CA2179639A1 - Compositions pour vaccins comprenant des vecteurs bacteriens vivants pour la protection contre l'infection a yersinia pestis - Google Patents
Compositions pour vaccins comprenant des vecteurs bacteriens vivants pour la protection contre l'infection a yersinia pestisInfo
- Publication number
- CA2179639A1 CA2179639A1 CA002179639A CA2179639A CA2179639A1 CA 2179639 A1 CA2179639 A1 CA 2179639A1 CA 002179639 A CA002179639 A CA 002179639A CA 2179639 A CA2179639 A CA 2179639A CA 2179639 A1 CA2179639 A1 CA 2179639A1
- Authority
- CA
- Canada
- Prior art keywords
- plasmid
- thr
- organism
- seq
- micro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 23
- 241000607479 Yersinia pestis Species 0.000 title claims description 22
- 239000013598 vector Substances 0.000 title claims description 13
- 239000000203 mixture Substances 0.000 title abstract description 5
- 238000002347 injection Methods 0.000 title description 3
- 239000007924 injection Substances 0.000 title description 3
- 230000001580 bacterial effect Effects 0.000 title 1
- 244000005700 microbiome Species 0.000 claims abstract description 42
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 34
- 239000013612 plasmid Substances 0.000 claims abstract description 29
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 25
- 241001465754 Metazoa Species 0.000 claims abstract description 22
- 241000282414 Homo sapiens Species 0.000 claims abstract description 19
- 239000000427 antigen Substances 0.000 claims abstract description 9
- 108091007433 antigens Proteins 0.000 claims abstract description 9
- 102000036639 antigens Human genes 0.000 claims abstract description 9
- 230000028993 immune response Effects 0.000 claims abstract description 9
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims abstract description 7
- 230000001131 transforming effect Effects 0.000 claims abstract description 7
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims abstract 2
- 108020004414 DNA Proteins 0.000 claims description 34
- 239000012634 fragment Substances 0.000 claims description 12
- 230000001681 protective effect Effects 0.000 claims description 11
- 101150066555 lacZ gene Proteins 0.000 claims description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 3
- 241000607734 Yersinia <bacteria> Species 0.000 claims description 3
- 230000003321 amplification Effects 0.000 claims description 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 3
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
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- 101100394265 Schizosaccharomyces pombe (strain 972 / ATCC 24843) hba1 gene Proteins 0.000 claims 1
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- 108020004705 Codon Proteins 0.000 description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
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- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
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- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Nouveaux produits de recombinaison d'ADN qui sont capables de transformer des micro-organismes de telle manière que ces derniers peuvent être utilisés comme vaccins vivants ou atténués induisant une réponse immunitaire au niveau des muqueuses. Des micro-organismes ainsi transformés et des compositions pour vaccins sont également décrits. Des produits de recombinaison préférés de la présente invention sont capables de transformer des micro-organismes de telle manière que ces derniers expriment la protéine à base de F1 tout en conservant la capacité de se loger dans un environnement intestinal humain ou animal. On a identifié plusieurs produits de recombinaison capables de transformer des micro-organismes séjournant dans les intestins tels que S. typhimurium ou S. typhi pour permettre la production d'antigène F1, mais la plupart de ces produits affectent le micro-organisme de telle manière qu'il ne peut plus fonctionner efficacement dans l'intestin, tout au moins dans la mesure où il ne peut plus exprimer l'antigène, par exemple parce qu'il est instable et perd le plasmide.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9326425.7 | 1993-12-24 | ||
| GB939326425A GB9326425D0 (en) | 1993-12-24 | 1993-12-24 | Vaccine compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2179639A1 true CA2179639A1 (fr) | 1995-07-06 |
Family
ID=10747201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002179639A Abandoned CA2179639A1 (fr) | 1993-12-24 | 1994-12-23 | Compositions pour vaccins comprenant des vecteurs bacteriens vivants pour la protection contre l'infection a yersinia pestis |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0741786A1 (fr) |
| JP (1) | JPH09507028A (fr) |
| AU (1) | AU1322295A (fr) |
| CA (1) | CA2179639A1 (fr) |
| GB (1) | GB9326425D0 (fr) |
| WO (1) | WO1995018231A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070043215A1 (en) | 1996-08-27 | 2007-02-22 | Heath David G | Recombinant f1-v plague vaccine |
| AU5597998A (en) * | 1996-12-04 | 1998-06-29 | Heska Corporation | Recombinant plague vaccine |
| EP1176966B1 (fr) * | 1999-04-12 | 2013-04-03 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Un oligodesoxynucleotide et son emploi pour induire une reponse immunitaire |
| GB9921275D0 (en) * | 1999-09-10 | 1999-11-10 | Secr Defence | Recombinant microorganisms |
| AU2001227889A1 (en) | 2000-01-14 | 2001-07-24 | The United States of America, represented by The Secretary, Department of Health & Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| GB0220257D0 (en) | 2002-08-31 | 2002-10-09 | Secr Defence | Vaccine |
| US7344718B2 (en) | 2003-01-31 | 2008-03-18 | University Of North Dakota | Yersinia species compositions |
| WO2012178078A2 (fr) | 2011-06-22 | 2012-12-27 | University Of North Dakota | Utilisation d'une yscf, d'une yscf tronquée et d'homologues de l'yscf comme adjuvants |
| IN2014DN09618A (fr) | 2012-05-23 | 2015-07-31 | Us Sec Dep Of Health And Human Services |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0474891A1 (fr) * | 1990-09-08 | 1992-03-18 | BEHRINGWERKE Aktiengesellschaft | Vecteurs pour l'expression d'antigènes malariales sur la surface de souches vaccinales de Salmonella |
| DK0556333T3 (da) * | 1990-11-09 | 2003-07-14 | Univ Washington | Avirulente Salmonella mikrober, der omfatter en mutation i cdt genet, og anvendelser deraf |
-
1993
- 1993-12-24 GB GB939326425A patent/GB9326425D0/en active Pending
-
1994
- 1994-12-23 CA CA002179639A patent/CA2179639A1/fr not_active Abandoned
- 1994-12-23 AU AU13222/95A patent/AU1322295A/en not_active Abandoned
- 1994-12-23 JP JP7517658A patent/JPH09507028A/ja active Pending
- 1994-12-23 EP EP95904620A patent/EP0741786A1/fr not_active Withdrawn
- 1994-12-23 WO PCT/GB1994/002818 patent/WO1995018231A1/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0741786A1 (fr) | 1996-11-13 |
| JPH09507028A (ja) | 1997-07-15 |
| GB9326425D0 (en) | 1994-02-23 |
| AU1322295A (en) | 1995-07-17 |
| WO1995018231A1 (fr) | 1995-07-06 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |