CA2163115C - Derives de beta-aryle-n substitue et de beta-heteroaryle-alpha-cyanoacrylamides et procede de preparation - Google Patents
Derives de beta-aryle-n substitue et de beta-heteroaryle-alpha-cyanoacrylamides et procede de preparation Download PDFInfo
- Publication number
- CA2163115C CA2163115C CA002163115A CA2163115A CA2163115C CA 2163115 C CA2163115 C CA 2163115C CA 002163115 A CA002163115 A CA 002163115A CA 2163115 A CA2163115 A CA 2163115A CA 2163115 C CA2163115 C CA 2163115C
- Authority
- CA
- Canada
- Prior art keywords
- beta
- alpha
- cyanoacrylamide
- indolyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
L'invention se rapporte à des nouveaux composés de la formule (I), ainsi qu'aux sels pharmacologiquement acceptables de ceux-ci, dans laquelle A est un noyau bicyclique choisi parmi naphtalène, tétrahydronaphtalène, quinoline, isoquinoline et indole; B est un noyau benzène substitué par R?2¿, ou un noyau pyridine ou thiophène non substitué; R représente hydrogène, alcoyle C¿1?-C¿6?, halogène, nitro, cyano, carboxy ou un groupe NR?3¿R?4¿ dans lequel chacun des R?3¿ et R?4¿ représente indépendamment hydrogène ou alcoyle C¿1?-C¿6?; R?1¿ représente hydrogène, alcoyle C¿1?-C¿6? ou alcanoyle C¿1?-C¿6?; R?2¿ représente hydrogène, alcoyle C¿1?-C¿6?, halogène, nitro, cyano, carboxy, hydroxy, alcoxy C¿1?-C¿6?, alcanoyloxy C¿1?-C¿6? ou un groupe NR?3¿R?4¿ dans lequel R?3¿ et R?4¿ sont tels que définis ci-dessus; n vaut zéro ou un nombre entier de 1 à 2; x vaut zéro ou un nombre entier de 1 à 5. Les composés de l'invention sont utiles en tant qu'inhibiteurs de la tyrosine kinase.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9406137.1 | 1994-03-28 | ||
GB9406137A GB9406137D0 (en) | 1994-03-28 | 1994-03-28 | N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation |
PCT/EP1995/000758 WO1995026341A1 (fr) | 1994-03-28 | 1995-03-02 | Derives beta-aryle et beta-heteroaryle-alpha-cyanoacrylamides substitues en tant qu'inhibiteurs de la tyrosine kinase |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2163115A1 CA2163115A1 (fr) | 1995-10-05 |
CA2163115C true CA2163115C (fr) | 2005-12-06 |
Family
ID=35519632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002163115A Expired - Fee Related CA2163115C (fr) | 1994-03-28 | 1995-03-02 | Derives de beta-aryle-n substitue et de beta-heteroaryle-alpha-cyanoacrylamides et procede de preparation |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2163115C (fr) |
-
1995
- 1995-03-02 CA CA002163115A patent/CA2163115C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2163115A1 (fr) | 1995-10-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |