CA2176460A1 - Method for dry blend compression of medicaments - Google Patents

Method for dry blend compression of medicaments

Info

Publication number
CA2176460A1
CA2176460A1 CA002176460A CA2176460A CA2176460A1 CA 2176460 A1 CA2176460 A1 CA 2176460A1 CA 002176460 A CA002176460 A CA 002176460A CA 2176460 A CA2176460 A CA 2176460A CA 2176460 A1 CA2176460 A1 CA 2176460A1
Authority
CA
Canada
Prior art keywords
medicaments
dry blend
agglomerated
excipients
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002176460A
Other languages
French (fr)
Other versions
CA2176460C (en
Inventor
Frank C. Greaves
James Swarbrick
Martin W. Beasley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Barr Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ZA939566A external-priority patent/ZA939566B/en
Application filed by Individual filed Critical Individual
Publication of CA2176460A1 publication Critical patent/CA2176460A1/en
Application granted granted Critical
Publication of CA2176460C publication Critical patent/CA2176460C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Disclosed is a method of dry blend compression of potent drugs with low solubility, such as steroidal medicaments using directly compressible agglomerated excipients that are not a conventional or spray dried polyalcohol or lactose. The agglomerated excipients include mannitol, maltodextrin or corn syrup solids which hold the medicaments (s) in the crevices of the agglomerates. Also disclosed are the critical ratios of the agglomerated excipients to steroidal agent, specifically estradiol, that is distributed uniformly throughout the dry blend and then compressed into tablets.
CA002176460A 1993-12-21 1994-12-20 Method for dry blend compression of medicaments Expired - Lifetime CA2176460C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ZA93/9566 1993-12-21
ZA939566A ZA939566B (en) 1993-12-21 1993-12-21 Method for dry blend compression od medicaments.
PCT/US1994/014639 WO1995017169A1 (en) 1993-12-21 1994-12-20 Method for dry blend compression of medicaments

Publications (2)

Publication Number Publication Date
CA2176460A1 true CA2176460A1 (en) 1995-06-29
CA2176460C CA2176460C (en) 2007-03-13

Family

ID=38007968

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002176460A Expired - Lifetime CA2176460C (en) 1993-12-21 1994-12-20 Method for dry blend compression of medicaments

Country Status (1)

Country Link
CA (1) CA2176460C (en)

Also Published As

Publication number Publication date
CA2176460C (en) 2007-03-13

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20141222