CA2168252A1 - Derives du thiazole, inhibiteurs de la lipoxygenase - Google Patents

Derives du thiazole, inhibiteurs de la lipoxygenase

Info

Publication number
CA2168252A1
CA2168252A1 CA002168252A CA2168252A CA2168252A1 CA 2168252 A1 CA2168252 A1 CA 2168252A1 CA 002168252 A CA002168252 A CA 002168252A CA 2168252 A CA2168252 A CA 2168252A CA 2168252 A1 CA2168252 A1 CA 2168252A1
Authority
CA
Canada
Prior art keywords
formula
compound
group
methyl
pharmaceutically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002168252A
Other languages
English (en)
Inventor
Thomas Geoffrey Colerick Bird
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca SAS
Syngenta Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2168252A1 publication Critical patent/CA2168252A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Dérivé de thiazole répondant à la formule (I), dans laquelle Q représente 2-oxo-1,2,3,4-tétrahydroquinoléin-6-yle ou 2-oxo-1,2-dihydroquinoléin-6-yle portant un substituant alkyle C1-4 en position 1 sur l'atome d'azote; X<1> représente thio, sulfinyle ou sulfonyle; Ar représente thiazolediyle; R<1> représente alkyle C1-4, alcényle C3-4 ou alcynyle C3-4; et R<2> et R<3> forment ensemble un groupe répondant à la formule -A<2>-X<2>-A<3>- et formant, conjointement avec l'atome de carbone auquel sont rattachés A<2> et A<3>, un cycle à 5 ou 6 atomes, A<2> et A<3>, identiques ou différents, représentant alkylène C1-3, tandis que X<2> représente oxy, et ledit cycle pouvant porter un ou deux substituants alkyle C1-4; ou son sel pharmaceutiquement acceptable; leurs procédés de préparation; compositions pharmaceutiques les contenant, et leur utilisation comme inhibiteurs de 5-lipoxydase.
CA002168252A 1993-07-27 1994-07-21 Derives du thiazole, inhibiteurs de la lipoxygenase Abandoned CA2168252A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP93401947.2 1993-07-27
EP93401947 1993-07-27
EP94400318.5 1994-02-14
EP94400318 1994-02-14

Publications (1)

Publication Number Publication Date
CA2168252A1 true CA2168252A1 (fr) 1995-02-09

Family

ID=26134720

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002168252A Abandoned CA2168252A1 (fr) 1993-07-27 1994-07-21 Derives du thiazole, inhibiteurs de la lipoxygenase

Country Status (9)

Country Link
JP (1) JPH0753378A (fr)
CN (1) CN1128029A (fr)
AU (1) AU7460094A (fr)
CA (1) CA2168252A1 (fr)
FI (1) FI960371A0 (fr)
GB (1) GB9414623D0 (fr)
IL (1) IL110280A0 (fr)
NO (1) NO960333L (fr)
WO (1) WO1995004055A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891460A (en) * 1995-06-07 1999-04-06 University Of Southern California University Park Campus Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
US7439260B2 (en) * 2003-06-11 2008-10-21 Merck Forsst Canada & Co. 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK167187A (da) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
GB8926981D0 (en) * 1988-12-23 1990-01-17 Ici Plc Heterocyclic derivatives
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
IL93344A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cyclic ethers
GB9018134D0 (en) * 1989-09-29 1990-10-03 Ici Plc Heterocyclic derivatives
IE911919A1 (en) * 1990-06-21 1992-01-01 Zeneca Ltd Bicyclic heterocyclic compounds
IE911853A1 (en) * 1990-06-21 1992-01-01 Ici Plc Heterocyclene derivatives
IE913655A1 (en) * 1990-11-06 1992-05-22 Zeneca Ltd Synergistic agents

Also Published As

Publication number Publication date
GB9414623D0 (en) 1994-09-07
AU7460094A (en) 1995-02-28
FI960371A (fi) 1996-01-26
NO960333L (no) 1996-01-29
FI960371A0 (fi) 1996-01-26
WO1995004055A1 (fr) 1995-02-09
IL110280A0 (en) 1994-10-21
CN1128029A (zh) 1996-07-31
NO960333D0 (no) 1996-01-26
JPH0753378A (ja) 1995-02-28

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Legal Events

Date Code Title Description
FZDE Discontinued