CA2155666A1 - Novel derivatives of 3-hydroxy anthranilic acid, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof - Google Patents

Novel derivatives of 3-hydroxy anthranilic acid, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof

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Publication number
CA2155666A1
CA2155666A1 CA002155666A CA2155666A CA2155666A1 CA 2155666 A1 CA2155666 A1 CA 2155666A1 CA 002155666 A CA002155666 A CA 002155666A CA 2155666 A CA2155666 A CA 2155666A CA 2155666 A1 CA2155666 A1 CA 2155666A1
Authority
CA
Canada
Prior art keywords
novel
intermediates
preparation
methods
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002155666A
Other languages
French (fr)
Other versions
CA2155666C (en
Inventor
Susanna Karin Maria Bjork
Barry K. Carpenter
Kristina Brigitta Gotthammar
Mat Torbjorn Linderberg
Per Johan Luthman
Kerstin Margareta Irma Persson
Robert Schwarcz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
University of Maryland at Baltimore
Original Assignee
Susanna Karin Maria Bjork
Barry K. Carpenter
Kristina Brigitta Gotthammar
Mat Torbjorn Linderberg
Per Johan Luthman
Kerstin Margareta Irma Persson
Robert Schwarcz
Aktiebolaget Astra
The University Of Maryland
Cornell Research Foundation, Inc.
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9300658A external-priority patent/SE9300658D0/en
Application filed by Susanna Karin Maria Bjork, Barry K. Carpenter, Kristina Brigitta Gotthammar, Mat Torbjorn Linderberg, Per Johan Luthman, Kerstin Margareta Irma Persson, Robert Schwarcz, Aktiebolaget Astra, The University Of Maryland, Cornell Research Foundation, Inc., Astra Aktiebolag filed Critical Susanna Karin Maria Bjork
Publication of CA2155666A1 publication Critical patent/CA2155666A1/en
Application granted granted Critical
Publication of CA2155666C publication Critical patent/CA2155666C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of general formula (I) wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula (I) wherein R1 and R2 = H, X = Br and Y
= Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.
CA002155666A 1993-02-26 1994-02-24 Novel derivatives of 3-hydroxy anthranilic acid, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof Expired - Lifetime CA2155666C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9300658-3 1993-02-26
SE9300658A SE9300658D0 (en) 1993-02-26 1993-02-26 NEW COMPOUNDS
PCT/SE1994/000153 WO1994019316A1 (en) 1993-02-26 1994-02-24 New compounds

Publications (2)

Publication Number Publication Date
CA2155666A1 true CA2155666A1 (en) 1994-09-01
CA2155666C CA2155666C (en) 2006-04-18

Family

ID=36250860

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002155666A Expired - Lifetime CA2155666C (en) 1993-02-26 1994-02-24 Novel derivatives of 3-hydroxy anthranilic acid, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof

Country Status (1)

Country Link
CA (1) CA2155666C (en)

Also Published As

Publication number Publication date
CA2155666C (en) 2006-04-18

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