CA2165800A1 - Antiallergic imidazoazepines - Google Patents

Antiallergic imidazoazepines

Info

Publication number
CA2165800A1
CA2165800A1 CA002165800A CA2165800A CA2165800A1 CA 2165800 A1 CA2165800 A1 CA 2165800A1 CA 002165800 A CA002165800 A CA 002165800A CA 2165800 A CA2165800 A CA 2165800A CA 2165800 A1 CA2165800 A1 CA 2165800A1
Authority
CA
Canada
Prior art keywords
formula
radical
6alkyl
imidazoazepines
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002165800A
Other languages
French (fr)
Other versions
CA2165800C (en
Inventor
Frans Eduard Janssens
Joseph Elisabeth Leenaerts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Frans Eduard Janssens
Joseph Elisabeth Leenaerts
Janssen Pharmaceutica, Naamloze Vennootschap
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frans Eduard Janssens, Joseph Elisabeth Leenaerts, Janssen Pharmaceutica, Naamloze Vennootschap filed Critical Frans Eduard Janssens
Priority claimed from PCT/EP1994/002287 external-priority patent/WO1995002600A1/en
Publication of CA2165800A1 publication Critical patent/CA2165800A1/en
Application granted granted Critical
Publication of CA2165800C publication Critical patent/CA2165800C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

The present invention is concerned with novel imidazoazepines of formula (I), the: pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently r<;presents an optional bond; -A-B- is a radical of formula -X-CH=CH- (a-1); -CH=CH-X- (a-2); or -CH=CH-CH=CH- (a-3); X represents O, S or NR1; R1 represents hydrogen or C1-6alkyl;
_~ Y is a radical of formula =O (b-1); -OH (b-2); or =N-OH (b-3); and L
represents hydrogen, C1-4alkylcarbonyl, C1-4alkyloxycarbonyl, phenylcarbonyl, C1-6alkyl or C1-6alkyl substituted with C1-4alkyloxycarbonyl, hydroxycarbonyl, aryl, aryloxy or a radical of formula (c), wherein -D-Z. is -S-CH=CH-, -S-CH2-CH2-, -S-CH2-CH2-CH2-, -CH=CH-CH=CH- or -CH2-CH2-CH2-CH2-; and aryl is phenyl or phenyl substituted with halo, hydtnxy or C1-4alkyloxy. Compositions comprising said compounds, processes for preparing the same and the use of these compounds for treating allergic diseases.
CA002165800A 1993-07-13 1994-07-06 Antiallergic imidazoazepines Expired - Fee Related CA2165800C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP93202154 1993-07-13
EP93202154.6 1993-07-13
PCT/EP1994/002287 WO1995002600A1 (en) 1993-07-13 1994-07-06 Antiallergic imidazoazepines

Publications (2)

Publication Number Publication Date
CA2165800A1 true CA2165800A1 (en) 1995-01-26
CA2165800C CA2165800C (en) 2006-03-14

Family

ID=36095677

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002165800A Expired - Fee Related CA2165800C (en) 1993-07-13 1994-07-06 Antiallergic imidazoazepines

Country Status (1)

Country Link
CA (1) CA2165800C (en)

Also Published As

Publication number Publication date
CA2165800C (en) 2006-03-14

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