CA2185524A1 - Ocular tension depressant - Google Patents

Ocular tension depressant

Info

Publication number
CA2185524A1
CA2185524A1 CA002185524A CA2185524A CA2185524A1 CA 2185524 A1 CA2185524 A1 CA 2185524A1 CA 002185524 A CA002185524 A CA 002185524A CA 2185524 A CA2185524 A CA 2185524A CA 2185524 A1 CA2185524 A1 CA 2185524A1
Authority
CA
Canada
Prior art keywords
alkyl
alkenyl
ocular tension
tension depressant
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002185524A
Other languages
French (fr)
Other versions
CA2185524C (en
Inventor
Tomihisa Yokoyama
Tsunemichi Hosokawa
Hiroaki Yanagisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/JP1995/000444 external-priority patent/WO1995024902A1/en
Publication of CA2185524A1 publication Critical patent/CA2185524A1/en
Application granted granted Critical
Publication of CA2185524C publication Critical patent/CA2185524C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

An eye-drop ocular tension depressant and/or an eye-drop glaucoma remedy containing a compound represented by general formula (I), or a salt, ester and the like thereof, wherein: R1 represents alkyl, alkenyl, or R5-A-B- (R5 being H, alkyl, cycloalkyl or acyl; A being O or S; and B being a single bond or alkylene); R2 represents alkyl, alkenyl or -CR6R7R8 (R6 being OH or alkoxy;
and R7 and R8 each being H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl or aralkyl); R3 represents COOH or -CONR9R10 (R9 and R10 being H or optionally substituted alkyl); and R4 represents COOH, COCOOH or tetrazolyl.
CA002185524A 1994-03-16 1995-03-16 Ocular tension depressant Expired - Fee Related CA2185524C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6/45404 1994-03-16
JP4540494 1994-03-16
PCT/JP1995/000444 WO1995024902A1 (en) 1994-03-16 1995-03-16 Ocular tension depressant

Publications (2)

Publication Number Publication Date
CA2185524A1 true CA2185524A1 (en) 1995-09-21
CA2185524C CA2185524C (en) 2006-12-05

Family

ID=37560801

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002185524A Expired - Fee Related CA2185524C (en) 1994-03-16 1995-03-16 Ocular tension depressant

Country Status (1)

Country Link
CA (1) CA2185524C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU773110B2 (en) * 1999-12-01 2004-05-20 Sankyo Company Limited Concomitant drugs for treating glaucoma

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU773110B2 (en) * 1999-12-01 2004-05-20 Sankyo Company Limited Concomitant drugs for treating glaucoma

Also Published As

Publication number Publication date
CA2185524C (en) 2006-12-05

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed