Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
Lawrence Horwitz
Marcus A. Horwitz
Bradford W. Gibson
Joseph Reeve
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/383,180external-prioritypatent/US5721209A/en
Application filed by Lawrence Horwitz, Marcus A. Horwitz, Bradford W. Gibson, Joseph Reeve, The Regents Of The University Of CaliforniafiledCriticalLawrence Horwitz
Publication of CA2185661A1publicationCriticalpatent/CA2185661A1/en
Application grantedgrantedCritical
Publication of CA2185661CpublicationCriticalpatent/CA2185661C/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
Exochelins can be used to prevent damage to living tissue from the formation or presence of the (OH) radical. In particular, the invention is directed to the administration of exochelins to infarcted myocardium prior to or coincidental with reperfusion to prevent damage to myocardium from iron mediated free radical formation. Also presented is the chemical structure of exochelins and modified exochelins at well as other applications of these materials in the treatment and diagnosis of disease in mammals.
CA002185661A1995-02-031996-01-26Novel iron chelator and inhibitor of iron-mediated oxidation
Expired - Fee RelatedCA2185661C
(en)
6.Alpha.,9.alpha.-difluoro-17.alpha.-'(2-furanylcarboxyl) oxy]-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothiotic acid s-fluoromethyl ester as an anti-inflammatory agent