CA2170739A1 - Method to reduce myocardial injury during acute myocardial infarction - Google Patents

Method to reduce myocardial injury during acute myocardial infarction

Info

Publication number
CA2170739A1
CA2170739A1 CA002170739A CA2170739A CA2170739A1 CA 2170739 A1 CA2170739 A1 CA 2170739A1 CA 002170739 A CA002170739 A CA 002170739A CA 2170739 A CA2170739 A CA 2170739A CA 2170739 A1 CA2170739 A1 CA 2170739A1
Authority
CA
Canada
Prior art keywords
myocardial infarction
acute myocardial
esterase inhibitor
injury during
during acute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002170739A
Other languages
French (fr)
Other versions
CA2170739C (en
Inventor
Willem Theodoor Hermens
Cornelis Erik Hack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STICHTING CENTRAAL LABORATORIUM VAN DE BLOEDTRANSFUSIEDIENST VAN HET NED ERLANDSE RODE KRUIS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/NL1994/000208 external-priority patent/WO1995006479A1/en
Publication of CA2170739A1 publication Critical patent/CA2170739A1/en
Application granted granted Critical
Publication of CA2170739C publication Critical patent/CA2170739C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A therapeutic or prophylactic treatment method of acute myocardial infarction, comprising administering exogenous C1-esterase inhibitor, alone or in combination with other drugs, to a patient with acute myocardial infarction or to a patient at risk for acute myocardial infarction. The treatment inhibits the inflammatory reaction, more specifically the activation of the complement system, which occurs in the course of acute myocardial infarction. The C1-esterase inhibitor may include C1-esterase inhibitor purified from plasma or other biological materials, or recombinant C1-esterase inhibitor or recombinant variants derived therefrom, or recombinant constructs of other inhibitors having a specificity similar to C1-esterase inhibitor.
CA002170739A 1993-09-01 1994-08-31 Method to reduce myocardial injury during acute myocardial infarction Expired - Lifetime CA2170739C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP93202572 1993-09-01
EP93202572.9 1993-09-01
PCT/NL1994/000208 WO1995006479A1 (en) 1993-09-01 1994-08-31 Method to reduce myocardial injury during acute myocardial infarction

Publications (2)

Publication Number Publication Date
CA2170739A1 true CA2170739A1 (en) 1995-03-09
CA2170739C CA2170739C (en) 2007-04-10

Family

ID=38007148

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002170739A Expired - Lifetime CA2170739C (en) 1993-09-01 1994-08-31 Method to reduce myocardial injury during acute myocardial infarction

Country Status (1)

Country Link
CA (1) CA2170739C (en)

Also Published As

Publication number Publication date
CA2170739C (en) 2007-04-10

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Legal Events

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MKEX Expiry

Effective date: 20140902