CA2189254C - Liberation modulee de polymeres biocompatibles - Google Patents

Liberation modulee de polymeres biocompatibles Download PDF

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Publication number
CA2189254C
CA2189254C CA002189254A CA2189254A CA2189254C CA 2189254 C CA2189254 C CA 2189254C CA 002189254 A CA002189254 A CA 002189254A CA 2189254 A CA2189254 A CA 2189254A CA 2189254 C CA2189254 C CA 2189254C
Authority
CA
Canada
Prior art keywords
polymer
biologically active
active agent
plga
metal cation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002189254A
Other languages
English (en)
Other versions
CA2189254A1 (fr
Inventor
Howard Bernstein
Yan Zhang
M. Amin Khan
Mark A. Tracy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Controlled Therapeutics Inc
Original Assignee
Alkermes Controlled Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/237,057 external-priority patent/US5656297A/en
Application filed by Alkermes Controlled Therapeutics Inc filed Critical Alkermes Controlled Therapeutics Inc
Publication of CA2189254A1 publication Critical patent/CA2189254A1/fr
Application granted granted Critical
Publication of CA2189254C publication Critical patent/CA2189254C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/35—Corticotropin [ACTH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur une composition permettant la libération modulée d'agents boilogiquement actifs et comprenant une matrice de polymères biocompatibles, un agent boilogiquement actif dispersé dans ladite matrice, et un composé cationique métallique dispersé séparément dans cette même matrice et dont la fonction est de moduler la libération de l'agent boilogiquement actif présent dans la matrice. L'invention porte également sur une méthode permettant de moduler la libération d'un agent biologiquement actif et consistant à dissoudre un polymère biocompatible dans un solvant de façon à former une solution dans laquelle on disperse séparément un composé cationique métallique et un agent biologiquement actif. La solution est ensuite solidifiée pour donner une matrice de polymères où une partie importante au moins de du composé cationique métallique se trouve dispersée séparément de la protéine boilogiquement active, ce par quoi le composé métallique module la libération de l'agent boilogiquement actif présent dans la matrice.
CA002189254A 1994-05-03 1995-05-03 Liberation modulee de polymeres biocompatibles Expired - Fee Related CA2189254C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/237,057 1994-05-03
US08/237,057 US5656297A (en) 1992-03-12 1994-05-03 Modulated release from biocompatible polymers
PCT/US1995/005511 WO1995029664A1 (fr) 1994-05-03 1995-05-03 Liberation modulee de polymeres biocompatibles

Publications (2)

Publication Number Publication Date
CA2189254A1 CA2189254A1 (fr) 1995-11-09
CA2189254C true CA2189254C (fr) 2006-10-10

Family

ID=37111128

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002189254A Expired - Fee Related CA2189254C (fr) 1994-05-03 1995-05-03 Liberation modulee de polymeres biocompatibles

Country Status (1)

Country Link
CA (1) CA2189254C (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9656228B2 (en) 2008-06-16 2017-05-23 Midatech Pharma (Wales) Limited Device and method for making solid beads

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9656228B2 (en) 2008-06-16 2017-05-23 Midatech Pharma (Wales) Limited Device and method for making solid beads

Also Published As

Publication number Publication date
CA2189254A1 (fr) 1995-11-09

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