CA2180444A1 - Sel onium de taxo-diterpenoide soluble dans l'eau - Google Patents
Sel onium de taxo-diterpenoide soluble dans l'eauInfo
- Publication number
- CA2180444A1 CA2180444A1 CA002180444A CA2180444A CA2180444A1 CA 2180444 A1 CA2180444 A1 CA 2180444A1 CA 002180444 A CA002180444 A CA 002180444A CA 2180444 A CA2180444 A CA 2180444A CA 2180444 A1 CA2180444 A1 CA 2180444A1
- Authority
- CA
- Canada
- Prior art keywords
- taxol
- arenes
- mpt
- aza
- taxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
- 229930012538 Paclitaxel Natural products 0.000 abstract 7
- 229960001592 paclitaxel Drugs 0.000 abstract 7
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 102000004506 Blood Proteins Human genes 0.000 abstract 1
- 108010017384 Blood Proteins Proteins 0.000 abstract 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000005580 one pot reaction Methods 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229940063683 taxotere Drugs 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18003494A | 1994-01-11 | 1994-01-11 | |
| US08/180,034 | 1994-01-11 | ||
| PCT/US1995/000478 WO1995018804A1 (fr) | 1994-01-11 | 1995-01-10 | Sel onium soluble dans l'eau de taxo-diterpenoïde |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2180444A1 true CA2180444A1 (fr) | 1995-07-13 |
| CA2180444C CA2180444C (fr) | 2006-02-28 |
Family
ID=36011107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002180444A Expired - Lifetime CA2180444C (fr) | 1994-01-11 | 1995-01-10 | Sel onium de taxo-diterpenoide soluble dans l'eau |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2180444C (fr) |
-
1995
- 1995-01-10 CA CA002180444A patent/CA2180444C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2180444C (fr) | 2006-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20150112 |