CA2198383A1 - Benzene compound and pharmaceutical use thereof - Google Patents

Benzene compound and pharmaceutical use thereof

Info

Publication number
CA2198383A1
CA2198383A1 CA002198383A CA2198383A CA2198383A1 CA 2198383 A1 CA2198383 A1 CA 2198383A1 CA 002198383 A CA002198383 A CA 002198383A CA 2198383 A CA2198383 A CA 2198383A CA 2198383 A1 CA2198383 A1 CA 2198383A1
Authority
CA
Canada
Prior art keywords
disease
syndrome
salt
useful
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002198383A
Other languages
French (fr)
Other versions
CA2198383C (en
Inventor
Tetsuro Fujita
Kunitomo Adachi
Toshiyuki Kohara
Masatoshi Kiuchi
Kenji Chiba
Koji Teshima
Tadashi Mishina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/JP1995/001654 external-priority patent/WO1996006068A1/en
Publication of CA2198383A1 publication Critical patent/CA2198383A1/en
Application granted granted Critical
Publication of CA2198383C publication Critical patent/CA2198383C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A benzene compound of the formula wherein each symbol is as defined in the specification;
an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active ingredient.
The compound, optically active isomer or salt has an excellent immunosuppressive effect and is useful as an inhibitor for the rejection reaction occurring in organ or bone marrow transplantation, and as a preventive or remedy for articular rheumatism, atopic eczema (dermatitis), Behget's disease, uveal disease, systemic lupus erythematosus, Sjogren's syndrome, multiple sclerosis, myasthenia gravis, type I diabetes, endocrine ophthalmopathy, primary biliary, cirrhosis, Crohn's disease, glomerulo-nephritis, sarcoidosis, psoriasis, pemphigus, aplastic anemia, idiopathic thrombocytopenic purpura, allergy, polyarteritis nodosa, progressive systemic sclerosis, mixed connective-tissue disease, aortitis syndrome, polymyositis, dermatomyositis, Wegener's granuloma, ulcerative colitis, active chronic hepatitis, autoimmune hemolytic anemia, Evans' syndrome, bronchial asthma and pollinosis. It is useful also as an antifungal agent and hair growth stimulant.
CA002198383A 1994-08-22 1995-08-22 Benzene compound and pharmaceutical use thereof Expired - Lifetime CA2198383C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP196888/1994 1994-08-22
JP19688894 1994-08-22
JP82934/1995 1995-04-07
JP8293495 1995-04-07
JP17254395 1995-07-07
JP172543/1995 1995-07-07
PCT/JP1995/001654 WO1996006068A1 (en) 1994-08-22 1995-08-22 Benzene compound and medicinal use thereof

Publications (2)

Publication Number Publication Date
CA2198383A1 true CA2198383A1 (en) 1996-02-29
CA2198383C CA2198383C (en) 2006-04-11

Family

ID=36178109

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002198383A Expired - Lifetime CA2198383C (en) 1994-08-22 1995-08-22 Benzene compound and pharmaceutical use thereof

Country Status (1)

Country Link
CA (1) CA2198383C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110380027A (en) * 2019-06-28 2019-10-25 惠州学院 A kind of preparation method of carbon containing bimetallic oxide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110380027A (en) * 2019-06-28 2019-10-25 惠州学院 A kind of preparation method of carbon containing bimetallic oxide

Also Published As

Publication number Publication date
CA2198383C (en) 2006-04-11

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Effective date: 20150824