CA2191753A1 - Biomateriaux degradables par la lysozyme - Google Patents

Biomateriaux degradables par la lysozyme

Info

Publication number
CA2191753A1
CA2191753A1 CA 2191753 CA2191753A CA2191753A1 CA 2191753 A1 CA2191753 A1 CA 2191753A1 CA 2191753 CA2191753 CA 2191753 CA 2191753 A CA2191753 A CA 2191753A CA 2191753 A1 CA2191753 A1 CA 2191753A1
Authority
CA
Canada
Prior art keywords
chitin
bioactive agent
composition according
cross
lysozyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2191753
Other languages
English (en)
Inventor
George L. Brode
Ronald K. Yamamoto
Jeff J. Prior
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vitaphore Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2191753A1 publication Critical patent/CA2191753A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un procédé et un dispositif permettant de préparer une composition destinée à l'administration d'un médicament. Ledit procédé consiste à réticuler de la chitine dégradable par la lysozyme et soluble dans l'eau avec un agent de réticulation et à charger la chitine ainsi réticulée avec un agent bioactif. Selon des modes de réalisation préférés de l'invention, la composition destinée à l'administration d'un médicament comprend également du collagène ou un dérivé de collagène dégradable par la collagénase.
CA 2191753 1994-06-02 1995-06-02 Biomateriaux degradables par la lysozyme Abandoned CA2191753A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25272194A 1994-06-02 1994-06-02
US08/252,721 1994-06-02

Publications (1)

Publication Number Publication Date
CA2191753A1 true CA2191753A1 (fr) 1995-12-14

Family

ID=22957249

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2191753 Abandoned CA2191753A1 (fr) 1994-06-02 1995-06-02 Biomateriaux degradables par la lysozyme

Country Status (5)

Country Link
EP (1) EP0763063A4 (fr)
JP (1) JPH10504277A (fr)
AU (1) AU2662995A (fr)
CA (1) CA2191753A1 (fr)
WO (1) WO1995033773A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1020716C2 (nl) * 2002-05-30 2003-12-02 Tno Antimicrobiele verpakkingen.
WO2004105485A2 (fr) * 2003-05-30 2004-12-09 Nederlandse Organisatie Voor Toegepast-Natuurwet Enschappelijk Onderzoek Tno Excipients a liberation sur demande

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993071A (en) * 1971-09-09 1976-11-23 Alza Corporation Bioerodible ocular device
US3993057A (en) * 1972-12-27 1976-11-23 Alza Corporation Intrauterine device that bioerodes in response to the environment of the uterus and method of using
US5290752A (en) * 1984-03-16 1994-03-01 Unitika Ltd. Method for preparation of a shaped chitin body containing a physiologically active substance
ATE144781T1 (de) * 1986-06-06 1996-11-15 Union Carbide Corp Saure dekristallisierung von hochkristallin chitosan oder teilentacetylierten chitin
US4929722A (en) * 1986-06-06 1990-05-29 Union Carbide Chemicals And Plastics Company Inc. Acid decrystallization of aminopolysaccharides and derivatives thereof
DE69015775T2 (de) * 1989-10-31 1995-05-11 Howmedica Chitinderivate enthaltende Zusammensetzungen zur Verhütung der Adhäsion.
US5219749A (en) * 1991-10-09 1993-06-15 Institute For Molecular Biology & Biotechnology/Forth Process for isolating and preparing purified chitin deacetylase
JP2998422B2 (ja) * 1992-04-02 2000-01-11 株式会社デンソー 熱交換器

Also Published As

Publication number Publication date
JPH10504277A (ja) 1998-04-28
EP0763063A1 (fr) 1997-03-19
EP0763063A4 (fr) 1998-09-16
AU2662995A (en) 1996-01-04
WO1995033773A1 (fr) 1995-12-14

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Legal Events

Date Code Title Description
FZDE Dead