CA2163115C - Derives de beta-aryle-n substitue et de beta-heteroaryle-alpha-cyanoacrylamides et procede de preparation - Google Patents

Derives de beta-aryle-n substitue et de beta-heteroaryle-alpha-cyanoacrylamides et procede de preparation Download PDF

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Publication number
CA2163115C
CA2163115C CA002163115A CA2163115A CA2163115C CA 2163115 C CA2163115 C CA 2163115C CA 002163115 A CA002163115 A CA 002163115A CA 2163115 A CA2163115 A CA 2163115A CA 2163115 C CA2163115 C CA 2163115C
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CA
Canada
Prior art keywords
beta
alpha
cyanoacrylamide
indolyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002163115A
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English (en)
Other versions
CA2163115A1 (fr
Inventor
Franco Buzzetti
Angelo Crugnola
Antonio Longo
Maria Gabriella Brasca
Dario Ballinari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9406137A external-priority patent/GB9406137D0/en
Application filed by Pharmacia SpA filed Critical Pharmacia SpA
Publication of CA2163115A1 publication Critical patent/CA2163115A1/fr
Application granted granted Critical
Publication of CA2163115C publication Critical patent/CA2163115C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

L'invention se rapporte à des nouveaux composés de la formule (I), ainsi qu'aux sels pharmacologiquement acceptables de ceux-ci, dans laquelle A est un noyau bicyclique choisi parmi naphtalène, tétrahydronaphtalène, quinoline, isoquinoline et indole; B est un noyau benzène substitué par R?2¿, ou un noyau pyridine ou thiophène non substitué; R représente hydrogène, alcoyle C¿1?-C¿6?, halogène, nitro, cyano, carboxy ou un groupe NR?3¿R?4¿ dans lequel chacun des R?3¿ et R?4¿ représente indépendamment hydrogène ou alcoyle C¿1?-C¿6?; R?1¿ représente hydrogène, alcoyle C¿1?-C¿6? ou alcanoyle C¿1?-C¿6?; R?2¿ représente hydrogène, alcoyle C¿1?-C¿6?, halogène, nitro, cyano, carboxy, hydroxy, alcoxy C¿1?-C¿6?, alcanoyloxy C¿1?-C¿6? ou un groupe NR?3¿R?4¿ dans lequel R?3¿ et R?4¿ sont tels que définis ci-dessus; n vaut zéro ou un nombre entier de 1 à 2; x vaut zéro ou un nombre entier de 1 à 5. Les composés de l'invention sont utiles en tant qu'inhibiteurs de la tyrosine kinase.
CA002163115A 1994-03-28 1995-03-02 Derives de beta-aryle-n substitue et de beta-heteroaryle-alpha-cyanoacrylamides et procede de preparation Expired - Fee Related CA2163115C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9406137.1 1994-03-28
GB9406137A GB9406137D0 (en) 1994-03-28 1994-03-28 N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation
PCT/EP1995/000758 WO1995026341A1 (fr) 1994-03-28 1995-03-02 Derives beta-aryle et beta-heteroaryle-alpha-cyanoacrylamides substitues en tant qu'inhibiteurs de la tyrosine kinase

Publications (2)

Publication Number Publication Date
CA2163115A1 CA2163115A1 (fr) 1995-10-05
CA2163115C true CA2163115C (fr) 2005-12-06

Family

ID=35519632

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002163115A Expired - Fee Related CA2163115C (fr) 1994-03-28 1995-03-02 Derives de beta-aryle-n substitue et de beta-heteroaryle-alpha-cyanoacrylamides et procede de preparation

Country Status (1)

Country Link
CA (1) CA2163115C (fr)

Also Published As

Publication number Publication date
CA2163115A1 (fr) 1995-10-05

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