CA2154714A1 - Breast cancer detection, imaging, and screening by electromagnetic millimeter waves - Google Patents
Breast cancer detection, imaging, and screening by electromagnetic millimeter wavesInfo
- Publication number
- CA2154714A1 CA2154714A1 CA 2154714 CA2154714A CA2154714A1 CA 2154714 A1 CA2154714 A1 CA 2154714A1 CA 2154714 CA2154714 CA 2154714 CA 2154714 A CA2154714 A CA 2154714A CA 2154714 A1 CA2154714 A1 CA 2154714A1
- Authority
- CA
- Canada
- Prior art keywords
- tumor
- breast
- tissue
- wave
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01V—GEOPHYSICS; GRAVITATIONAL MEASUREMENTS; DETECTING MASSES OR OBJECTS; TAGS
- G01V8/00—Prospecting or detecting by optical means
- G01V8/005—Prospecting or detecting by optical means operating with millimetre waves, e.g. measuring the black losey radiation
Landscapes
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Geophysics (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
A method and system for detecting an incipient tumor in living tissue such as that of a human breast in accordance with differences in relative dielectric characteristics . A generator produces a non-ionizing electromagnetic input wave of preselected frequency, usually exceeding three gigahertz, and that input wave is used to illuminate the living tissue, being focused into a small, discrete volume within the tissue to develop a non-ionizing electromagnetic wave at that position. The illumination location is moved over a portion of the living tissue in a predetermined scanning pattern. Scattered signal returns collected from the living tissue are collected to develop a scattered return signal. The scattered return signal is employed to detect any anomaly, caused by differences in relative dielectric characteristics, that is indicative of the presence of a tumor in the scanned living tissue.
Description
21~4~1~
.
Bridges 94007C
BREAST CANCER DETECTION, IMAGING, AND S~ N~
BY ELEC~RflM~N~TIC MILLIMETER WAVES
This application is a continuation-in-part of U . S .
Serial No. 08/269,691, filed July 1, 1994.
Background of the Invention Breast cancer is one of the leading causes of death for women. About one out of eight or nine women are expected to develop tumors of the breast, and about one out of sixteen to twenty are e~pected to die prematurely from breast cancer.
Mammography or other X-ray methods are currently most used for detection of breast cancers. However, every time a mammogram is taken, the patient incurs a small risk of having a breast tumor induced by the ionizing radiation properties of the X-rays used during the mammogram. Also, lS the process is costly and sometimes imprecise_ Accordingly, the National Cancer Institute has not rec n~ 1 mammograms for women under fifty years of age, who are not as likely to develop breast cancers as are older women. However, while only about twenty two percent of breast cancers occur in women under fifty, data suggests that breast cancer is more aggressive in pre-menopausal women. Furth~ ~, women under forty are getting the disease in increasing numbers--about eleven thousand annually now--and no one knows why.
.
Bridges 94007C
BREAST CANCER DETECTION, IMAGING, AND S~ N~
BY ELEC~RflM~N~TIC MILLIMETER WAVES
This application is a continuation-in-part of U . S .
Serial No. 08/269,691, filed July 1, 1994.
Background of the Invention Breast cancer is one of the leading causes of death for women. About one out of eight or nine women are expected to develop tumors of the breast, and about one out of sixteen to twenty are e~pected to die prematurely from breast cancer.
Mammography or other X-ray methods are currently most used for detection of breast cancers. However, every time a mammogram is taken, the patient incurs a small risk of having a breast tumor induced by the ionizing radiation properties of the X-rays used during the mammogram. Also, lS the process is costly and sometimes imprecise_ Accordingly, the National Cancer Institute has not rec n~ 1 mammograms for women under fifty years of age, who are not as likely to develop breast cancers as are older women. However, while only about twenty two percent of breast cancers occur in women under fifty, data suggests that breast cancer is more aggressive in pre-menopausal women. Furth~ ~, women under forty are getting the disease in increasing numbers--about eleven thousand annually now--and no one knows why.
2~
Mammograms require interpretation by radiologists. One radiologist has said " I generally can spot cancers between five and ten millimeters in diameter. The prognosis is ~YrPl 1 ~nt then. ' ~owever, about ten to fifteen percent of tumors of this size are not detected. One study showed major rl inir;ll disagreements for about one-third of the same mammograms that were interpreted by a group of radiologists.
~urther, many women find that undergoing a mammogram is a decidedly painful experience.
Thus, alternative methods to detect breast cancers are needed, especially those that do not entail added risks, that can detect tumors as small as two millimeters in diameter, that are not unduly unpleasant to the patient, and that can be used for mass screening. A screening system is needed because extensive studies have demonstrated that early detection of small breast tumors leads to the most effective treatment . While X-ray mammography can detect lesions of approximately five mm or larger, the accuracy may range between 30~O and 7596, ~ r~n~inq on the skill of the diagnostic radiologist. Repeated X-ray examinations, however, are not encouraged because these may become carcinogenic. These considerations, in addition to cost considerations, have led physicians to r~l~ d that women wait until the age of fifty before having routine mammograms. One solution would be a non-ionizing, non-invasive, and low cost detection or ~creening metho~. It coul~ gre.ltly i~re~e wituout h~z.lr~
21~714 the number of patients r~rAmined and would identify those patients who need diagnostic X-ray examinations, where the added hazards and costs could be justified. Thus, there is a need for a low-cost, non-invasive, screening method.
About one in eight women develop breast cancers and about one in sixteen die prematurely from this disease.
Despite strong encouragement, less than half of the m; 11 ;nnq of women who should be are routinely screened. Some of the reasons are cost and discomfort exr~r; rnred during mammography. Other concerns are the additional risks associated with ionizing radiation, especially for routine exams for women under fifty. E~owever, while only twenty two percent of breast cancers occur in women under fifty, data suggest that breast cancer is more aggressive in pre-menopausal women. A screening procedure need only identify breasts with abnormalities. The precision and imaging requirements associated with diagnostic purposes and treatment monitoring, while desirable, need not apply.
There are several generic detection methods: sonic, rhrm;rAl, nuclear and non-irni ~in~ electromagnetic. The sonic, rhrmirAl and nuclear (such as ~RI) techniques have been under study for some time and, while some interesting approaches are being followed, none have been publicized as being available in the near future for low cost screening.
Non-ionizing electromagnetic methods have also been under investigation. Studies have considered the use of ~` 21~4714 elec L., ~n~tic, non-ionizing methods to detect or image portions of the human body. An excellent summary of such activity Ls presented in a publication entitled "Medical Applications of Microwave Imaging", edited by L. E. 1arsen and J. H. Jacobi, IEEE Pre3s 1986 . * These activities include microwave thermography, radar techniques to image biological tissues, microwave holography and tomography, video pulse radar, frequency modulation pulse compression techniques for biological imaging, microwave imaging with diffraction tomography, inverse scattering approaches, and medical imaging using an electrical irnro~iAnre The publications in this book contain about five hundred citations, some of which are duplicates. The technology cited not only includes electromagnetic disciplines, but also notes related studies ill sonic imaging and seismic imaging. To update these data, the IEEE transactions on Medical Imaging, Biomedical Engineering, Microwave Theory and Techniques and Antennas and Propagation have been reviewed. Also surveyed was the publication Microwave Power and Engineering. This update has indicated little significant progress in the af~,L, ~ ~' ioned electromagnetic techniques that would be important to detect * See the list of references at the end of this specif ication .
215~714 .
breast cancers. Breast cancer detection systems based on the concepts ~iPc~rih~<l in this specification were not presented.
Many important reasons e:cist for this lack of progress.
In the case of microwave thermography, adequate depth of penetration, along with the required resolution, may not be realized, except for large cancers. In the case of holography, reflections at the sk}n-air interface tend to mask the desired returns from breast tumors beneath the skin.
Further, illuminating the entire volume of a breast either requires excessive power (with possible biological hazards ) or acceptance of poor signal-to-noise ratios. In the case of through-the-body ele~L., -~nl~tic techni~ues, such as t. - c~,hy, the attenuation characteristics of the body are such that long wavelengths are usually used, with an attendant loss of resolution. Imaging by de~Prminin~
p~:. LulbclLions in body i~r~nre caused by the presence of tumors as sensed by multi-electrode arrays have been either inadequate in sensitivity or sub~ect to false alarms.
A mi l l i ter wave F~ radar weapons detection system developed and tested for the FAA (DTFA03-87-C-00056~ by the inventor employed a 94 GEz FM radar operating with a 300 Mhz bandwidth. A half-meter diameter antenna with a half inch spot size focused the radiated 94 G3Iz energy through the air onto a possible passenger boarding an aircraft. This system successfully detected both metallic and plastic weapons, with an overall detection pro~ability of 96.2%. The false alarm rate was 31. 0996 . It was hoped, initially, that the system could be used to detect breast cancers, slnce there wa3 some empirLcal evidence suggested that the 94 GHz waves were penetrating the skin sufficiently that some portions of the shoulder blades could be resolved. However, subsequent research has disclosed that the air-skin interface would not only enlarge the spot size, but would reflect a very substantial fraction of the impinging waveform.
To mitigate the resolution problem, a much higher frequency is needed to realize a usable spot size. However, the use of higher frequencies greatly increases the path attenuation of the penetrating energy, thereby introducing ma~or design ~li f firlll ties. These findings largely negated the use of this system for breast cancer détection.
Nevertheless, the results of this FAA pro~ect suggested that at least some features of a millimeter wave weapons detection system, designed from existing data, could ~e revised and integrated into a successful prototyoe system for detecting breast tumors.
SummarY of the Inven~ion The ob~ective of this invention is to propagate non-ionizing ele~ i ~gnQtic waves having wavelengths not much greater than three times the circumference of the smallest tumor to be detected, preferably having wavelengths, in normal breast tissue, of the order of thirty millimeters or ..
` 2~5~71~
less and preferably of the order of ten millimeters.
Propagation ls effected without incurring intractable path losses, while at the same time being able to discern breast tumors of the order of t~ree mi 11 i -ters . ~he penetration is realized by: l) avoiding interface reflections by employing media that have about the same dielectric constant as the breast tissues; 2) choosing a frequency (and wavelength that readily penetrates normal breast tissue; and 3) providing means to extract tumor-scattered power from the applied or impinging power. ~he desired resolution is achieved by: l) choosing a frequency such that its wavelength in breast tissue is comparable to the minimum size tumor to be detected; 2) using a wide aperture antenna that focuses the mmw energy at discrete points within the breast;
and 3) relying on significant differences between the dielectric properties of the normal breast tissue and those of the breast tumors. Optimum operation is usually achieved at frequencies in the range of three to ninety gigahertz.
A principal feature of this invention includes means to introduce microwave or millimeter wave energy into a breast with a minimum of interface reflections and loss of resolution (or increased spot size). ~his is done by means of dielectric materials in the illuminator that have about the same relative dielectric constant as the breast tissue and by use of gels, liquids, slurries and/or solids that have a similar relative dielectrLc constant around the breast to ` 2~ S~714 further suppress interface gaps that could cause reflections and loss of resolution.
Another important feature is the selection of a band of operating frequencies wherein the attenuatiDn of the propagating energy in a non-lactating breast is relatively small, preferably of the order of 1.5 to 15 dB/cm, in combination with an antenna or illuminator aperture size that produces a spot size preferably in a range of about 2 . 5 to 12 millimeters in normal, non-lactating breast tissue.
Another important feature comprises the use of a wide aperture scanning system. The construction of the scanner is such that the focus of the energy introduced is scanned at different depths, at depth increments comparable to the depth of focus, to provide a quasi-three-dimensional picture of the backscattered returns. To overcome path ~nr~~ that might cause ambiguous results, different scanning patterns can be employed to average out such ef f ects . Also, advantage can be taken of other features inherent in electromagnetic propagation systems, such as the use of dif ferent polarization effects, including circular polarization, and enhancement of the bac3cscatter cross-section wherein the circumference of the tumor is eriual to the wavelength. Also, use of forward and side scatter can be employed to help resolve ambiguities.
Yet another important feature employs techniriues that aid in separating the desired scattered returns from a tumor ` 21~714 .
from those originating either directly from the impinglng waveform or from spurious reflections from scatterers of no interest. This may be done by "passive methods, such as employed in microwave circuits (magic tees or circulators ) or by tumor-unique scattering ph. - - (wherein the polarization, side-scatter, forward-scatter returns or tumor-induced resonant effects are ~ 7F~d). Additionally, "active methods ', such as time-gating or pulse-compression methods tsometimes employed in modern radar systems) may also be used.
Another feature of this invention is the use of a stepped frequency technique to develop a synthetic time domain response. As opposed to applying a large amplitude short duration pulse and then using time-gating or the use of swept frequency FM ''ChirpU radar pulse compression methods, the stepped or swept frequency input i ~ s~ lAn~~e method can be more easily implemented. The d~7ell time at each frequency can be ad~usted to give adequate signal-to-noise ratios, digital processing and control can be used, and the hardware needed to implement this method is available.
Another feature of this invention is the use of confocal techniques, where the focal point of the i 1 1 11mi nAtion and the focal point of the collection system are nearly the same point in the breast tissue. Such arrangements suppress the effects of incidental sources of scattering that might occur at locations outslde the common focal point.
21~14 Another feature is the combined use of the confocal method with the stepped frequency synthetic time domain method, especially for detecting An( ~1 iP~ at depth. On one hand, the confocal method is most effective at shallow depths, and loses its ability to suppress incidental scattering for deeper tumors. The synthetic time domain method, if used 6eparately from the confocal aLL~llly t with more commonly available antennas, will generate back scatter from sources over a wide area. Scatter from such incidental sources could mask the desired returns from any tumor.
However, the combined use will provide more benefit than would be suggested by the performance of each subsystem separately. The confocal method suppresses clutter sources ( incidental scattering) that are transversé to the direction of propagation and the time domain system suppresses clutter sources in the longitudinal direction.
Another feature of the invention is convenience to conduct screening. As opposed to other microwave methods that require access to nearly all sides of the breast, the method noted here needs access to only one side.
Another f eature of the invention is that it can provide non-hazardous screening functions, such that breasts, over time, can be compared to detect Ahn~nT~ l ities that would not otherwise be possible with an ionizing approach or more expensive methods, such as NRI.
215~71~
One version of the invention includes a quasi holographic technique wherein the amplitude and phase of the scattered returns are compared to a reference signal and subsequently-used to form some type of three dimensional display. A ~ d interferometer technique can be used to do this. The interferometer provides 3-D displays of the backscattered power and the cumulative phase shift of the returns with respect to a reference point.
Brief Description of the Drawin~i The following figures are used to explain the concepts and design of the breast cancer detection system of the invention:
Fig. lA, is a conceptual view an active mi 11 i ter wave breast cancer detection system, with a patient;
Fig, lB illustrates displays for plural focal lengths, with the gl~nern1 i~ed system of Fig. IA;
Fig. 2 is a simplified block diagram that illustrates the principal ~unctions of a mmw breast cancer detection system constructed in accordance with the invention;
Fig. 3 is a graph of relative dielectric constants of muscle, fat, breast tissue and breast cancer as reported ~y various investigators;
Fig. 4 is a graph of conductivity of muscle, fat, breast tissue and breast cancers as reported by various investigators; 11 21~14 Fig. 5 is a graph of attenuation, wavelength, and depth of penetration in normal breast tissue as a function of frequency, based on the data presented in Eigures 3 and ~;
Fig. 6 is a block diagram of a Gunw breast cancer detection system, according to the invention, that employs a "passive" signal separation technique in combination with a conv~nt i f)n~ 1 heterodyne receiver to detect tumor-scattered returns;
Fig. 7 is a block diagram of a breast cancer detection system, again according to the invention, that employs phase coherent detection;
Fig. 8 is a diagram of resolution (or spot size) and depth of focus as functions of the diameter of an aperture or lens and of wavelength;
Fig. 9 shows Snell s Law effects that illustrate quasi-optical propagation from a medium with a low relative dielectric constant into a medium with a very high relative dielectric constant;
Fig. 10 is a schematic cross-sectional illustration of a large aperture ; l l llmi n~tor in the form of an ellipsoidal reflector in combination with a boot that contains a material having relative dielectric properties similar to those for normal breast tissues;
Fig. 11 is a graph that shows the backscatter cross-section of a perfectly conducting sphere norr~l i7ed to the .
21~4~1~
cross sectional area of the sphere as a function of the circumference-to-wavelength ratio;
Fig. 12 presents a simplified block diagram of another detection system, according to the invention, that employs an -active or time domain technique to help extract power scattered by a tumor from applied or impinging mmw power;
Fig. 13 illustrates an array of double ridged wave guides that can be used to replace the ellipsoidal reflector;
Fig. 14 presents a simplified functional block diagram on how the phased array can be controlled to position the focal point without the need for r--hAni~ Al scanning;
Fig. 1~ shows how the a wave guide like that of Fig. 13 can be positioned directly on the breast for screening purposes; and Fig. 16 illustrates how forward scattering oan be sensed by a confocal arrangement wherein the focal point of the receiving array tracks the focal point of the illuminating array .
Fig. 17 illustrates, schematically, how forward scattering can be sensed by an arrangement where the focal points of one or both of the antennas are not well defined to simplify trAr-kinlJ and Al ili lt;
Fig. 18 illustrates, schematically, an ellipsoidal reflector or ill~lminAtor that is capable of being positioned in three dimensions near the breast by means of a flexible ..
215~
boot filled with a liquid that has about the same dielectric constants as normal breast tissue;
Fig. 19 illustrates, schematically, how the arrangement shown in Fig. 18 can develop an in-tis6ue focal point near the extremities of the breast; and Fig. 20 illustrates, schematically, how an ellipsoidal reflector assembly can be moved without direct sliding --^hs-ni~l contact in the strongly illuminated area between two dielectric plates.
r)escription of the Preferred Embot~i ~ntS
The use of electromagnetic microwave or millimeter waves offers several advantages over x-ray mammography in detecting incipient breast cancers. (To simplify this discussion both microwave and mi 11; I.er wavelength regimes will be referred to as mm waves, or mmw. ) Non-i--ni7inq electromagnetic systems can be operated at sufficiently low levels so as to preclude biological hazards. A contrast ratio of the order of 20:1 is potentially usable for mm waves in tissue, whereas there is less than a few per cent range of densities for X-rays for soft tissue. The tissue-mm wave ~nteraction also exhibits additional ~ht~nt -n;~ that can be drawn upon to enhance the performance. For example, when the diameter of a highly conducting sphere (e.g., an incipient cancer) is of the order of a wavelength in the breast tissue, a resonance ~5 effect occurs th~t incre~ses the ~ffe~tive sc-~tterlrg cross-.
section of the tumor. If the tumor is non-spherical, then the polarization of the scattered waves may be different than that of the impinging waveform. In some cases, side-scattered or forward scattered energy can also be utilized.
For purposes of this specification, tissue-mm waves are def ined in terms of wavelength in a medium having a dielectric constant like that of breast tissue, not air.
Thus, the operating frequency for an ele~ L ~gn~tiC wave source used in the inventive system is preferably in the range of three to ninety GE~z.
Other than the use of mi 11 i~- Ler wave and microwave thermography to detect breast cancers, there has been little activity toward use of such mm wave approaches to detect breast cancers. As noted earlier, some of the problems that have to be UVel~ - are formi~1~hle First, simply flooding the torso of a female with mmw energy introduces numerous problems. How does one single out the scattered return from a three mi 11 i l er circumference tumor out of the immensely larger scattered returns from the tor~io? E~ow is the defocusing effect of the air-skin interface overcome? Is the breast tissue sufficiently transparent, at mmw frequencies, to propagate energy into and out of the breast? Are the dielectric properties of the tumors sufficiently different from normal breast tissue for effective detection of small ( e . g ., three mm circumference ) incipient cancers ?
21~4714 .
To understand the invention and its novel features, the basic concept will first be briefly described. Next, the ability of the millimeter wave electromagnetic energy to penetrate normal breast tissues will be demonstrated. Then, the special equipment and operating conditions will be ~"5, rih~r~ to realize the needed high resolution simultaneously with good penetration.
Figs. lA and lB illustrate the basic concepts.
Fig. lA illustrates, on a conceptual basis, possible prototype equipment. The patient 21 arranges one of her breasts 22 to contact an i111lmin~tor 23 as shown. Mm waves are g~n.~t~d within the equipment housing 24. These mm waves are then propagated into the selected breast 22 as a reiracted or reflected electromagnetic mm wave that is focused at a predet~rmin.o~l point or volume (voxel) within the breast. This is done by means of a unique combination of an interface and focusing apparatus, as described hereinafter.
Further apparatus is used to cause the focal point of the beam to scan dif f erent small volumes or voxels within the breast. Nhen this happens, the scattered mmw energy from any tumor present in the breast becomes much larger that other scattering sources, since the dielectric properties of a tumor are r~ 11y different than that of the breast tissue.
The scattered returns may be collected as backscattered power -via the same interface and focusing apparatus that is used to propagate the mmw power into the breast. The collected power 21 ~714 .
can then be processed by either analog or digital methods to form an image of the tumor.
A stepped F~ sweep similar to pulse compression in "Chirp" radar to synthesize a time domain response to isolate shallow from in-depth scattering can be used to mitigate the effects of heterogeneity in the dielectric characteristic of the breast. The functional goal of the combined confocal and time-domain features is to isolate the returns from tumors from spurious returns generated by heterogeneity in ad~acent normal tissues.
Electromagnetic waves in the mm wave region, in combination with the shape and dielectric properties of tumors in the breast, offer additional methods to detect the presence of a tumor beyond using ~ust simple back, forward, or side scatter. In some cases, the tumor can exhibit both internal and external ele.: LL- gn~tic resonances which are unique to its presence. Such resonances can be detected by varying the mmw frequency, by observing changes in polarization, by observing transient responses to an impulse function, or by noting changes in the ratio of the forward, side, backscattered and spurious returns. If the geometry of the tumor is asymmetrical, then the plane of polarization of the scattered energy may change; this change can be used to conf irm the presence of a small tumor .
The amount of collected backscattered energy and its accumulated phase shift (or time of flight or round trip time delay) can be presented in a 3-D format, as shown generally in Fig. lB. For illustrative purposes, it is assumed that the impinging energy can be selectiYely and sharply focused into three vertical planes that are parailel to the patient ~ s chest, wherein the x-y planes at maximum depth 25, medium depth 26, and shallow depth 27 are shown. The three coordinates show the backscatter returns 2~, the "x"
coordinate 30 and the "y ' coordinate 29 . Small vertical lines 31 are shown for ~ s combinations of x and y coordinates.
The amplitudes or heights of most of these lines 31 are proportional to the non-target returns that can arise from, for example, the tissues that surround the rib cage. Note that a very large return 32 exists in the center of the medium depth display 26. This large return 32 is assumed to arise from a tumor that is at the focus of the impinging energy in the medium depth plane 26. In the center of the shallow plane 27 there is a somewhat smaller response 33 caused by the tumor intercepting and only scattering a small portion of the impinging beam. Note that in the center of the deeper plane 25, the return 3~ is smaller because, it is assumed, the focused energy has largely been scattered by the tumor in the medium depth plane 26 before it arrives at the center of the deeper plane 25.
Figure 2 presents a block diagram that Lllustrates the principal functions of the mmw breast cancer detectlon and 215~71~
imaging apparatus. ~icrowave or millimeter wave power is generated by a mmw power generator 41. This power is supplied to a power and signal director 43 via a cable or waveguide 42. The power output 44 from the director 43 flows to an illuminator 47 via a waveguide 46. The illuminator 47, via a scanning plate 49 of dielectric material, causes the power to ~e focused at a point 62 within the breast 22. A
scan control 48, via a ~hAn;ci~l connection 50, causes the illuminator 47 to move along the plate 49 in a predet~rm1 n~l scanning pattern. When the focus of the power encounters a tumor 61, backscattered power 45 is collected by illum. inator 47 and is returned, via waveguide 46, to the power and signal director 4 3 .
To prevent the applLed power from swamping or masking returns from the tumor 61, means must be included to extract the desired return or signal from the tumor from the applied power. The initial function of the director 43 is to direct the mmw power output 44 from the generator 41 to the .focusing illuminator 47 through the cable or waveguide 46. The director 43 also is employed to eYtract the tumor-scattered returns 45 that are collected by the focusing il lllminAtor 47.
The e~tracted returns 45 from the power and signal director 43 are applied to a mmw receiver 53 via a cable or waveguide 52 .
The requisite directing action of the director 43 can be realized by several ~passive" means, such as a balanced ` 21~71~
bridge circuit or magic tee, a directional coupler, or a cireulator ~see Ramo et al. (1965) Fields and Waves in r, i- ation Eleetronics, John Wiley and Sons, New York, sections 11.17, 11.8 and 9.16). "Active" means of separating the applied power 44 from the tumor-seattered power 45 are possible in the time domain. For example, very short =
duration pulses of mmw energy can be applied and the returns separated by time gating methods. Other "active" methods currently employed in some modern radar systems can be used, such as pulse eompression, chirp or frequency modulation radar; see Skolnik, Introduction to ~odern Radar Systems, NeGraw-Hill ( 1980 ) .
The focusing illuminator 47 of Fig. 2 has several functions. One principal funetion is to foeus the applied power at a prede~f~rm;n-~d point within the breast 22. Another principal funetion is to condition the spatial distribution of dielectric material to enhance resolution. Yet another function is to suppress dielectrie and electrical interface reflections that could mask the scattered returns from a possible tumor 61 in the breast 22 of the patient 21. These functions may be done by matehing the wave propagation characteristic or dielectric constant of the illuminator 47 and the seanning plate 49 to that of the breast 22 and also matching the electrical interfaee between the cable/waveguide -46 and the focusing ~ m;n~tor 47 by means of eleetrical 215~14 matching networks, such as the mmw equivalent of a pi " or n tee " or " I~ " network .
The 3can control 48 controls the position of the focal point 62 of the illuminator 47 via a r---hAn;ri~l connection 50 that slides the il l~lmin~tor 47 over the scanning plate 49 in a predetc~rrni n~l scanning pattern. This action provides x and y positioning of the focal point. Alternatively, other techniques may be used in conjunction with the scan control 48 to create an apparent focal point, such as by means of phased arrays or synthetic aperture methods.
The scattered returns 45 from a possible tumor or other scattering sources are applied to the mmw receiver 53 via the wave guide 52 and the power and signal director 43. This mmw receiver 53 may be a conventional heterodyhe receiver that provides an output proportional to the power received.
Alternatively, using a waveguide 58 connected from the mmw generator 41 to the receiver 53, a reference signal can be compared with the return signal 45 to develop composite phase and amplitude data.
The outputs from the mmw receiver 53 are supplied, via a cable 54, to a signal processing and display unit 55. This unit 55, with a further input from the scan control 48 via a cable 51, processes the received data into a suitable display, such as illustrated in Fig. lB.
In the case of screening for breast cancer, the performance requirements can be relaxed, since the detection . 2~71~
of an abnormality is the real goal. This can be done by comparing the returns from one breast with the other. In addition, year-to-year examination data can be compared. As shown in Fig. 2, information via cable bundle 70 on the returns from each breast can be c ~-rPd; see block 71.
Cable bundle 72 carries similar data for storage and subsequent comparison via block 73 after each yearly examination .
Various known comparison techniques can be used for this purpose. For example, a transparency of a positive image taken of the breast at one time may be overlain with a transparency of a negative image taken at a later time. Any sign i f i c~nt return on the positive is presented as a very light gray area in the refrence-gray background and the return taken a later time is displayed as a dark area in the reference-gray background. If no change has occurred, the light gray area on the positive and the dark gray area on the negative will tend to cancel and result in a nearly reference-gray density. If some change has occurred in a specific area, the images will not cancel in this region, and the Ahn~rr~ I i ty will be indicated as either a darker or lighter region in the reference-gray background. A similar process can ~e done digitally, and the difference displayed visually in a two dimensional display for a given ' slice~ or do~th lnto the ~rea~t.
2~714 Figs. 3, 4 and 5 provide data that demonstrate that non-lactating breast tissue has different dielectric properties than either tumors or muscle tissues. Moreover, the attenuation of mm waves in such breast tissue is not excessive Ln the 5 to 15 GHz region and hence permits reasonable operating conditions for -passive" power and signal directors. Additional attenuation can be tolerated by the use of "active" power and signal directors such that operation up to sixty GHz is possible.
Figure 3 summarizes data on relative permittivity, scale lO1, as a function of frequency, scale 102. These data demonstrate that the relative dielectric properties of low-water-content tissues and normal breast tissues are significantly lower than for high-water-content tissues and tumors, either human or non-human. The low-water content data for curve 103 were developed by rh~ h;~ry ( 1984 ) for human breast tumors . Johnson ( 1972 ) developed the data for curve 105 for fat, bone and low-water content tissue. Edrich (1976) generated the data for cattle fat, shown in the curve 107. Burdette (1986~ generated in vivo data for canine fat, illustrated in a curve lO9. The high-water-content data for another curve 104 was developed by rhA~flh~ry (1984) for human breast tumors. Johnson (1972) developed data for muscle and high water content tissues, shown in a curve 106. Rogers (1983) generated the data, shown in a curve 108, for mouse tumors. Edrich (1986) collected data for canine muscle, 2154~ ~
illustrated in a curve 110. Burdette (1986) provided in vivo data, shown in curve 112, for c~nine muscle tissue. Note that in the case of muscle or tumor tissues, the relative dielectric constant is of the order of forty or more, depending on the frequency. In the case of low-water-content tissues, such as breast or fat, the dielectric constant is in the order of five to ten, as measured for in vitro studies.
The in vivo measurements of Burdette (1986), shown in curves 109 and 112, show an approximate increase by a factor of two in the relative pe ~hi 1 i ty over the data developed by Johnson ( 1972 ), curves 105 and 106 . The in vitro breast tissue measurements by ('hAi~hAry (1984), curves 103 and 104, fall somewhat in ~etween the in vitro values developed by Johnson ( 1972 ) and the in vivo meaau, ~ Ls of Burdette (1986).
Fig. 4 presents similar data on the conductivity of both low and high-water-content tissues. The conductivity in mhos/meter, scale 121, is the ordinate and the frequency, curve 122, is the abscissa. The low-water-content tissues are human breast tissues, shown in a curve 123 derived from f`hAl~lhAry (1984). The low-water-content fat and bone of the curve 125 is from Johnson (1972). Cattle fat, shown in a curve 127 is from Edrich (1986). The high-water-content tissues of the curve 124 are human breast tumors, data by ~-hAll~hAry (1984). IIigh-water-content muscle tissue is in a curve 126, data by Johnson (1972). Mouse tumors, shown in a 2~5~1 4 curve 128, are from Rogers (1983). Rat muscle data for a curve 130 is derived from Edrich ( 1986) . Canine fat data are presented in a curve 131 from Burdette ( 1980 ~, and canine muscle data in a curve 132 taken from Burdette 1930). Note that conductivity, as a function of frequency, tends to increase substantially above 6 GHz and that the 40 to 90 GHz meabu,- - Ls of Edrich (curves 127 and 130) tend to fall in line with the trends established by mea~lul. ~ t made up to 10 G~Iz Based on the data presented in Figures 2 and 3, Fig. 4 shows the depth of penetration 140, wavelength 142, and attenuation 144 as a function of frequency 146 for the propagation of mi 11 i~- Ler waves in non-lactating breast tissue. Above ten GHz, some uncertainty associated with the trend extrapolation is suggested by the range of possible values of the penetration depth 140 or attenuation 144. A
value of nine was used for the relative dielectric constant and the extrapolated values of ~ hAll-ihAry (relative to the data developed by Johnson) from Fig. 4 were used for the conductivity. From these data, it is seen that the breast tissue behaves as a lossy dielectric for frequencies substantially .olrrP~ inr five GHz, wherein ~i) =211F and ~=~o~r (permittivity of free space) x (relative dielectric constant), tJ is the conductivity, 1l is the permeability, f is the frequency, ~ is the wavelength, and ~ is the depth of penetration (see Ramo (1965) page 334 Sec. 6.05).
21~
Since ~>>~, the approximate lossy dielectric equations are as follows:
( 2 ) ~=2 [a( ~)1/2 ] -1 This defines the generic feasibility of the system to be described hereinaf ter . There are two requirements that must be met . First, the total path loss attenuation ( in and out) should be substAntiAlly less than the dynamic range, typically in the order of 100 dB, wherein the dynamic range is defined in dB as equal to: 10 log[ (largest signal power)/(smallest detectable signal power) ] . Second, the wavelength in the irradiation apparatus ( illuminator 47 ) and in the breast of the patient should be sufficiently small so that small tumors can be resolved. This, for the system discussed here, requires that, preferably, the wavelength in illuminator 47 and in the breast tissue should not exceed two or three times the circumference of the smallest tumor. If an operating frequency of 15 GHz is chosen for a passive power and signal detector, it is seen that the path loss is about 5 dB/cm, or 50 dB total path loss, in and out, for a 5 cm path length. The wavelen~th at 15 GHz is about 0 . 6 cm, which is about equal to the diameter of the smaller tumors.
Figure 6 illustrates a functional block diagram of a microwave breast cancer detectian and imaging system 200 that employs a conventional heterodyne receiver. System 200 comprises the following subsystems: a millimeter power 215~
generator subsystem 241, a passive power and signal director 243, a focusing ~ min~tor subsystem 228, a heterodyne receiver 253 employed for signal detection, a scanner control 248, and a signal processing and display subsystem 255.
Ele-: L ~ ~n~tiC wave energy f lows, via the power and signal director 243, from the power generation system 241 to the illuminator subsystem 228. The illl-minAtor subsystem 228 comprises three ma~or parts: a beam focusing apparatus 247, a matching network 226, and a dielectric e~-~l i7 jn~ interface 249. The focusing apparatus 247 of the illuminator 228 focuses the energy into a small point 262 within the breast of the patient 259. The scanner 248, through a mechanical connection 250, controls the location of the focal point 262 in three dimensions ( 3-D) such that the focal point 262 is progressively positioned into each voxel (smallest volume element) of the breast under consideration. When the focal point encounters a tumor 261, the scattered returns are substantially increased, since the electrical permeability and conductivity of the tumor is greater than similar parameters for breast tissue. The scattered returns are collected by the illuminator 247 of subsystem 228 and then the scattered power (arrow 245) is supplied via the matching network 226 and the power and signal director 243 to the detection subsystem 253.
The scattered power 245 is separated from the impinginq power 24~ (s~pli~ po Oe illl~m~ to by me~m~ o~ ~
21~
circulator 224 within the power and signal director 243. A
discussion of each of the aforementioned subsystems follows.
The power generation and control subsystem 241 is comprised of two functional blocks: an electromagnetic wave power source 220 connected via a cable 221 to an isolator and power splitter 222. This, in turn, is connected, via a cable 242, to the power input port 225 of the circulator 224 in the power and signal director 243. The power output and backscattered input port 227 of the circulator 224 is connected, via a cable 246, to the matching network 226 at the input of the illuminator sybsystem 228. The output port 234 of the circulator 224 is connected to the signal processor subsystem via a cable 252.
~any of the functions of these componénts are obvious.
The isolator/power splitter 222 electrically isolates the power source 220 from any load variations that might be introduced by the circulator 224, the matching network 226, or other ,-, In~ntS of the illuminator subsystem 228. The function of the circulator 224 is to extract the backscattered returns from the applied power. Otherwise, the high level of the power applied to the illuminator subsystem 228 would tend to mask the desired scattered returns. Thus, the electromagnetic input signal in~ected into port 225 is directed out of port 227 and thence to the matching metwork 226 . The backscattered returns ( from the matching metwork 226 ) that are applied to port 227 appear at port 234, wherein 215~14 the amplitude of the applied power is greatly suppressed.
The purpose of the matching network 226 in subsystem 228 is to suppress ref lections that might take place at the interfaces of different dielectric materials or where some 5wave imrP~1An~e discontinuity occurs in the illllminAtor s ubsystem 2 2 8 .
The performance requirements for the signal detection system 253 are not too strinrJr~n~ The simplest version may use a simple heterodyne receiver as an RF voltmeter to 10measure the output of the circulator 224 at port 234. A
reference signal from the power generation subsystem 241 can be supplied to the hetrodyne receiver 253 via a conductor 258 to stabilize the local oscillators in the receiver.
Other versions of the invention, such as the system 300 15shown in Fig. 7, offer additional signal proce$sing options.
The system 300 of Fig. 7 illustrates the use of two synchronous receivers or detectors in a modif ication of the system of Fig. 6 in which only the signal detection subsystem is changed, with subsystem 253 of Fig. 6 replaced by a dual 20subsystem 353 that includes two hybrid tee synchroneous detectors 361 and 362. The power splitter 222 (Fig. 6) provides a reference signal, on conductor 258 (Fig. 7) to system 353 as well as to the power and signal director 243. --Each of the hybrid tee devices 361 and 362 forms a product ~ =
25between the applied input signal and the composite ~=~
backscattered returns. Xowever, one of the reference 21~714 waveforms is shifted ninety degrees with respect to the other reference waveform; the following relationships result, where:
~ is the angular frequency of the millimeter waves;
19 i5 an arbitrary reference fixed phase angle;
;~. is the wavelength;
7C is the path length from the scatterer to the hybrid tee;
,~ is the propagation phase constant and ,~=2r~
~!3 is the ~cc~m~ ted phase shift.
The output from each of the hybrid tees 361,362 is the product of the returned, scattered waveform and the reference waveform. Considering ~ust the low frequency components of such products, the output of each of the hybrid tees is as follows:
t3~ cosr;C~f e-2~] cP~S~tf~
= A/2 ~ -2~ f ~ ~cf. comp~
2~5~71 - t41 AC,~ t,~-2,~7 ~s~ t/z~
-~z L~ z~7)1 T ~ f The outputs can be defined as an in phase "I" vector ,- mnPnt and a quadrature or "Q" vector component. These are combined as vectors so the phase angle of the c, ' i nP-l vector becomes tan=1(2 X13). Typically, when no tumor is at the focal point 262 (Fig. 6), the backscatter irom the chest tissue-lung inte}face can be assumed to form the zero reference distance for %. During sc~nnin~ the focal point will begin to encounter a tumor that is spaced a few or more 0 m; 1 l; Pr wavelengths away ~rom the chest muscles . Nhen this happens, the effective distance X progressively decreases, thereby causing the equivalent phase angle to rotate counter-clockwise. The number of rotations can be counted to develop the total accumulated phase angle change.
The above rela~imn~hir~ can be manipulated to present an accumulated path delay presentation that is responsive to the approximate distance of the scatterer from the illuminator.
Such an option can be valuable in conf irming the presence of a weak scatterer and can provide conf;rminq location data for a strong scatter.
The dual receiver system depicted in Fig. 7 draws the reference waveforms from the isolator-power splitter 222 via cable 258. An attenuator-poweF splitter 339 is used to .
215~14 reduce the amplitude of the waveform presented to the two phase shifters 340 and 341 via appropriate cables or other conductors 352 and 351. The output waveform of phase shifter 341 is advanced or retarded ninety degrees relative to phase shifter 340 to provide the desired quadrature relationship.
The quadrature reference waveforms from circuits 340 and 341 are applied/ via cables 342 and 343, to the hybrid tees 362 and 361, respectively. The output of port 234 of the circulator 224 supplies the power from the backscattered returns, via cable 252, to the power splitter-isolator 335.
This circuit 335 diverts the return signal equally into cables 336 and 337, thus supplying the backscattered signals to the hybrid tees 361 and 362. These tees 361 and 362 each form a product between the reference waveform ( from conductors 343 and 342, respectively) and the backscattered signals (on lines 336 and 337, respectively). The low frequency output from these two devices 361 and 362, on cables 345 and 346, provides critical inputs to the signal processor and display subsystem 255 ( Fig . 6 ) . Other variations of the above technique may be used to improve the signal-to-noise ratio, such as modulating the reference waveforms with another frequency well above the highest frequency of interest in the detected backscattered return.
This removes the output signal well away from the troublesome shot uoi~ 'ch.~t ooours at e~y l ow fr~ uenc~es .
. ` . 21547~4 The scanner control subsystems 48 and 248 (Figs. 2 and 6 ) control how the breast of the patient is scanned. In the case of the prototype system of Figure 2, scanner control 4 8 controls the x and the y positions of an ellipsoidal reflecting antenna 47, which may be the antenna 170 shown in Fig. 10. Several antennas of different focal lengths may be used to access the location of a tumor. The scanner control (48 or 248) is AhAni~A~lly connected to the illllminAtor (47 or 2~7) and to the signal processing unit (55 or 255) in each of the described systems of Figs. 2 and 6. Phased arrays (not shown) could be used instead of a AhAn j~ ly positioned illuminator to reali~e approximately the same scanning performance. Other methods, particularly techni~ues that synthesize large aperture antennas, could also be used.
In any of the described systems the signal processing and display subsystem (e.g., subsystem 255 in Fig. 6) can employ any number of processing or display methods so as to suitably display the scatter returns. It should be noted that since the scatter waveforms are referenced to the initial unperturbed ele~:L ~AJnr~tic wave illumination, quasi-holographic processing techniques can be considered.
Fig . 8 def ines the parameters needed to determine the spot sL~e wherein the diameter of the aperture D, the focal distance R, the spot diameter d, and the wavelength of the milli---ter wave in the med a. See Kay (1966) and Smith 21~714 (1966) for more complete development of relatinnqh;rq] Here, the spot size becomes:
( 5 ) d=2R i~/D
As was noted earLier in Figure 5, reasonable penetration losses of about fiYe dB/cm occur for wavelengths of the or~er of six mm. Thus, if tumors in the order of three mm in circumference are to be resolved, the beam width or spot size should not exceed the tumor circumference by much more than a factor of three. Preferably, for improved spatial resolution, the wavelength should not exceed the tumor circumference by a factor of three. To achieve a spot diameter of 6 mm, the ratio of the focal distance R to the aperture diameter, D should be about O. 5 .
Another design consideration is the depth of field a, as related to the aforementioned parameter5 and the apparent angle of resolution ~ . Thus the depth of f ield becomes:
(6) ~ =[R2qi]/[D+Rq~3, where ~=d/R
Again, to obtain good spatial discrimination, the focal distance R should be small compared to the aperture diameter D.
However, short focal lengths cannot be easily developed if the dielectric constant between the media that form an interface are greatly different. This would be the case if an attempt is made to propagate millimeter wave power in air and thence into the breast. As seen in Figure 3, the dielectric constant of breast tissue is of the order of nine, 21~71~
and such a large value (relative to a value of one for air) causes substantial reflection of the incident power at the air-breast interface More importantly, the apparent R/D
ratio is reduced; that can lead to a radical increase in the spot size. This is best seen by referring to Fig. 9 (see Ramo (1965) p. 358 Sec. 6.13 -for more complete background).
Here the incident ray 151 impinges on a dielectric interface 150. This produces a reflected wave 153 and a penetrating wave 155. The angle of incidence 157 must equal the angle of reflection 159 . Also, Snell ' s Law must be satisfied where angle 161 is the angle of the transmitted penetrating wave 155 with respect to a normal to the plane of incidence 150 and ~1 and ~2 are the dielectric constants for air and for the breast tissue, respectively:
(7) [sin 161]/[sin 157]=[~ 2] l/2 This interface reduction in the angle 161 of the transmitted penetration wave 155 will tend to increase the apparent R/D
ratio (focal distance to aperture size ratio). For example, assume that a focused mm wave front with an R/D ratio of 0 . 5 in air impinges on a dielectric interface where the ratio of the relative dielectric constant of the second media to the first media is nine. Based on Snell ~ s Law, the maximum value of angle 161 can be no more than about fourteen degrees.
This would increase the apparent focal distance from R to about ~R and increase the spot diameter d by a factor of f our .
21~471~
Fig. 10 illustrates one way the defocusing and reflecting effect of the dielectric interfaces between a breast (or other tissue) and air can be mitigated. The mm wave power from a feed point 171 in a medium 175 is introduced, via an interface medium 176, into the breast 177, with the respective relative dielectric constants ~ 2 and E3 made approximately the same. For illustrative purposes, an elliptical reflector 1?0 is chosen; reflector 170 has an R/D ratio of about 0 . S that would produce a spot &ize comparable to the wavelength, which is of the order of 6 mm.
This elliptical ref lector 17 0 and related apparatus is deslgned to exhibit two focal points: one at the feed point 171 and the other at a point 172 in a voxel within the breast 177. An interface boot 180 is used to contain a liquid or slurry 176 having a dielectric constant, ~2, that is contained by a boot wall 181, a thin, liquid-impermeable brassiere 182, and a thin, solid dielectric sheet 183 that has the same relative dielectric constant as ~1. For orientation purposes, the dash curve 178 represents the curve of the ellipse of reflector 170 if it were to extend into the human body.
The thin brassiere 182 is caused to f it as closely as possible to the breast 177 of the person under examination, as by withdrawing air from the voids 17g. The breast is compressed into a relatively flat surface by the dielectric plate 183. This permits moving the focal point 172 by moving 215~7~ ~
the elliptical reflector 170 along the surface of the dielectric plate 183 to scan the breast. The focal point 172 may be moved upwardly by increasing the thickness of the dielectric plate 183.
This arrangement assures that the mmw power that is applied to the breast is focused in the voxels of interest.
Future, the mi 71 i Ler wave power that is scattered from a possible tumor at the focal point 172 returns to point 171 via paths that have equal time delay, thus allowing constructive recombination of the scattered returns at the feed point 171. On the other hand, power that is not intercepted by a tumor at focal point 172 progresses on to the breast-lung interface 185 via plural paths such as the path 186. A portion 187 of the unscattered wave 186 progresses into the muscle and rib cage of the patient;
another portion 189 is reflected. In order for these back-scattered or reflected muscle wall waves to add constructively at the feed point 171, the waves would have to ~lrr,~ri ,-nl-e the same path lengths, in terms of integral multiples of a wavelength, as for the paths of the waves scattered at the focal point 172. For most of the unscattared waves that are ref lected from the breast-lung-rib cage interface, constructive addition at the feed point 171 is quite unlikely. An arrangement as shown in Fig. 10, therefore, suppresses unwanted returns or clutter from ~ le~ d from the p~ti~nt s rib c~ relative to the 2~L71~
returns that are scattered at the focal point of interest, point 172.
other dielectric i~n~ 190, such as might arise from a blood vessel, will also scatter the incident mi 11 i Ler wave power. However, like the clutter returns from the muscle-rib cage, such returns will be suppressed in amplitude or even omitted, relative to the returns f rom the voxel containing the focal point 172. Furthermore, since many ray paths are used, any minor and random variations of the dielectric constant will tend to be averaged out.
other methods of discriminating the presence of a tumor from the clutter scatter returns are possible. Fig. ll illustrates one such rhf~nl -nnn, a resonant enhancement of the scattering cross section, a, that occurs when the circumference of a highly conductive spherical scatterer equals the wavelength in the media around the sphere. The cros~-section relative to the pro~ected area of the sphere is shown as the ordinate 401. The abscissa 402 is the ratio of the circumference to the wavelength. The curve 403 illustrates how the cross ~ection is enhanced by the resonant scattering that takes place between the Rayliegh region 404 and the Mie (resonance) region 405. In addition, internal resonances within the tumor are possible. Despite the hLgher conductivity within the tumor, the material withill the tumor still behaves as a lossy dielectric because of the very large value of its relative dielectric constant. Therefore, 21~71~
internal resonances within the very high dielectric constant tumor can be considered to occur where the internal dimensions are in the order of a one half wave length--or about 3 mm for an operating frequency of 10 GHz. Such resonances can generate a unique response, quite different from those generated from dielectric interfaces or other sources of clutter. Such resonant responses can be observed by 8weeping the frequency over a wide bandwidth or exciting the breast tissues with a very short duration mmw pulse and then observing the resonant quasi-sinusoidal decay.
The foregoing description was aimed primarily at a prototype suitable for clinical evaluations. A commercial version may avoid the use of the boot and the elLiptical reflector (Fig. 10). For example, arrays of 6 mm rectangular waveguides may be f illed with dielectric material that has a relative dlelectric constant similar to that of the breast, roughly in the order of nine to sixteen. The rectangular guide in the TEol mode readily propagates 10 to 15 GHz frequencies. Each of the guides would be positioned in 2 0 contact with the breast, directly or through a very thin material used for one of several standard brassieres. The phase angle of the power presented to the guide-breast contact point would be i d~nt; ~ 1 to the phase angle of each ray path, some of which paths are shown in Fig. 10. For example, at positions ~92 and 194 of Fig. 10, the phase angle of the power at each of the waveguide exits would be the same 21~71~
as the phase angle for each of ray paths 191 and 193 respectively. One hundred such 6 mm guides could be positioned in a 60 mm by 60 mm flat faced rectangular array to replace the egg-shaped elliptical antenna 170 shown in Figure 10. Given a computer-aided ability to ad~ust the phase of the output power at each of the guldes, the position of each of the guides could be made to fit the contours of many dif ferent breasts . The advantage of this approach would be to permit mass screening, but at the expense of a rather complex piece of equipment. The use of computer-controlled functions and data analysis does make 6uch an approach feasible .
The foregoing can be better understood by referring to Fig. 13, which shows a nine aperture wave guide module 450.
lS Nine double-ridged wave guides 451 are used. 13ach of these are filled with a dielectric material 452 that approximates the relative dielectric constant of normal breast tissue. In the case of a screenlng system, only four wave guide apertures might be used. The com~ination of modules are pressed against the breast in place of the dielectric plate 183 of Fig. 10. By proper phasing of the signals to each of the wave guides, focal point can be positioned within the breast without the need for ^h;~nir;~l movement.
Fig. 14 illustrates one way that the phase or timing of the signal applied to the wave guides may be controlled to position the focal point in a medium 418 which contains the 2~
.
aperture antennas 410A, 410B, 410C and 410D and focal points 412 and 413. A source 400 of microwave power applies equi-phased power via wave guides 401 and 402 to two power splitters 403 and 404. The outputs of the splitters are applied, via wave guides 405A, 405B, 405C and 405D, to the circulators or directional couplers 406A, 406B, 406C and 406D. The forward power through these devices is transferred via the guides 407A, 407B, 407C and 407D to the variable time delay or phase control devices 408A, 408B, 408C and 408D.
The return power is transferred via wave guides 416A, 416B, 416C and 416D to a subsystem 417 that collects the returns in a format suitable for additional processing by subsystem 255 of Figure 6. The time delay in each device 408 may be controlled by changing the ~ n~t i r f ield bias applied to a ferrite element within each of the devices. Such bias may be supplied via the caoles 414a, 414B, 414C nd 414D from the time delay control subsystem 405. The outputs from wave guides 405 are controlled by the signal processing and display subsystem 225 of Fig. 6. Via wave guides 408A-408D, the time delayed or phased controlled power is supplied to the aperture antennas 410A - 410D. A portion of the outputs from these apertures reaches the desired focal point 412 via pathways 411A, 411B, 411C and 411D. At point 412, the phases of the rays shown are nearly identical.
~qSllminq a time delay of tl, t2, etc. for each of the delay control elements 408 and path lengths (411) dl, d2, 21~714 etc., then t1+d1/v=d4/v for constructive addition where v is the velocity of propagation in the medium 418. To meet this requirement, tl-(d4-d1)/v. Other time delays can be calculated in the same way.
other methods of control are possible by controlling the phase of the signals applied to each aperture instead of by the timing devices. In this case, the relative phase between the signals applied to apertures 411C and 411D can be fin~-l. by noting the following, where ¢~ is the radian frequency [2~Cf~ andl312 is the phase difference between 411C
and 411D, such that ~12 -~[t2 ~ tl]-The confocal arrangement permits the scattered signals to return by the same pathways as the applied wave form.
These signals are collected by the perture antennas 410 and progress back through the time delay devices 408 to the circulators 406. These, in turn supply data on the scattered returns to subsystem 417.
~ig. 15 illustrates an alternate method of scanning the interior of the breast. The microwave generation and signal recovery sybsystem 460 supplies power to an array of h~nit~;~l ly positionable wave guides 461A, 461B, 461C and 461D. Waveguides 461 are designed to slide into guides 462 so that the distal end of guides 461 is in intimate contact with the breast 463 on the ches 464 of an examination subject. As noted before, the position of each guide can be measured and this information can be used to calculate the -21~
timing or phase data needed to posltion the focal point throughout the breast. This method has the advantage that an interface plate such as 183 of Fig. 10 is not needed to compress the breast 463 and that better and more reproductible contact with the breast can be made.
Dielectric materials in solid form are available with relative dielectric constants that can eYceed 100, that have relative low losses, and that can be r^-^h i n~-l. These materials could be used to fill the elliptical reflector or the waveguides (Fig. 10). Liquid or slurry-like dielectrics with both low losses and dielectric constants at 10 GEz in the order of ten may not be readily available. However, some liquids, such as the silicones, have dielectric constants of nearly three. Such oils could be mixed with particles of materials that have dielectric constants that exceed 30 to 50 to form a slurry exhibiting a dielectric constant of the order of nine. Conversely, acetone has a dielectric constant of 22 at ten OErz, and it could be mixed with a silicone oil to produce a dielectric constant of nine for the mixture.
Other possibilities exist, including emulsions and similar techniques that allow suspensions o one liquid in another or suspensions of particles in a liquid.
The aforementioned techniques are not limited to backscatter; they can be modified or augmented to detect both side scatter and forward scatter. One forward scatter approach could use a paddle-like source antenna and a paddle-21~71~
like receiving antenna. At least one of these would function similar to the antenna illustrated in Figure 10. For example, the more pendulous portion of a breast can be placed between the paddles This would permit examination of a breast that is 100 mm thick with a system optimized for a 50 mm penetration depth.
The above may be better understood by referring to Fig.
16. Here, the breast 480 is positioned within two dielectric plates 472A and 472B. 1~ cover plate 483 and gaskets 482, together with plates 472, form a box-like structure that surrounds breast 480. The relative dielectric constant of the box wall material is similar to that of the breast. A
thin plastic film 481 covers the portion of the breast that is not in contact with the box. The space between this plastic film and the breast is filled with a liquid that has the same dielectric constant as the normal breast. A cable bundle 470 supplies microwave power to a series of waveguides 471 that are in a housing 479A on plate 472A. Upon excitation, the power in these guides is timed or phased such that the ray paths 474 come to a focal point 476. The time delay in the guides 477 in the receiving assembly 479B are timed such that any scattering occuring at point 476 will add constructively. The output of these guides is carried to the signal processing subsystem via a cable bundle 471.
The afu-, ti-~n~d techniques may also be readily modified to detect changes in the plane of polari~ation. For 21~71~
example, a Srluare TEo1 waveguide could in~ect a vertically prlAri7e~ wave and respond to a horizontally polarized wave.
Similar arrangements could be used for either side scatter or forward scatter pr,l ;'ri 7ation anomaly sensing arrangements .
Another variation would be to use the illuminator and focusing arrAn Ls described above in combination with an ~ active" or time domain method of separating the applied power from the scattered power. Other such active or time domain methods utilize a chirp radar" to produce added resolution in depth and additional clutter suppression. At a center frequency of 15 GHz a chirp radar with a swept frequency bandwidth in the order of 5 GHz and with phase correction for the dielectric behavior of the breast tissue could produce range cell resolutions of thé order of 10 mi 11 i Lers. Alternatively, sequences of very short duration bursts of 15 to 25 GHz waveforms should also provide isolation of the applied power from the backscattered power by time gating techniriues. Burst durations in the order of 100 picoseconds will provide depth discrimination of the order of 10 to 20 milli Lers. This added <li~rriminAtion would not only suppress the incident power, but also could suppress backscatter returns from the different dielectric interf aces, such as the muscles around the rib cage .
Active methods are of particular interest because these methods may be functional with total path losses in excess of 100 dB. Such path losses might be difficult to overcome with 21~714 a passive system, since it may be dif f icult to reduce clutter levels below 50 to 70 dB the applied power. Since some of the clutter can be reduced by considering only the returns in ~ust one voxel, active systems might be viable over a wider dynamic range. Also, shorter wavelengths with greater resolution can be used, since active systems can accept greater path losses, possibly as much as might be experienced by a system with an operating frequency as high as 60 GHz.
To illustrate how time domain separation can be realized in broad band pulse systems, Fig. 12 presents a further possible system 500 . Nany of the ,- ~ r~n~nts are similar to those noted in FLg. 6; they are not repeated in Fig. 12. In system 500 the power and signal direction functions of the isolator of Fig. 6 have been augmented by a modulator 540 and a source 541 of 100 to 200 picosecond pulses. In some systems, the isolator 224 may be omitted. A pulse from the pulse source 541, via cable 543, gates on the modulator 540.
This causes the modulator to ~enerate a short burst of 15 Gllz sine waves that i5 applied, via a cable 242, to the input 225 of the circulator 224. Also, the pulse source 541 supplies a timing pulse to a blanker-modulator circuit 542 and to a signal processor 575. The blanker-modulator 542 suppresses any leakage of the incident pulse through the isolator 224 from impinging on a broad-band receiver 516. The timing pulse, via the cable 544, is used by the signal processor 515 to ~ t~rminp the spatial position of the different scattered 215~
.
returns by noting the time of arrival of each of the returns.
For example, the more distant returns that might arise from the patient ' 5 rib cage would be delayed the most. The combination of a pulsed sine wave source and a hlAnkin~ -function (often called a transmit and receive function) essentially provides a power and signal direction function that could replace the cLrculator 224 function as illustrated in Fig. 6.
The pico-second-duration-pulse, time-domain system described for Fig. 1~ has some drawbacks that may be overcome by a stepped-frequency, synthetic-time domain method. For example, the noise level of the wide bandwidths needed to accommodate such short duration pulses can be quite high. On the other hand, the stepped-frequency method can have long well times at each frequency, thereby reducing the bandwidth and noise level for the signal processing system. Nhile the confocal system is a powerful tool to suppress the effect of some classes of heterogeneities, it may not provide sufficient discrimination at deep penetration depths. To mitigate this problem, a time gating technique can be used to suppress scattered returns from shallow depths. Such a method may note the presence of a weakly scattering tumor at depth. If the relative dielectric constants of the intervening material are uncertain, the geometrical position of the tumor cannot be precisely determlned. While this uncertainty poses a difficulty for an imaging system, it 21~471~
.
should not affect the via-hility of a screening system designed to detect Ahn~ l ities.
Swept frequency methods can be considered. For example, an FM Chirp radar method that has been used in weapons detection systems ef fectively separates desired returns from those generated by system discontinuities. A version of this would be attractive in con~unction with the confocal illllminAtion method to separate the effects of near surface discontinuities or hetrogeneities from the returns at greater depth. Linear F~6 pulse compression radar (PCR) techniques might also be considered. These have been described by Jacofi (7) for biological imaging applications. The theoretical resolution of a PCR is given by ~ R=C/2B, where C
is the is the velocity of propagation in the media, and B is bandwidth of the transmitted wave form. Assuming a mid-band frequency of 8 GHz, a 5 GHz sweep and a medium with a dielectric constant of nine, a range resolution of one cm is indicated. However, a 2 . 5 GHz sweep may be more readily realized and could produce an in-tissue resolution of two cm.
To realize this performance, the F3~ sweep must be highly linear, a pulse compression filter developed for this application and the dispersion effects of the dielectric compensated .
A stepped or swept frequency input impedance Fourier inversion alternative exists. This option transforms data developed from the frequency domain measurements to the time domain via digital processing, thereby eliminating the need for a pulse conpression filter. This can be implemented by using eLther the confocal illuminator of Fig. 10 or the phased array of Fig. 14. The output signals from the circuit shown in Fig. 7 on lines 346 and 345 can be viewed as a complex input ~m~ qnre, S( j ~D ), at a radian frequency of ~(~)= 2~f) to the illllminqtor. As the frequency ifi stepped from a low freque~cy to a higher frequency, the complex input imr~lAnre for each frequency is stored in a digital computer.
If the frequency is swept or stepped over a band similar to that noted for the PCR system, similar spatial resolutions can be realized. Via digital processing, the complex input impedance data is converted from the frequency domain to the tLme domain using inverse Fourier transformation. The transformed data is then in the form of an amplitude vs. time response, similar to a radar A scope display, as if an impulse or stepped function had been applied at port 234 of the cLrculator 224 in Fig. 7. Initially, the returns from system discontinuities, such as from connectors and the int~rfq--e with the antenna in the 1111lminAtor, will be displayed. Then, the reflections from qn~ c in the breast will be displayed, the reflections from the deeper ~n, ql i,~q occurring at the longer times. The stepped frequency option of fers the opportunity to include a s~andard correction at each frequency increment for a typical dispersion characteristic for normal breast tissues and could 4~
21~
.
also include compensation for other factors such as path loss or system dispersion in the ferrite phase shifters. Some of the more modern network analyzers include a built-in stepped or swept frequency to time domain processing option.
The underlying mathematical basis i8 as follows. The general Pourier trans f ormations are:
s 4-cv) _ ~, F ~ e i d~
f co ~C~f) = 2~,~- 5~J~ )e; l~v ~ .
Where F ( f ) is the impulse or step response S( j ~) is the Fourier transformation of F(f) l~= 2 ~ f, t is time.
~hroughout the foregoing specification and in the appended claims the terms millimeter waves, or mm waves or mmw have ~een used to g~n~ri ~'A 1 1 y ~.'p ~ es~l~t the wavelengths of the electromagnetic waves that propagate in the human breast tissue. Since the relative dielectric constant of the breast is in the order of 9 to 12, the free-space wave length will be reduced by a factor of three or more. ~hus, the in-tissue wavelengths over a frequency range of 3 to 60 Gl~z will range from about 30 mm to l mm.
As opposed to certain microwave hypothermia cancer treatment technology, none of the technology presented here is intended to heat significantly any portion of the breast.
2~5~71~
This requirement limits the power deposition density onto the surface of the breast to less than 10 milliwatts/cm2 and the volumetric heating rate in any portion of the breast to less than 0 . 8 milliwatts per gram of tissue as averaged over a time period of a few minutes. To further assure minimal thermal effects, the input power is to be turned off if the SrAnnin~ system falters for any reason.
Other usages are as follows: The term i ~ nre refers to the ratio of the voltage to the current or to the electric field to the magnetic field at a speci~ied location. This term imrP~i~nre is q~ if i~ as electrical~ or wave~-respectively, depending on whether voltages and current8 or electromagnetic fields are concerned. The term wave guide is used in the generic sense and inr~ s both cables and higher lS mode wave guides with just a single transverse field. The terms effective aperture and effective focal point are used in the generic sense wherein ap~ L~ s and focal points can be created physically or synthetically (such as often used in synthetic aperture radar ) .
The effective focal point is not a point but rather is defined here as a region where the i 7 ~ ~lmi n;lting energy is most concentrated in the breast. The effective focal point is further defined as the region or volume where this energy concentration occurs as affected by the heterogeneity of dielectric characteristics of the normal breast tissues, the in-tissue wavelength, the size and distance of the 21~471'1 .
illuminating globular aperture or the geometry and number of apertures used in a phased array. The focal point positioning may be either -~h~ni-~l or electronic as in the case of a phased array.
The terms "detect" or "detection" are also used in the generic sense, and may mean simply indicating the presence of a tumor or more broadly providing data that permits imaging the location, size and geometry of the tumor. Detecting, identifying, imaging or locating a tumor also means noting the presence of an ~hn~ l i ty. The terms "power and signal director~- or "input power and signal separation are also used in a generic sense. Both passive and active techniques not only enhance detection by suppressing the direct effects of impinging power waves, but also can reduce false signals or clutter. Such are introduced by imperfect matches between ;rnreriAn.-eS or by non-tumor scattering sources, such as the breast/lung interface.
Another less rl -n,iin~ mode of operation of apparatus like that of Fig. 16 is illustrated in Fig. 17. As opposed to; 1 ltlmin~ting and collecting energy from a common focal point, it may be advantageous to widen the focal point of either the i 11 llmi n~tor or the collector. The advantage is that coordinating the positions of the focal point of both the illuminator and the collector can be relaxed. As shown, the energy from the illuminator 485 is not sharply focused, but rather is contained in a region 484. On the other hand, 2~471~
.
the focal point 487 of the collector 486 i5 more tightly constrained in the breast 480. The other components illustrated in Fig. 17 are the same as for Fig. 16.
Some .1; f f i rll 1 ties have been experienced in ~aintaining a very small air gap between the base of the illuminator 47 and the scAnnin~ plate 49 for the arrangement Lllustrated in Fig.
2. In this case, the bottom of the illllminAtor is terminated by a base plate that has the same dielectric properties as the scAnnin~ plate or normal breast tissue. The ~iffjrl~lty is that, as the illuminator is ~hAnirAl ly moved, the slightest separation between the plates creates a f alse in~iratirn. The wide differences between the dielQctric constant of the plates and of the air gap between the plates is responsible.
To avoid this difficulty, the arrangements shown schematically in Figs. 18, 19 and 20 may be used. In Fig.
18, the cabinet 606 that houses the electronic circuits also supports a positioning arm 605. Arm 605 locates the position of an illuminator 604. A flf~ihlr boot 603 is attached to the base plate 610 of the i 11 llmi nAtor 604 and also to a scanning plate 602. The boot contains a liquid (or a flowable dielectric slurry or powder 611) that has about the same dielectric characteristic as a normal human breast. The scanning plate 602 compresses the breast 601 of a patient 600. 33ecause the dielectric properties of the materials within illuminator 604, base plate 610, liquid 611, scanning 2~
.
plate 602, and breast 601 are all about the same, the focal point 60g can J:e moved in three dimensions without air gap discontLnuities by positioning the; 1 l~lminAtor 604, using the positioning arm 605.
The arrzLngement shown in Fig. 19 is similar to that shown in Fig. 18, except that the scanning plate 602 has been removed and ~he liquid dielectric 611 within the boot 603 is allowed to contact the breast directly. A gasket 616 is attached to the boot 603 to prevent the liquid 611 from lealcing. The surface 612 of the dielectric liquid should be well above the breast. This arrAn~, L has the advantage that all intr~rinr portions of the breast can be readily scanned. An arrangement similar to that shown in Fig. 19 is also attractive when the patient is placed in a prone position.
Fig . 2 0 illustrates how the illuminator and its base plate 610 can be positioned with the scanning plate 602 without ^hAn~rAl sliding contact in areas of intense illumination 617. Spacers 61~ are used to position the base plate 610 with respect to the scanning plate 602. The dielectric liquid 611 fills the space between the plates, preventing the development of an air gap such as might occur if just the base plate contacted the scanning plate dLrectly.
..
21~714 .
The following references are of utility in understanding the foregoing specification:
Burdette, E. C., et. al.(l980): In vivo mea~l L
technioues for de~Prm;n;n~ dielectric properties at V~IF
through microwave frequencies, IEEE Trans. on ~TT, Vol MTT-28, No. 4 April, pp 414-427 Burdette, E. C., et. al. (1986): In situ permittivity at microwave frequenciesz perspective, techniques, results, medical applications of microwave imaging, Medical Applications of Microwave Imaging, Larsen, 1. E. and J. 11.
Jacobi, IEEE press pp 13-40 ~h~l]~h;lry, S . S ., et. al. ( 1984 ): Dielectric properties of normal and malignant human breast tissues at radiowave and microwave frequencies, Indian Jr. of Biochemistry and biophysiscs, Vol. 21, Feb pp76-79 Edrich, J., et. al. (1976~: Complex permittivity and penetration depth of muscle and fat tissues between 40 and 90 GHz, (1976) IEEE Trans. NTT, vol. MTT-24, Nay pp273-275.
Johnson, E. C., et. al. (1972): yon;~ni~inJ electromagnetic wave effects in biological materials and systems, Proc. of the IEEE, Vol. 60, No. 6, June pp 694-695.
Ray A. F. (1966): Mi11i Ler wave antennas, Proc. of the IEEÉ, Vol. 54, No. 4, pp 641-647 Larson, E. E. and J. H. Jacobi, Eds. ( 1986): Medical Applications of Microwave Imaging, IEEE press. Institute of Electrical and Electronic ~ntJi nf~rS, New York Ramo, S., et. al. (1965): Fields and Waves in C~ i, ation Electronics, John Niley and Sons, New York Rogers, J. A., et. al. (1983): The dielectric properties of normal and tumor mouse tissue between 50 M~Iz and 10 GE~z, British Jr. of Radiology, vol. 56, May, pp 335-338.
Smith, N. J., (1966): Modern Optical Eng;n~ r;n~, Mc Graw-Eiill, New York, N. Y.
Mammograms require interpretation by radiologists. One radiologist has said " I generally can spot cancers between five and ten millimeters in diameter. The prognosis is ~YrPl 1 ~nt then. ' ~owever, about ten to fifteen percent of tumors of this size are not detected. One study showed major rl inir;ll disagreements for about one-third of the same mammograms that were interpreted by a group of radiologists.
~urther, many women find that undergoing a mammogram is a decidedly painful experience.
Thus, alternative methods to detect breast cancers are needed, especially those that do not entail added risks, that can detect tumors as small as two millimeters in diameter, that are not unduly unpleasant to the patient, and that can be used for mass screening. A screening system is needed because extensive studies have demonstrated that early detection of small breast tumors leads to the most effective treatment . While X-ray mammography can detect lesions of approximately five mm or larger, the accuracy may range between 30~O and 7596, ~ r~n~inq on the skill of the diagnostic radiologist. Repeated X-ray examinations, however, are not encouraged because these may become carcinogenic. These considerations, in addition to cost considerations, have led physicians to r~l~ d that women wait until the age of fifty before having routine mammograms. One solution would be a non-ionizing, non-invasive, and low cost detection or ~creening metho~. It coul~ gre.ltly i~re~e wituout h~z.lr~
21~714 the number of patients r~rAmined and would identify those patients who need diagnostic X-ray examinations, where the added hazards and costs could be justified. Thus, there is a need for a low-cost, non-invasive, screening method.
About one in eight women develop breast cancers and about one in sixteen die prematurely from this disease.
Despite strong encouragement, less than half of the m; 11 ;nnq of women who should be are routinely screened. Some of the reasons are cost and discomfort exr~r; rnred during mammography. Other concerns are the additional risks associated with ionizing radiation, especially for routine exams for women under fifty. E~owever, while only twenty two percent of breast cancers occur in women under fifty, data suggest that breast cancer is more aggressive in pre-menopausal women. A screening procedure need only identify breasts with abnormalities. The precision and imaging requirements associated with diagnostic purposes and treatment monitoring, while desirable, need not apply.
There are several generic detection methods: sonic, rhrm;rAl, nuclear and non-irni ~in~ electromagnetic. The sonic, rhrmirAl and nuclear (such as ~RI) techniques have been under study for some time and, while some interesting approaches are being followed, none have been publicized as being available in the near future for low cost screening.
Non-ionizing electromagnetic methods have also been under investigation. Studies have considered the use of ~` 21~4714 elec L., ~n~tic, non-ionizing methods to detect or image portions of the human body. An excellent summary of such activity Ls presented in a publication entitled "Medical Applications of Microwave Imaging", edited by L. E. 1arsen and J. H. Jacobi, IEEE Pre3s 1986 . * These activities include microwave thermography, radar techniques to image biological tissues, microwave holography and tomography, video pulse radar, frequency modulation pulse compression techniques for biological imaging, microwave imaging with diffraction tomography, inverse scattering approaches, and medical imaging using an electrical irnro~iAnre The publications in this book contain about five hundred citations, some of which are duplicates. The technology cited not only includes electromagnetic disciplines, but also notes related studies ill sonic imaging and seismic imaging. To update these data, the IEEE transactions on Medical Imaging, Biomedical Engineering, Microwave Theory and Techniques and Antennas and Propagation have been reviewed. Also surveyed was the publication Microwave Power and Engineering. This update has indicated little significant progress in the af~,L, ~ ~' ioned electromagnetic techniques that would be important to detect * See the list of references at the end of this specif ication .
215~714 .
breast cancers. Breast cancer detection systems based on the concepts ~iPc~rih~<l in this specification were not presented.
Many important reasons e:cist for this lack of progress.
In the case of microwave thermography, adequate depth of penetration, along with the required resolution, may not be realized, except for large cancers. In the case of holography, reflections at the sk}n-air interface tend to mask the desired returns from breast tumors beneath the skin.
Further, illuminating the entire volume of a breast either requires excessive power (with possible biological hazards ) or acceptance of poor signal-to-noise ratios. In the case of through-the-body ele~L., -~nl~tic techni~ues, such as t. - c~,hy, the attenuation characteristics of the body are such that long wavelengths are usually used, with an attendant loss of resolution. Imaging by de~Prminin~
p~:. LulbclLions in body i~r~nre caused by the presence of tumors as sensed by multi-electrode arrays have been either inadequate in sensitivity or sub~ect to false alarms.
A mi l l i ter wave F~ radar weapons detection system developed and tested for the FAA (DTFA03-87-C-00056~ by the inventor employed a 94 GEz FM radar operating with a 300 Mhz bandwidth. A half-meter diameter antenna with a half inch spot size focused the radiated 94 G3Iz energy through the air onto a possible passenger boarding an aircraft. This system successfully detected both metallic and plastic weapons, with an overall detection pro~ability of 96.2%. The false alarm rate was 31. 0996 . It was hoped, initially, that the system could be used to detect breast cancers, slnce there wa3 some empirLcal evidence suggested that the 94 GHz waves were penetrating the skin sufficiently that some portions of the shoulder blades could be resolved. However, subsequent research has disclosed that the air-skin interface would not only enlarge the spot size, but would reflect a very substantial fraction of the impinging waveform.
To mitigate the resolution problem, a much higher frequency is needed to realize a usable spot size. However, the use of higher frequencies greatly increases the path attenuation of the penetrating energy, thereby introducing ma~or design ~li f firlll ties. These findings largely negated the use of this system for breast cancer détection.
Nevertheless, the results of this FAA pro~ect suggested that at least some features of a millimeter wave weapons detection system, designed from existing data, could ~e revised and integrated into a successful prototyoe system for detecting breast tumors.
SummarY of the Inven~ion The ob~ective of this invention is to propagate non-ionizing ele~ i ~gnQtic waves having wavelengths not much greater than three times the circumference of the smallest tumor to be detected, preferably having wavelengths, in normal breast tissue, of the order of thirty millimeters or ..
` 2~5~71~
less and preferably of the order of ten millimeters.
Propagation ls effected without incurring intractable path losses, while at the same time being able to discern breast tumors of the order of t~ree mi 11 i -ters . ~he penetration is realized by: l) avoiding interface reflections by employing media that have about the same dielectric constant as the breast tissues; 2) choosing a frequency (and wavelength that readily penetrates normal breast tissue; and 3) providing means to extract tumor-scattered power from the applied or impinging power. ~he desired resolution is achieved by: l) choosing a frequency such that its wavelength in breast tissue is comparable to the minimum size tumor to be detected; 2) using a wide aperture antenna that focuses the mmw energy at discrete points within the breast;
and 3) relying on significant differences between the dielectric properties of the normal breast tissue and those of the breast tumors. Optimum operation is usually achieved at frequencies in the range of three to ninety gigahertz.
A principal feature of this invention includes means to introduce microwave or millimeter wave energy into a breast with a minimum of interface reflections and loss of resolution (or increased spot size). ~his is done by means of dielectric materials in the illuminator that have about the same relative dielectric constant as the breast tissue and by use of gels, liquids, slurries and/or solids that have a similar relative dielectrLc constant around the breast to ` 2~ S~714 further suppress interface gaps that could cause reflections and loss of resolution.
Another important feature is the selection of a band of operating frequencies wherein the attenuatiDn of the propagating energy in a non-lactating breast is relatively small, preferably of the order of 1.5 to 15 dB/cm, in combination with an antenna or illuminator aperture size that produces a spot size preferably in a range of about 2 . 5 to 12 millimeters in normal, non-lactating breast tissue.
Another important feature comprises the use of a wide aperture scanning system. The construction of the scanner is such that the focus of the energy introduced is scanned at different depths, at depth increments comparable to the depth of focus, to provide a quasi-three-dimensional picture of the backscattered returns. To overcome path ~nr~~ that might cause ambiguous results, different scanning patterns can be employed to average out such ef f ects . Also, advantage can be taken of other features inherent in electromagnetic propagation systems, such as the use of dif ferent polarization effects, including circular polarization, and enhancement of the bac3cscatter cross-section wherein the circumference of the tumor is eriual to the wavelength. Also, use of forward and side scatter can be employed to help resolve ambiguities.
Yet another important feature employs techniriues that aid in separating the desired scattered returns from a tumor ` 21~714 .
from those originating either directly from the impinglng waveform or from spurious reflections from scatterers of no interest. This may be done by "passive methods, such as employed in microwave circuits (magic tees or circulators ) or by tumor-unique scattering ph. - - (wherein the polarization, side-scatter, forward-scatter returns or tumor-induced resonant effects are ~ 7F~d). Additionally, "active methods ', such as time-gating or pulse-compression methods tsometimes employed in modern radar systems) may also be used.
Another feature of this invention is the use of a stepped frequency technique to develop a synthetic time domain response. As opposed to applying a large amplitude short duration pulse and then using time-gating or the use of swept frequency FM ''ChirpU radar pulse compression methods, the stepped or swept frequency input i ~ s~ lAn~~e method can be more easily implemented. The d~7ell time at each frequency can be ad~usted to give adequate signal-to-noise ratios, digital processing and control can be used, and the hardware needed to implement this method is available.
Another feature of this invention is the use of confocal techniques, where the focal point of the i 1 1 11mi nAtion and the focal point of the collection system are nearly the same point in the breast tissue. Such arrangements suppress the effects of incidental sources of scattering that might occur at locations outslde the common focal point.
21~14 Another feature is the combined use of the confocal method with the stepped frequency synthetic time domain method, especially for detecting An( ~1 iP~ at depth. On one hand, the confocal method is most effective at shallow depths, and loses its ability to suppress incidental scattering for deeper tumors. The synthetic time domain method, if used 6eparately from the confocal aLL~llly t with more commonly available antennas, will generate back scatter from sources over a wide area. Scatter from such incidental sources could mask the desired returns from any tumor.
However, the combined use will provide more benefit than would be suggested by the performance of each subsystem separately. The confocal method suppresses clutter sources ( incidental scattering) that are transversé to the direction of propagation and the time domain system suppresses clutter sources in the longitudinal direction.
Another feature of the invention is convenience to conduct screening. As opposed to other microwave methods that require access to nearly all sides of the breast, the method noted here needs access to only one side.
Another f eature of the invention is that it can provide non-hazardous screening functions, such that breasts, over time, can be compared to detect Ahn~nT~ l ities that would not otherwise be possible with an ionizing approach or more expensive methods, such as NRI.
215~71~
One version of the invention includes a quasi holographic technique wherein the amplitude and phase of the scattered returns are compared to a reference signal and subsequently-used to form some type of three dimensional display. A ~ d interferometer technique can be used to do this. The interferometer provides 3-D displays of the backscattered power and the cumulative phase shift of the returns with respect to a reference point.
Brief Description of the Drawin~i The following figures are used to explain the concepts and design of the breast cancer detection system of the invention:
Fig. lA, is a conceptual view an active mi 11 i ter wave breast cancer detection system, with a patient;
Fig, lB illustrates displays for plural focal lengths, with the gl~nern1 i~ed system of Fig. IA;
Fig. 2 is a simplified block diagram that illustrates the principal ~unctions of a mmw breast cancer detection system constructed in accordance with the invention;
Fig. 3 is a graph of relative dielectric constants of muscle, fat, breast tissue and breast cancer as reported ~y various investigators;
Fig. 4 is a graph of conductivity of muscle, fat, breast tissue and breast cancers as reported by various investigators; 11 21~14 Fig. 5 is a graph of attenuation, wavelength, and depth of penetration in normal breast tissue as a function of frequency, based on the data presented in Eigures 3 and ~;
Fig. 6 is a block diagram of a Gunw breast cancer detection system, according to the invention, that employs a "passive" signal separation technique in combination with a conv~nt i f)n~ 1 heterodyne receiver to detect tumor-scattered returns;
Fig. 7 is a block diagram of a breast cancer detection system, again according to the invention, that employs phase coherent detection;
Fig. 8 is a diagram of resolution (or spot size) and depth of focus as functions of the diameter of an aperture or lens and of wavelength;
Fig. 9 shows Snell s Law effects that illustrate quasi-optical propagation from a medium with a low relative dielectric constant into a medium with a very high relative dielectric constant;
Fig. 10 is a schematic cross-sectional illustration of a large aperture ; l l llmi n~tor in the form of an ellipsoidal reflector in combination with a boot that contains a material having relative dielectric properties similar to those for normal breast tissues;
Fig. 11 is a graph that shows the backscatter cross-section of a perfectly conducting sphere norr~l i7ed to the .
21~4~1~
cross sectional area of the sphere as a function of the circumference-to-wavelength ratio;
Fig. 12 presents a simplified block diagram of another detection system, according to the invention, that employs an -active or time domain technique to help extract power scattered by a tumor from applied or impinging mmw power;
Fig. 13 illustrates an array of double ridged wave guides that can be used to replace the ellipsoidal reflector;
Fig. 14 presents a simplified functional block diagram on how the phased array can be controlled to position the focal point without the need for r--hAni~ Al scanning;
Fig. 1~ shows how the a wave guide like that of Fig. 13 can be positioned directly on the breast for screening purposes; and Fig. 16 illustrates how forward scattering oan be sensed by a confocal arrangement wherein the focal point of the receiving array tracks the focal point of the illuminating array .
Fig. 17 illustrates, schematically, how forward scattering can be sensed by an arrangement where the focal points of one or both of the antennas are not well defined to simplify trAr-kinlJ and Al ili lt;
Fig. 18 illustrates, schematically, an ellipsoidal reflector or ill~lminAtor that is capable of being positioned in three dimensions near the breast by means of a flexible ..
215~
boot filled with a liquid that has about the same dielectric constants as normal breast tissue;
Fig. 19 illustrates, schematically, how the arrangement shown in Fig. 18 can develop an in-tis6ue focal point near the extremities of the breast; and Fig. 20 illustrates, schematically, how an ellipsoidal reflector assembly can be moved without direct sliding --^hs-ni~l contact in the strongly illuminated area between two dielectric plates.
r)escription of the Preferred Embot~i ~ntS
The use of electromagnetic microwave or millimeter waves offers several advantages over x-ray mammography in detecting incipient breast cancers. (To simplify this discussion both microwave and mi 11; I.er wavelength regimes will be referred to as mm waves, or mmw. ) Non-i--ni7inq electromagnetic systems can be operated at sufficiently low levels so as to preclude biological hazards. A contrast ratio of the order of 20:1 is potentially usable for mm waves in tissue, whereas there is less than a few per cent range of densities for X-rays for soft tissue. The tissue-mm wave ~nteraction also exhibits additional ~ht~nt -n;~ that can be drawn upon to enhance the performance. For example, when the diameter of a highly conducting sphere (e.g., an incipient cancer) is of the order of a wavelength in the breast tissue, a resonance ~5 effect occurs th~t incre~ses the ~ffe~tive sc-~tterlrg cross-.
section of the tumor. If the tumor is non-spherical, then the polarization of the scattered waves may be different than that of the impinging waveform. In some cases, side-scattered or forward scattered energy can also be utilized.
For purposes of this specification, tissue-mm waves are def ined in terms of wavelength in a medium having a dielectric constant like that of breast tissue, not air.
Thus, the operating frequency for an ele~ L ~gn~tiC wave source used in the inventive system is preferably in the range of three to ninety GE~z.
Other than the use of mi 11 i~- Ler wave and microwave thermography to detect breast cancers, there has been little activity toward use of such mm wave approaches to detect breast cancers. As noted earlier, some of the problems that have to be UVel~ - are formi~1~hle First, simply flooding the torso of a female with mmw energy introduces numerous problems. How does one single out the scattered return from a three mi 11 i l er circumference tumor out of the immensely larger scattered returns from the tor~io? E~ow is the defocusing effect of the air-skin interface overcome? Is the breast tissue sufficiently transparent, at mmw frequencies, to propagate energy into and out of the breast? Are the dielectric properties of the tumors sufficiently different from normal breast tissue for effective detection of small ( e . g ., three mm circumference ) incipient cancers ?
21~4714 .
To understand the invention and its novel features, the basic concept will first be briefly described. Next, the ability of the millimeter wave electromagnetic energy to penetrate normal breast tissues will be demonstrated. Then, the special equipment and operating conditions will be ~"5, rih~r~ to realize the needed high resolution simultaneously with good penetration.
Figs. lA and lB illustrate the basic concepts.
Fig. lA illustrates, on a conceptual basis, possible prototype equipment. The patient 21 arranges one of her breasts 22 to contact an i111lmin~tor 23 as shown. Mm waves are g~n.~t~d within the equipment housing 24. These mm waves are then propagated into the selected breast 22 as a reiracted or reflected electromagnetic mm wave that is focused at a predet~rmin.o~l point or volume (voxel) within the breast. This is done by means of a unique combination of an interface and focusing apparatus, as described hereinafter.
Further apparatus is used to cause the focal point of the beam to scan dif f erent small volumes or voxels within the breast. Nhen this happens, the scattered mmw energy from any tumor present in the breast becomes much larger that other scattering sources, since the dielectric properties of a tumor are r~ 11y different than that of the breast tissue.
The scattered returns may be collected as backscattered power -via the same interface and focusing apparatus that is used to propagate the mmw power into the breast. The collected power 21 ~714 .
can then be processed by either analog or digital methods to form an image of the tumor.
A stepped F~ sweep similar to pulse compression in "Chirp" radar to synthesize a time domain response to isolate shallow from in-depth scattering can be used to mitigate the effects of heterogeneity in the dielectric characteristic of the breast. The functional goal of the combined confocal and time-domain features is to isolate the returns from tumors from spurious returns generated by heterogeneity in ad~acent normal tissues.
Electromagnetic waves in the mm wave region, in combination with the shape and dielectric properties of tumors in the breast, offer additional methods to detect the presence of a tumor beyond using ~ust simple back, forward, or side scatter. In some cases, the tumor can exhibit both internal and external ele.: LL- gn~tic resonances which are unique to its presence. Such resonances can be detected by varying the mmw frequency, by observing changes in polarization, by observing transient responses to an impulse function, or by noting changes in the ratio of the forward, side, backscattered and spurious returns. If the geometry of the tumor is asymmetrical, then the plane of polarization of the scattered energy may change; this change can be used to conf irm the presence of a small tumor .
The amount of collected backscattered energy and its accumulated phase shift (or time of flight or round trip time delay) can be presented in a 3-D format, as shown generally in Fig. lB. For illustrative purposes, it is assumed that the impinging energy can be selectiYely and sharply focused into three vertical planes that are parailel to the patient ~ s chest, wherein the x-y planes at maximum depth 25, medium depth 26, and shallow depth 27 are shown. The three coordinates show the backscatter returns 2~, the "x"
coordinate 30 and the "y ' coordinate 29 . Small vertical lines 31 are shown for ~ s combinations of x and y coordinates.
The amplitudes or heights of most of these lines 31 are proportional to the non-target returns that can arise from, for example, the tissues that surround the rib cage. Note that a very large return 32 exists in the center of the medium depth display 26. This large return 32 is assumed to arise from a tumor that is at the focus of the impinging energy in the medium depth plane 26. In the center of the shallow plane 27 there is a somewhat smaller response 33 caused by the tumor intercepting and only scattering a small portion of the impinging beam. Note that in the center of the deeper plane 25, the return 3~ is smaller because, it is assumed, the focused energy has largely been scattered by the tumor in the medium depth plane 26 before it arrives at the center of the deeper plane 25.
Figure 2 presents a block diagram that Lllustrates the principal functions of the mmw breast cancer detectlon and 215~71~
imaging apparatus. ~icrowave or millimeter wave power is generated by a mmw power generator 41. This power is supplied to a power and signal director 43 via a cable or waveguide 42. The power output 44 from the director 43 flows to an illuminator 47 via a waveguide 46. The illuminator 47, via a scanning plate 49 of dielectric material, causes the power to ~e focused at a point 62 within the breast 22. A
scan control 48, via a ~hAn;ci~l connection 50, causes the illuminator 47 to move along the plate 49 in a predet~rm1 n~l scanning pattern. When the focus of the power encounters a tumor 61, backscattered power 45 is collected by illum. inator 47 and is returned, via waveguide 46, to the power and signal director 4 3 .
To prevent the applLed power from swamping or masking returns from the tumor 61, means must be included to extract the desired return or signal from the tumor from the applied power. The initial function of the director 43 is to direct the mmw power output 44 from the generator 41 to the .focusing illuminator 47 through the cable or waveguide 46. The director 43 also is employed to eYtract the tumor-scattered returns 45 that are collected by the focusing il lllminAtor 47.
The e~tracted returns 45 from the power and signal director 43 are applied to a mmw receiver 53 via a cable or waveguide 52 .
The requisite directing action of the director 43 can be realized by several ~passive" means, such as a balanced ` 21~71~
bridge circuit or magic tee, a directional coupler, or a cireulator ~see Ramo et al. (1965) Fields and Waves in r, i- ation Eleetronics, John Wiley and Sons, New York, sections 11.17, 11.8 and 9.16). "Active" means of separating the applied power 44 from the tumor-seattered power 45 are possible in the time domain. For example, very short =
duration pulses of mmw energy can be applied and the returns separated by time gating methods. Other "active" methods currently employed in some modern radar systems can be used, such as pulse eompression, chirp or frequency modulation radar; see Skolnik, Introduction to ~odern Radar Systems, NeGraw-Hill ( 1980 ) .
The focusing illuminator 47 of Fig. 2 has several functions. One principal funetion is to foeus the applied power at a prede~f~rm;n-~d point within the breast 22. Another principal funetion is to condition the spatial distribution of dielectric material to enhance resolution. Yet another function is to suppress dielectrie and electrical interface reflections that could mask the scattered returns from a possible tumor 61 in the breast 22 of the patient 21. These functions may be done by matehing the wave propagation characteristic or dielectric constant of the illuminator 47 and the seanning plate 49 to that of the breast 22 and also matching the electrical interfaee between the cable/waveguide -46 and the focusing ~ m;n~tor 47 by means of eleetrical 215~14 matching networks, such as the mmw equivalent of a pi " or n tee " or " I~ " network .
The 3can control 48 controls the position of the focal point 62 of the illuminator 47 via a r---hAn;ri~l connection 50 that slides the il l~lmin~tor 47 over the scanning plate 49 in a predetc~rrni n~l scanning pattern. This action provides x and y positioning of the focal point. Alternatively, other techniques may be used in conjunction with the scan control 48 to create an apparent focal point, such as by means of phased arrays or synthetic aperture methods.
The scattered returns 45 from a possible tumor or other scattering sources are applied to the mmw receiver 53 via the wave guide 52 and the power and signal director 43. This mmw receiver 53 may be a conventional heterodyhe receiver that provides an output proportional to the power received.
Alternatively, using a waveguide 58 connected from the mmw generator 41 to the receiver 53, a reference signal can be compared with the return signal 45 to develop composite phase and amplitude data.
The outputs from the mmw receiver 53 are supplied, via a cable 54, to a signal processing and display unit 55. This unit 55, with a further input from the scan control 48 via a cable 51, processes the received data into a suitable display, such as illustrated in Fig. lB.
In the case of screening for breast cancer, the performance requirements can be relaxed, since the detection . 2~71~
of an abnormality is the real goal. This can be done by comparing the returns from one breast with the other. In addition, year-to-year examination data can be compared. As shown in Fig. 2, information via cable bundle 70 on the returns from each breast can be c ~-rPd; see block 71.
Cable bundle 72 carries similar data for storage and subsequent comparison via block 73 after each yearly examination .
Various known comparison techniques can be used for this purpose. For example, a transparency of a positive image taken of the breast at one time may be overlain with a transparency of a negative image taken at a later time. Any sign i f i c~nt return on the positive is presented as a very light gray area in the refrence-gray background and the return taken a later time is displayed as a dark area in the reference-gray background. If no change has occurred, the light gray area on the positive and the dark gray area on the negative will tend to cancel and result in a nearly reference-gray density. If some change has occurred in a specific area, the images will not cancel in this region, and the Ahn~rr~ I i ty will be indicated as either a darker or lighter region in the reference-gray background. A similar process can ~e done digitally, and the difference displayed visually in a two dimensional display for a given ' slice~ or do~th lnto the ~rea~t.
2~714 Figs. 3, 4 and 5 provide data that demonstrate that non-lactating breast tissue has different dielectric properties than either tumors or muscle tissues. Moreover, the attenuation of mm waves in such breast tissue is not excessive Ln the 5 to 15 GHz region and hence permits reasonable operating conditions for -passive" power and signal directors. Additional attenuation can be tolerated by the use of "active" power and signal directors such that operation up to sixty GHz is possible.
Figure 3 summarizes data on relative permittivity, scale lO1, as a function of frequency, scale 102. These data demonstrate that the relative dielectric properties of low-water-content tissues and normal breast tissues are significantly lower than for high-water-content tissues and tumors, either human or non-human. The low-water content data for curve 103 were developed by rh~ h;~ry ( 1984 ) for human breast tumors . Johnson ( 1972 ) developed the data for curve 105 for fat, bone and low-water content tissue. Edrich (1976) generated the data for cattle fat, shown in the curve 107. Burdette (1986~ generated in vivo data for canine fat, illustrated in a curve lO9. The high-water-content data for another curve 104 was developed by rhA~flh~ry (1984) for human breast tumors. Johnson (1972) developed data for muscle and high water content tissues, shown in a curve 106. Rogers (1983) generated the data, shown in a curve 108, for mouse tumors. Edrich (1986) collected data for canine muscle, 2154~ ~
illustrated in a curve 110. Burdette (1986) provided in vivo data, shown in curve 112, for c~nine muscle tissue. Note that in the case of muscle or tumor tissues, the relative dielectric constant is of the order of forty or more, depending on the frequency. In the case of low-water-content tissues, such as breast or fat, the dielectric constant is in the order of five to ten, as measured for in vitro studies.
The in vivo measurements of Burdette (1986), shown in curves 109 and 112, show an approximate increase by a factor of two in the relative pe ~hi 1 i ty over the data developed by Johnson ( 1972 ), curves 105 and 106 . The in vitro breast tissue measurements by ('hAi~hAry (1984), curves 103 and 104, fall somewhat in ~etween the in vitro values developed by Johnson ( 1972 ) and the in vivo meaau, ~ Ls of Burdette (1986).
Fig. 4 presents similar data on the conductivity of both low and high-water-content tissues. The conductivity in mhos/meter, scale 121, is the ordinate and the frequency, curve 122, is the abscissa. The low-water-content tissues are human breast tissues, shown in a curve 123 derived from f`hAl~lhAry (1984). The low-water-content fat and bone of the curve 125 is from Johnson (1972). Cattle fat, shown in a curve 127 is from Edrich (1986). The high-water-content tissues of the curve 124 are human breast tumors, data by ~-hAll~hAry (1984). IIigh-water-content muscle tissue is in a curve 126, data by Johnson (1972). Mouse tumors, shown in a 2~5~1 4 curve 128, are from Rogers (1983). Rat muscle data for a curve 130 is derived from Edrich ( 1986) . Canine fat data are presented in a curve 131 from Burdette ( 1980 ~, and canine muscle data in a curve 132 taken from Burdette 1930). Note that conductivity, as a function of frequency, tends to increase substantially above 6 GHz and that the 40 to 90 GHz meabu,- - Ls of Edrich (curves 127 and 130) tend to fall in line with the trends established by mea~lul. ~ t made up to 10 G~Iz Based on the data presented in Figures 2 and 3, Fig. 4 shows the depth of penetration 140, wavelength 142, and attenuation 144 as a function of frequency 146 for the propagation of mi 11 i~- Ler waves in non-lactating breast tissue. Above ten GHz, some uncertainty associated with the trend extrapolation is suggested by the range of possible values of the penetration depth 140 or attenuation 144. A
value of nine was used for the relative dielectric constant and the extrapolated values of ~ hAll-ihAry (relative to the data developed by Johnson) from Fig. 4 were used for the conductivity. From these data, it is seen that the breast tissue behaves as a lossy dielectric for frequencies substantially .olrrP~ inr five GHz, wherein ~i) =211F and ~=~o~r (permittivity of free space) x (relative dielectric constant), tJ is the conductivity, 1l is the permeability, f is the frequency, ~ is the wavelength, and ~ is the depth of penetration (see Ramo (1965) page 334 Sec. 6.05).
21~
Since ~>>~, the approximate lossy dielectric equations are as follows:
( 2 ) ~=2 [a( ~)1/2 ] -1 This defines the generic feasibility of the system to be described hereinaf ter . There are two requirements that must be met . First, the total path loss attenuation ( in and out) should be substAntiAlly less than the dynamic range, typically in the order of 100 dB, wherein the dynamic range is defined in dB as equal to: 10 log[ (largest signal power)/(smallest detectable signal power) ] . Second, the wavelength in the irradiation apparatus ( illuminator 47 ) and in the breast of the patient should be sufficiently small so that small tumors can be resolved. This, for the system discussed here, requires that, preferably, the wavelength in illuminator 47 and in the breast tissue should not exceed two or three times the circumference of the smallest tumor. If an operating frequency of 15 GHz is chosen for a passive power and signal detector, it is seen that the path loss is about 5 dB/cm, or 50 dB total path loss, in and out, for a 5 cm path length. The wavelen~th at 15 GHz is about 0 . 6 cm, which is about equal to the diameter of the smaller tumors.
Figure 6 illustrates a functional block diagram of a microwave breast cancer detectian and imaging system 200 that employs a conventional heterodyne receiver. System 200 comprises the following subsystems: a millimeter power 215~
generator subsystem 241, a passive power and signal director 243, a focusing ~ min~tor subsystem 228, a heterodyne receiver 253 employed for signal detection, a scanner control 248, and a signal processing and display subsystem 255.
Ele-: L ~ ~n~tiC wave energy f lows, via the power and signal director 243, from the power generation system 241 to the illuminator subsystem 228. The illl-minAtor subsystem 228 comprises three ma~or parts: a beam focusing apparatus 247, a matching network 226, and a dielectric e~-~l i7 jn~ interface 249. The focusing apparatus 247 of the illuminator 228 focuses the energy into a small point 262 within the breast of the patient 259. The scanner 248, through a mechanical connection 250, controls the location of the focal point 262 in three dimensions ( 3-D) such that the focal point 262 is progressively positioned into each voxel (smallest volume element) of the breast under consideration. When the focal point encounters a tumor 261, the scattered returns are substantially increased, since the electrical permeability and conductivity of the tumor is greater than similar parameters for breast tissue. The scattered returns are collected by the illuminator 247 of subsystem 228 and then the scattered power (arrow 245) is supplied via the matching network 226 and the power and signal director 243 to the detection subsystem 253.
The scattered power 245 is separated from the impinginq power 24~ (s~pli~ po Oe illl~m~ to by me~m~ o~ ~
21~
circulator 224 within the power and signal director 243. A
discussion of each of the aforementioned subsystems follows.
The power generation and control subsystem 241 is comprised of two functional blocks: an electromagnetic wave power source 220 connected via a cable 221 to an isolator and power splitter 222. This, in turn, is connected, via a cable 242, to the power input port 225 of the circulator 224 in the power and signal director 243. The power output and backscattered input port 227 of the circulator 224 is connected, via a cable 246, to the matching network 226 at the input of the illuminator sybsystem 228. The output port 234 of the circulator 224 is connected to the signal processor subsystem via a cable 252.
~any of the functions of these componénts are obvious.
The isolator/power splitter 222 electrically isolates the power source 220 from any load variations that might be introduced by the circulator 224, the matching network 226, or other ,-, In~ntS of the illuminator subsystem 228. The function of the circulator 224 is to extract the backscattered returns from the applied power. Otherwise, the high level of the power applied to the illuminator subsystem 228 would tend to mask the desired scattered returns. Thus, the electromagnetic input signal in~ected into port 225 is directed out of port 227 and thence to the matching metwork 226 . The backscattered returns ( from the matching metwork 226 ) that are applied to port 227 appear at port 234, wherein 215~14 the amplitude of the applied power is greatly suppressed.
The purpose of the matching network 226 in subsystem 228 is to suppress ref lections that might take place at the interfaces of different dielectric materials or where some 5wave imrP~1An~e discontinuity occurs in the illllminAtor s ubsystem 2 2 8 .
The performance requirements for the signal detection system 253 are not too strinrJr~n~ The simplest version may use a simple heterodyne receiver as an RF voltmeter to 10measure the output of the circulator 224 at port 234. A
reference signal from the power generation subsystem 241 can be supplied to the hetrodyne receiver 253 via a conductor 258 to stabilize the local oscillators in the receiver.
Other versions of the invention, such as the system 300 15shown in Fig. 7, offer additional signal proce$sing options.
The system 300 of Fig. 7 illustrates the use of two synchronous receivers or detectors in a modif ication of the system of Fig. 6 in which only the signal detection subsystem is changed, with subsystem 253 of Fig. 6 replaced by a dual 20subsystem 353 that includes two hybrid tee synchroneous detectors 361 and 362. The power splitter 222 (Fig. 6) provides a reference signal, on conductor 258 (Fig. 7) to system 353 as well as to the power and signal director 243. --Each of the hybrid tee devices 361 and 362 forms a product ~ =
25between the applied input signal and the composite ~=~
backscattered returns. Xowever, one of the reference 21~714 waveforms is shifted ninety degrees with respect to the other reference waveform; the following relationships result, where:
~ is the angular frequency of the millimeter waves;
19 i5 an arbitrary reference fixed phase angle;
;~. is the wavelength;
7C is the path length from the scatterer to the hybrid tee;
,~ is the propagation phase constant and ,~=2r~
~!3 is the ~cc~m~ ted phase shift.
The output from each of the hybrid tees 361,362 is the product of the returned, scattered waveform and the reference waveform. Considering ~ust the low frequency components of such products, the output of each of the hybrid tees is as follows:
t3~ cosr;C~f e-2~] cP~S~tf~
= A/2 ~ -2~ f ~ ~cf. comp~
2~5~71 - t41 AC,~ t,~-2,~7 ~s~ t/z~
-~z L~ z~7)1 T ~ f The outputs can be defined as an in phase "I" vector ,- mnPnt and a quadrature or "Q" vector component. These are combined as vectors so the phase angle of the c, ' i nP-l vector becomes tan=1(2 X13). Typically, when no tumor is at the focal point 262 (Fig. 6), the backscatter irom the chest tissue-lung inte}face can be assumed to form the zero reference distance for %. During sc~nnin~ the focal point will begin to encounter a tumor that is spaced a few or more 0 m; 1 l; Pr wavelengths away ~rom the chest muscles . Nhen this happens, the effective distance X progressively decreases, thereby causing the equivalent phase angle to rotate counter-clockwise. The number of rotations can be counted to develop the total accumulated phase angle change.
The above rela~imn~hir~ can be manipulated to present an accumulated path delay presentation that is responsive to the approximate distance of the scatterer from the illuminator.
Such an option can be valuable in conf irming the presence of a weak scatterer and can provide conf;rminq location data for a strong scatter.
The dual receiver system depicted in Fig. 7 draws the reference waveforms from the isolator-power splitter 222 via cable 258. An attenuator-poweF splitter 339 is used to .
215~14 reduce the amplitude of the waveform presented to the two phase shifters 340 and 341 via appropriate cables or other conductors 352 and 351. The output waveform of phase shifter 341 is advanced or retarded ninety degrees relative to phase shifter 340 to provide the desired quadrature relationship.
The quadrature reference waveforms from circuits 340 and 341 are applied/ via cables 342 and 343, to the hybrid tees 362 and 361, respectively. The output of port 234 of the circulator 224 supplies the power from the backscattered returns, via cable 252, to the power splitter-isolator 335.
This circuit 335 diverts the return signal equally into cables 336 and 337, thus supplying the backscattered signals to the hybrid tees 361 and 362. These tees 361 and 362 each form a product between the reference waveform ( from conductors 343 and 342, respectively) and the backscattered signals (on lines 336 and 337, respectively). The low frequency output from these two devices 361 and 362, on cables 345 and 346, provides critical inputs to the signal processor and display subsystem 255 ( Fig . 6 ) . Other variations of the above technique may be used to improve the signal-to-noise ratio, such as modulating the reference waveforms with another frequency well above the highest frequency of interest in the detected backscattered return.
This removes the output signal well away from the troublesome shot uoi~ 'ch.~t ooours at e~y l ow fr~ uenc~es .
. ` . 21547~4 The scanner control subsystems 48 and 248 (Figs. 2 and 6 ) control how the breast of the patient is scanned. In the case of the prototype system of Figure 2, scanner control 4 8 controls the x and the y positions of an ellipsoidal reflecting antenna 47, which may be the antenna 170 shown in Fig. 10. Several antennas of different focal lengths may be used to access the location of a tumor. The scanner control (48 or 248) is AhAni~A~lly connected to the illllminAtor (47 or 2~7) and to the signal processing unit (55 or 255) in each of the described systems of Figs. 2 and 6. Phased arrays (not shown) could be used instead of a AhAn j~ ly positioned illuminator to reali~e approximately the same scanning performance. Other methods, particularly techni~ues that synthesize large aperture antennas, could also be used.
In any of the described systems the signal processing and display subsystem (e.g., subsystem 255 in Fig. 6) can employ any number of processing or display methods so as to suitably display the scatter returns. It should be noted that since the scatter waveforms are referenced to the initial unperturbed ele~:L ~AJnr~tic wave illumination, quasi-holographic processing techniques can be considered.
Fig . 8 def ines the parameters needed to determine the spot sL~e wherein the diameter of the aperture D, the focal distance R, the spot diameter d, and the wavelength of the milli---ter wave in the med a. See Kay (1966) and Smith 21~714 (1966) for more complete development of relatinnqh;rq] Here, the spot size becomes:
( 5 ) d=2R i~/D
As was noted earLier in Figure 5, reasonable penetration losses of about fiYe dB/cm occur for wavelengths of the or~er of six mm. Thus, if tumors in the order of three mm in circumference are to be resolved, the beam width or spot size should not exceed the tumor circumference by much more than a factor of three. Preferably, for improved spatial resolution, the wavelength should not exceed the tumor circumference by a factor of three. To achieve a spot diameter of 6 mm, the ratio of the focal distance R to the aperture diameter, D should be about O. 5 .
Another design consideration is the depth of field a, as related to the aforementioned parameter5 and the apparent angle of resolution ~ . Thus the depth of f ield becomes:
(6) ~ =[R2qi]/[D+Rq~3, where ~=d/R
Again, to obtain good spatial discrimination, the focal distance R should be small compared to the aperture diameter D.
However, short focal lengths cannot be easily developed if the dielectric constant between the media that form an interface are greatly different. This would be the case if an attempt is made to propagate millimeter wave power in air and thence into the breast. As seen in Figure 3, the dielectric constant of breast tissue is of the order of nine, 21~71~
and such a large value (relative to a value of one for air) causes substantial reflection of the incident power at the air-breast interface More importantly, the apparent R/D
ratio is reduced; that can lead to a radical increase in the spot size. This is best seen by referring to Fig. 9 (see Ramo (1965) p. 358 Sec. 6.13 -for more complete background).
Here the incident ray 151 impinges on a dielectric interface 150. This produces a reflected wave 153 and a penetrating wave 155. The angle of incidence 157 must equal the angle of reflection 159 . Also, Snell ' s Law must be satisfied where angle 161 is the angle of the transmitted penetrating wave 155 with respect to a normal to the plane of incidence 150 and ~1 and ~2 are the dielectric constants for air and for the breast tissue, respectively:
(7) [sin 161]/[sin 157]=[~ 2] l/2 This interface reduction in the angle 161 of the transmitted penetration wave 155 will tend to increase the apparent R/D
ratio (focal distance to aperture size ratio). For example, assume that a focused mm wave front with an R/D ratio of 0 . 5 in air impinges on a dielectric interface where the ratio of the relative dielectric constant of the second media to the first media is nine. Based on Snell ~ s Law, the maximum value of angle 161 can be no more than about fourteen degrees.
This would increase the apparent focal distance from R to about ~R and increase the spot diameter d by a factor of f our .
21~471~
Fig. 10 illustrates one way the defocusing and reflecting effect of the dielectric interfaces between a breast (or other tissue) and air can be mitigated. The mm wave power from a feed point 171 in a medium 175 is introduced, via an interface medium 176, into the breast 177, with the respective relative dielectric constants ~ 2 and E3 made approximately the same. For illustrative purposes, an elliptical reflector 1?0 is chosen; reflector 170 has an R/D ratio of about 0 . S that would produce a spot &ize comparable to the wavelength, which is of the order of 6 mm.
This elliptical ref lector 17 0 and related apparatus is deslgned to exhibit two focal points: one at the feed point 171 and the other at a point 172 in a voxel within the breast 177. An interface boot 180 is used to contain a liquid or slurry 176 having a dielectric constant, ~2, that is contained by a boot wall 181, a thin, liquid-impermeable brassiere 182, and a thin, solid dielectric sheet 183 that has the same relative dielectric constant as ~1. For orientation purposes, the dash curve 178 represents the curve of the ellipse of reflector 170 if it were to extend into the human body.
The thin brassiere 182 is caused to f it as closely as possible to the breast 177 of the person under examination, as by withdrawing air from the voids 17g. The breast is compressed into a relatively flat surface by the dielectric plate 183. This permits moving the focal point 172 by moving 215~7~ ~
the elliptical reflector 170 along the surface of the dielectric plate 183 to scan the breast. The focal point 172 may be moved upwardly by increasing the thickness of the dielectric plate 183.
This arrangement assures that the mmw power that is applied to the breast is focused in the voxels of interest.
Future, the mi 71 i Ler wave power that is scattered from a possible tumor at the focal point 172 returns to point 171 via paths that have equal time delay, thus allowing constructive recombination of the scattered returns at the feed point 171. On the other hand, power that is not intercepted by a tumor at focal point 172 progresses on to the breast-lung interface 185 via plural paths such as the path 186. A portion 187 of the unscattered wave 186 progresses into the muscle and rib cage of the patient;
another portion 189 is reflected. In order for these back-scattered or reflected muscle wall waves to add constructively at the feed point 171, the waves would have to ~lrr,~ri ,-nl-e the same path lengths, in terms of integral multiples of a wavelength, as for the paths of the waves scattered at the focal point 172. For most of the unscattared waves that are ref lected from the breast-lung-rib cage interface, constructive addition at the feed point 171 is quite unlikely. An arrangement as shown in Fig. 10, therefore, suppresses unwanted returns or clutter from ~ le~ d from the p~ti~nt s rib c~ relative to the 2~L71~
returns that are scattered at the focal point of interest, point 172.
other dielectric i~n~ 190, such as might arise from a blood vessel, will also scatter the incident mi 11 i Ler wave power. However, like the clutter returns from the muscle-rib cage, such returns will be suppressed in amplitude or even omitted, relative to the returns f rom the voxel containing the focal point 172. Furthermore, since many ray paths are used, any minor and random variations of the dielectric constant will tend to be averaged out.
other methods of discriminating the presence of a tumor from the clutter scatter returns are possible. Fig. ll illustrates one such rhf~nl -nnn, a resonant enhancement of the scattering cross section, a, that occurs when the circumference of a highly conductive spherical scatterer equals the wavelength in the media around the sphere. The cros~-section relative to the pro~ected area of the sphere is shown as the ordinate 401. The abscissa 402 is the ratio of the circumference to the wavelength. The curve 403 illustrates how the cross ~ection is enhanced by the resonant scattering that takes place between the Rayliegh region 404 and the Mie (resonance) region 405. In addition, internal resonances within the tumor are possible. Despite the hLgher conductivity within the tumor, the material withill the tumor still behaves as a lossy dielectric because of the very large value of its relative dielectric constant. Therefore, 21~71~
internal resonances within the very high dielectric constant tumor can be considered to occur where the internal dimensions are in the order of a one half wave length--or about 3 mm for an operating frequency of 10 GHz. Such resonances can generate a unique response, quite different from those generated from dielectric interfaces or other sources of clutter. Such resonant responses can be observed by 8weeping the frequency over a wide bandwidth or exciting the breast tissues with a very short duration mmw pulse and then observing the resonant quasi-sinusoidal decay.
The foregoing description was aimed primarily at a prototype suitable for clinical evaluations. A commercial version may avoid the use of the boot and the elLiptical reflector (Fig. 10). For example, arrays of 6 mm rectangular waveguides may be f illed with dielectric material that has a relative dlelectric constant similar to that of the breast, roughly in the order of nine to sixteen. The rectangular guide in the TEol mode readily propagates 10 to 15 GHz frequencies. Each of the guides would be positioned in 2 0 contact with the breast, directly or through a very thin material used for one of several standard brassieres. The phase angle of the power presented to the guide-breast contact point would be i d~nt; ~ 1 to the phase angle of each ray path, some of which paths are shown in Fig. 10. For example, at positions ~92 and 194 of Fig. 10, the phase angle of the power at each of the waveguide exits would be the same 21~71~
as the phase angle for each of ray paths 191 and 193 respectively. One hundred such 6 mm guides could be positioned in a 60 mm by 60 mm flat faced rectangular array to replace the egg-shaped elliptical antenna 170 shown in Figure 10. Given a computer-aided ability to ad~ust the phase of the output power at each of the guldes, the position of each of the guides could be made to fit the contours of many dif ferent breasts . The advantage of this approach would be to permit mass screening, but at the expense of a rather complex piece of equipment. The use of computer-controlled functions and data analysis does make 6uch an approach feasible .
The foregoing can be better understood by referring to Fig. 13, which shows a nine aperture wave guide module 450.
lS Nine double-ridged wave guides 451 are used. 13ach of these are filled with a dielectric material 452 that approximates the relative dielectric constant of normal breast tissue. In the case of a screenlng system, only four wave guide apertures might be used. The com~ination of modules are pressed against the breast in place of the dielectric plate 183 of Fig. 10. By proper phasing of the signals to each of the wave guides, focal point can be positioned within the breast without the need for ^h;~nir;~l movement.
Fig. 14 illustrates one way that the phase or timing of the signal applied to the wave guides may be controlled to position the focal point in a medium 418 which contains the 2~
.
aperture antennas 410A, 410B, 410C and 410D and focal points 412 and 413. A source 400 of microwave power applies equi-phased power via wave guides 401 and 402 to two power splitters 403 and 404. The outputs of the splitters are applied, via wave guides 405A, 405B, 405C and 405D, to the circulators or directional couplers 406A, 406B, 406C and 406D. The forward power through these devices is transferred via the guides 407A, 407B, 407C and 407D to the variable time delay or phase control devices 408A, 408B, 408C and 408D.
The return power is transferred via wave guides 416A, 416B, 416C and 416D to a subsystem 417 that collects the returns in a format suitable for additional processing by subsystem 255 of Figure 6. The time delay in each device 408 may be controlled by changing the ~ n~t i r f ield bias applied to a ferrite element within each of the devices. Such bias may be supplied via the caoles 414a, 414B, 414C nd 414D from the time delay control subsystem 405. The outputs from wave guides 405 are controlled by the signal processing and display subsystem 225 of Fig. 6. Via wave guides 408A-408D, the time delayed or phased controlled power is supplied to the aperture antennas 410A - 410D. A portion of the outputs from these apertures reaches the desired focal point 412 via pathways 411A, 411B, 411C and 411D. At point 412, the phases of the rays shown are nearly identical.
~qSllminq a time delay of tl, t2, etc. for each of the delay control elements 408 and path lengths (411) dl, d2, 21~714 etc., then t1+d1/v=d4/v for constructive addition where v is the velocity of propagation in the medium 418. To meet this requirement, tl-(d4-d1)/v. Other time delays can be calculated in the same way.
other methods of control are possible by controlling the phase of the signals applied to each aperture instead of by the timing devices. In this case, the relative phase between the signals applied to apertures 411C and 411D can be fin~-l. by noting the following, where ¢~ is the radian frequency [2~Cf~ andl312 is the phase difference between 411C
and 411D, such that ~12 -~[t2 ~ tl]-The confocal arrangement permits the scattered signals to return by the same pathways as the applied wave form.
These signals are collected by the perture antennas 410 and progress back through the time delay devices 408 to the circulators 406. These, in turn supply data on the scattered returns to subsystem 417.
~ig. 15 illustrates an alternate method of scanning the interior of the breast. The microwave generation and signal recovery sybsystem 460 supplies power to an array of h~nit~;~l ly positionable wave guides 461A, 461B, 461C and 461D. Waveguides 461 are designed to slide into guides 462 so that the distal end of guides 461 is in intimate contact with the breast 463 on the ches 464 of an examination subject. As noted before, the position of each guide can be measured and this information can be used to calculate the -21~
timing or phase data needed to posltion the focal point throughout the breast. This method has the advantage that an interface plate such as 183 of Fig. 10 is not needed to compress the breast 463 and that better and more reproductible contact with the breast can be made.
Dielectric materials in solid form are available with relative dielectric constants that can eYceed 100, that have relative low losses, and that can be r^-^h i n~-l. These materials could be used to fill the elliptical reflector or the waveguides (Fig. 10). Liquid or slurry-like dielectrics with both low losses and dielectric constants at 10 GEz in the order of ten may not be readily available. However, some liquids, such as the silicones, have dielectric constants of nearly three. Such oils could be mixed with particles of materials that have dielectric constants that exceed 30 to 50 to form a slurry exhibiting a dielectric constant of the order of nine. Conversely, acetone has a dielectric constant of 22 at ten OErz, and it could be mixed with a silicone oil to produce a dielectric constant of nine for the mixture.
Other possibilities exist, including emulsions and similar techniques that allow suspensions o one liquid in another or suspensions of particles in a liquid.
The aforementioned techniques are not limited to backscatter; they can be modified or augmented to detect both side scatter and forward scatter. One forward scatter approach could use a paddle-like source antenna and a paddle-21~71~
like receiving antenna. At least one of these would function similar to the antenna illustrated in Figure 10. For example, the more pendulous portion of a breast can be placed between the paddles This would permit examination of a breast that is 100 mm thick with a system optimized for a 50 mm penetration depth.
The above may be better understood by referring to Fig.
16. Here, the breast 480 is positioned within two dielectric plates 472A and 472B. 1~ cover plate 483 and gaskets 482, together with plates 472, form a box-like structure that surrounds breast 480. The relative dielectric constant of the box wall material is similar to that of the breast. A
thin plastic film 481 covers the portion of the breast that is not in contact with the box. The space between this plastic film and the breast is filled with a liquid that has the same dielectric constant as the normal breast. A cable bundle 470 supplies microwave power to a series of waveguides 471 that are in a housing 479A on plate 472A. Upon excitation, the power in these guides is timed or phased such that the ray paths 474 come to a focal point 476. The time delay in the guides 477 in the receiving assembly 479B are timed such that any scattering occuring at point 476 will add constructively. The output of these guides is carried to the signal processing subsystem via a cable bundle 471.
The afu-, ti-~n~d techniques may also be readily modified to detect changes in the plane of polari~ation. For 21~71~
example, a Srluare TEo1 waveguide could in~ect a vertically prlAri7e~ wave and respond to a horizontally polarized wave.
Similar arrangements could be used for either side scatter or forward scatter pr,l ;'ri 7ation anomaly sensing arrangements .
Another variation would be to use the illuminator and focusing arrAn Ls described above in combination with an ~ active" or time domain method of separating the applied power from the scattered power. Other such active or time domain methods utilize a chirp radar" to produce added resolution in depth and additional clutter suppression. At a center frequency of 15 GHz a chirp radar with a swept frequency bandwidth in the order of 5 GHz and with phase correction for the dielectric behavior of the breast tissue could produce range cell resolutions of thé order of 10 mi 11 i Lers. Alternatively, sequences of very short duration bursts of 15 to 25 GHz waveforms should also provide isolation of the applied power from the backscattered power by time gating techniriues. Burst durations in the order of 100 picoseconds will provide depth discrimination of the order of 10 to 20 milli Lers. This added <li~rriminAtion would not only suppress the incident power, but also could suppress backscatter returns from the different dielectric interf aces, such as the muscles around the rib cage .
Active methods are of particular interest because these methods may be functional with total path losses in excess of 100 dB. Such path losses might be difficult to overcome with 21~714 a passive system, since it may be dif f icult to reduce clutter levels below 50 to 70 dB the applied power. Since some of the clutter can be reduced by considering only the returns in ~ust one voxel, active systems might be viable over a wider dynamic range. Also, shorter wavelengths with greater resolution can be used, since active systems can accept greater path losses, possibly as much as might be experienced by a system with an operating frequency as high as 60 GHz.
To illustrate how time domain separation can be realized in broad band pulse systems, Fig. 12 presents a further possible system 500 . Nany of the ,- ~ r~n~nts are similar to those noted in FLg. 6; they are not repeated in Fig. 12. In system 500 the power and signal direction functions of the isolator of Fig. 6 have been augmented by a modulator 540 and a source 541 of 100 to 200 picosecond pulses. In some systems, the isolator 224 may be omitted. A pulse from the pulse source 541, via cable 543, gates on the modulator 540.
This causes the modulator to ~enerate a short burst of 15 Gllz sine waves that i5 applied, via a cable 242, to the input 225 of the circulator 224. Also, the pulse source 541 supplies a timing pulse to a blanker-modulator circuit 542 and to a signal processor 575. The blanker-modulator 542 suppresses any leakage of the incident pulse through the isolator 224 from impinging on a broad-band receiver 516. The timing pulse, via the cable 544, is used by the signal processor 515 to ~ t~rminp the spatial position of the different scattered 215~
.
returns by noting the time of arrival of each of the returns.
For example, the more distant returns that might arise from the patient ' 5 rib cage would be delayed the most. The combination of a pulsed sine wave source and a hlAnkin~ -function (often called a transmit and receive function) essentially provides a power and signal direction function that could replace the cLrculator 224 function as illustrated in Fig. 6.
The pico-second-duration-pulse, time-domain system described for Fig. 1~ has some drawbacks that may be overcome by a stepped-frequency, synthetic-time domain method. For example, the noise level of the wide bandwidths needed to accommodate such short duration pulses can be quite high. On the other hand, the stepped-frequency method can have long well times at each frequency, thereby reducing the bandwidth and noise level for the signal processing system. Nhile the confocal system is a powerful tool to suppress the effect of some classes of heterogeneities, it may not provide sufficient discrimination at deep penetration depths. To mitigate this problem, a time gating technique can be used to suppress scattered returns from shallow depths. Such a method may note the presence of a weakly scattering tumor at depth. If the relative dielectric constants of the intervening material are uncertain, the geometrical position of the tumor cannot be precisely determlned. While this uncertainty poses a difficulty for an imaging system, it 21~471~
.
should not affect the via-hility of a screening system designed to detect Ahn~ l ities.
Swept frequency methods can be considered. For example, an FM Chirp radar method that has been used in weapons detection systems ef fectively separates desired returns from those generated by system discontinuities. A version of this would be attractive in con~unction with the confocal illllminAtion method to separate the effects of near surface discontinuities or hetrogeneities from the returns at greater depth. Linear F~6 pulse compression radar (PCR) techniques might also be considered. These have been described by Jacofi (7) for biological imaging applications. The theoretical resolution of a PCR is given by ~ R=C/2B, where C
is the is the velocity of propagation in the media, and B is bandwidth of the transmitted wave form. Assuming a mid-band frequency of 8 GHz, a 5 GHz sweep and a medium with a dielectric constant of nine, a range resolution of one cm is indicated. However, a 2 . 5 GHz sweep may be more readily realized and could produce an in-tissue resolution of two cm.
To realize this performance, the F3~ sweep must be highly linear, a pulse compression filter developed for this application and the dispersion effects of the dielectric compensated .
A stepped or swept frequency input impedance Fourier inversion alternative exists. This option transforms data developed from the frequency domain measurements to the time domain via digital processing, thereby eliminating the need for a pulse conpression filter. This can be implemented by using eLther the confocal illuminator of Fig. 10 or the phased array of Fig. 14. The output signals from the circuit shown in Fig. 7 on lines 346 and 345 can be viewed as a complex input ~m~ qnre, S( j ~D ), at a radian frequency of ~(~)= 2~f) to the illllminqtor. As the frequency ifi stepped from a low freque~cy to a higher frequency, the complex input imr~lAnre for each frequency is stored in a digital computer.
If the frequency is swept or stepped over a band similar to that noted for the PCR system, similar spatial resolutions can be realized. Via digital processing, the complex input impedance data is converted from the frequency domain to the tLme domain using inverse Fourier transformation. The transformed data is then in the form of an amplitude vs. time response, similar to a radar A scope display, as if an impulse or stepped function had been applied at port 234 of the cLrculator 224 in Fig. 7. Initially, the returns from system discontinuities, such as from connectors and the int~rfq--e with the antenna in the 1111lminAtor, will be displayed. Then, the reflections from qn~ c in the breast will be displayed, the reflections from the deeper ~n, ql i,~q occurring at the longer times. The stepped frequency option of fers the opportunity to include a s~andard correction at each frequency increment for a typical dispersion characteristic for normal breast tissues and could 4~
21~
.
also include compensation for other factors such as path loss or system dispersion in the ferrite phase shifters. Some of the more modern network analyzers include a built-in stepped or swept frequency to time domain processing option.
The underlying mathematical basis i8 as follows. The general Pourier trans f ormations are:
s 4-cv) _ ~, F ~ e i d~
f co ~C~f) = 2~,~- 5~J~ )e; l~v ~ .
Where F ( f ) is the impulse or step response S( j ~) is the Fourier transformation of F(f) l~= 2 ~ f, t is time.
~hroughout the foregoing specification and in the appended claims the terms millimeter waves, or mm waves or mmw have ~een used to g~n~ri ~'A 1 1 y ~.'p ~ es~l~t the wavelengths of the electromagnetic waves that propagate in the human breast tissue. Since the relative dielectric constant of the breast is in the order of 9 to 12, the free-space wave length will be reduced by a factor of three or more. ~hus, the in-tissue wavelengths over a frequency range of 3 to 60 Gl~z will range from about 30 mm to l mm.
As opposed to certain microwave hypothermia cancer treatment technology, none of the technology presented here is intended to heat significantly any portion of the breast.
2~5~71~
This requirement limits the power deposition density onto the surface of the breast to less than 10 milliwatts/cm2 and the volumetric heating rate in any portion of the breast to less than 0 . 8 milliwatts per gram of tissue as averaged over a time period of a few minutes. To further assure minimal thermal effects, the input power is to be turned off if the SrAnnin~ system falters for any reason.
Other usages are as follows: The term i ~ nre refers to the ratio of the voltage to the current or to the electric field to the magnetic field at a speci~ied location. This term imrP~i~nre is q~ if i~ as electrical~ or wave~-respectively, depending on whether voltages and current8 or electromagnetic fields are concerned. The term wave guide is used in the generic sense and inr~ s both cables and higher lS mode wave guides with just a single transverse field. The terms effective aperture and effective focal point are used in the generic sense wherein ap~ L~ s and focal points can be created physically or synthetically (such as often used in synthetic aperture radar ) .
The effective focal point is not a point but rather is defined here as a region where the i 7 ~ ~lmi n;lting energy is most concentrated in the breast. The effective focal point is further defined as the region or volume where this energy concentration occurs as affected by the heterogeneity of dielectric characteristics of the normal breast tissues, the in-tissue wavelength, the size and distance of the 21~471'1 .
illuminating globular aperture or the geometry and number of apertures used in a phased array. The focal point positioning may be either -~h~ni-~l or electronic as in the case of a phased array.
The terms "detect" or "detection" are also used in the generic sense, and may mean simply indicating the presence of a tumor or more broadly providing data that permits imaging the location, size and geometry of the tumor. Detecting, identifying, imaging or locating a tumor also means noting the presence of an ~hn~ l i ty. The terms "power and signal director~- or "input power and signal separation are also used in a generic sense. Both passive and active techniques not only enhance detection by suppressing the direct effects of impinging power waves, but also can reduce false signals or clutter. Such are introduced by imperfect matches between ;rnreriAn.-eS or by non-tumor scattering sources, such as the breast/lung interface.
Another less rl -n,iin~ mode of operation of apparatus like that of Fig. 16 is illustrated in Fig. 17. As opposed to; 1 ltlmin~ting and collecting energy from a common focal point, it may be advantageous to widen the focal point of either the i 11 llmi n~tor or the collector. The advantage is that coordinating the positions of the focal point of both the illuminator and the collector can be relaxed. As shown, the energy from the illuminator 485 is not sharply focused, but rather is contained in a region 484. On the other hand, 2~471~
.
the focal point 487 of the collector 486 i5 more tightly constrained in the breast 480. The other components illustrated in Fig. 17 are the same as for Fig. 16.
Some .1; f f i rll 1 ties have been experienced in ~aintaining a very small air gap between the base of the illuminator 47 and the scAnnin~ plate 49 for the arrangement Lllustrated in Fig.
2. In this case, the bottom of the illllminAtor is terminated by a base plate that has the same dielectric properties as the scAnnin~ plate or normal breast tissue. The ~iffjrl~lty is that, as the illuminator is ~hAnirAl ly moved, the slightest separation between the plates creates a f alse in~iratirn. The wide differences between the dielQctric constant of the plates and of the air gap between the plates is responsible.
To avoid this difficulty, the arrangements shown schematically in Figs. 18, 19 and 20 may be used. In Fig.
18, the cabinet 606 that houses the electronic circuits also supports a positioning arm 605. Arm 605 locates the position of an illuminator 604. A flf~ihlr boot 603 is attached to the base plate 610 of the i 11 llmi nAtor 604 and also to a scanning plate 602. The boot contains a liquid (or a flowable dielectric slurry or powder 611) that has about the same dielectric characteristic as a normal human breast. The scanning plate 602 compresses the breast 601 of a patient 600. 33ecause the dielectric properties of the materials within illuminator 604, base plate 610, liquid 611, scanning 2~
.
plate 602, and breast 601 are all about the same, the focal point 60g can J:e moved in three dimensions without air gap discontLnuities by positioning the; 1 l~lminAtor 604, using the positioning arm 605.
The arrzLngement shown in Fig. 19 is similar to that shown in Fig. 18, except that the scanning plate 602 has been removed and ~he liquid dielectric 611 within the boot 603 is allowed to contact the breast directly. A gasket 616 is attached to the boot 603 to prevent the liquid 611 from lealcing. The surface 612 of the dielectric liquid should be well above the breast. This arrAn~, L has the advantage that all intr~rinr portions of the breast can be readily scanned. An arrangement similar to that shown in Fig. 19 is also attractive when the patient is placed in a prone position.
Fig . 2 0 illustrates how the illuminator and its base plate 610 can be positioned with the scanning plate 602 without ^hAn~rAl sliding contact in areas of intense illumination 617. Spacers 61~ are used to position the base plate 610 with respect to the scanning plate 602. The dielectric liquid 611 fills the space between the plates, preventing the development of an air gap such as might occur if just the base plate contacted the scanning plate dLrectly.
..
21~714 .
The following references are of utility in understanding the foregoing specification:
Burdette, E. C., et. al.(l980): In vivo mea~l L
technioues for de~Prm;n;n~ dielectric properties at V~IF
through microwave frequencies, IEEE Trans. on ~TT, Vol MTT-28, No. 4 April, pp 414-427 Burdette, E. C., et. al. (1986): In situ permittivity at microwave frequenciesz perspective, techniques, results, medical applications of microwave imaging, Medical Applications of Microwave Imaging, Larsen, 1. E. and J. 11.
Jacobi, IEEE press pp 13-40 ~h~l]~h;lry, S . S ., et. al. ( 1984 ): Dielectric properties of normal and malignant human breast tissues at radiowave and microwave frequencies, Indian Jr. of Biochemistry and biophysiscs, Vol. 21, Feb pp76-79 Edrich, J., et. al. (1976~: Complex permittivity and penetration depth of muscle and fat tissues between 40 and 90 GHz, (1976) IEEE Trans. NTT, vol. MTT-24, Nay pp273-275.
Johnson, E. C., et. al. (1972): yon;~ni~inJ electromagnetic wave effects in biological materials and systems, Proc. of the IEEE, Vol. 60, No. 6, June pp 694-695.
Ray A. F. (1966): Mi11i Ler wave antennas, Proc. of the IEEÉ, Vol. 54, No. 4, pp 641-647 Larson, E. E. and J. H. Jacobi, Eds. ( 1986): Medical Applications of Microwave Imaging, IEEE press. Institute of Electrical and Electronic ~ntJi nf~rS, New York Ramo, S., et. al. (1965): Fields and Waves in C~ i, ation Electronics, John Niley and Sons, New York Rogers, J. A., et. al. (1983): The dielectric properties of normal and tumor mouse tissue between 50 M~Iz and 10 GE~z, British Jr. of Radiology, vol. 56, May, pp 335-338.
Smith, N. J., (1966): Modern Optical Eng;n~ r;n~, Mc Graw-Eiill, New York, N. Y.
Claims (53)
1. A method of detecting the presence of a tumor or an incipient tumor in the tissue of a living organism, such as the tissue of a human breast, which non-tumor tissue has a predetermined dielectric characteristic different from the corresponding dielectric characteristic of a tumor, the method comprising the following steps:
A . generating a non-ionizing electromagnetic input wave of preselected frequency;
B. illuminating the tissue of a living organism with the input wave of step A, focused into a first small, discrete volume at a predetermined illumination position within the tissue to develop a non-ionizing electromagnetic wave at that position;
C. moving the illumination location of step B over a preselected portion of the tissue in a predetermined scanning pattern;
D. receiving scattered returns from the tissue while it is being scanned in step C to develop a scattered return signal; and E. processing the scattered return signal to detect any anomaly in that signal indicative of the presence of a tumor in the scanned tissue.
A . generating a non-ionizing electromagnetic input wave of preselected frequency;
B. illuminating the tissue of a living organism with the input wave of step A, focused into a first small, discrete volume at a predetermined illumination position within the tissue to develop a non-ionizing electromagnetic wave at that position;
C. moving the illumination location of step B over a preselected portion of the tissue in a predetermined scanning pattern;
D. receiving scattered returns from the tissue while it is being scanned in step C to develop a scattered return signal; and E. processing the scattered return signal to detect any anomaly in that signal indicative of the presence of a tumor in the scanned tissue.
2. A method of detecting a tumor in the tissue of a living organism, according to Claim 1, in which, in step E, the scattered return signal of step D is processed to form a multi-dimensional image of a tumor.
3. A method of detecting a tumor in the tissue of a living organism, according to Claim 1, in which, in step A, the preselected frequency has a wavelength, in a medium having a dielectric characteristic corresponding to that of non-tumor tissue, no greater than three times the circumference of the smallest tumor to be detected.
4. A method of detecting a tumor in the tissue of a living organism, according to Claim 1, in which, in step A, the wavelength of the electromagnetic input wave, in a medium having a dielectric characteristic corresponding to that of non-tumor tissue, is in a range of one to thirty millimeters.
5. A method of detecting a tumor in the tissue of a living organism, according to Claim 1, in which, in step B, illumination of the tissue is effected through a medium having a dielectric characteristic like that of the non-tumor tissue and different from that of a tumor.
6. A method of detecting a tumor in the tissue of a living organism, according to Claim 1, including the following additional step:
X. controlling the input wave of step B and the scattered return signal of step D to separate the scattered return signal from the input wave .
X. controlling the input wave of step B and the scattered return signal of step D to separate the scattered return signal from the input wave .
7. A method of detecting a tumor in the tissue of a living organism, according to Claim 6, in which, in step A, the preselected frequency is in a range of three to ninety gigahertz.
8. A method of detecting a tumor in the tissue of a living organism, according to Claim 7, in which the separation of step X
is effected by passive devices.
is effected by passive devices.
9. A method of detecting a tumor in the tissue of a living organism, according to Claim 7, in which the separation of step X
is effected by active devices.
is effected by active devices.
10. A method of detecting a tumor in the tissue of a living organism, according to Claim 6, in which the separation of step X
is effected by passive devices.
is effected by passive devices.
11. A method of detecting a tumor in the tissue of a living organism, according to Claim 6, in which the separation of step X is effected by active devices.
12. A method of detecting a tumor in the tissue of a living organism, according to Claim 1, in which, in step A, the preselected frequency is in a range of three to ninety gigahertz.
13. A method of detecting a tumor in the tissue of a living organism, according to Claim 12, in which polarization of scattered returns are utilized to enhance the reliability of detecting the presence of a tumor.
14. A method of detecting a tumor in the tissue of a living organism, according to Claim 12, in which tumor-induced resonant anomalies in the scattered returns are utilized to enhance the reliability of detecting the presence of a tumor.
15. A method of detecting a tumor in the tissue of a living organism, according to Claim 12, in which tumor-induced anomalies in the direction of scatter, such as back scatter, forward scatter, or side scatter, are utilized to enhance the reliability of detecting the presence of a tumor.
16. A method of detecting a tumor in the tissue of a living organism, according to Claim 1, including the following additional steps:
B'. after step C, focusing the illuminating wave at a second predetermined illumination position at a level within the tissue different from the level of the first position; and C'. moving the illumination location of step B' over the preselected portion of the tissue in the predetermined scanning pattern, thereby scanning the tissue in a three-dimensional pattern.
B'. after step C, focusing the illuminating wave at a second predetermined illumination position at a level within the tissue different from the level of the first position; and C'. moving the illumination location of step B' over the preselected portion of the tissue in the predetermined scanning pattern, thereby scanning the tissue in a three-dimensional pattern.
17. A non-invasive system utilizing non-ionizing electromagnetic millimeter waves of minimal thermal heating capacity for detection of a tumor in a breast, comprising:
a generator for generating a non-ionizing electromagnetic input wave having a frequency in excess of three gigahertz;
illumination means for focusing and directing an electromagnetic wave to impinge upon an effective focal point at a predetermined position within a breast;
wave impedance matching means, in the illumination means, matching the impedance of the illumination means to the wave impedance of normal breast tissue;
a wave guide for applying the input wave from the generator to the breast through the illumination means;
focal point positioner means, connected to the illumination means, for moving the focal point across the breast in a predetermined pattern to scan selected incremental volumes within the breast;
a scattered wave collector positioned to intercept scattered waves from the incremental volumes within the breast and develop a return signal representative of the scattered waves from within the breast;
and a receiver, including a detector, connected to the scattered wave collector, for detecting anomalies in the return signal to identify a tumor and its location in the breast.
a generator for generating a non-ionizing electromagnetic input wave having a frequency in excess of three gigahertz;
illumination means for focusing and directing an electromagnetic wave to impinge upon an effective focal point at a predetermined position within a breast;
wave impedance matching means, in the illumination means, matching the impedance of the illumination means to the wave impedance of normal breast tissue;
a wave guide for applying the input wave from the generator to the breast through the illumination means;
focal point positioner means, connected to the illumination means, for moving the focal point across the breast in a predetermined pattern to scan selected incremental volumes within the breast;
a scattered wave collector positioned to intercept scattered waves from the incremental volumes within the breast and develop a return signal representative of the scattered waves from within the breast;
and a receiver, including a detector, connected to the scattered wave collector, for detecting anomalies in the return signal to identify a tumor and its location in the breast.
18. A non-invasive system for detection of a tumor in a breast according to Claim 17 and further comprising:
separator means, connected to the scattered wave collector, for separating the scattered wave signals from the input wave in developing the return signal.
separator means, connected to the scattered wave collector, for separating the scattered wave signals from the input wave in developing the return signal.
19. A non-invasive system for detection of a tumor in a breast according to Claim 17, in which:
the reflection receiver is a part of the illumination means;
and further comprising separator means, connected to the scattered wave collector, for separating the scattered wave signals from the input wave in developing the return signal.
the reflection receiver is a part of the illumination means;
and further comprising separator means, connected to the scattered wave collector, for separating the scattered wave signals from the input wave in developing the return signal.
20. A non-invasive system for detection of a tumor in a breast according to Claim 17 in which:
the illumination means comprises a globular antenna filled with a first dielectric medium;
the illumination means further comprises a connecting device, connecting the antenna to the breast, filled with a second dielectric medium; and the dielectric constants of the breast, the first dielectric medium, and the second dielectric medium are all approximately equal to each other.
the illumination means comprises a globular antenna filled with a first dielectric medium;
the illumination means further comprises a connecting device, connecting the antenna to the breast, filled with a second dielectric medium; and the dielectric constants of the breast, the first dielectric medium, and the second dielectric medium are all approximately equal to each other.
21. A non-invasive system for detection of a tumor in a breast according to Claim 20 in which the globular antenna is of truncated ellipsoidal configuration and functions as a part of the transmitter and a part of the collector.
22. A non-invasive system for detection of a tumor in a breast according to Claim 17 in which the focal point positioner means includes a mechanical scanner to change the location of the illuminator means relative to the breast.
23. A non-invasive system for detection of a tumor in a breast according to Claim 22 and further comprising:
focal point indication means, connected to the mechanical scanner; and imaging means, connected to the receiver and to the focal point indication means for displaying an image of the breast including a representation of any tumor therein.
focal point indication means, connected to the mechanical scanner; and imaging means, connected to the receiver and to the focal point indication means for displaying an image of the breast including a representation of any tumor therein.
24. A non-invasive system for detection of a tumor in a breast according to Claim 17 and further comprising a connection from the generator to the receiver, for applying a portion of the input wave to the receiver to provide a frequency and phase reference receiver.
25. A non-invasive system for detection of a tumor in a breast according to Claim 24 in which the receiver includes two detectors operated in phase quadrature to each other.
26. A non-invasive system for detection of a tumor in a breast according to Claim 25 in which the connection from the generator to the receiver includes a phase shift circuit for shifting the input wave, as applied to one of the detectors, by an add multiple of 90° relative to the input wave as supplied to the other detector.
27. A non-invasive system for detection of a tumor in a breast according to Claim 26 in which each of the detectors is a hybrid tee.
28. A non-invasive system for detection of a tumor in a breast according to Claim 17 in which the receiver includes both an amplitude detector and a phase detector, whereby both amplitude and phase of the return signal are used to identify an anomalous return signifying a possible tumor.
29. A non-invasive system for detection of a tumor in a breast according to Claim 18 in which the separator means includes a circulator.
30. A non-invasive system for detection of a tumor in a breast according to Claim 18 in which the separator means includes polarization-responsive means for separating the input wave from the return signal based on polarization of the return signal .
31. A non-invasive system for detection of a tumor in a breast according to Claim 18 in which:
the separator means includes a pulse source of repetitive pulse signals; and the system further comprises display means, connected to the pulse source of the separator means and to the receiver, for displaying the returns as a function of time;
the rise time for each pulse signal being no greater than 300 pico-seconds.
the separator means includes a pulse source of repetitive pulse signals; and the system further comprises display means, connected to the pulse source of the separator means and to the receiver, for displaying the returns as a function of time;
the rise time for each pulse signal being no greater than 300 pico-seconds.
32. A non-invasive system for detection of a tumor in a breast according to Claim 18 in which the pulse source is a part of a frequency-modulated pulse compression system that employs a frequency bandwidth of at least three gigahertz.
33. A non-invasive system for detection of a tumor in a breast according to Claim 18 and further comprising compensation means for compensating for change in the dielectric constant of the breast as a function of frequency.
34. A non-invasive system for detection of a tumor in a breast according to Claim 17 in which the distance from the effective focal point to the effective aperture of the illuminator is no greater than four times the diameter of the effective aperture.
35. An illumination means for a non-invasive system for the detection of a tumor in the breast according to Claim 17 comprising:
an array of independently excitable and movable wave guides;
means to controllably and independently position the open end of each of the wave guides to contact the surface of the breast with little or no space between the open end of the guide and the breast;
means to note the position of each of the contact points between the open ends of the wave guide and the surface of the breast;
means to control the phase angle of the input wave presented at the contact points in accordance with the position of the contact point; and means to change the phase angle of the input wave at the contact point such that the individual waves that propagate from each of the wave guides add constructively to form an effective focal point within a predetermined incremental volume within the breast.
an array of independently excitable and movable wave guides;
means to controllably and independently position the open end of each of the wave guides to contact the surface of the breast with little or no space between the open end of the guide and the breast;
means to note the position of each of the contact points between the open ends of the wave guide and the surface of the breast;
means to control the phase angle of the input wave presented at the contact points in accordance with the position of the contact point; and means to change the phase angle of the input wave at the contact point such that the individual waves that propagate from each of the wave guides add constructively to form an effective focal point within a predetermined incremental volume within the breast.
36. An illumination means for a non-invasive system for the detection of a tumor in the breast according to Claim 35, wherein each of the wave guides is filled with a material whose dielectric properties are similar to those of the human breast.
37. An illumination means for a non-invasive system for detection of a breast tumor according to Claim 36 in which the material filling the wave guides has a relative dielectric constant in a range of four to twenty.
38. An illumination means for a non-invasive system for detection of a breast tumor according to Claim 37 and further comprising:
an interface, between the breast and the wave guides, having a relative dielectric constant in a range of four to twenty.
an interface, between the breast and the wave guides, having a relative dielectric constant in a range of four to twenty.
39. An illumination means for a non-invasive system for detection of a breast tumor according to Claim 37 and further comprising means to move the array of wave guides and the interface mechanically to scan the breast.
40. A non-invasive system utilizing non-ionizing electromagnetic millimeter waves of minimal thermal heating capacity for detection of a tumor in a breast, comprising:
a generator for generating a non-ionizing electromagnetic input wave having a frequency in excess of three gigahertz;
illumination means for directing an electromagnetic wave into a volume that contains a predetermined effective focal point within a breast;
wave impedance matching means, in the illumination means, matching the impedance of the illumination means to the wave impedance of normal breast tissue;
a wave guide for applying the input wave from the generator to the breast through the illumination means;
focal point positioner means, connected to the illumination means, for moving the focal point across the breast in a predetermined pattern to scan selected incremental volumes within the breast;
scattered wave collector means for collecting scattered waves from the predetermined effective focal point and developing a return signal representative of scattered waves from within the breast;
and a receiver, including a detector, connected to the scattered wave collector means, for detecting anomalies in the return signal to identify a tumor and its location in the breast .
a generator for generating a non-ionizing electromagnetic input wave having a frequency in excess of three gigahertz;
illumination means for directing an electromagnetic wave into a volume that contains a predetermined effective focal point within a breast;
wave impedance matching means, in the illumination means, matching the impedance of the illumination means to the wave impedance of normal breast tissue;
a wave guide for applying the input wave from the generator to the breast through the illumination means;
focal point positioner means, connected to the illumination means, for moving the focal point across the breast in a predetermined pattern to scan selected incremental volumes within the breast;
scattered wave collector means for collecting scattered waves from the predetermined effective focal point and developing a return signal representative of scattered waves from within the breast;
and a receiver, including a detector, connected to the scattered wave collector means, for detecting anomalies in the return signal to identify a tumor and its location in the breast .
41. A non-invasive system for detection of a tumor in a breast, according to Claim 40 in which the generator further generates a synchronizing signal and supplies that synchronizing signal to the receiver.
42. A non-invasive system for detection of a tumor in a breast, according to Claim 40, in which the dielectric constants are in a range of four to twenty.
43. A method of detecting a tumor in the tissue of a living organism, according to Claim 3, in which the dielectric characteristic of the medium is a relative dielectric constant in a range of four to twenty.
44. A non-invasive system for detection of a tumor in a breast, according to Claim 17 in which the generator further generates a synchronizing signal and supplies that synchronizing signal to the receiver.
45. A non-invasive system for detection of a tumor in a breast, according to Claim 17, comprising at least two scattered wave collectors, disposed on opposite sides of the breast.
46. A non-invasive system for detection of a tumor in a breast, according to Claim 20, in which the dielectric constants are in a range of four to twenty.
47. A non-invasive system for detection of a tumor in a breast, according to Claim 25, in which the receiver includes 2 directional coupler.
48. A non-invasive system for detection of a tumor in a breast, according to Claim 18, in which a synthetic time-domain response is developed from the Fourier inversion of the complex input impedance data as the frequency of the illumination signal is progressively changed over a bandwidth of at least two gigahertz.
49. A non-invasive system for the detection of a tumor, according to Claim 48, and further comprising means to compensate for the changes in the equipment behavoir as a function of frequency.
50. A non-invasive system for the detection of a tumor, according to Claim 48, and further comprising means to compensate for the path loss attenuation as the illuminating signal progresses into the breast.
51. A method of detecting a tumor in the tissue of a living organism, according to Claim 1, in which, in step E, the scattered return signals of step D taken at one time are compared with the scattered return signals of step D taken at a different time .
52. A method of detecting a tumor in the tissue of a living organism, according to Claim 1, in which, in step E, the scattered return signals of step D taken from one breast are compared with the scattered return signals of step D taken from the opposite breast.
53. A non-invasive system for detection of a tumor in a breast, according to Claim 17, and further comprising a flowable dielectric between the illumination means and the wave collector
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2154714 CA2154714A1 (en) | 1995-07-26 | 1995-07-26 | Breast cancer detection, imaging, and screening by electromagnetic millimeter waves |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2154714 CA2154714A1 (en) | 1995-07-26 | 1995-07-26 | Breast cancer detection, imaging, and screening by electromagnetic millimeter waves |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2154714A1 true CA2154714A1 (en) | 1997-01-27 |
Family
ID=4156300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2154714 Abandoned CA2154714A1 (en) | 1995-07-26 | 1995-07-26 | Breast cancer detection, imaging, and screening by electromagnetic millimeter waves |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2154714A1 (en) |
-
1995
- 1995-07-26 CA CA 2154714 patent/CA2154714A1/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0694282B1 (en) | Breast cancer detection and imaging by electromagnetic millimeter waves | |
US5704355A (en) | Non-invasive system for breast cancer detection | |
US5829437A (en) | Microwave method and system to detect and locate cancers in heterogenous tissues | |
Porter et al. | A wearable microwave antenna array for time-domain breast tumor screening | |
Klemm et al. | Radar-based breast cancer detection using a hemispherical antenna array—Experimental results | |
Li et al. | Microwave imaging via space-time beamforming: Experimental investigation of tumor detection in multilayer breast phantoms | |
Hagness et al. | Three-dimensional FDTD analysis of a pulsed microwave confocal system for breast cancer detection: Design of an antenna-array element | |
Nikolova | Microwave imaging for breast cancer | |
Smith et al. | Microwave imaging using indirect holographic techniques | |
EP2234539B1 (en) | Synthetic aperture radar system | |
WO1998052464A1 (en) | Electromagnetical imaging and therapeutic (emit) systems | |
EP3315075B1 (en) | System and method for combined microwave and ultrasound imaging | |
US8948847B2 (en) | Millimeter wave 3-D breast imaging | |
Moscato et al. | A mm‐wave 2D ultra‐wideband imaging radar for breast cancer detection | |
Alsaedi et al. | A breast cancer detection system using metasurfaces with a convolution neural network: A feasibility study | |
Porter et al. | Microwave breast screening in the time-domain: Identification and compensation of measurement-induced uncertainties | |
Curtis | Factors affecting image quality in near-field ultra-wideband radar imaging for biomedical applications | |
CA2154714A1 (en) | Breast cancer detection, imaging, and screening by electromagnetic millimeter waves | |
Diaz-Bolado et al. | Towards a planar Microwave Tomography system for early stage breast cancer detection | |
Jacobsen et al. | Improved Resolution and Reduced Clutter in Ultra‐Wideband Microwave Imaging Using Cross‐Correlated Back Projection: Experimental and Numerical Results | |
Hagness et al. | FDTD analysis of a pulsed microwave confocal system for breast cancer detection | |
Khor et al. | Investigations into breast cancer detection using ultra wide band microwave radar technique | |
Zhang et al. | Experimental study on radar-based breast cancer detection using UWB antennas without background subtraction | |
Bindu et al. | Detection of dielectric contrast of breast tissues using confocal microwave technique | |
Lalitha et al. | Design Of Uwb Vivaldi Antenna For Stroke Detection And Monitoring Based OnQualitative Microwave Imaging Technique. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |
Effective date: 20060526 |