CA2172534C - Analogues de nucleosides structurellement bloques - Google Patents

Analogues de nucleosides structurellement bloques Download PDF

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Publication number
CA2172534C
CA2172534C CA002172534A CA2172534A CA2172534C CA 2172534 C CA2172534 C CA 2172534C CA 002172534 A CA002172534 A CA 002172534A CA 2172534 A CA2172534 A CA 2172534A CA 2172534 C CA2172534 C CA 2172534C
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Canada
Prior art keywords
carbocyclic
compound
cyclopropyl
group
ribonucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CA002172534A
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English (en)
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CA2172534A1 (fr
Inventor
Victor E. Marquez
Juan B. Rodriguez
Marc C. Nicklaus
Joseph J. Barchi, Jr.
Maqbool A. Siddiqui
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US Department of Health and Human Services
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US Department of Health and Human Services
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Priority claimed from PCT/US1994/010794 external-priority patent/WO1995008541A1/fr
Publication of CA2172534A1 publication Critical patent/CA2172534A1/fr
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Publication of CA2172534C publication Critical patent/CA2172534C/fr
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Expired - Lifetime legal-status Critical Current

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Abstract

L'invention concerne des analogues de nucléosides carbocycliques fusionnés à 4',6'-cyclopropane, de conformation verrouillée. Les composés sont préparés en condensant un alcool allylique carbocyclique fusionné à cyclopropane avec des bases à substitution purine ou pyrimidine. Les produits de condensation sont ensuite modifiés afin d'obtenir adénosine, guanosine, cytidine, thymidine et des analogues de nucléoside uracil. Les composés sont utiles en thérapie comme antimétabolites, ou dans la préparation d'agents antimétaboliques.
CA002172534A 1993-09-24 1994-09-23 Analogues de nucleosides structurellement bloques Expired - Lifetime CA2172534C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12679693A 1993-09-24 1993-09-24
US08/126,796 1993-09-24
PCT/US1994/010794 WO1995008541A1 (fr) 1993-09-24 1994-09-23 Analogues de nucleosides de conformation verrouillee

Publications (2)

Publication Number Publication Date
CA2172534A1 CA2172534A1 (fr) 1995-03-30
CA2172534C true CA2172534C (fr) 2005-11-15

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CA002172534A Expired - Lifetime CA2172534C (fr) 1993-09-24 1994-09-23 Analogues de nucleosides structurellement bloques

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CA2172534A1 (fr) 1995-03-30

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