CA2195841A1 - Process and intermediates for (s)-.alpha.-amino-1-carboxycyclopentaneacetic acid - Google Patents

Process and intermediates for (s)-.alpha.-amino-1-carboxycyclopentaneacetic acid

Info

Publication number
CA2195841A1
CA2195841A1 CA002195841A CA2195841A CA2195841A1 CA 2195841 A1 CA2195841 A1 CA 2195841A1 CA 002195841 A CA002195841 A CA 002195841A CA 2195841 A CA2195841 A CA 2195841A CA 2195841 A1 CA2195841 A1 CA 2195841A1
Authority
CA
Canada
Prior art keywords
alpha
amino
intermediates
carboxycyclopentaneacetic acid
carboxycyclopentaneacetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002195841A
Other languages
French (fr)
Other versions
CA2195841C (en
Inventor
Jean-Marie Ferland
Ingrid Guse
Eric Malenfant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Boehringer Ingelheim Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Canada Ltd filed Critical Boehringer Ingelheim Canada Ltd
Priority to CA002195841A priority Critical patent/CA2195841C/en
Publication of CA2195841A1 publication Critical patent/CA2195841A1/en
Application granted granted Critical
Publication of CA2195841C publication Critical patent/CA2195841C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Disclosed herein is a process for preparing (S) -.alpha.-amino-1-carboxycyclopentaneacetic acid which is a useful intermediate for preparing peptidomimetic inhibitors of herpes viral ribonucleotide reductase.
The process comprises the preparation of the key intermediate (see formula one) and its subsequent conversion to the desired product.
CA002195841A 1997-01-23 1997-01-23 Process and intermediates for (s)-.alpha.-amino-1-carboxycyclopentaneacetic acid Expired - Fee Related CA2195841C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002195841A CA2195841C (en) 1997-01-23 1997-01-23 Process and intermediates for (s)-.alpha.-amino-1-carboxycyclopentaneacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002195841A CA2195841C (en) 1997-01-23 1997-01-23 Process and intermediates for (s)-.alpha.-amino-1-carboxycyclopentaneacetic acid

Publications (2)

Publication Number Publication Date
CA2195841A1 true CA2195841A1 (en) 1998-07-23
CA2195841C CA2195841C (en) 2004-12-14

Family

ID=4159735

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002195841A Expired - Fee Related CA2195841C (en) 1997-01-23 1997-01-23 Process and intermediates for (s)-.alpha.-amino-1-carboxycyclopentaneacetic acid

Country Status (1)

Country Link
CA (1) CA2195841C (en)

Also Published As

Publication number Publication date
CA2195841C (en) 2004-12-14

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130123