CA2161652A1 - Topical compositions for re-epitheliazation of persistent epithelial defects - Google Patents

Topical compositions for re-epitheliazation of persistent epithelial defects

Info

Publication number
CA2161652A1
CA2161652A1 CA002161652A CA2161652A CA2161652A1 CA 2161652 A1 CA2161652 A1 CA 2161652A1 CA 002161652 A CA002161652 A CA 002161652A CA 2161652 A CA2161652 A CA 2161652A CA 2161652 A1 CA2161652 A1 CA 2161652A1
Authority
CA
Canada
Prior art keywords
epitheliazation
epithelial defects
topical compositions
persistent epithelial
gelatinous composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002161652A
Other languages
French (fr)
Other versions
CA2161652C (en
Inventor
Patricia B. Williams
Earl R. Crouch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eastern Virginia Medical School
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1994/004470 external-priority patent/WO1994025058A1/en
Publication of CA2161652A1 publication Critical patent/CA2161652A1/en
Application granted granted Critical
Publication of CA2161652C publication Critical patent/CA2161652C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Persistent epithelial defects are effectively treated by topically applying a gelatinous composition containing either aminocaproic acid or tranexamic acid to the eye. In vivo results demonstrate improved healing of the epithelium and basement membrane complex. The gelatinous composition is prepared by a process that ensures sterility and proper pH conditions throughout the gel.
CA002161652A 1993-04-30 1994-04-25 Topical compositions for re-epitheliazation of persistent epithelial defects Expired - Fee Related CA2161652C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5571793A 1993-04-30 1993-04-30
US08/055,717 1993-04-30
PCT/US1994/004470 WO1994025058A1 (en) 1993-04-30 1994-04-25 Topical compositions for re-epitheliazation of persistent epithelial defects

Publications (2)

Publication Number Publication Date
CA2161652A1 true CA2161652A1 (en) 1994-11-10
CA2161652C CA2161652C (en) 2007-07-10

Family

ID=38254903

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002161652A Expired - Fee Related CA2161652C (en) 1993-04-30 1994-04-25 Topical compositions for re-epitheliazation of persistent epithelial defects

Country Status (1)

Country Link
CA (1) CA2161652C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013093164A1 (en) * 2011-12-22 2013-06-27 Laboratorios Kin S.A. Tranexamic acid gel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013093164A1 (en) * 2011-12-22 2013-06-27 Laboratorios Kin S.A. Tranexamic acid gel

Also Published As

Publication number Publication date
CA2161652C (en) 2007-07-10

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