CA2177970A1 - Plaster containing an active substance - Google Patents

Plaster containing an active substance

Info

Publication number
CA2177970A1
CA2177970A1 CA002177970A CA2177970A CA2177970A1 CA 2177970 A1 CA2177970 A1 CA 2177970A1 CA 002177970 A CA002177970 A CA 002177970A CA 2177970 A CA2177970 A CA 2177970A CA 2177970 A1 CA2177970 A1 CA 2177970A1
Authority
CA
Canada
Prior art keywords
active substance
plaster
membrane
reservoir
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002177970A
Other languages
French (fr)
Other versions
CA2177970C (en
Inventor
Reinhold Meconi
Frank Seibertz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of CA2177970A1 publication Critical patent/CA2177970A1/en
Application granted granted Critical
Publication of CA2177970C publication Critical patent/CA2177970C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The proposed plaster containing an active substance for the controlled release of active substances comprises a backing layer, a reservoir layer adjacent to it which contains active substance and softens at body temperature, a membrane which controls the release of the active substance, an adhesive system with which the plaster can be fixed to the skin, and a removable protective layer. The proposed plaster is characterized by the fact that the reservoir layer which softens at body temperature is separated from the control membrane by a device made of a material which is not permeable to the active substance and extends right across the mutually opposing surfaces of the reservoir and membrane and has at least one passage for the reservoir layer.
CA002177970A 1993-12-04 1994-11-23 Plaster containing an active substance Expired - Fee Related CA2177970C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4341444.3 1993-12-04
DE4341444A DE4341444C2 (en) 1993-12-04 1993-12-04 Active substance-containing plaster and process for its production
PCT/EP1994/003866 WO1995015158A1 (en) 1993-12-04 1994-11-23 Pflaster containing an active substance

Publications (2)

Publication Number Publication Date
CA2177970A1 true CA2177970A1 (en) 1995-06-08
CA2177970C CA2177970C (en) 2006-01-10

Family

ID=6504235

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002177970A Expired - Fee Related CA2177970C (en) 1993-12-04 1994-11-23 Plaster containing an active substance

Country Status (10)

Country Link
US (1) US5770220A (en)
EP (1) EP0731695B1 (en)
JP (1) JP3549888B2 (en)
AT (1) ATE165736T1 (en)
CA (1) CA2177970C (en)
DE (2) DE4341444C2 (en)
DK (1) DK0731695T3 (en)
ES (1) ES2118535T3 (en)
GR (1) GR3027575T3 (en)
WO (1) WO1995015158A1 (en)

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US6277401B1 (en) 1999-05-07 2001-08-21 U.S. Dermatologics, Inc. Drug delivery device
JP5334346B2 (en) * 1999-08-10 2013-11-06 久光製薬株式会社 Roll external patch
DE20001165U1 (en) 2000-01-18 2000-03-30 Lichtenberg, Frank-Michael, 12439 Berlin Wet wipe
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
DE10042412B4 (en) * 2000-08-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag Transceiver for bus subscriber of bus system of building system engineering, has two wires, where microcontroller is connected with receiver unit over connection on one hand, which is connected to two wires of bus system
US6559180B2 (en) 2001-03-27 2003-05-06 Yuri Busiashvili Nitroglycerin-menthol potentiation for treatment of angina
DE10118282A1 (en) * 2001-04-12 2002-12-05 Lohmann Therapie Syst Lts Pressure sensitive adhesive based on ethylene-vinyl acetate copolymers and adhesive resins, for medical purposes
CN101129327A (en) * 2001-04-20 2008-02-27 阿尔扎公司 Micro-projection array having a beneficial agent containing coating
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
DE60239528D1 (en) * 2001-05-01 2011-05-05 Corium International Redwood City TWO-PHASE, WATER-ABSORBING BIOADHESIVE COMPOSITION
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US8541021B2 (en) * 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8728445B2 (en) * 2001-05-01 2014-05-20 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences Hydrogel Compositions
US20050215727A1 (en) * 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US8524200B2 (en) 2002-09-11 2013-09-03 The Procter & Gamble Company Tooth whitening products
CA2729967C (en) * 2002-12-13 2018-01-16 Schering-Plough Healthcare Products, Inc. Use of a transdermal or transmucosal ingredient delivery device
ES2437565T3 (en) * 2003-06-30 2014-01-13 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CA2530996C (en) * 2003-07-03 2013-05-07 Corium International, Inc. Wound dressing, ingredient delivery device and iv hold-down, and method relating to same
US7470266B2 (en) * 2003-09-16 2008-12-30 I-Flow Corporation Fluid medication delivery device
KR20070007299A (en) 2004-01-30 2007-01-15 코리움 인터네셔널, 인크. Rapidly dissolving film for delivery of an active agent
ES2568259T3 (en) 2004-05-13 2016-04-28 Alza Corporation Apparatus and method for transdermal administration of parathyroid hormone agents
CN103497713B (en) * 2004-08-05 2018-07-17 考里安国际公司 Adhesive composition
US7704522B2 (en) * 2004-09-08 2010-04-27 Clyde Morgan Topical medicament
DE102005050431A1 (en) * 2005-10-21 2007-04-26 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for the administration of lipophilic and / or less skin-permeable active ingredients
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
AU2009300184A1 (en) * 2008-09-30 2010-04-08 Teikoku Pharma Usa, Inc. Transdermal extended-delivery donepezil compositions and methods for using the same
WO2010083035A2 (en) 2009-01-14 2010-07-22 Corium International, Inc. Transdermal administration of tamsulosin
US20100178307A1 (en) * 2010-01-13 2010-07-15 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
US8952038B2 (en) 2010-03-26 2015-02-10 Philip Morris Usa Inc. Inhibition of undesired sensory effects by the compound camphor
WO2011117740A2 (en) 2010-03-26 2011-09-29 Philip Morris Products S.A. Inhibition of sensory irritation during consumption of non-smokeable tobacco products
US20140034058A1 (en) * 2011-03-29 2014-02-06 Resmed R&D Germany Gmbh Cushion for patient interface
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
HUE055562T2 (en) 2011-11-23 2021-11-29 Therapeuticsmd Inc Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
EP3906956B1 (en) * 2013-11-14 2023-10-25 ResMed Pty Ltd A patient interface
RU2016143081A (en) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. NATURAL COMBINED HORMONE SUBSTITUTION COMPOSITIONS AND THERAPIES
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR20180126582A (en) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
GB2561262B (en) * 2017-07-13 2019-03-20 Dentmed Ltd A targeted drug delivery pad
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
DE102020214263A1 (en) 2020-11-12 2022-05-12 OPTIMA life science GmbH Device and method for transferring a membrane

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US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
DE3315272C2 (en) * 1983-04-27 1986-03-27 Lohmann Gmbh & Co Kg, 5450 Neuwied Pharmaceutical product and process for its manufacture
DE3503111A1 (en) * 1985-01-31 1986-08-07 Rainer K. Dr. 8022 Grünwald Liedtke Medicinal plaster
GB8512358D0 (en) * 1985-05-16 1985-06-19 Euro Celtique Sa Transdermal delivery system
DE3522060A1 (en) * 1985-06-20 1987-01-08 Liedtke Pharmed Gmbh MEDICAL PLASTER FOR SYSTEMIC APPLICATIONS
EP0249475A3 (en) * 1986-06-13 1989-10-11 Alza Corporation Delayed percutaneous delivery
ES2028074T3 (en) * 1986-06-13 1992-07-01 Alza Corporation ACTIVATION BY MOISTURE OF A TRANSDERMIC PHARMACY SUPPLY SYSTEM.
US4911707A (en) * 1987-02-13 1990-03-27 Ciba-Geigy Corporation Monolithic user-activated transdermal therapeutic system
US5071656A (en) * 1987-03-05 1991-12-10 Alza Corporation Delayed onset transdermal delivery device
US4983395A (en) * 1987-11-12 1991-01-08 Theratech Inc. Device for administering an active agent to the skin or mucosa
US4877618A (en) * 1988-03-18 1989-10-31 Reed Jr Fred D Transdermal drug delivery device
US5008110A (en) * 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
DE3908431A1 (en) * 1989-03-15 1990-09-27 Lohmann Therapie Syst Lts TRANSDERMAL SYSTEM WITH STAGE SUBSTANCE DELIVERY AND USE FOR LOCAL OR SYSTEMIC DISPENSER
US4963261A (en) * 1989-08-28 1990-10-16 Chromex Corp. Microporous membrane having a macroporous support
US5314694A (en) * 1990-10-29 1994-05-24 Alza Corporation Transdermal formulations, methods and devices
US5273756A (en) * 1991-08-23 1993-12-28 Cygnus Therapeutic Systems Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset

Also Published As

Publication number Publication date
DK0731695T3 (en) 1999-03-01
ATE165736T1 (en) 1998-05-15
DE4341444C2 (en) 1996-03-14
JP3549888B2 (en) 2004-08-04
JPH09505815A (en) 1997-06-10
ES2118535T3 (en) 1998-09-16
EP0731695A1 (en) 1996-09-18
GR3027575T3 (en) 1998-11-30
CA2177970C (en) 2006-01-10
DE59405920D1 (en) 1998-06-10
EP0731695B1 (en) 1998-05-06
DE4341444A1 (en) 1995-06-08
US5770220A (en) 1998-06-23
WO1995015158A1 (en) 1995-06-08

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20121123