CA2155666A1 - Novel derivatives of 3-hydroxy anthranilic acid, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof - Google Patents
Novel derivatives of 3-hydroxy anthranilic acid, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereofInfo
- Publication number
- CA2155666A1 CA2155666A1 CA002155666A CA2155666A CA2155666A1 CA 2155666 A1 CA2155666 A1 CA 2155666A1 CA 002155666 A CA002155666 A CA 002155666A CA 2155666 A CA2155666 A CA 2155666A CA 2155666 A1 CA2155666 A1 CA 2155666A1
- Authority
- CA
- Canada
- Prior art keywords
- novel
- intermediates
- preparation
- methods
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of general formula (I) wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula (I) wherein R1 and R2 = H, X = Br and Y
= Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.
= Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9300658-3 | 1993-02-26 | ||
SE9300658A SE9300658D0 (en) | 1993-02-26 | 1993-02-26 | NEW COMPOUNDS |
PCT/SE1994/000153 WO1994019316A1 (en) | 1993-02-26 | 1994-02-24 | New compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2155666A1 true CA2155666A1 (en) | 1994-09-01 |
CA2155666C CA2155666C (en) | 2006-04-18 |
Family
ID=36250860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002155666A Expired - Lifetime CA2155666C (en) | 1993-02-26 | 1994-02-24 | Novel derivatives of 3-hydroxy anthranilic acid, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2155666C (en) |
-
1994
- 1994-02-24 CA CA002155666A patent/CA2155666C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2155666C (en) | 2006-04-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20140224 |