CA2193900A1 - Heterocyclic thiol sulfenimide compounds - Google Patents

Abstract

Heterocyclic thiol sulfenimide compounds are useful as an accelerator in the curing of natural and/or synthetic rubbers. The compound can be represented by the formula (see fig. I) wherein each of A1 and A2, independently, is at least one heterocyclic ring containing one or more nitrogen atoms therein, or at least one heterocyclic ring containing one or more nitrogen atoms therein and (1) one or more hydrocarbyl substituents, or (2) one or more electron withdrawing groups, or (3) one or more electron releasing groups, wherein A1 alternatively is thiazyl or a dithiocarbamoyl, and wherein R is a (a) hydrogen atom, or (b) a hydrocarbyl radical having from 1 to 16 carbon atoms, or (c) the hydrocarbon radical of (b) wherein one or more of the carbon atoms is an oxygen atom, a nitrogen atom, or a substituted nitrogen atom wherein said substituted group is an alkyl and in combination with said nitrogen atom forms a heterocyclic ring having a total of from 1 to 7 carbon atoms, or (d) the hydrocarbyl radical of (b) containing a halogen, an amino, a cyano, an alkoxy, a hydroxy, or an alkoxycarbonyl. When the heterocyclic thiol sulfenimide compound is utilized as an accelerator for rubber, improved cure rates, longer scorch delay, and better reversion resistance are obtained in comparison to conventional sulfenamides.

Description

HETEROCYCLIC THIOL SULFENIMIDE COMPOUNDS
FIELD OF THE INVENTION
This application is a division of co-pending Canadian Application Serial No. 2,024,595 filed September 4, 1990.
The present invention relates to novel heterocyclic thiol sulfenimide compounds and to the preparation thereof.
BACKGROUND
Heretofore, numerous primary accelerators such as the various well known sulfenamides of2-mercaptobenzothiazole, and to a lesser extent, sulfenimides of 2-mercaptobenzothiazole [also referred to as bis(sulfenamides)] have been utilized to cure natural and/or synthetic rubbers. While they improved upon the art preceding them, still faster cure rate, longer scorch delay, and better reversion resistance are desirable.
U.S. Patent No. 2,321,305 to Messer relates to rubber vulcanization accelerators represented by the formula C CAR ~ ~ C - ~ X

where AR is an arylene group; when n is 1, X is NH-alkyl, NH-aryl, N-diaryl, O-alkyl or O-aryl; when n is 2, X is oxygen, NH, N-alkyl, or N-alicyclic; when n is 3, X is N.
U.S. Patent No. 2,321,306 to Messer also relates to rubber vulcanization accelerators of the type set forth in U.S. Patent No. 2,321,305.
U.S. Patent Nos. 2,860,142 to Conly; 2,873,277 to Sundholm; 2,889,331 to Sundholm; 3,151,122 to Sundholm; and 3,875,177 to Maison, all relate to bis(sulfenamides) (sulfen-imides) of 2-mercaptobenzothiazole as accelerators. While referred to in the prior art as bis(sulfenamides), it is chemically correct to refer to these compounds as sulfenimides.

21 939~0 -2- 24-51(7547) A

- SUMMARY OF THE INVENTION
Novel heterocyclic thiol sulfenimides are provided. The compounds are generally made via the corresponding sulfenyl chloride, by reacting a diheterocyclic disulfide compound with a chlorine source in a suitable solvent. The intermediate sulfenyl chloride compound is then reacted with a primary amine in the presence of an acid acceptor usually at a low temperature to produce the hetero-cyclic thiol sulfenimide compound of the present invention. The compounds of the present invention when utilized as accelerators for curing natural rubber, synthetic rubbers such as polybutadiene or styrene-butadiene rubber, blends of synthetic ! rubbers such as natural rubber and polybutadiene, styrene-butadiene rubber and polybutadiene, or combinations thereof, result in improved cure rates as indicated by t90-t2 values, t25-t2 values and maximum rate of vulcanization (Vmax), better scorch delay, and reduced reversion in comparison with traditional or conventional sulfenamide accelera-tors such as 2-mercaptobenzothiazolyl-t-butyl sulfenamide (Santocure NS ~ ) and sulfenimides of 2-mercaptobenzothiazole. Increased cure rates are very desirable since faster rates of production of rubber articles can be obtained. Molded rubber articles can thus be removed from the mold at earlier times without the danger of undercure.
While it is generally possible to increase the cure rate of a rubber compound (up to a point) by using combinations of accelerators and/or higher levels of accelerators, these changes are often accompa-nied by unacceptable losses of scorch delay or unacceptable increases in the moduli of the vul--~ canized articles. Longer scorch delay is desirable to provide a longer time for the rubber article to be shaped and molded before the onset of vulcaniza--3- 24-51(7547)A

tion. Reduced reversion is desirable because it results in a more stable network which imparts more favorable physical properties to the vulcanizate.
BRIEF DESCRIPTION OF THE DRA~ING
The drawing is a typical rheograph show-ing the parameters of the vulcanization.
DETAILED DESCRIPTION OF THE INVENTION
The heterocyclic thiol sulfenimide com-pounds of the present invention generally can be represented by the following formula R

Al - S - N - S - A2 where each of A1 and A2, independently, is at least one heterocyclic ring containing one or more nitro-gen atoms therein, or at least one heterocyclic ring containing one or more nitrogen atoms therein and (1) one or more hydrocarbyl substituents, or (2) one or more electron withdrawing radicals, or (3) one or more electron releasing radicals.
Although the heterocyclic ring can contain three nitrogen atoms therein, it desirably contains no more than two nitrogen atoms therein with one nitrogen atom therein being preferred. When the heterocyclic ring contains one nitrogen atom there-in, the sulfur atom can be located at the three or four position with the two position being highly preferred. However, at least one of said A1 or ~aid A2 group is not a benzothiazolyl group, that is, is free therefrom, and furthermore at least one of said A1 or said A2 groups is free of any sulfur atoms and preferably both said A1 and said A2 are free of any sulfur atoms. Desirably A1 contains one heterocyclic ring. The hydrocarbyl substituent of the one or more heterocyclic rings 3 can independently be an aromatic, an aliphatic and preferably alkyl, or combinations thereof, e.g., aryl substituted alkyl, alkyl substituted aryl, 21 ~3qOO

-4- 24-51(7547)A

etc. having from l to about 12 carbon atoms. The aromatic substituent can be either attached at one carbon atom, for example phenyl, or an aromatic wherein two of the carbon atoms are actually part of the fused heterocyclic ring system such as in quinoline and lepidine. The aliphatic substit~ent desirably is an alkyl having from 1 to 6 carbon atoms and preferably is methyl. Examples of elec-tron withdrawing radicals include chloro, fluoro, lo methoxycarbonyl, and the like. Examples of elec-tron releasing radicals include methoxy, ethoxy, phenoxy, dimethylamino, phenylamino, and the like.
Examples of such suitable A1 groups include tri-azinyl, pyrazyl, pyridazyl, pyrimidyl, methylpyri-midyl, dimethylpyrimidyl, pyridyl, picolyl, quino-lyl, lepidyl, dimethylpyridyl, phenylpyridyl, methoxypyridyl, chloropyridyl, and the like. A1 groups include pyridyl, picolyl, and quinolyl. A2 can generally be the same as A1 and hence indepen-dently is defined as the same immediately set forth hereinabove.
In lieu of the above definition of A1, alternatively Al can be thiazyl such as benzothi-azyl, or dithiocarbamoyl.
R can be a hydrogen atom, additionally, R can b~ a hydrocarbyl, for example, an aliphatic, a cycloaliphatic, an aromatic substituted alipha-tic, and the like, having from 1 to 16 carbon atoms and preferably from l or 6 carbon atoms. An alkyl radical is preferred. When R is an aromatic or an alkyl substituted aromatic, it has from 6 to 16 carbon atoms and preferably from 6 to lO carbon atoms. One or more of the carbon atoms of the hydrocarbyl radical can be replaced by an oxygen :~ atom, a nitrogen atom, or a substituted nitrogen atom wherein the substituent group is an alkyl and with the nitrogen atom forms a heterocyclic ring -5- 24-51(7547)A

having a total of from 1 to 7 carbon atoms. R can also be a hydrocarbyl radical containing from 1 to 16 carbon- atoms, as noted above, and containing substituents such as halogen, amino, cyano, alkoxy, hydroxy, or alkoxycarbonyl, and the like. R can also be A1 as defined hereinabove. Of the various R radicals, preferably R is an alkyl having from 1 to 8 carbon atoms such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, t-butyl, amyl, hexyl, cyclohexyl, heptyl, octyl, benzyl, phenyl, and the like, including various isomers thereof. In accordance with the above description of Al, A2, and R, examples of heterocyclic thiol sulfenimide compounds include N,N-bis(2-pyridylthiyl)-t-butyl sulfenimide, N,N-bis(2-pyridylthiyl)-isopropyl sul-fenimide, N,N-bis(2-pyridylthiyl)-cyclohexyl sul-fenimide, N,N-bis(2-quinolylthiyl)-t-butyl sulfen-imide, and N,N-bis(2-lepidylthiyl)-t-butyl sulfen-imide.
A method of making or preparing the heterocyclic thiol sulfenimides of the present invention is via a solution reaction in an inert atmosphere. The atmosphere can generally be nitro-gen, helium, or argon. The starting compound is a disul~ide having a heterocyclic radical substi-tuted on each sulfur atom, that is Al and A2. The h~terocyclic disulfide is reacted with a chlorine source. The chlorine sourcQ can be chlorine gas, or chlorine-containing compounds such as sulfuryl chloride. When a chlorine-cont~;~ing compound is utilized, generally an amide type compound such as urea, dimethylformamide, and the like i~ utilized as a catalyst. The amount o~ the chlorine gas or chlorine-containing compound is generally an equivalent amount or a slight excess as from about 0.90 to about l.l equivalents for every 1 equiva-lent of the heterocyclic disulfide. If the amide --6- 24-51(7547)A

type catalyst is utilized, only a small amount thereof, such as from about O.OS to about 1 or 2 percent by weight based upon the total weight of the reactants, is utilized. The reaction is car-ried out in the presence of an inert solvent, that is, a solvent which is unreactive with respect to chlorine. Suitable solvents are generally non-polar hydrocarbons, desirably aromatic or aliphatic hydrocarbons having a total of from about 5 or 6 to about 25 carbon atoms such as hexane, heptane, octane, nonane, decane, etc., benzene, toluene, cyclohexane, naphtha, the various kerosenes, and the like, as well as chlorinated hydrocarbons having from 1 to 6 carbon atoms and from 1 to 4 -~ halogen atoms such as carbon tetrachloride, methyl-ene chloride, chloroform, chlorobenzene, dichloro-benzene, trichlorobenzene, and the like. The reaction is carried out generally under stirring at normal or slightly elevated pressure under mild temperatures as from about 40~C to about 90~C, with from 60~C to about 80~C being preferred, for a sufficient amount of time to yield a heterocyclic sulfenyl chloride compound. The amount of reaction time is generally from about 10 or 20 minutes to 3 ; or 4 hours. After formation of the heterocyclic sulfenyl chloride compound, the solution is cooled to room temperature. The reaction time i8 general-ly 10, 20 or 30 minutes to about 3 or 4 hours.
The Al or A2 heterocyclic sulfenyl chlo-ride solution is subsequently reacted with a pri-mary amine wherein the hydrocarbyl group is R, as set forth hereinabove and accordingly fully in-corporated by reference, along with a reaction acid acceptor. The amount of the primary amine is generally about one equivalent for every two equivalents of the heterocyclic sulfenyl chloride compound although a slight excess thereof can be -7- 24-51(7547)A

utilized to ensure complete reaction of all the primary amine. The reaction acid acceptor is generally an amine compound such as triethylamine, pyridine, dimethylaniline, and the like having - from 3 to 15 carbon atoms. The amount of the acid acceptor is generally at least two equivalents as from about 2.0 to about 2.5 equivalents for every one equivalent of the primary amine. Alterna-tively, the acid acceptor can be a primary amine and thus the equivalent ratio is from about 3.0 to about 3.5 for every two equivalent of the sulfenyl chloride. The reaction with the primary amine is generally carried out in the presence of additional inert solvent which can be either added directly to the reaction vessel, or along with the primary amine, or both. Inasmuch as this reaction is very rapid, low reaction temperatures such as from about minus 40~C to about plus 15~C are utilized. The yield generally varies with reaction time which can be anywhere from one to approximately 16 hours.
Yields are typically 80 percent or greater. The salt such as triethylamine hydrochloride which is retained after filtering is washed with additional solvent such as carbon tetrachloride. The removed solvent, including the wash solvent, i8 then gener-ally evaporated off as by the utilization of re-duced pressure, heat, or both, thereby leaving the heterocyclic thiol sulfenimide compound.
The heterocyclic thiol sulfenimides described in this invention may also be prepared by methods other than that noted above. Other mQthods include those described in U.S. Patent No.
2,860,142 and U.S. Patent No. 3,875,177 which involves the treatment of an N-substituted monosul-fenamide with a carboxylic acid anhydride. Another method which can be used to prepare such sulfen-imides is described in U.S. Patent No. 3,151,122 21 93~00 .

-8- 24-51(7547)A

and involves the treatment of N-monosulfenamides with a strong acid.
The heterocyclic thiol sulfenimide com-pounds of the present invention are ideally suited for use as a primary accelerator in the cure or vulcanization of rubber. Generally any type of rubber can be utilized such as natural rubber, synthetic rubber, various blends of synthetic rubber, and combinations thereof. Natural rubber, of course, is obtained from plants, trees, and shrubs generally grown in the tropics or hot por-tions of the earth. Synthetic rubbers include those made from various dienes such as those having from 4 to 12 carbon atoms and preferably from 4 to 8 carbon atoms including 1,3-butadiene, isoprene, 2,3-dimethyl-1,3-butadiene, 2-methyl-1,3-penta-diene, 3,4-dimethyl-1,3-hexadiene, 4,5-diethyl-1,3-octadiene, phenyl-1,3-butadiene, pentadiene, hexa-diene, octadiene, and the like. Synthetic rubbers also include copolymers made from the immediately above-noted dienes having from 4 to 12 carbon atoms with a vinyl substituted aromatic compound having from 8 to 20 carbon atoms such as styrene, alpha-methylstyrene, 4-n-propylstyrene, 4-t-butylstyrene, 4-dodecylstyrene, 4-p-tolylstyrene, 4-phenylsty-rene, and the like, l-vinylnaphthalene, 2-vinyl-naphthalene, and the alkyl, cycloalkyl, aryl, alkaryl, and the aralky~ derivatives thereof in which the total number of carbon atoms and the combined substituents is generally not greater than 12 carbon atoms.
Another class of synthetic rubbers which can be utilized in the present invention are EPDM
rubbers. These are polymers made from ethylene, propylene, and a non-conjugated diene monomer such as norbornene, methylnorbornene, ethylidenenor-bornene, dicyclopentadiene, and the like. Other -9- 24-51(7547)A

sulfur vulcanizable rubbers known to the art and to the literature can also be utilized.
The rubber polymers made from conjugated dienes or copolymers of a conjugated diene or the vinyl substituted aromatic are preferably "elasto-meric" materials, that is they conform, when vul-canized, to the definition of an elastomeric or rubber material found in ASTM D 1566.
As noted above, either natural rubber, one or more synthetic rubbers, that is either a single type of synthetic rubber or blends of two or more synthetic rubbers, as well as a blend of natural rubber and one or more synthetic rubbers can be cured utilizing the heterocyclic thiol sulfenimide compounds of the present invention as a primary accelerator. When utilized as an accelera-tor, the amount thereof is generally from about 0.1 to about 10 and preferably from about 0.2 to about 2.0 parts by weight per 100 parts by weight of the rubber polymer or blend. When the sulfenimides of the invention are utilized as accelerators for curing rubber compounds, the natural or synthetic rubber compositions of the present invention gener-ally contain other conventional compounding in-gredient~ in conventional amounts, both of which ar~ well known to the art and to the literature.
For example, various fillers and reinforcing a-gents, such as clay, silica, and carbon black, can be utilized in amounts up to about 200 phr. Vari-ous oils, for example aromatic, naphthenic, or paraffinic, can be utilized to plasticize the rubber in amounts up to about 200 phr. Various activators such as zinc oxide, stearic acid, and the like, can also be used in amounts up to about 15 or more phr. Various antidegradants, and the like, can al~o be utilized. Such materials are . 21q3900 -10- 24-51(7547)A

generally mixed into the rubber by utilizing a mill, a Banbury mixer, or the like.
When utilized as a primary accelerator in combination with the one or more types of rubber noted hereinabove, the rubber compositions can be used in a large number of applications, including finished articles such as tires.
The heterocyclic thiol sulfenimides of the present invention when utilized as primary accelerators with rubber have been found to yield very much improved cure rates, i.e., lower t25-t2 values and higher Vmax values. The improved cure rate values were generally superior to the values obtained utilizing conventional sulfenamide primary -~ accelerators such as 2-mercaptobenzothiazolyl cyclohexyl sulfenamide, 2-mercaptobenzothiazolyl tertiary-butyl sulfenamide, N,N- bis(2-benzothia-zolylthiyl)-t-butyl-sulfenimide, and the like.
Another unexpected result was that improved scorch delay was obtained.- Yet another unexpected result was reduced reversion values as set forth in the following data.
The invention will be better understood by reference to the following examples in which all parts are by weight and all temperatures are in degreQs Celsius, unless otherwise specified.
EXAMPLES
Various heterocyclic sulfenimides of the present invention were tested in accordance with ap~LG~Liate ASTM procedures for rubber. Parameters which characterize vulcanization were taken from ODR (oscillating disc rheometer) cure curves ("rheographs"), which were obtained for vulcaniza-tion at 153~C and/or 160~C. The parameters Rmin and Rmax are the minimum rheometer torque (before the onset of vulcanization) and the maximum rheome-ter torque (due to vulcanization), respectively.

21-93qOO

~ 24-51(7547)A

The parameter t2 is the time required for an in-crease (over Rmin) in rheometer torque of 2.2dNm joule (2.0 in-lb); t25 is the time required for the occurrence of 25 percent of the increase in torque due to vulcanization (time at which torque equals (Rmax-Rmin) 0.25 + Rmin); t90 is the time required for the occurrence of 90 percent of the increase in torque due to vulcanization (time at which torque equals (Rmax-Rmin) O.9 + Rmin). Vmax is the maxi-mum slope of the vulcanization curve, expressed in terms of a percent of Rmax-Rmin per minute.
The invention will be better understood by reference to the following examples in which all parts are per 100 parts by weight of rubber (phr) and all temperatures are in degrees Celsius, unless otherwise specified.

Preparation of Rnhh~r Masterbatches for Accelerator Evalùation The various examples of heterocyclic thiol sulfenimide accelerators which were prepared were tested in typical NR and SBR carbon-black reinforced compounds.
Masterbatch SBR
An SBR rubber masterbatch was prepared, based on SBR-lSOO, and the SBR masterbatch con-tA; n~~ the following ingredients:
SBR Masterbatch Parts SBR-1500 lOO.o Carbon Black N-330 50.0 Circosol 4240, a Naphthenic Oil, ASTM D2226, Type 103 10.0 Zinc Oxide . 4.0 Stearic Acid 2.0 Total 166.0 The SBR masterbatch was prepared by mixing the above-noted components in a Banbury 21 q3~00 -12- 24-51(7547)A

mixer according to standard techniques. Subse-quently, various accelerators, sulfur, and an antidegradant were added on a laboratory roll mill in the amounts set forth hereinbelow and blended by using standard laboratory mill mixing techniques.
Parts SBR-Masterbatch 166.0 SANTOFLEX 13 2.0 Sulfur 2.0 Accelerators As indicated SBR-1500 is a cold emulsion-polymerized, non-pigmented styrene/butadiene copolymer rubber containing nominally 23.5 percent bound styrene;
SANTOFLEX ~ 13 is N-(1,3-dimethylbutyl)-N'-phenyl-para-phenylenediamine, an antidegradant.
In a similar manner, a natural rubber masterbatch was made:
Natural Rubber Masterbatch Parts Natural Rubber (SMR-CV) 100.0 Carbon Black N-330 50.0 Naphthenic Oil; Circosol 4240 5.0 Zinc Oxide 5.0 Stearic Acid 2.0 Total 162.0 The natural rubber masterbatch was blended with the following compounds according to s~A~Ard laboratory mill-mixing techniques.
Parts Natural Rllhher Masterbatch162.0 SANTOFLEX 13 2.0 Sulfur 2.5 Accelerators As indicated An SBR/BR masterbatch was prepared, based on SBR-1712 cont~ining the following ingre-dients:

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Masterbatch SBR/BR
SBR 1712 89.0 BR 1203 35.0 N-330 Black 65.0 *Sundex 790 10 0 Zinc Oxide 3.0 Stearic Acid 1.0 - *Sunlite 240 2.0 Santoflex 13 2.0 Total 207.. 0 The SBR/BR masterbatch was prepared by mixing the above-noted components in a Banbury mixer according to st~ rd tPchn;ques. Subse-guently, various accelerators, sulfur, and an antidegradant were added on a laboratory roll mill in the amounts set forth hereinbelow and blended by using standard laboratory mill mixing t~hniques.
Parts SBR/BR Masterbatch 207.0 Sulfur 2.0 Accelerators as indicated SBR-1712 is a cold emulsion-polymerized, non-pigmented styrene/butadiene copolymer rubber cont~ing nominally 23.5 percent bound styrene;
BR 1203 is a solution polybutadiene of high Ci8 content.
Sundex 790 is an aromatic oil, ASTM
D2226, type 101.
Sunlite 240 is a blend of petroleum waxes produced by WITCO.
Test data for various heterocyclic thiol sulfenimides as SBR and NR accelerators arQ sum-marized in Tables I through IX. The control stoc~
contained a conventional sulfenamidQ accelerator or N,N-bis(2-benzothiazolylthiyl)-t-butyl-sulfenimide.
The control stock was prepared from the same masterbatch as was the experimental stoc~ and *Trade Mark 21 ~3q~)0 -14- 24-51(7547)A

measured in the same set on the same day as was the experimental stock.

N N-Bis(2-P~ridYlthiyl)-t-Butyl Sulfenimide Sulfuryl chloride (30.65 g., 0.22 moles) and urea catalyst (300 mg.) were added to reagent grade carbon tetrachloride (700 ml) in a 2 liter, three-necked flask equipped with mechanical stir-rer, condenser, and heating mantle controlled by a Thermowatch ~ device. Then charged to the flask was 2,2'-pyridyl disulfide (50 g., 0.22 moles).
The mixture was gradually heated to 70~C and main-tained at this temperature for three hours, while off-gases were vented. At the end of this time, the orange slurry/solution was transferred to a dropping funnel and added to a three-necked flask containing a mixture of t-butylamine (16.6 g, 0.22 moles) and triethylamine (50.4 g) as an acid acceptor in 150 ml carbon tetrachloride. The temperature was maint~ine~ at minus 5~C to about 5~C over the course of 2.25 hours by the use of an ice/methanol cooling bath and by adjusting the rate of addition. After the addition of the 2-pyridyl sulfenyl chloride was completed, the slurry was stirred overnight.
The next day the slurry was filtered from precipitated triethylamine hydrochloride and evapo-rated under reduced pressure to give 54.2 g of light brown solid, m.p. 85 ~ 110~C, over 90 percent pure by liguid chromatographic analysis. The compound gave a characteristic nuclear magnetic resonance spectrum (chemical shift c1~, multiplici-ty, assignment, integration) 6.8-8.6, m, aromatic, 8 H; 1.4, s, t-butyl, 9 H.

21 93qOO
-15- 24-51(7S47)A

N N-Bis(2-Pyridylthiyl)-CYclohex~l Sulfenimide A solution containing pyridyl sulfenyl chloride (32.9 g, 0.226 moles) was prepared as in Example 1 in carbon tetrachloride solution and transferred to a dropping funnel. The solution was added to a mixture of cyclohexylamine (11.2 g, 0.113 moles), triethylamine (25.2 g) and carbon tetrachloride (75 ml). The temperature was main-tained at minus 10~C to minus 5~C using an isopro-panol/dry ice bath. After overnight stirring at room temperature, the triethylammonium chloride was removed by filtration, and the solvent evapor-ated under reduced pressure to give a nearly quan-titative yield of the crude sulfenimide. ~ecry-stallization from acetonitrile gave material m.p.
72-74~C NMR:(chemical shift ~ , multiplicity, assignment, integration) 6.8-8.6, m, aromatic, 8H;
3.3, m, methine, 1 H, 1.0-2.2, m, methylene, 10 H.

N.N-Bis(2-PyridvlthiYl~-Iso~ropyl Sulfenimide A solution of 2-pyridyl sulfenyl chloride in carbon tetrachloride was mad~ up as in Example 1, starting from 50 g. of 2-pyridyl disulfide, and the solution was stored for two days in the re-frigerator before use. The solution was then brought to room temperature, placed in a dropping funnel, and added to a mixture of isopropylamine (13.4 g., 0.22 moles), triethylamine (50.4 g) and carbon tetrachloride (150 ml) at minus 5~C to plus 10~C. After stirring overnight at room tempera-ture, the solids were removed from the reaction medium by filtration. The solution was then evapo-rated under reduced pressure (using a rotary evaporator) and decanted away from a small amount of dark oil which separated. The product was obtained as a thick oil which partially solidified 21 93q30 -16- 24-51(7547)A

upon cooling in the refrigerator. A crystalline product was obtained by dissolving the thicX oil in hexane at room temperature and allowing the solu-tion to cool while evaporating on the rotary evapo-rator under aspirator pressure. The solution was decanted from any oil which separated, and the recrystallized product collected by filtration.
It had nearly the same melting point as 2,2'-pyridyl disulfide, 56-58~C. NMR: (Chemical shift cr~ multiplicity, assignment, integration) 6.8-8.6, m, aromatic, 8H;-3.8, m, methine, lH; 1.3, d, methyl, 6H.

.N-Bisr2-Ouinolylthi~l)-t-butyl Sulfenimide 2-Quinolyl disulfide (17.1 g., .053 moles) was converted to the sulfenyl chloride by refluxing with sulfuryl chloride (7.2 g., .053 moles) in carbon tetrachloride (170 ml) containing dimethylformamide (.07 g) for three hours with provision for gas evolution. The solvent was stripped off under vacuum to give an orange oil which was redissolved in carbon tetrachloride (42 ml).
This solution was placed in a dropping ~unn~l and added over thirty minutes to a three-necked ~lask equipped with stirrer and thermometer and con~a~n~ng t-butylamine (3.9 g, .053 moles), triethylamine (14.2 g), and dimethylformamide (106 ml). The contents of the flask were protected from moisture and cooled to 0~C in an ice/methanol bath.
The mixture was stirred ~or 30 minutes at room temperature and transferred to a hq~er fitted with a mech~nical stirrer. Ice water (850 ml) was added and the cold mixture extracted twice with 200 ml portions of chloroform. The chloroform solution was washed with water (3 portions totaling liter), and dried over anhydrous sodium sulfate.

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Evaporation of the solvent gave crude product (25.5 g) which was washed with acetonitrile (100 ml) and treated with anhydrous diethyl ether (300 ml).
After filtering off the white solid impurity from the solution, and further washings and extractions with ether, 8.1 g of product, m.p. 105-115~C was obtained. This was analyzed by liquid chroma-tography and NMR spectroscopy: (chemical shiftc~, multiplicity, assignment, integration) 7.2-8.1, m, aromatic, 12H; 1.5, s, t-butyl, 9H.

N,N-Bis(4-Methyl-2-Quinolylthiyl)-t-Butyl Sulfenimide In this Example, the common name "lepi-dine" is used to refer to the structure 4-methyl-quinoline. 4-methyl-2-guinolinethiyl-t-butyl sul-fenamide was prepared using conventional technology to effect the oxidative coupling of 2-mercapto-lepidine and t-butylamine. It was routinely iso-lated in approximately 85 percent purity, as measured by NMR and LC, m.p. 111-115~C.
About 25 grams of the crude lepidine-t-butyl sulfenamide (containing about 20 g of the pure compound by NMR) was dissolved in chloroform (75 ml) and acetic anhydride (10.3 g) was added to the solution. The solution was allowed to stand at room temperature for 20.5 hours, when it was di-luted to 100 ml volume with additional chloroform, washed with two equal volumes of 5 percent sodium bicarbonate solution, and dried over anhydrous sodium sulfate. The chloroform solution was mixed with hexane (200 ml) and a small first crop of solid filtered off. The reaction mixture was then fractionally crystallized by concentration under reduced pressure. A main fraction (11.9 g) was isolated of 95 area percent purity by liquid chromatography, m.p. 136-142~C, NMR: (chemical -18- 24-51(7547)A

shift ~ , multiplicity, assignment, integration) 7.3-8, m, aromatic, lOH; 2.5, s, methyl, 6H; 1.5, s, t-butyl, 9H.

N-(2-Pyridylthiyl)-N-(2-Benzothiazolylthiyl)-t-8utyl-Sulfenimide A 500-ml, three-necked flask was fitted with a condenser, thermometer and gas inlet valves.
After the vessel had been evacuated and flushed with nitrogen, 250 ml of nitrogen-purged CCl4 was added along with 12.5 g of 2,2'-dipyridyl disul-fide, O.lOg of urea, and 7.7 g of S02Cl2. The solution was heated to 70~C with stirring for three hours. The resulting homogeneous orange solution was then cooled in an ice bath to about 10~C. The condenser was removed and replaced with an addition funnel containing 27.2 g of 2-mercaptobenzothia-zolyl-t-butyl sulfenamide slurried in a 100-ml solution of CCl4 containing 11.5 g of triethyl-amine. The slurry was added to the solution of 2-pyridyl sulfenyl chloride over a half hour such that the temperature of the reaction mixture did not eYcee~ 10~C. The mixture was allowed to warm to room temperature and stirred for 16 hours. At this time, it was filtered and the filter cake was washed with fresh CC14 until the liquid emerging from the filter was colorless. The CC14 filtrate was stripped under reduced pressure leaving a golden-brown viscous oil which solidified upon trituration with pentane. The resulting yellow solid was filtered and dried. The weight of N-(2-pyridylthiyl)-N-(2-benzothiazolylthiyl)-t-butyl-sulfenimide was 29.5 g, 75 percent yield. NMR:
(chemical shift c~~ , multiplicity, assignment, integration) 8.47, d, aromatic, lH; 6.9-7.9, m, aromatic, 7H; 1.45, s, t-butyl, 9H. Mass Spect: M+
= 348. The compound showed a single unique and -19- 24-51(7547)A

discrete peak when analyzed by liquid chromatogra-phy.

N,N-Bis(4,6-Dimethyl-2-Pyrimidylthiyl)-t-Butyl Sulfenimide 4,6-dimethyl-2,2'-pyrimidine disulfide (27.8 g. 0.1 mole) was charged into a mixture of sulfuryl chloride (13.5 g, 0.1 mole), urea (120 mg) and carbon tetrachloride (300 ml), was heated for two hours at 70~C in a reaction flask equipped with mechanical stirrer and protected from atmospheric moisture by a Drierite ~ tube. The reaction solu-tion was filtered from green insoluble solid (8.0 g) and placed in a three-necked reaction flask equipped with magnetic stirrer and protected from atmospheric moisture. At a temperature of 5-10~C, a solution of t-butylamine (7.3 g, 0.1 moles) and triethylamine ~25 g) dissolved in carbon tetrachlo-ride (50 ml) was added dropwise. After stirring overnight, the solution was filtered from solids and evaporated under reduced pressure. Solid impurities were removed by filtration of an ether solution of the crude product to give a clear oil product (10.4 g), estimated by NMR to be approxi-mately 25 percent of the sulfenimide and 75 percent of the sulfenamide. A portion of this product (6.3 g) was combined with triethylamine (4.0 g) in carbon tetrachloride (15 ml) and added to a fil-tered preparation of crude 4,6-dimethyl-2-sulfenyl chloride prepared from the corresponding disulfide (6.35 g, 0.023 moles) in carbon tetrachloride solution as described above. A water bath was used to control the temperature of this second addition at 25-30~C. After stirring overnight and filtering the reaction solution, the crude product (9 g) was obtained upon evaporation of the solvent as a thick 2 1 939~
-20- 24-51(7547)A

oil which crystallized on standing. Treatment of the crude product with acetonitrile (25 ml) and collection of the undissolved solid yielded the pure sulfenimide (2.8 g), m.p. 166-176~C, a single component by LC analysis. NMR: (chemical shift ~ , multiplicity, assignment, integration) ~.65, s, aromatic, 2H; 2.4, s, methyl, 12H; ~.4, s, t-butyl, 9H.

N N-Bis(2-PyrimidylthiYl~-t-Butyl Sulfenimide A solution of sulfuryl chloride (10.2 g, .075 moles) in carbon tetrachloride (lOo ml) was made up in a round bottom reaction flask, then urea (100 mg) and 2-pyrimidyl disulfide (16.7 g, .075 moles) was added. The mixture was heated to 70~C
for one hour with provision made for venting the off-gases. The thus formed sulfenyl chloride solution was then placed in a dropping funnel and added to a mixture of t-butylamine (5.0 g, .068 moles) and triethylamine (16.7 g) in carbon tetra-chloride (50 ml). The reaction was carried out in a three-necked reaction flask, equipped with mec-h~n~cal stirring and protected from atmospheric moisture. An ice/methanol cooling bath was used to control the temperature of the reaction at minus 5~C to plus 5~C. After stirring the reaction mixture overnight at room temperature, the crude product was recovered by evaporation of the solvent after the precipitated salts had been removed by filtration. The salt filter cake was washed with additional solvent (CC14, 80 ml).
Analysis of the crude reaction product by NMR and li~uid chromatography indicated the pres-ence of considerable sulfenamide. The yield of crude product was 7.9 g. It was combined with equivalent material from a previous reaction to make 10.8 g of mixed sulfenamide/sulfenimide pro-21 939(~0 - -21- 24-51(7547)A

duct and dissolved in CC14 (120 ml) and triethyl-amine (1.2 g). A small amount of additional sul-fenyl chloride was made in the above manner in CCl4 solution from 2-pyrimidyl disulfide (1.3 g) and sulfuryl chloride (0.6 ml). The sulfenyl chloride solution was added dropwise to the mixed sulfenamide/sulfenimide/triethylamine solution at minus 5~ to plus 5~C and the reaction stirred overnight. The precipitated salts were removed by filtration and the solvent evaporated under reduced pressure to give 7.5 g crude product. This was stirred with acetonitrile (31.5 ml) at room temper-ature to give 3.2 g of purified product which was collected by filtration. The sulfenimide, mp 140-143~C was shown to be pure by LC and characterized by NMR: (chemical shift C~, multiplicity, assign-ment, integration) 7.0 and 8.6, m, aromatic, 6H;
1.4, s, t-butyl, 9H.
Curing data utilizing the sulfenimide accelerators of Examples 1-8 are set forth in Table~ I-IX.

21 93qCO
-22- 24-51 t7547)A

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-31- 24-51(7547)A

As apparent from the above Tables, the sulfenimide accelerators of the present invention gave excellent cure rates (especially in natural rubber), excellent scorch delay, and reduced rever-sion.
Similar excellent results were obtained when the heterocyclic thiol sulfenimide accelera-tors were used to cure blends of natural rubber and butadiene rubber.
While in accordance with the Patent Statutes, the best mode and preferred embodiment has been set forth, the scope of the invention is not limited thereto, but rather by the scope of the attached claims.

Claims (4)

1. A composition comprising sulfur-vulcanizable rubber, sulfur, and from 0.1 to 10 parts by weight, based on 100 parts by weight of the rubber, of a compound having the formula wherein A1 is selected from triazinyl, pyrazyl, pyridazyl, pyrimadyl, pyridyl, picolyl, quinolyl and lepidyl, optionally ring-substituted by one or more C1-12 hydrocarbon substituents, one or more electron withdrawing radicals selected from chloro, fluoro and methoxycarbonyl or one or more electron releasing radicals selected from methoxy, ethoxy, phenoxy, dimethylamino and phenylamino, A2 is A, or benzothiazolyl, and R is a hydrogen atom or a C1-16 hydrocarbon radical optionally containing a halogen, an amino, a cyano, an alkoxy, a hydroxy or an alkoxy carbonyl substituent.

2. A composition according to claim 1, wherein R is an alkyl containing from 1 to 8 carbon atoms.

3. A composition according to claim 1, comprising from 0.2 to 2.0 parts by weight, based on 100 parts by weight of the rubber of the compound of claim 1, wherein said heterocyclic thiol sulfenimide is N,N-bis(2-pyridylthiyl)-t-butyl sulfenimide, N,N-bis(2-pyridylthiyl)-isopropyl sulfenimide, N,N-bis(2-pyridylthiyl)-cyclohexyl sulfenimide, N,N-bis(2-quinolylthiyl)-t-butyl sulfenimide, or N,N-bis(2-lepidylthiyl)-t-butyl sulfenimide.

4. A composition according to claim 3, wherein the rubber is natural rubber, one or more different synthetic rubbers, or blends thereof.