CA2182105A1 - Chloropyrimide intermediates - Google Patents

Chloropyrimide intermediates

Info

Publication number
CA2182105A1
CA2182105A1 CA002182105A CA2182105A CA2182105A1 CA 2182105 A1 CA2182105 A1 CA 2182105A1 CA 002182105 A CA002182105 A CA 002182105A CA 2182105 A CA2182105 A CA 2182105A CA 2182105 A1 CA2182105 A1 CA 2182105A1
Authority
CA
Canada
Prior art keywords
intermediates
chloropyrimide
processes
iii
aminopurines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002182105A
Other languages
French (fr)
Other versions
CA2182105C (en
Inventor
Susan Mary Daluge
Michael Tolar Martin
Michelle Joanne Ferry Fugett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Susan Mary Daluge
Michael Tolar Martin
Michelle Joanne Ferry Fugett
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9402161A external-priority patent/GB9402161D0/en
Application filed by Susan Mary Daluge, Michael Tolar Martin, Michelle Joanne Ferry Fugett, The Wellcome Foundation Limited filed Critical Susan Mary Daluge
Publication of CA2182105A1 publication Critical patent/CA2182105A1/en
Application granted granted Critical
Publication of CA2182105C publication Critical patent/CA2182105C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Abstract

The present invention relates to certain novel pyrimidine intermediates of formulae I, II and III indicated hereinafter and their salts, processes for their preparation and processes for their conversion to 9-substituted-2-aminopurines which are useful in medical therapy:
(see figure I, II, III)
CA002182105A 1994-02-04 1995-02-03 Chloropyrimide intermediates Expired - Lifetime CA2182105C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9402161A GB9402161D0 (en) 1994-02-04 1994-02-04 Chloropyrimidine intermediates
GB9402161.5 1994-02-04
PCT/GB1995/000225 WO1995021161A1 (en) 1994-02-04 1995-02-03 Chloropyrimide intermediates

Publications (2)

Publication Number Publication Date
CA2182105A1 true CA2182105A1 (en) 1995-08-10
CA2182105C CA2182105C (en) 2006-07-25

Family

ID=36707428

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002182105A Expired - Lifetime CA2182105C (en) 1994-02-04 1995-02-03 Chloropyrimide intermediates

Country Status (1)

Country Link
CA (1) CA2182105C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117050024A (en) * 2023-10-13 2023-11-14 苏州开元民生科技股份有限公司 Synthesis method of 2-amino-4, 6-dichloro-5-formamidopyrimidine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117050024A (en) * 2023-10-13 2023-11-14 苏州开元民生科技股份有限公司 Synthesis method of 2-amino-4, 6-dichloro-5-formamidopyrimidine
CN117050024B (en) * 2023-10-13 2024-01-05 苏州开元民生科技股份有限公司 Synthesis method of 2-amino-4, 6-dichloro-5-formamidopyrimidine

Also Published As

Publication number Publication date
CA2182105C (en) 2006-07-25

Similar Documents

Publication Publication Date Title
IL112539A0 (en) Pyrimidine derivatives and their preparation
CA2201785A1 (en) New carboxylic acid derivatives, their preparation and their use
HK1066010A1 (en) Optically active compounds which are useful as intermediates in the preparation of optically acitve-2-imidazoline-5-thione derivatives
AU5304094A (en) Intermediates useful in the preparation of 7-azaisoindolinyl-quinolone- and-naphthyridonecarboxylic acid derivatives
MY115679A (en) Process for preparing intermediates to florfenicol
CA2311922A1 (en) Thienopyrimidines
IL132599A0 (en) Substituted 3,3-diamino-2-propenenitriles their preparation and use
AU4912090A (en) Intermediates useful in the synthesis of 2-oxy-4h-3, 1-benzoxazin-4-one derivative
CA2219359A1 (en) Hydantoin derivatives as intermediates for pharmaceutical active compounds
CA2182105A1 (en) Chloropyrimide intermediates
CA2208630A1 (en) 4-amino-2-ureidopyrimidine-5-carboxamides, processes for their preparation, pharmaceuticals comprising these compounds, and their use
AU2253088A (en) Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
AU6922994A (en) Use of acylcarnitin to treat illnesses caused by aids
IL140786A0 (en) Process for the preparation of 4,6-disubstituted 2-isocyanatopyrimidines and their use as intermediates for active compound syntheses
CA2208611A1 (en) 4-amino-2-ureidopyrimidine-5-carboxamides, processes for their preparation, pharmaceuticals comprising these compounds, and their use
HUT71549A (en) Process for producing pharmaceutical active 4-hydroxy 1h-pyrazolo [3,4d] pyrimidine of high purity
AU4448497A (en) Novel 6 or 7 substituted analogues of swainsonine, processes for their preparation and their use as therapeutic agents
IL111770A0 (en) Triarylborane derivatives, their preparation and their use as synthesis intermediates
CA2155802A1 (en) Enantiomerically pure pyridylcycloalkylethylamines and the salts thereof and processes for preparing them
ITMI942632A0 (en) PROCEDURE FOR THE PREPARATION OF HIGH PURITY 3 ALPHA-7 BETA-DIHYDROXYCHOLANIC ACID
PL309329A1 (en) Novel triazopyrimidones, methods of obtaining them and their application
IT1289503B1 (en) HIGH PURITY PROCEDURE FOR THE PREPARATION OF 3 ALPHA-7 BETA-DIHYDROXICOLANIC ACID

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20150203