CA2188135A1 - Biological material pre-fixation treatment - Google Patents

Biological material pre-fixation treatment

Info

Publication number
CA2188135A1
CA2188135A1 CA002188135A CA2188135A CA2188135A1 CA 2188135 A1 CA2188135 A1 CA 2188135A1 CA 002188135 A CA002188135 A CA 002188135A CA 2188135 A CA2188135 A CA 2188135A CA 2188135 A1 CA2188135 A1 CA 2188135A1
Authority
CA
Canada
Prior art keywords
biological
biological material
heart valve
controlled
rial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002188135A
Other languages
French (fr)
Other versions
CA2188135C (en
Inventor
Norman Jaffe
Warren D. Hancock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Envveno Medical Corp
Original Assignee
Norman Jaffe
Warren D. Hancock
Hancock Jaffe Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/229,452 external-priority patent/US5595571A/en
Application filed by Norman Jaffe, Warren D. Hancock, Hancock Jaffe Laboratories filed Critical Norman Jaffe
Publication of CA2188135A1 publication Critical patent/CA2188135A1/en
Application granted granted Critical
Publication of CA2188135C publication Critical patent/CA2188135C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix

Abstract

Disclosed is a controlled au-tolysis method for making biological tissue substantially acellular by ex-posing the biological material, prior to any fixation thereof, to at least one buffered solution having a pH
in the range from about 5.0 to 8.0 and a temperature in the range from about 12 °C to 30 °C for a suff-cent period of time to render at least one region of the biological mate-rial substantially acellular while sub-stantially preserving the structural integrity and non-cellular structural components of the biological mate-rial. Also disclosed is a method of making a bioprosthetic heart valve using biological material that has been treated by controlled autolysis and a method of treating a mammal having a defective heart valve using a bioprosthetic heart valve made, in part, by controlled autolysis.
CA002188135A 1994-04-18 1995-03-21 Biological material pre-fixation treatment Expired - Fee Related CA2188135C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/229,452 1994-04-18
US08/229,452 US5595571A (en) 1994-04-18 1994-04-18 Biological material pre-fixation treatment
PCT/US1995/003569 WO1995028183A1 (en) 1994-04-18 1995-03-21 Biological material pre-fixation treatment

Publications (2)

Publication Number Publication Date
CA2188135A1 true CA2188135A1 (en) 1995-10-26
CA2188135C CA2188135C (en) 2007-06-26

Family

ID=38278963

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002188135A Expired - Fee Related CA2188135C (en) 1994-04-18 1995-03-21 Biological material pre-fixation treatment

Country Status (1)

Country Link
CA (1) CA2188135C (en)

Also Published As

Publication number Publication date
CA2188135C (en) 2007-06-26

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