CA2170739A1 - Method to reduce myocardial injury during acute myocardial infarction - Google Patents
Method to reduce myocardial injury during acute myocardial infarctionInfo
- Publication number
- CA2170739A1 CA2170739A1 CA002170739A CA2170739A CA2170739A1 CA 2170739 A1 CA2170739 A1 CA 2170739A1 CA 002170739 A CA002170739 A CA 002170739A CA 2170739 A CA2170739 A CA 2170739A CA 2170739 A1 CA2170739 A1 CA 2170739A1
- Authority
- CA
- Canada
- Prior art keywords
- myocardial infarction
- acute myocardial
- esterase inhibitor
- injury during
- during acute
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010000891 acute myocardial infarction Diseases 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 208000037891 myocardial injury Diseases 0.000 title 1
- 229940009550 c1 esterase inhibitor Drugs 0.000 abstract 5
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 230000004154 complement system Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A therapeutic or prophylactic treatment method of acute myocardial infarction, comprising administering exogenous C1-esterase inhibitor, alone or in combination with other drugs, to a patient with acute myocardial infarction or to a patient at risk for acute myocardial infarction. The treatment inhibits the inflammatory reaction, more specifically the activation of the complement system, which occurs in the course of acute myocardial infarction. The C1-esterase inhibitor may include C1-esterase inhibitor purified from plasma or other biological materials, or recombinant C1-esterase inhibitor or recombinant variants derived therefrom, or recombinant constructs of other inhibitors having a specificity similar to C1-esterase inhibitor.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93202572 | 1993-09-01 | ||
| EP93202572.9 | 1993-09-01 | ||
| PCT/NL1994/000208 WO1995006479A1 (en) | 1993-09-01 | 1994-08-31 | Method to reduce myocardial injury during acute myocardial infarction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2170739A1 true CA2170739A1 (en) | 1995-03-09 |
| CA2170739C CA2170739C (en) | 2007-04-10 |
Family
ID=38007148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002170739A Expired - Lifetime CA2170739C (en) | 1993-09-01 | 1994-08-31 | Method to reduce myocardial injury during acute myocardial infarction |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2170739C (en) |
-
1994
- 1994-08-31 CA CA002170739A patent/CA2170739C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2170739C (en) | 2007-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20140902 |