CA2198383A1 - Benzene compound and pharmaceutical use thereof - Google Patents
Benzene compound and pharmaceutical use thereofInfo
- Publication number
- CA2198383A1 CA2198383A1 CA002198383A CA2198383A CA2198383A1 CA 2198383 A1 CA2198383 A1 CA 2198383A1 CA 002198383 A CA002198383 A CA 002198383A CA 2198383 A CA2198383 A CA 2198383A CA 2198383 A1 CA2198383 A1 CA 2198383A1
- Authority
- CA
- Canada
- Prior art keywords
- disease
- syndrome
- salt
- useful
- optically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title abstract 4
- -1 Benzene compound Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 1
- 208000032467 Aplastic anaemia Diseases 0.000 abstract 1
- 206010008909 Chronic Hepatitis Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 201000003066 Diffuse Scleroderma Diseases 0.000 abstract 1
- 206010060742 Endocrine ophthalmopathy Diseases 0.000 abstract 1
- 208000004332 Evans syndrome Diseases 0.000 abstract 1
- 201000003675 Evans' syndrome Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010018364 Glomerulonephritis Diseases 0.000 abstract 1
- 206010018691 Granuloma Diseases 0.000 abstract 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 abstract 1
- 208000003250 Mixed connective tissue disease Diseases 0.000 abstract 1
- 241000721454 Pemphigus Species 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010048908 Seasonal allergy Diseases 0.000 abstract 1
- 208000021386 Sjogren Syndrome Diseases 0.000 abstract 1
- 201000009594 Systemic Scleroderma Diseases 0.000 abstract 1
- 206010042953 Systemic sclerosis Diseases 0.000 abstract 1
- 208000001106 Takayasu Arteritis Diseases 0.000 abstract 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 208000027076 Uveal disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 abstract 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 abstract 1
- 238000010322 bone marrow transplantation Methods 0.000 abstract 1
- 230000007882 cirrhosis Effects 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000001981 dermatomyositis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940124563 hair growth stimulant Drugs 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 206010028417 myasthenia gravis Diseases 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 201000006292 polyarteritis nodosa Diseases 0.000 abstract 1
- 208000005987 polymyositis Diseases 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 201000000306 sarcoidosis Diseases 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A benzene compound of the formula wherein each symbol is as defined in the specification;
an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient.
The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behget's disease, uveal disease, systemic lupus erythematosus, Sjogren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulo-nephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.
an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient.
The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behget's disease, uveal disease, systemic lupus erythematosus, Sjogren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulo-nephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP196888/1994 | 1994-08-22 | ||
| JP19688894 | 1994-08-22 | ||
| JP82934/1995 | 1995-04-07 | ||
| JP8293495 | 1995-04-07 | ||
| JP17254395 | 1995-07-07 | ||
| JP172543/1995 | 1995-07-07 | ||
| PCT/JP1995/001654 WO1996006068A1 (en) | 1994-08-22 | 1995-08-22 | Benzene compound and medicinal use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2198383A1 true CA2198383A1 (en) | 1996-02-29 |
| CA2198383C CA2198383C (en) | 2006-04-11 |
Family
ID=36178109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002198383A Expired - Lifetime CA2198383C (en) | 1994-08-22 | 1995-08-22 | Benzene compound and pharmaceutical use thereof |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2198383C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110380027A (en) * | 2019-06-28 | 2019-10-25 | 惠州学院 | A kind of preparation method of carbon containing bimetallic oxide |
-
1995
- 1995-08-22 CA CA002198383A patent/CA2198383C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110380027A (en) * | 2019-06-28 | 2019-10-25 | 惠州学院 | A kind of preparation method of carbon containing bimetallic oxide |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2198383C (en) | 2006-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20150824 |