131C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4431973 1994-09-08
DEP4431973.8 1994-09-08
DE19503952A DE19503952A1 (en) 1994-09-08 1995-02-07 Retroviral vector hybrids and their use for gene transfer
DE19503952.1 1995-02-07
PCT/EP1995/003175 WO1996007747A1 (en) 1994-09-08 1995-08-10 Retroviral vector hybrids and the use thereof for gene transfer

Publications (2)

Publication Number Publication Date
CA2199131A1 true CA2199131A1 (en) 1996-03-14
CA2199131C CA2199131C (en) 2007-04-10

Family

ID=38007181

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002199131A Expired - Fee Related CA2199131C (en) 1994-09-08 1995-08-10 Retroviral vector hybrids and the use thereof for gene transfer

Country Status (1)

Country Link
CA (1) CA2199131C (en)

Also Published As

Publication number Publication date
CA2199131C (en) 2007-04-10

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed